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{{Infobox_gene}}
{{PBB_Controls
'''Solute carrier family 12 member 7''' is a [[protein]] that in humans is encoded by the ''SLC12A7'' [[gene]].<ref name="pmid10347194">{{cite journal | vauthors = Mount DB, Mercado A, Song L, Xu J, George AL, Delpire E, Gamba G | title = Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family | journal = The Journal of Biological Chemistry | volume = 274 | issue = 23 | pages = 16355–62 | date = June 1999 | pmid = 10347194 | pmc =  | doi = 10.1074/jbc.274.23.16355 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10723| accessdate = }}</ref>
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| update_protein_box = yes
| update_summary = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Solute carrier family 12 (potassium/chloride transporters), member 7
| HGNCid = 10915
| Symbol = SLC12A7
| AltSymbols =; DKFZP434F076; KCC4
| OMIM = 604879
| ECnumber = 
| Homologene = 21312
| MGIid = 1342283
| GeneAtlas_image1 = PBB_GE_SLC12A7_218066_at_tn.png
| Function = {{GNF_GO|id=GO:0005215 |text = transporter activity}} {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015379 |text = potassium:chloride symporter activity}} {{GNF_GO|id=GO:0030955 |text = potassium ion binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006813 |text = potassium ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006821 |text = chloride transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10723
    | Hs_Ensembl = ENSG00000113504
    | Hs_RefseqProtein = NP_006589
    | Hs_RefseqmRNA = NM_006598
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 1103500
    | Hs_GenLoc_end = 1165152
    | Hs_Uniprot = Q9Y666
    | Mm_EntrezGene = 20499
    | Mm_Ensembl = ENSMUSG00000017756
    | Mm_RefseqmRNA = NM_011390
    | Mm_RefseqProtein = NP_035520
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 13
    | Mm_GenLoc_start = 74199096
    | Mm_GenLoc_end = 74282754
    | Mm_Uniprot = Q3TB23
  }}
}}
'''Solute carrier family 12 (potassium/chloride transporters), member 7''', also known as '''SLC12A7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10723| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== See also ==
{{PBB_Summary
| section_title =
| summary_text =
}}
 
==See also==
* [[Solute carrier family]]
* [[Solute carrier family]]
* [[cotransporter]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Mercado A, Song L, Vazquez N, Mount DB, Gamba G | title = Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 39 | pages = 30326–34 | date = September 2000 | pmid = 10913127 | doi = 10.1074/jbc.M003112200 }}
| citations =
* {{cite journal | vauthors = Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O | title = Characterization of long cDNA clones from human adult spleen | journal = DNA Research | volume = 7 | issue = 6 | pages = 357–66 | date = December 2000 | pmid = 11214971 | doi = 10.1093/dnares/7.6.357 }}
*{{cite journal | author=Mount DB, Mercado A, Song L, ''et al.'' |title=Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family. |journal=J. Biol. Chem. |volume=274 |issue= 23 |pages= 16355-62 |year= 1999 |pmid= 10347194 |doi=  }}
* {{cite journal | vauthors = Boettger T, Hübner CA, Maier H, Rust MB, Beck FX, Jentsch TJ | title = Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4 | journal = Nature | volume = 416 | issue = 6883 | pages = 874–8 | date = April 2002 | pmid = 11976689 | doi = 10.1038/416874a }}
*{{cite journal  | author=Mercado A, Song L, Vazquez N, ''et al.'' |title=Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4. |journal=J. Biol. Chem. |volume=275 |issue= 39 |pages= 30326-34 |year= 2000 |pmid= 10913127 |doi= 10.1074/jbc.M003112200 }}
* {{cite journal | vauthors = Bräuer M, Frei E, Claes L, Grissmer S, Jäger H | title = Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts | journal = American Journal of Physiology. Cell Physiology | volume = 285 | issue = 1 | pages = C22-30 | date = July 2003 | pmid = 12637262 | doi = 10.1152/ajpcell.00289.2002 }}
*{{cite journal | author=Hattori A, Okumura K, Nagase T, ''et al.'' |title=Characterization of long cDNA clones from human adult spleen. |journal=DNA Res. |volume=7 |issue= 6 |pages= 357-66 |year= 2001 |pmid= 11214971 |doi= }}
* {{cite journal | vauthors = Karadsheh MF, Byun N, Mount DB, Delpire E | title = Localization of the KCC4 potassium-chloride cotransporter in the nervous system | journal = Neuroscience | volume = 123 | issue = 2 | pages = 381–91 | year = 2004 | pmid = 14698746 | doi = 10.1016/j.neuroscience.2003.10.004 }}
*{{cite journal | author=Boettger T, Hübner CA, Maier H, ''et al.'' |title=Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4. |journal=Nature |volume=416 |issue= 6883 |pages= 874-8 |year= 2002 |pmid= 11976689 |doi= 10.1038/416874a }}
* {{cite journal | vauthors = Shen MR, Lin AC, Hsu YM, Chang TJ, Tang MJ, Alper SL, Ellory JC, Chou CY | title = Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells | journal = The Journal of Biological Chemistry | volume = 279 | issue = 38 | pages = 40017–25 | date = September 2004 | pmid = 15262997 | doi = 10.1074/jbc.M406706200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Hsu YM, Chou CY, Chen HH, Lee WY, Chen YF, Lin PW, Alper SL, Ellory JC, Shen MR | title = IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness | journal = Journal of Cellular Physiology | volume = 210 | issue = 3 | pages = 626–36 | date = March 2007 | pmid = 17133354 | doi = 10.1002/jcp.20859 }}
*{{cite journal  | author=Bräuer M, Frei E, Claes L, ''et al.'' |title=Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts. |journal=Am. J. Physiol., Cell Physiol. |volume=285 |issue= 1 |pages= C22-30 |year= 2003 |pmid= 12637262 |doi= 10.1152/ajpcell.00289.2002 }}
*{{cite journal | author=Karadsheh MF, Byun N, Mount DB, Delpire E |title=Localization of the KCC4 potassium-chloride cotransporter in the nervous system. |journal=Neuroscience |volume=123 |issue= 2 |pages= 381-91 |year= 2004 |pmid= 14698746 |doi= }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Shen MR, Lin AC, Hsu YM, ''et al.'' |title=Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells. |journal=J. Biol. Chem. |volume=279 |issue= 38 |pages= 40017-25 |year= 2004 |pmid= 15262997 |doi= 10.1074/jbc.M406706200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Hsu YM, Chou CY, Chen HH, ''et al.'' |title=IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness. |journal=J. Cell. Physiol. |volume=210 |issue= 3 |pages= 626-36 |year= 2007 |pmid= 17133354 |doi= 10.1002/jcp.20859 }}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
{{membrane-protein-stub}}

