SLC22A4: Difference between revisions

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(→‎Further reading: 10.3748/wjg.v12.i23.36)
 
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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Solute carrier family 22, member 4''', also known as '''SLC22A4''', is a human [[gene]]; the encoded protein is known as the '''[[ergothioneine]] transporter'''.<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A4 solute carrier family 22 (ergothioneine transporter), member 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6583| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 22 (organic cation transporter), member 4
| HGNCid = 10968
| Symbol = SLC22A4
| AltSymbols =; MGC34546; MGC40524; OCTN1
| OMIM = 604190
| ECnumber = 
| Homologene = 81701
| MGIid = 1353479
| GeneAtlas_image1 = PBB_GE_SLC22A4_205896_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008513 |text = secondary active organic cation transmembrane transporter activity}} {{GNF_GO|id=GO:0015075 |text = ion transmembrane transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
| Component = {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}}
| Process = {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0007589 |text = fluid secretion}} {{GNF_GO|id=GO:0015695 |text = organic cation transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6583
    | Hs_Ensembl = ENSG00000197208
    | Hs_RefseqProtein = NP_003050
    | Hs_RefseqmRNA = NM_003059
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 131658035
    | Hs_GenLoc_end = 131707798
    | Hs_Uniprot = Q9H015
    | Mm_EntrezGene = 30805
    | Mm_Ensembl = ENSMUSG00000020334
    | Mm_RefseqmRNA = NM_019687
    | Mm_RefseqProtein = NP_062661
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 53826549
    | Mm_GenLoc_end = 53871513
    | Mm_Uniprot = Q5SWV1
  }}
}}
'''Solute carrier family 22 (organic cation transporter), member 4''', also known as '''SLC22A4''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A4 solute carrier family 22 (organic cation transporter), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6583| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments. The first functional designation of this protein was OCTN1 ("organic cation transporter, novel, type 1"), but efficiency of transport for organic cations (e.g., [[tetraethylammonium]]) is very low.<ref>{{cite journal | vauthors = Grigat S, Harlfinger S, Pal S, Striebinger R, Golz S, Geerts A, Lazar A, Schömig E, Gründemann D | title = Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations | journal = Biochemical Pharmacology | volume = 74 | issue = 2 | pages = 309–16 | date = Jul 2007 | pmid = 17532304 | doi = 10.1016/j.bcp.2007.04.015 }}</ref> The transport efficiency for carnitine is also negligible. Instead, the protein is responsible for the [[cotransport]] of sodium ions and [[ergothioneine]], which is an [[antioxidant]], into cells.<ref>{{cite journal | vauthors = Gründemann D, Harlfinger S, Golz S, Geerts A, Lazar A, Berkels R, Jung N, Rubbert A, Schömig E | title = Discovery of the ergothioneine transporter | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 14 | pages = 5256–61 | date = Apr 2005 | pmid = 15795384 | pmc = 555966 | doi = 10.1073/pnas.0408624102 }}</ref> Thus, a more appropriate functional designation is ETT ("ergothioneine transporter").
{{PBB_Summary
| section_title =  
| summary_text = Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. The encoded protein is an organic cation transporter and plasma integral membrane protein containing eleven putative transmembrane domains as well as a nucleotide-binding site motif. Transport by this protein is at least partially ATP-dependent.<ref name="entrez">{{cite web | title = Entrez Gene: SLC22A4 solute carrier family 22 (organic cation transporter), member 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6583| accessdate = }}</ref>
}}


==See also==
== Interactions ==
SLC22A4 has been shown to [[Protein-protein interaction|interact]] with [[PDZK1]].<ref name=pmid14531806>{{cite journal | vauthors = Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H | title = PDZK1: I. a major scaffolder in brush borders of proximal tubular cells | journal = Kidney International | volume = 64 | issue = 5 | pages = 1733–45 | date = Nov 2003 | pmid = 14531806 | doi = 10.1046/j.1523-1755.2003.00266.x }}</ref>
 
