PHKA2: Difference between revisions

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Latest revision as of 18:03, 7 September 2017

Phosphorylase b kinase regulatory subunit alpha, liver isoform is an enzyme that in humans is encoded by the PHKA2 gene.^[1]^[2]

References

↑ Willems P (Sep 1990). "Families with X-linked liver glycogenosis due to phosphorylase kinase deficiency". Clin Genet. 38 (1): 80. doi:10.1111/j.1399-0004.1990.tb03552.x. PMID 2387090.
↑ "Entrez Gene: PHKA2 phosphorylase kinase, alpha 2 (liver)".

Davidson JJ, Ozçelik T, Hamacher C, et al. (1992). "cDNA cloning of a liver isoform of the phosphorylase kinase alpha subunit and mapping of the gene to Xp22.2-p22.1, the region of human X-linked liver glycogenosis". Proc. Natl. Acad. Sci. U.S.A. 89 (6): 2096–100. doi:10.1073/pnas.89.6.2096. PMC 48603. PMID 1372435.
Wauters JG, Bossuyt PJ, Davidson J, et al. (1992). "Regional mapping of a liver alpha-subunit gene of phosphorylase kinase (PHKA) to the distal region of human chromosome Xp". Cytogenet. Cell Genet. 60 (3–4): 194–6. doi:10.1159/000133334. PMID 1505214.
Daube H, Billich A, Mann K, Schramm HJ (1991). "Cleavage of phosphorylase kinase and calcium-free calmodulin by HIV-1 protease". Biochem. Biophys. Res. Commun. 178 (3): 892–8. doi:10.1016/0006-291X(91)90975-D. PMID 1872871.
Willems PJ, Gerver WJ, Berger R, Fernandes J (1990). "The natural history of liver glycogenosis due to phosphorylase kinase deficiency: a longitudinal study of 41 patients". Eur. J. Pediatr. 149 (4): 268–71. doi:10.1007/BF02106291. PMID 2303074.
Huijing F, Fernandes J (1969). "X-chromosomal inheritance of liver glycogenosis with phosphorylase kinase deficiency". Am. J. Hum. Genet. 21 (3): 275–84. PMC 1706412. PMID 5306139.
Hirono H, Hayasaka K, Sato W, et al. (1995). "Isolation of cDNA encoding the human liver phosphorylase kinase alpha subunit (PHKA2) and identification of a missense mutation of the PHKA2 gene in a family with liver phosphorylase kinase deficiency". Biochem. Mol. Biol. Int. 36 (3): 505–11. PMID 7549948.
Hendrickx J, Coucke P, Dams E, et al. (1995). "Mutations in the phosphorylase kinase gene PHKA2 are responsible for X-linked liver glycogen storage disease". Hum. Mol. Genet. 4 (1): 77–83. doi:10.1093/hmg/4.1.77. PMID 7711737.
van den Berg IE, van Beurden EA, Malingré HE, et al. (1995). "X-linked liver phosphorylase kinase deficiency is associated with mutations in the human liver phosphorylase kinase alpha subunit". Am. J. Hum. Genet. 56 (2): 381–7. PMC 1801119. PMID 7847371.
