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{{ | '''Thiamin pyrophosphokinase 1''' is an [[enzyme]] that in humans is encoded by the ''TPK1'' [[gene]].<ref name="pmid11342111">{{cite journal |vauthors=Nosaka K, Onozuka M, Kakazu N, Hibi S, Nishimura H, Nishino H, Abe T | title = Isolation and characterization of a human thiamine pyrophosphokinase cDNA | journal = Biochim Biophys Acta | volume = 1517 | issue = 2 | pages = 293–7 |date=May 2001 | pmid = 11342111 | pmc = | doi = 10.1016/s0167-4781(00)00247-5}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TPK1 thiamin pyrophosphokinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27010| accessdate = }}</ref> | ||
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| section_title = | | section_title = | ||
| summary_text = This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice | | summary_text = This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional [[splice variant]]s, encoding different isoforms, have been characterized.<ref name="entrez"/> | ||
}} | }} | ||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | author=Egi Y | *{{cite journal | author=Egi Y |title=Identification, purification and reconstitution of thiamin metabolizing enzymes in human red blood cells |journal=Biochim. Biophys. Acta |volume=1160 |issue= 2 |pages= 171–8 |year= 1992 |pmid= 1332781 |doi=10.1016/0167-4838(92)90004-W |name-list-format=vanc| author2=Koyama S | author3=Shioda T | display-authors=3 | last4=Yamada | first4=K | last5=Kawasaki | first5=T }} | ||
*{{cite journal |vauthors=Bohn H, Winckler W |title=Isolation and characterization of four new placental tissue proteins (PP18, PP19, PP20, PP21) |journal=Arch. Gynecol. |volume=236 |issue= 4 |pages= 235–42 |year= 1985 |pmid= 3896163 |doi=10.1007/BF02133941 }} | |||
*{{cite journal | | *{{cite journal |vauthors=Iwashima A, Kinugasa A, Nose Y |title=Radiometric assay for thiamine pyrophosphokinase activity in human leukocytes |journal=Acta Vitaminol. Enzymol. |volume=5 |issue= 1 |pages= 41–5 |year= 1983 |pmid= 6303095 |doi= }} | ||
*{{cite journal | | *{{cite journal |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi= 10.1101/gr.8.11.1097 | author1= <Please add first missing authors to populate metadata.>}} | ||
*{{cite journal | | *{{cite journal | author=Nosaka K |title=Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA |journal=J. Biol. Chem. |volume=274 |issue= 48 |pages= 34129–33 |year= 1999 |pmid= 10567383 |doi=10.1074/jbc.274.48.34129 |name-list-format=vanc| author2=Onozuka M | author3=Nishino H | display-authors=3 | last4=Nishimura | first4=H | last5=Kawasaki | first5=Y | last6=Ueyama | first6=H }} | ||
*{{cite journal |vauthors=Zhao R, Gao F, Goldman ID |title=Molecular cloning of human thiamin pyrophosphokinase |journal=Biochim. Biophys. Acta |volume=1517 |issue= 2 |pages= 320–2 |year= 2001 |pmid= 11342117 |doi= 10.1016/s0167-4781(00)00264-5}} | |||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | |||
*{{cite journal | | *{{cite journal | author=Scherer SW |title=Human Chromosome 7: DNA Sequence and Biology |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 | pmc=2882961 |name-list-format=vanc| author2=Cheung J | author3=MacDonald JR | display-authors=3 | last4=Osborne | first4=LR | last5=Nakabayashi | first5=K | last6=Herbrick | first6=JA | last7=Carson | first7=AR | last8=Parker-Katiraee | first8=L | last9=Skaug | first9=J }} | ||
*{{cite journal | author= | *{{cite journal |vauthors=Onozuka M, Nosaka K |title=Steady-state kinetics and mutational studies of recombinant human thiamin pyrophosphokinase |journal=J. Nutr. Sci. Vitaminol. |volume=49 |issue= 3 |pages= 156–62 |year= 2004 |pmid= 12953792 |doi= 10.3177/jnsv.49.156}} | ||
*{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | |||
*{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | |||
*{{cite journal | author= | *{{cite journal | author=Bellyei S |title=Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK) |journal=Placenta |volume=26 |issue= 1 |pages= 34–46 |year= 2005 |pmid= 15664409 |doi= 10.1016/j.placenta.2004.03.008 |name-list-format=vanc| author2=Szigeti A | author3=Boronkai A | display-authors=3 | last4=Szabo | first4=Z. | last5=Bene | first5=J. | last6=Janaky | first6=T. | last7=Barna | first7=L. | last8=Sipos | first8=K. | last9=Minik | first9=O. }} | ||