== See also ==
* [[Solute carrier family]]
* [[Solute carrier family]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Xuan W, Lamhonwah AM, Librach C, Jarvi K, Tein I | title = Characterization of organic cation/carnitine transporter family in human sperm | journal = Biochemical and Biophysical Research Communications | volume = 306 | issue = 1 | pages = 121–8 | date = Jun 2003 | pmid = 12788076 | doi = 10.1016/S0006-291X(03)00930-6 }}
| citations =
* {{cite journal | vauthors = Yamada R, Tokuhiro S, Chang X, Yamamoto K | title = SLC22A4 and RUNX1: identification of RA susceptible genes | journal = Journal of Molecular Medicine | volume = 82 | issue = 9 | pages = 558–64 | date = Sep 2004 | pmid = 15184985 | doi = 10.1007/s00109-004-0547-y }}
*{{cite journal | author=Xuan W, Lamhonwah AM, Librach C, ''et al.'' |title=Characterization of organic cation/carnitine transporter family in human sperm. |journal=Biochem. Biophys. Res. Commun. |volume=306 |issue= 1 |pages= 121-8 |year= 2003 |pmid= 12788076 |doi= }}
* {{cite journal | vauthors = Silverberg MS | title = OCTNs: will the real IBD5 gene please stand up? | journal = World Journal of Gastroenterology | volume = 12 | issue = 23 | pages = 3678–81 | date = Jun 2006 | pmid = 16773684 | doi = 10.3748/wjg.v12.i23.36 }}
*{{cite journal | author=Yamada R, Tokuhiro S, Chang X, Yamamoto K |title=SLC22A4 and RUNX1: identification of RA susceptible genes. |journal=J. Mol. Med. |volume=82 |issue= 9 |pages= 558-64 |year= 2005 |pmid= 15184985 |doi= 10.1007/s00109-004-0547-y }}
* {{cite journal | vauthors = Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, Shimane M, Tsuji A | title = Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1 | journal = FEBS Letters | volume = 419 | issue = 1 | pages = 107–11 | date = Dec 1997 | pmid = 9426230 | doi = 10.1016/S0014-5793(97)01441-5 }}
*{{cite journal | author=Silverberg MS |title=OCTNs: will the real IBD5 gene please stand up? |journal=World J. Gastroenterol. |volume=12 |issue= 23 |pages= 3678-81 |year= 2006 |pmid= 16773684 |doi= }}
* {{cite journal | vauthors = Meyer-Wentrup F, Karbach U, Gorboulev V, Arndt P, Koepsell H | title = Membrane localization of the electrogenic cation transporter rOCT1 in rat liver | journal = Biochemical and Biophysical Research Communications | volume = 248 | issue = 3 | pages = 673–8 | date = Jul 1998 | pmid = 9703985 | doi = 10.1006/bbrc.1998.9034 }}
*{{cite journal | author=Tamai I, Yabuuchi H, Nezu J, ''et al.'' |title=Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1. |journal=FEBS Lett. |volume=419 |issue= 1 |pages= 107-11 |year= 1998 |pmid= 9426230 |doi= }}
* {{cite journal | vauthors = Urakami Y, Okuda M, Masuda S, Saito H, Inui KI | title = Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 287 | issue = 2 | pages = 800–5 | date = Nov 1998 | pmid = 9808712 | doi =  }}
*{{cite journal | author=Meyer-Wentrup F, Karbach U, Gorboulev V, ''et al.'' |title=Membrane localization of the electrogenic cation transporter rOCT1 in rat liver. |journal=Biochem. Biophys. Res. Commun. |volume=248 |issue= 3 |pages= 673-8 |year= 1998 |pmid= 9703985 |doi= 10.1006/bbrc.1998.9034 }}
* {{cite journal | vauthors = Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A | title = Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 289 | issue = 2 | pages = 768–73 | date = May 1999 | pmid = 10215651 | doi =  }}
*{{cite journal | author=Urakami Y, Okuda M, Masuda S, ''et al.'' |title=Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs. |journal=J. Pharmacol. Exp. Ther. |volume=287 |issue= 2 |pages= 800-5 |year= 1998 |pmid= 9808712 |doi=  }}
* {{cite journal | vauthors = Alcorn J, Lu X, Moscow JA, McNamara PJ | title = Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction | journal = The Journal of Pharmacology and Experimental Therapeutics | volume = 303 | issue = 2 | pages = 487–96 | date = Nov 2002 | pmid = 12388627 | doi = 10.1124/jpet.102.038315 }}
*{{cite journal | author=Yabuuchi H, Tamai I, Nezu J, ''et al.'' |title=Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations. |journal=J. Pharmacol. Exp. Ther. |volume=289 |issue= 2 |pages= 768-73 |year= 1999 |pmid= 10215651 |doi=  }}
* {{cite journal | vauthors = Saito S, Iida A, Sekine A, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y | title = Catalog of 238 variations among six human genes encoding solute carriers ( hSLCs) in the Japanese population | journal = Journal of Human Genetics | volume = 47 | issue = 11 | pages = 576–84 | year = 2003 | pmid = 12436193 | doi = 10.1007/s100380200088 }}
*{{cite journal | author=Alcorn J, Lu X, Moscow JA, McNamara PJ |title=Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction. |journal=J. Pharmacol. Exp. Ther. |volume=303 |issue= 2 |pages= 487-96 |year= 2002 |pmid= 12388627 |doi= 10.1124/jpet.102.038315 }}
