SIN3B: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Paired amphipathic helix protein Sin3b''' is a [[protein]] that in humans is encoded by the ''SIN3B'' [[gene]].<ref name="pmid9734811">{{cite journal | vauthors = Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Research | volume = 5 | issue = 3 | pages = 169–76 | date = Jun 1998 | pmid = 9734811 | pmc =  | doi = 10.1093/dnares/5.3.169 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23309| accessdate = }}</ref>
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| require_manual_inspection = no
| update_protein_box = yes
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| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_SIN3B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1e91.
| PDB = {{PDB2|1e91}}, {{PDB2|1pd7}}, {{PDB2|2cr7}}, {{PDB2|2czy}}, {{PDB2|2f05}}
| Name = SIN3 homolog B, transcription regulator (yeast)
| HGNCid = 19354
| Symbol = SIN3B
| AltSymbols =; KIAA0700
| OMIM = 607777
| ECnumber = 
| Homologene = 81810
| MGIid = 107158
| GeneAtlas_image1 = PBB_GE_SIN3B_209352_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SIN3B_39705_at_tn.png
| Function = {{GNF_GO|id=GO:0003714 |text = transcription corepressor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0045892 |text = negative regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23309
    | Hs_Ensembl = ENSG00000127511
    | Hs_RefseqProtein = NP_056075
    | Hs_RefseqmRNA = NM_015260
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 16801211
    | Hs_GenLoc_end = 16852164
    | Hs_Uniprot = O75182
    | Mm_EntrezGene = 20467
    | Mm_Ensembl = ENSMUSG00000031622
    | Mm_RefseqmRNA = NM_009188
    | Mm_RefseqProtein = NP_033214
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 8
    | Mm_GenLoc_start = 75619370
    | Mm_GenLoc_end = 75653477
    | Mm_Uniprot = Q3TN09
  }}
}}
'''SIN3 homolog B, transcription regulator (yeast)''', also known as '''SIN3B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23309| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
SIN3B has been shown to [[Protein-protein interaction|interact]] with [[HDAC1]],<ref name=pmid10444591>{{cite journal | vauthors = Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D | title = Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation | journal = Genes & Development | volume = 13 | issue = 15 | pages = 1924–35 | date = Aug 1999 | pmid = 10444591 | pmc = 316920 | doi = 10.1101/gad.13.15.1924 }}</ref><ref name=pmid10357820>{{cite journal | vauthors = Koipally J, Renold A, Kim J, Georgopoulos K | title = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | journal = The EMBO Journal | volume = 18 | issue = 11 | pages = 3090–100 | date = Jun 1999 | pmid = 10357820 | pmc = 1171390 | doi = 10.1093/emboj/18.11.3090 }}</ref> [[Zinc finger and BTB domain-containing protein 16]],<ref name=pmid9627120>{{cite journal | vauthors = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–56 | date = May 1998 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043 }}</ref> [[SUDS3]]<ref name=pmid11909966>{{cite journal | vauthors = Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA | title = Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2743–50 | date = Apr 2002 | pmid = 11909966 | pmc = 133736 | doi = 10.1128/MCB.22.8.2743-2750.2002 }}</ref> and [[IKZF1]].<ref name=pmid10357820/><ref name=pmid12015313>{{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–705 | date = Aug 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==See also==
== See also ==
* [[Transcription coregulator]]
* [[Transcription coregulator]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Ayer DE, Lawrence QA, Eisenman RN | title = Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3 | journal = Cell | volume = 80 | issue = 5 | pages = 767–76 | date = Mar 1995 | pmid = 7889570 | doi = 10.1016/0092-8674(95)90355-0 }}
| citations =
* {{cite journal | vauthors = David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A | title = Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein | journal = Oncogene | volume = 16 | issue = 19 | pages = 2549–56 | date = May 1998 | pmid = 9627120 | doi = 10.1038/sj.onc.1202043 }}