*{{cite journal | author=Toyoshima M |title=Thiamine-responsive congenital lactic acidosis: clinical and biochemical studies |journal=Pediatr. Neurol. |volume=33 |issue= 2 |pages= 98–104 |year= 2005 |pmid= 16087053 |doi= 10.1016/j.pediatrneurol.2005.02.007 |name-list-format=vanc| author2=Oka A | author3=Egi Y | display-authors=3 | last4=Yamamoto | first4=T | last5=Onozuka | first5=M | last6=Nosaka | first6=K | last7=Naito | first7=E | last8=Yamada | first8=K }} | |||
*{{cite journal | | *{{cite journal | author=Onozuka M |title=Molecular cloning and analysis of the 5'-flanking region of the human thiamin pyrophosphokinase gene |journal=J. Nutr. Sci. Vitaminol. |volume=51 |issue= 4 |pages= 274–7 |year= 2006 |pmid= 16262001 |doi= 10.3177/jnsv.51.274|name-list-format=vanc| author2=Konno H | author3=Akaji K | display-authors=3 | last4=Nishino | first4=H | last5=Nosaka | first5=K }} | ||
*{{cite journal | author= | *{{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-format=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }} | ||
*{{cite journal |vauthors=Fradin D, Bougneres P |title=Three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight |journal=Ann. Hum. Genet. |volume=71 |issue= Pt 5 |pages= 578–85 |year= 2007 |pmid= 17295612 |doi= 10.1111/j.1469-1809.2007.00348.x }} | |||
*{{cite journal | | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
{{protein- | {{Serine/threonine-specific protein kinases}} | ||
{{ | {{Enzymes}} | ||
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[[Category:EC 2.7.11]] | |||
{{gene-7-stub}} |
Latest revision as of 12:12, 15 September 2017
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
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Thiamin pyrophosphokinase 1 is an enzyme that in humans is encoded by the TPK1 gene.[1][2]
This gene encodes a protein, that exists as a homodimer, which catalyzes the conversion of thiamine to thiamine pyrophosphate. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.[2]
References
- ↑ Nosaka K, Onozuka M, Kakazu N, Hibi S, Nishimura H, Nishino H, Abe T (May 2001). "Isolation and characterization of a human thiamine pyrophosphokinase cDNA". Biochim Biophys Acta. 1517 (2): 293–7. doi:10.1016/s0167-4781(00)00247-5. PMID 11342111.
- ↑ 2.0 2.1 "Entrez Gene: TPK1 thiamin pyrophosphokinase 1".
Further reading
- Egi Y, Koyama S, Shioda T, et al. (1992). "Identification, purification and reconstitution of thiamin metabolizing enzymes in human red blood cells". Biochim. Biophys. Acta. 1160 (2): 171–8. doi:10.1016/0167-4838(92)90004-W. PMID 1332781.
- Bohn H, Winckler W (1985). "Isolation and characterization of four new placental tissue proteins (PP18, PP19, PP20, PP21)". Arch. Gynecol. 236 (4): 235–42. doi:10.1007/BF02133941. PMID 3896163.
- Iwashima A, Kinugasa A, Nose Y (1983). "Radiometric assay for thiamine pyrophosphokinase activity in human leukocytes". Acta Vitaminol. Enzymol. 5 (1): 41–5. PMID 6303095.
- <Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
- Nosaka K, Onozuka M, Nishino H, et al. (1999). "Molecular cloning and expression of a mouse thiamin pyrophosphokinase cDNA". J. Biol. Chem. 274 (48): 34129–33. doi:10.1074/jbc.274.48.34129. PMID 10567383.
- Zhao R, Gao F, Goldman ID (2001). "Molecular cloning of human thiamin pyrophosphokinase". Biochim. Biophys. Acta. 1517 (2): 320–2. doi:10.1016/s0167-4781(00)00264-5. PMID 11342117.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human Chromosome 7: DNA Sequence and Biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Onozuka M, Nosaka K (2004). "Steady-state kinetics and mutational studies of recombinant human thiamin pyrophosphokinase". J. Nutr. Sci. Vitaminol. 49 (3): 156–62. doi:10.3177/jnsv.49.156. PMID 12953792.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Bellyei S, Szigeti A, Boronkai A, et al. (2005). "Cloning, sequencing, structural and molecular biological characterization of placental protein 20 (PP20)/human thiamin pyrophosphokinase (hTPK)". Placenta. 26 (1): 34–46. doi:10.1016/j.placenta.2004.03.008. PMID 15664409.
- Toyoshima M, Oka A, Egi Y, et al. (2005). "Thiamine-responsive congenital lactic acidosis: clinical and biochemical studies". Pediatr. Neurol. 33 (2): 98–104. doi:10.1016/j.pediatrneurol.2005.02.007. PMID 16087053.
- Onozuka M, Konno H, Akaji K, et al. (2006). "Molecular cloning and analysis of the 5'-flanking region of the human thiamin pyrophosphokinase gene". J. Nutr. Sci. Vitaminol. 51 (4): 274–7. doi:10.3177/jnsv.51.274. PMID 16262001.
- Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
- Fradin D, Bougneres P (2007). "Three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight". Ann. Hum. Genet. 71 (Pt 5): 578–85. doi:10.1111/j.1469-1809.2007.00348.x. PMID 17295612.
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