* {{cite journal | vauthors = Eraly SA, Hamilton BA, Nigam SK | title = Organic anion and cation transporters occur in pairs of similar and similarly expressed genes | journal = Biochemical and Biophysical Research Communications | volume = 300 | issue = 2 | pages = 333–42 | date = Jan 2003 | pmid = 12504088 | doi = 10.1016/S0006-291X(02)02853-X }}
*{{cite journal | author=Saito S, Iida A, Sekine A, ''et al.'' |title=Catalog of 238 variations among six human genes encoding solute carriers ( hSLCs) in the Japanese population. |journal=J. Hum. Genet. |volume=47 |issue= 11 |pages= 576-84 |year= 2003 |pmid= 12436193 |doi= 10.1007/s100380200088 }}
* {{cite journal | vauthors = Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H | title = PDZK1: I. a major scaffolder in brush borders of proximal tubular cells | journal = Kidney International | volume = 64 | issue = 5 | pages = 1733–45 | date = Nov 2003 | pmid = 14531806 | doi = 10.1046/j.1523-1755.2003.00266.x }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, Sawada T, Suzuki M, Nagasaki M, Ohtsuki M, Ono M, Furukawa H, Nagashima M, Yoshino S, Mabuchi A, Sekine A, Saito S, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K | title = An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis | journal = Nature Genetics | volume = 35 | issue = 4 | pages = 341–8 | date = Dec 2003 | pmid = 14608356 | doi = 10.1038/ng1267 }}
*{{cite journal  | author=Eraly SA, Hamilton BA, Nigam SK |title=Organic anion and cation transporters occur in pairs of similar and similarly expressed genes. |journal=Biochem. Biophys. Res. Commun. |volume=300 |issue= 2 |pages= 333-42 |year= 2003 |pmid= 12504088 |doi= }}
* {{cite journal | vauthors = Peltekova VD, Wintle RF, Rubin LA, Amos CI, Huang Q, Gu X, Newman B, Van Oene M, Cescon D, Greenberg G, Griffiths AM, St George-Hyslop PH, Siminovitch KA | title = Functional variants of OCTN cation transporter genes are associated with Crohn disease | journal = Nature Genetics | volume = 36 | issue = 5 | pages = 471–5 | date = May 2004 | pmid = 15107849 | doi = 10.1038/ng1339 }}
*{{cite journal | author=Gisler SM, Pribanic S, Bacic D, ''et al.'' |title=PDZK1: I. a major scaffolder in brush borders of proximal tubular cells. |journal=Kidney Int. |volume=64 |issue= 5 |pages= 1733-45 |year= 2004 |pmid= 14531806 |doi= 10.1046/j.1523-1755.2003.00266.x }}
* {{cite journal | vauthors = Kawasaki Y, Kato Y, Sai Y, Tsuji A | title = Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population | journal = Journal of Pharmaceutical Sciences | volume = 93 | issue = 12 | pages = 2920–6 | date = Dec 2004 | pmid = 15459889 | doi = 10.1002/jps.20190 }}
*{{cite journal | author=Tokuhiro S, Yamada R, Chang X, ''et al.'' |title=An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. |journal=Nat. Genet. |volume=35 |issue= 4 |pages= 341-8 |year= 2004 |pmid= 14608356 |doi= 10.1038/ng1267 }}
* {{cite journal | vauthors = Newman B, Gu X, Wintle R, Cescon D, Yazdanpanah M, Liu X, Peltekova V, Van Oene M, Amos CI, Siminovitch KA | title = A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease | journal = Gastroenterology | volume = 128 | issue = 2 | pages = 260–9 | date = Feb 2005 | pmid = 15685536 | doi = 10.1053/j.gastro.2004.11.056 }}
*{{cite journal | author=Peltekova VD, Wintle RF, Rubin LA, ''et al.'' |title=Functional variants of OCTN cation transporter genes are associated with Crohn disease. |journal=Nat. Genet. |volume=36 |issue= 5 |pages= 471-5 |year= 2004 |pmid= 15107849 |doi= 10.1038/ng1339 }}
*{{cite journal | author=Kawasaki Y, Kato Y, Sai Y, Tsuji A |title=Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population. |journal=Journal of pharmaceutical sciences |volume=93 |issue= 12 |pages= 2920-6 |year= 2005 |pmid= 15459889 |doi= 10.1002/jps.20190 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Newman B, Gu X, Wintle R, ''et al.'' |title=A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease. |journal=Gastroenterology |volume=128 |issue= 2 |pages= 260-9 |year= 2005 |pmid= 15685536 |doi= }}
*{{cite journal  | author=Gründemann D, Harlfinger S, Golz S, ''et al.'' |title=Discovery of the ergothioneine transporter. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 14 |pages= 5256-61 |year= 2005 |pmid= 15795384 |doi= 10.1073/pnas.0408624102 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{NLM content}}
{{NLM content}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 18:36, 4 December 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Solute carrier family 22, member 4, also known as SLC22A4, is a human gene; the encoded protein is known as the ergothioneine transporter.[1]