*{{cite journal | author=Ayer DE, Lawrence QA, Eisenman RN |title=Mad-Max transcriptional repression is mediated by ternary complex formation with mammalian homologs of yeast repressor Sin3. |journal=Cell |volume=80 |issue= 5 |pages= 767-76 |year= 1995 |pmid= 7889570 |doi= }}
* {{cite journal | vauthors = Koipally J, Renold A, Kim J, Georgopoulos K | title = Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes | journal = The EMBO Journal | volume = 18 | issue = 11 | pages = 3090–100 | date = Jun 1999 | pmid = 10357820 | pmc = 1171390 | doi = 10.1093/emboj/18.11.3090 }}
*{{cite journal | author=David G, Alland L, Hong SH, ''et al.'' |title=Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein. |journal=Oncogene |volume=16 |issue= 19 |pages= 2549-56 |year= 1998 |pmid= 9627120 |doi= 10.1038/sj.onc.1202043 }}
* {{cite journal | vauthors = Naruse Y, Aoki T, Kojima T, Mori N | title = Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 24 | pages = 13691–6 | date = Nov 1999 | pmid = 10570134 | pmc = 24126 | doi = 10.1073/pnas.96.24.13691 }}
*{{cite journal | author=Ishikawa K, Nagase T, Suyama M, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 3 |pages= 169-76 |year= 1998 |pmid= 9734811 |doi=  }}
* {{cite journal | vauthors = Spronk CA, Tessari M, Kaan AM, Jansen JF, Vermeulen M, Stunnenberg HG, Vuister GW | title = The Mad1-Sin3B interaction involves a novel helical fold | journal = Nature Structural Biology | volume = 7 | issue = 12 | pages = 1100–4 | date = Dec 2000 | pmid = 11101889 | doi = 10.1038/81944 }}
*{{cite journal  | author=Koipally J, Renold A, Kim J, Georgopoulos K |title=Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes. |journal=EMBO J. |volume=18 |issue= 11 |pages= 3090-100 |year= 1999 |pmid= 10357820 |doi= 10.1093/emboj/18.11.3090 }}
* {{cite journal | vauthors = Spronk CA, Jansen JF, Tessari M, Kaan AM, Aelen J, Lasonder E, Stunnenberg HG, Vuister GW | title = Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1 | journal = Journal of Biomolecular NMR | volume = 19 | issue = 4 | pages = 377–8 | date = Apr 2001 | pmid = 11370785 | doi = 10.1023/A:1011262214741 }}
*{{cite journal | author=Naruse Y, Aoki T, Kojima T, Mori N |title=Neural restrictive silencer factor recruits mSin3 and histone deacetylase complex to repress neuron-specific target genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 24 |pages= 13691-6 |year= 2000 |pmid= 10570134 |doi= }}
* {{cite journal | vauthors = Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA | title = Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2743–50 | date = Apr 2002 | pmid = 11909966 | pmc = 133736 | doi = 10.1128/MCB.22.8.2743-2750.2002 }}
*{{cite journal | author=Spronk CA, Tessari M, Kaan AM, ''et al.'' |title=The Mad1-Sin3B interaction involves a novel helical fold. |journal=Nat. Struct. Biol. |volume=7 |issue= 12 |pages= 1100-4 |year= 2001 |pmid= 11101889 |doi= 10.1038/81944 }}
* {{cite journal | vauthors = Rayman JB, Takahashi Y, Indjeian VB, Dannenberg JH, Catchpole S, Watson RJ, te Riele H, Dynlacht BD | title = E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex | journal = Genes & Development | volume = 16 | issue = 8 | pages = 933–47 | date = Apr 2002 | pmid = 11959842 | pmc = 152357 | doi = 10.1101/gad.969202 }}
*{{cite journal | author=Spronk CA, Jansen JF, Tessari M, ''et al.'' |title=Sequence-specific assignment of the PAH2 domain of Sin3B free and bound to Mad1. |journal=J. Biomol. NMR |volume=19 |issue= 4 |pages= 377-8 |year= 2001 |pmid= 11370785 |doi= }}
* {{cite journal | vauthors = Koipally J, Georgopoulos K | title = A molecular dissection of the repression circuitry of Ikaros | journal = The Journal of Biological Chemistry | volume = 277 | issue = 31 | pages = 27697–705 | date = Aug 2002 | pmid = 12015313 | doi = 10.1074/jbc.M201694200 }}
*{{cite journal | author=Alland L, David G, Shen-Li H, ''et al.'' |title=Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex. |journal=Mol. Cell. Biol. |volume=22 |issue= 8 |pages= 2743-50 |year= 2002 |pmid= 11909966 |doi= }}