Wüllrich A, Hamacher C, Schneider A, Kilimann MW (1993). "The multiphosphorylation domain of the phosphorylase kinase alpha M and alpha L subunits is a hotspot of differential mRNA processing and of molecular evolution". J. Biol. Chem. 268 (31): 23208–14. PMID 8226841.
Hendrickx J, Coucke P, Bossuyt P, et al. (1993). "X-linked liver glycogenosis: localization and isolation of a candidate gene". Hum. Mol. Genet. 2 (5): 583–9. doi:10.1093/hmg/2.5.583. PMID 8518797.
Hendrickx J, Dams E, Coucke P, et al. (1997). "X-linked liver glycogenosis type II (XLG II) is caused by mutations in PHKA2, the gene encoding the liver alpha subunit of phosphorylase kinase". Hum. Mol. Genet. 5 (5): 649–52. doi:10.1093/hmg/5.5.649. PMID 8733133.
Burwinkel B, Shin YS, Bakker HD, et al. (1997). "Mutation hotspots in the PHKA2 gene in X-linked liver glycogenosis due to phosphorylase kinase deficiency with atypical activity in blood cells (XLG2)". Hum. Mol. Genet. 5 (5): 653–8. doi:10.1093/hmg/5.5.653. PMID 8733134.
Burwinkel B, Amat L, Gray RG, et al. (1998). "Variability of biochemical and clinical phenotype in X-linked liver glycogenosis with mutations in the phosphorylase kinase PHKA2 gene". Hum. Genet. 102 (4): 423–9. doi:10.1007/s004390050715. PMID 9600238.
Hendrickx J, Bosshard NU, Willems P, Gitzelmann R (1999). "Clinical, biochemical and molecular findings in a patient with X-linked liver glycogenosis followed for 40 years". Eur. J. Pediatr. 157 (11): 919–23. doi:10.1007/s004310050967. PMID 9835437.
Hendrickx J, Lee P, Keating JP, et al. (1999). "Complete genomic structure and mutational spectrum of PHKA2 in patients with x-linked liver glycogenosis type I and II". Am. J. Hum. Genet. 64 (6): 1541–9. doi:10.1086/302399. PMC 1377897. PMID 10330341.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ban K, Sugiyama K, Goto K, et al. (2004). "Detection of PHKA2 gene mutation in four Japanese patients with hepatic phosphorylase kinase deficiency". Tohoku J. Exp. Med. 200 (1): 47–53. doi:10.1620/tjem.200.47. PMID 12862311.
Pallen MJ (2004). "Glucoamylase-like domains in the alpha- and beta-subunits of phosphorylase kinase". Protein Sci. 12 (8): 1804–7. doi:10.1110/ps.0371103. PMC 2323967. PMID 12876330.
Johnson JM, Castle J, Garrett-Engele P, et al. (2004). "Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays". Science. 302 (5653): 2141–4. doi:10.1126/science.1090100. PMID 14684825.