Function

The encoded protein is an integral protein of the plasma membrane containing 12 transmembrane segments. The first functional designation of this protein was OCTN1 ("organic cation transporter, novel, type 1"), but efficiency of transport for organic cations (e.g., tetraethylammonium) is very low.[2] The transport efficiency for carnitine is also negligible. Instead, the protein is responsible for the cotransport of sodium ions and ergothioneine, which is an antioxidant, into cells.[3] Thus, a more appropriate functional designation is ETT ("ergothioneine transporter").

Interactions

SLC22A4 has been shown to interact with PDZK1.[4]

See also

References

  1. ↑ "Entrez Gene: SLC22A4 solute carrier family 22 (ergothioneine transporter), member 4".
  2. ↑ Grigat S, Harlfinger S, Pal S, Striebinger R, Golz S, Geerts A, Lazar A, Schömig E, Gründemann D (Jul 2007). "Probing the substrate specificity of the ergothioneine transporter with methimazole, hercynine, and organic cations". Biochemical Pharmacology. 74 (2): 309–16. doi:10.1016/j.bcp.2007.04.015. PMID 17532304.
  3. ↑ Gründemann D, Harlfinger S, Golz S, Geerts A, Lazar A, Berkels R, Jung N, Rubbert A, Schömig E (Apr 2005). "Discovery of the ergothioneine transporter". Proceedings of the National Academy of Sciences of the United States of America. 102 (14): 5256–61. doi:10.1073/pnas.0408624102. PMC 555966. PMID 15795384.
  4. ↑ Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.