* {{cite journal | vauthors = Yang L, Mei Q, Zielinska-Kwiatkowska A, Matsui Y, Blackburn ML, Benedetti D, Krumm AA, Taborsky GJ, Chansky HA | title = An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B | journal = The Biochemical Journal | volume = 369 | issue = Pt 3 | pages = 651–7 | date = Feb 2003 | pmid = 12398767 | pmc = 1223118 | doi = 10.1042/BJ20020854 }}
*{{cite journal | author=Rayman JB, Takahashi Y, Indjeian VB, ''et al.'' |title=E2F mediates cell cycle-dependent transcriptional repression in vivo by recruitment of an HDAC1/mSin3B corepressor complex. |journal=Genes Dev. |volume=16 |issue= 8 |pages= 933-47 |year= 2002 |pmid= 11959842 |doi= 10.1101/gad.969202 }}
* {{cite journal | vauthors = Petrie K, Guidez F, Howell L, Healy L, Waxman S, Greaves M, Zelent A | title = The histone deacetylase 9 gene encodes multiple protein isoforms | journal = The Journal of Biological Chemistry | volume = 278 | issue = 18 | pages = 16059–72 | date = May 2003 | pmid = 12590135 | doi = 10.1074/jbc.M212935200 }}
*{{cite journal | author=Koipally J, Georgopoulos K |title=A molecular dissection of the repression circuitry of Ikaros. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27697-705 |year= 2002 |pmid= 12015313 |doi= 10.1074/jbc.M201694200 }}
* {{cite journal | vauthors = Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W | title = Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1 | journal = Genes & Development | volume = 17 | issue = 7 | pages = 896–911 | date = Apr 2003 | pmid = 12670868 | pmc = 196026 | doi = 10.1101/gad.252103 }}
*{{cite journal | author=Yang L, Mei Q, Zielinska-Kwiatkowska A, ''et al.'' |title=An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B. |journal=Biochem. J. |volume=369 |issue= Pt 3 |pages= 651-7 |year= 2003 |pmid= 12398767 |doi= 10.1042/BJ20020854 }}
* {{cite journal | vauthors = Dugast-Darzacq C, Pirity M, Blanck JK, Scherl A, Schreiber-Agus N | title = Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential | journal = Oncogene | volume = 23 | issue = 55 | pages = 8887–99 | date = Nov 2004 | pmid = 15467743 | doi = 10.1038/sj.onc.1208107 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Rampalli S, Pavithra L, Bhatt A, Kundu TK, Chattopadhyay S | title = Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex | journal = Molecular and Cellular Biology | volume = 25 | issue = 19 | pages = 8415–29 | date = Oct 2005 | pmid = 16166625 | pmc = 1265755 | doi = 10.1128/MCB.25.19.8415-8429.2005 }}
*{{cite journal  | author=Petrie K, Guidez F, Howell L, ''et al.'' |title=The histone deacetylase 9 gene encodes multiple protein isoforms. |journal=J. Biol. Chem. |volume=278 |issue= 18 |pages= 16059-72 |year= 2003 |pmid= 12590135 |doi= 10.1074/jbc.M212935200 }}
* {{cite journal | vauthors = Xu Y, Sengupta PK, Seto E, Smith BD | title = Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression | journal = The Journal of Biological Chemistry | volume = 281 | issue = 14 | pages = 9260–70 | date = Apr 2006 | pmid = 16464847 | pmc = 1434794 | doi = 10.1074/jbc.M511724200 }}
*{{cite journal | author=Wysocka J, Myers MP, Laherty CD, ''et al.'' |title=Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1. |journal=Genes Dev. |volume=17 |issue= 7 |pages= 896-911 |year= 2003 |pmid= 12670868 |doi= 10.1101/gad.252103 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Dugast-Darzacq C, Pirity M, Blanck JK, ''et al.'' |title=Mxi1-SRalpha: a novel Mxi1 isoform with enhanced transcriptional repression potential. |journal=Oncogene |volume=23 |issue= 55 |pages= 8887-99 |year= 2004 |pmid= 15467743 |doi= 10.1038/sj.onc.1208107 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Rampalli S, Pavithra L, Bhatt A, ''et al.'' |title=Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex. |journal=Mol. Cell. Biol. |volume=25 |issue= 19 |pages= 8415-29 |year= 2005 |pmid= 16166625 |doi= 10.1128/MCB.25.19.8415-8429.2005 }}
*{{cite journal | author=Xu Y, Sengupta PK, Seto E, Smith BD |title=Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression. |journal=J. Biol. Chem. |volume=281 |issue= 14 |pages= 9260-70 |year= 2006 |pmid= 16464847 |doi= 10.1074/jbc.M511724200 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=23309}}