Latest revision as of 03:21, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Solute carrier family 12 member 7 is a protein that in humans is encoded by the SLC12A7 gene.[1][2]


See also

References

  1. ↑ Mount DB, Mercado A, Song L, Xu J, George AL, Delpire E, Gamba G (June 1999). "Cloning and characterization of KCC3 and KCC4, new members of the cation-chloride cotransporter gene family". The Journal of Biological Chemistry. 274 (23): 16355–62. doi:10.1074/jbc.274.23.16355. PMID 10347194.
  2. ↑ "Entrez Gene: SLC12A7 solute carrier family 12 (potassium/chloride transporters), member 7".

Further reading

  • Mercado A, Song L, Vazquez N, Mount DB, Gamba G (September 2000). "Functional comparison of the K+-Cl- cotransporters KCC1 and KCC4". The Journal of Biological Chemistry. 275 (39): 30326–34. doi:10.1074/jbc.M003112200. PMID 10913127.
  • Hattori A, Okumura K, Nagase T, Kikuno R, Hirosawa M, Ohara O (December 2000). "Characterization of long cDNA clones from human adult spleen". DNA Research. 7 (6): 357–66. doi:10.1093/dnares/7.6.357. PMID 11214971.
  • Boettger T, Hübner CA, Maier H, Rust MB, Beck FX, Jentsch TJ (April 2002). "Deafness and renal tubular acidosis in mice lacking the K-Cl co-transporter Kcc4". Nature. 416 (6883): 874–8. doi:10.1038/416874a. PMID 11976689.
  • Bräuer M, Frei E, Claes L, Grissmer S, Jäger H (July 2003). "Influence of K-Cl cotransporter activity on activation of volume-sensitive Cl- channels in human osteoblasts". American Journal of Physiology. Cell Physiology. 285 (1): C22–30. doi:10.1152/ajpcell.00289.2002. PMID 12637262.
  • Karadsheh MF, Byun N, Mount DB, Delpire E (2004). "Localization of the KCC4 potassium-chloride cotransporter in the nervous system". Neuroscience. 123 (2): 381–91. doi:10.1016/j.neuroscience.2003.10.004. PMID 14698746.
  • Shen MR, Lin AC, Hsu YM, Chang TJ, Tang MJ, Alper SL, Ellory JC, Chou CY (September 2004). "Insulin-like growth factor 1 stimulates KCl cotransport, which is necessary for invasion and proliferation of cervical cancer and ovarian cancer cells". The Journal of Biological Chemistry. 279 (38): 40017–25. doi:10.1074/jbc.M406706200. PMID 15262997.
  • Hsu YM, Chou CY, Chen HH, Lee WY, Chen YF, Lin PW, Alper SL, Ellory JC, Shen MR (March 2007). "IGF-1 upregulates electroneutral K-Cl cotransporter KCC3 and KCC4 which are differentially required for breast cancer cell proliferation and invasiveness". Journal of Cellular Physiology. 210 (3): 626–36. doi:10.1002/jcp.20859. PMID 17133354.
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