Further reading

  • Xuan W, Lamhonwah AM, Librach C, Jarvi K, Tein I (Jun 2003). "Characterization of organic cation/carnitine transporter family in human sperm". Biochemical and Biophysical Research Communications. 306 (1): 121–8. doi:10.1016/S0006-291X(03)00930-6. PMID 12788076.
  • Yamada R, Tokuhiro S, Chang X, Yamamoto K (Sep 2004). "SLC22A4 and RUNX1: identification of RA susceptible genes". Journal of Molecular Medicine. 82 (9): 558–64. doi:10.1007/s00109-004-0547-y. PMID 15184985.
  • Silverberg MS (Jun 2006). "OCTNs: will the real IBD5 gene please stand up?". World Journal of Gastroenterology. 12 (23): 3678–81. doi:10.3748/wjg.v12.i23.36. PMID 16773684.
  • Tamai I, Yabuuchi H, Nezu J, Sai Y, Oku A, Shimane M, Tsuji A (Dec 1997). "Cloning and characterization of a novel human pH-dependent organic cation transporter, OCTN1". FEBS Letters. 419 (1): 107–11. doi:10.1016/S0014-5793(97)01441-5. PMID 9426230.
  • Meyer-Wentrup F, Karbach U, Gorboulev V, Arndt P, Koepsell H (Jul 1998). "Membrane localization of the electrogenic cation transporter rOCT1 in rat liver". Biochemical and Biophysical Research Communications. 248 (3): 673–8. doi:10.1006/bbrc.1998.9034. PMID 9703985.
  • Urakami Y, Okuda M, Masuda S, Saito H, Inui KI (Nov 1998). "Functional characteristics and membrane localization of rat multispecific organic cation transporters, OCT1 and OCT2, mediating tubular secretion of cationic drugs". The Journal of Pharmacology and Experimental Therapeutics. 287 (2): 800–5. PMID 9808712.
  • Yabuuchi H, Tamai I, Nezu J, Sakamoto K, Oku A, Shimane M, Sai Y, Tsuji A (May 1999). "Novel membrane transporter OCTN1 mediates multispecific, bidirectional, and pH-dependent transport of organic cations". The Journal of Pharmacology and Experimental Therapeutics. 289 (2): 768–73. PMID 10215651.
  • Alcorn J, Lu X, Moscow JA, McNamara PJ (Nov 2002). "Transporter gene expression in lactating and nonlactating human mammary epithelial cells using real-time reverse transcription-polymerase chain reaction". The Journal of Pharmacology and Experimental Therapeutics. 303 (2): 487–96. doi:10.1124/jpet.102.038315. PMID 12388627.
  • Saito S, Iida A, Sekine A, Ogawa C, Kawauchi S, Higuchi S, Nakamura Y (2003). "Catalog of 238 variations among six human genes encoding solute carriers ( hSLCs) in the Japanese population". Journal of Human Genetics. 47 (11): 576–84. doi:10.1007/s100380200088. PMID 12436193.
  • Eraly SA, Hamilton BA, Nigam SK (Jan 2003). "Organic anion and cation transporters occur in pairs of similar and similarly expressed genes". Biochemical and Biophysical Research Communications. 300 (2): 333–42. doi:10.1016/S0006-291X(02)02853-X. PMID 12504088.
  • Gisler SM, Pribanic S, Bacic D, Forrer P, Gantenbein A, Sabourin LA, Tsuji A, Zhao ZS, Manser E, Biber J, Murer H (Nov 2003). "PDZK1: I. a major scaffolder in brush borders of proximal tubular cells". Kidney International. 64 (5): 1733–45. doi:10.1046/j.1523-1755.2003.00266.x. PMID 14531806.
  • Tokuhiro S, Yamada R, Chang X, Suzuki A, Kochi Y, Sawada T, Suzuki M, Nagasaki M, Ohtsuki M, Ono M, Furukawa H, Nagashima M, Yoshino S, Mabuchi A, Sekine A, Saito S, Takahashi A, Tsunoda T, Nakamura Y, Yamamoto K (Dec 2003). "An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis". Nature Genetics. 35 (4): 341–8. doi:10.1038/ng1267. PMID 14608356.
  • Peltekova VD, Wintle RF, Rubin LA, Amos CI, Huang Q, Gu X, Newman B, Van Oene M, Cescon D, Greenberg G, Griffiths AM, St George-Hyslop PH, Siminovitch KA (May 2004). "Functional variants of OCTN cation transporter genes are associated with Crohn disease". Nature Genetics. 36 (5): 471–5. doi:10.1038/ng1339. PMID 15107849.
  • Kawasaki Y, Kato Y, Sai Y, Tsuji A (Dec 2004). "Functional characterization of human organic cation transporter OCTN1 single nucleotide polymorphisms in the Japanese population". Journal of Pharmaceutical Sciences. 93 (12): 2920–6. doi:10.1002/jps.20190. PMID 15459889.
  • Newman B, Gu X, Wintle R, Cescon D, Yazdanpanah M, Liu X, Peltekova V, Van Oene M, Amos CI, Siminovitch KA (Feb 2005). "A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease". Gastroenterology. 128 (2): 260–9. doi:10.1053/j.gastro.2004.11.056. PMID 15685536.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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