External links

GeneReviews/NCBI/NIH/UW entry on Phosphorylase Kinase Deficiency, Glycogen Storage Disease Type IX

This article on a gene on the human X chromosome and/or its associated protein is a stub. You can help Wikipedia by expanding it.

[pmid2387090-1] Willems P (Sep 1990). "Families with X-linked liver glycogenosis due to phosphorylase kinase deficiency". Clin Genet. 38 (1): 80. doi:10.1111/j.1399-0004.1990.tb03552.x. PMID 2387090.

[entrez-2] "Entrez Gene: PHKA2 phosphorylase kinase, alpha 2 (liver)".

[1]

[2]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Phosphorylase b kinase regulatory subunit alpha, liver isoform''' is an [[enzyme]] that in humans is encoded by the ''PHKA2'' [[gene]].<ref name="pmid2387090">{{cite journal | author = Willems P | title = Families with X-linked liver glycogenosis due to phosphorylase kinase deficiency | journal = Clin Genet | volume = 38 | issue = 1 | pages = 80 |date=Sep 1990 | pmid = 2387090 | pmc =  | doi =10.1111/j.1399-0004.1990.tb03552.x  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PHKA2 phosphorylase kinase, alpha 2 (liver)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5256| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Phosphorylase kinase, alpha 2 (liver)
- | HGNCid = 8926
- | Symbol = PHKA2
- | AltSymbols =; PHK; PYK; PYKL; XLG; XLG2
- | OMIM = 306000
- | ECnumber =
- | Homologene = 246
- | MGIid = 97577
- | GeneAtlas_image1 = PBB_GE_PHKA2_209438_at_tn.png
- | GeneAtlas_image2 = PBB_GE_PHKA2_209439_s_at_tn.png
- | Function = {{GNF_GO|id=GO:0004689 |text = phosphorylase kinase activity}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}}
- | Component = {{GNF_GO|id=GO:0005964 |text = phosphorylase kinase complex}} {{GNF_GO|id=GO:0016020 |text = membrane}}
-  | Process = {{GNF_GO|id=GO:0005975 |text = carbohydrate metabolic process}} {{GNF_GO|id=GO:0005977 |text = glycogen metabolic process}} {{GNF_GO|id=GO:0006091 |text = generation of precursor metabolites and energy}} {{GNF_GO|id=GO:0006464 |text = protein modification process}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5256
-    | Hs_Ensembl = ENSG00000044446
-    | Hs_RefseqProtein = NP_000283
-    | Hs_RefseqmRNA = NM_000292
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = X
-    | Hs_GenLoc_start = 18820339
-    | Hs_GenLoc_end = 18912637
-    | Hs_Uniprot = P46019
-    | Mm_EntrezGene = 110094
-    | Mm_Ensembl = ENSMUSG00000031295
-    | Mm_RefseqmRNA = NM_172783
-    | Mm_RefseqProtein = NP_766371
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = X
-    | Mm_GenLoc_start = 155846795
-    | Mm_GenLoc_end = 155935827
-    | Mm_Uniprot = Q6PE66
-  }}
-}}
-'''Phosphorylase kinase, alpha 2 (liver)''', also known as '''PHKA2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PHKA2 phosphorylase kinase, alpha 2 (liver)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5256| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 56: / Line 9: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Davidson JJ, Ozçelik T, Hamacher C, ''et al.'' |title=cDNA cloning of a liver isoform of the phosphorylase kinase alpha subunit and mapping of the gene to Xp22.2-p22.1, the region of human X-linked liver glycogenosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 6 |pages= 2096-100 |year= 1992 |pmid= 1372435 |doi=  }}
+*{{cite journal   |vauthors=Davidson JJ, Ozçelik T, Hamacher C, etal |title=cDNA cloning of a liver isoform of the phosphorylase kinase alpha subunit and mapping of the gene to Xp22.2-p22.1, the region of human X-linked liver glycogenosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 6 |pages= 2096–100 |year= 1992 |pmid= 1372435 |doi=10.1073/pnas.89.6.2096  | pmc=48603  }}