==External links==
== External links ==
* {{MeshName|SIN3B+protein,+human}}
* {{MeshName|SIN3B+protein,+human}}


{{protein-stub}}
{{NLM content}}
{{NLM content}}
{{Transcription coregulators}}
{{Transcription coregulators}}
[[Category:Gene expression]]
[[Category:Gene expression]]
[[Category:Transcription coregulators]]
[[Category:Transcription coregulators]]
{{WikiDoc Sources}}
 
 
{{gene-19-stub}}

Latest revision as of 06:22, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Paired amphipathic helix protein Sin3b is a protein that in humans is encoded by the SIN3B gene.[1][2]

Interactions

SIN3B has been shown to interact with HDAC1,[3][4] Zinc finger and BTB domain-containing protein 16,[5] SUDS3[6] and IKZF1.[4][7]

See also

References

  1. ↑ Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Jun 1998). "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Research. 5 (3): 169–76. doi:10.1093/dnares/5.3.169. PMID 9734811.
  2. ↑ "Entrez Gene: SIN3B SIN3 homolog B, transcription regulator (yeast)".
  3. ↑ Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D (Aug 1999). "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation". Genes & Development. 13 (15): 1924–35. doi:10.1101/gad.13.15.1924. PMC 316920. PMID 10444591.
  4. ↑ 4.0 4.1 Koipally J, Renold A, Kim J, Georgopoulos K (Jun 1999). "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal. 18 (11): 3090–100. doi:10.1093/emboj/18.11.3090. PMC 1171390. PMID 10357820.
  5. ↑ David G, Alland L, Hong SH, Wong CW, DePinho RA, Dejean A (May 1998). "Histone deacetylase associated with mSin3A mediates repression by the acute promyelocytic leukemia-associated PLZF protein". Oncogene. 16 (19): 2549–56. doi:10.1038/sj.onc.1202043. PMID 9627120.
  6. ↑ Alland L, David G, Shen-Li H, Potes J, Muhle R, Lee HC, Hou H, Chen K, DePinho RA (Apr 2002). "Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex". Molecular and Cellular Biology. 22 (8): 2743–50. doi:10.1128/MCB.22.8.2743-2750.2002. PMC 133736. PMID 11909966.
  7. ↑ Koipally J, Georgopoulos K (Aug 2002). "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry. 277 (31): 27697–705. doi:10.1074/jbc.M201694200. PMID 12015313.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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