-*{{cite journal  | author=Wauters JG, Bossuyt PJ, Davidson J, ''et al.'' |title=Regional mapping of a liver alpha-subunit gene of phosphorylase kinase (PHKA) to the distal region of human chromosome Xp. |journal=Cytogenet. Cell Genet. |volume=60 |issue= 3-4 |pages= 194-6 |year= 1992 |pmid= 1505214 |doi=  }}
+*{{cite journal   |vauthors=Wauters JG, Bossuyt PJ, Davidson J, etal |title=Regional mapping of a liver alpha-subunit gene of phosphorylase kinase (PHKA) to the distal region of human chromosome Xp. |journal=Cytogenet. Cell Genet. |volume=60 |issue= 3-4 |pages= 194–6 |year= 1992 |pmid= 1505214 |doi=10.1159/000133334  }}
-*{{cite journal  | author=Daube H, Billich A, Mann K, Schramm HJ |title=Cleavage of phosphorylase kinase and calcium-free calmodulin by HIV-1 protease. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 3 |pages= 892-8 |year= 1991 |pmid= 1872871 |doi=  }}
+*{{cite journal  |vauthors=Daube H, Billich A, Mann K, Schramm HJ |title=Cleavage of phosphorylase kinase and calcium-free calmodulin by HIV-1 protease. |journal=Biochem. Biophys. Res. Commun. |volume=178 |issue= 3 |pages= 892–8 |year= 1991 |pmid= 1872871 |doi=10.1016/0006-291X(91)90975-D  }}
-*{{cite journal  | author=Willems PJ, Gerver WJ, Berger R, Fernandes J |title=The natural history of liver glycogenosis due to phosphorylase kinase deficiency: a longitudinal study of 41 patients. |journal=Eur. J. Pediatr. |volume=149 |issue= 4 |pages= 268-71 |year= 1990 |pmid= 2303074 |doi=  }}
+*{{cite journal  |vauthors=Willems PJ, Gerver WJ, Berger R, Fernandes J |title=The natural history of liver glycogenosis due to phosphorylase kinase deficiency: a longitudinal study of 41 patients. |journal=Eur. J. Pediatr. |volume=149 |issue= 4 |pages= 268–71 |year= 1990 |pmid= 2303074 |doi=10.1007/BF02106291  }}
-*{{cite journal  | author=Willems P |title=Families with X-linked liver glycogenosis due to phosphorylase kinase deficiency. |journal=Clin. Genet. |volume=38 |issue= 1 |pages= 80 |year= 1990 |pmid= 2387090 |doi=  }}
+*{{cite journal  |vauthors=Huijing F, Fernandes J |title=X-chromosomal inheritance of liver glycogenosis with phosphorylase kinase deficiency. |journal=Am. J. Hum. Genet. |volume=21 |issue= 3 |pages= 275–84 |year= 1969 |pmid= 5306139 |doi=  | pmc=1706412  }}
-*{{cite journal  | author=Huijing F, Fernandes J |title=X-chromosomal inheritance of liver glycogenosis with phosphorylase kinase deficiency. |journal=Am. J. Hum. Genet. |volume=21 |issue= 3 |pages= 275-84 |year= 1969 |pmid= 5306139 |doi=  }}
+*{{cite journal   |vauthors=Hirono H, Hayasaka K, Sato W, etal |title=Isolation of cDNA encoding the human liver phosphorylase kinase alpha subunit (PHKA2) and identification of a missense mutation of the PHKA2 gene in a family with liver phosphorylase kinase deficiency. |journal=Biochem. Mol. Biol. Int. |volume=36 |issue= 3 |pages= 505–11 |year= 1995 |pmid= 7549948 |doi=  }}
-*{{cite journal  | author=Hirono H, Hayasaka K, Sato W, ''et al.'' |title=Isolation of cDNA encoding the human liver phosphorylase kinase alpha subunit (PHKA2) and identification of a missense mutation of the PHKA2 gene in a family with liver phosphorylase kinase deficiency. |journal=Biochem. Mol. Biol. Int. |volume=36 |issue= 3 |pages= 505-11 |year= 1995 |pmid= 7549948 |doi=  }}
+*{{cite journal   |vauthors=Hendrickx J, Coucke P, Dams E, etal |title=Mutations in the phosphorylase kinase gene PHKA2 are responsible for X-linked liver glycogen storage disease. |journal=Hum. Mol. Genet. |volume=4 |issue= 1 |pages= 77–83 |year= 1995 |pmid= 7711737 |doi=  10.1093/hmg/4.1.77}}
-*{{cite journal  | author=Hendrickx J, Coucke P, Dams E, ''et al.'' |title=Mutations in the phosphorylase kinase gene PHKA2 are responsible for X-linked liver glycogen storage disease. |journal=Hum. Mol. Genet. |volume=4 |issue= 1 |pages= 77-83 |year= 1995 |pmid= 7711737 |doi=  }}
+*{{cite journal   |vauthors=van den Berg IE, van Beurden EA, Malingré HE, etal |title=X-linked liver phosphorylase kinase deficiency is associated with mutations in the human liver phosphorylase kinase alpha subunit. |journal=Am. J. Hum. Genet. |volume=56 |issue= 2 |pages= 381–7 |year= 1995 |pmid= 7847371 |doi=  | pmc=1801119  }}
-*{{cite journal  | author=van den Berg IE, van Beurden EA, Malingré HE, ''et al.'' |title=X-linked liver phosphorylase kinase deficiency is associated with mutations in the human liver phosphorylase kinase alpha subunit. |journal=Am. J. Hum. Genet. |volume=56 |issue= 2 |pages= 381-7 |year= 1995 |pmid= 7847371 |doi=  }}
+*{{cite journal  |vauthors=Wüllrich A, Hamacher C, Schneider A, Kilimann MW |title=The multiphosphorylation domain of the phosphorylase kinase alpha M and alpha L subunits is a hotspot of differential mRNA processing and of molecular evolution. |journal=J. Biol. Chem. |volume=268 |issue= 31 |pages= 23208–14 |year= 1993 |pmid= 8226841 |doi=  }}
-*{{cite journal  | author=Wüllrich A, Hamacher C, Schneider A, Kilimann MW |title=The multiphosphorylation domain of the phosphorylase kinase alpha M and alpha L subunits is a hotspot of differential mRNA processing and of molecular evolution. |journal=J. Biol. Chem. |volume=268 |issue= 31 |pages= 23208-14 |year= 1993 |pmid= 8226841 |doi=  }}
+*{{cite journal   |vauthors=Hendrickx J, Coucke P, Bossuyt P, etal |title=X-linked liver glycogenosis: localization and isolation of a candidate gene. |journal=Hum. Mol. Genet. |volume=2 |issue= 5 |pages= 583–9 |year= 1993 |pmid= 8518797 |doi=10.1093/hmg/2.5.583  }}
-*{{cite journal  | author=Hendrickx J, Coucke P, Bossuyt P, ''et al.'' |title=X-linked liver glycogenosis: localization and isolation of a candidate gene. |journal=Hum. Mol. Genet. |volume=2 |issue= 5 |pages= 583-9 |year= 1993 |pmid= 8518797 |doi=  }}
+*{{cite journal   |vauthors=Hendrickx J, Dams E, Coucke P, etal |title=X-linked liver glycogenosis type II (XLG II) is caused by mutations in PHKA2, the gene encoding the liver alpha subunit of phosphorylase kinase. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 649–52 |year= 1997 |pmid= 8733133 |doi=10.1093/hmg/5.5.649  }}
-*{{cite journal  | author=Hendrickx J, Dams E, Coucke P, ''et al.'' |title=X-linked liver glycogenosis type II (XLG II) is caused by mutations in PHKA2, the gene encoding the liver alpha subunit of phosphorylase kinase. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 649-52 |year= 1997 |pmid= 8733133 |doi=  }}
+*{{cite journal   |vauthors=Burwinkel B, Shin YS, Bakker HD, etal |title=Mutation hotspots in the PHKA2 gene in X-linked liver glycogenosis due to phosphorylase kinase deficiency with atypical activity in blood cells (XLG2). |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 653–8 |year= 1997 |pmid= 8733134 |doi=10.1093/hmg/5.5.653  }}
-*{{cite journal  | author=Burwinkel B, Shin YS, Bakker HD, ''et al.'' |title=Mutation hotspots in the PHKA2 gene in X-linked liver glycogenosis due to phosphorylase kinase deficiency with atypical activity in blood cells (XLG2). |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 653-8 |year= 1997 |pmid= 8733134 |doi=  }}
+*{{cite journal   |vauthors=Burwinkel B, Amat L, Gray RG, etal |title=Variability of biochemical and clinical phenotype in X-linked liver glycogenosis with mutations in the phosphorylase kinase PHKA2 gene. |journal=Hum. Genet. |volume=102 |issue= 4 |pages= 423–9 |year= 1998 |pmid= 9600238 |doi=10.1007/s004390050715  }}
-*{{cite journal  | author=Burwinkel B, Amat L, Gray RG, ''et al.'' |title=Variability of biochemical and clinical phenotype in X-linked liver glycogenosis with mutations in the phosphorylase kinase PHKA2 gene. |journal=Hum. Genet. |volume=102 |issue= 4 |pages= 423-9 |year= 1998 |pmid= 9600238 |doi=  }}
+*{{cite journal  |vauthors=Hendrickx J, Bosshard NU, Willems P, Gitzelmann R |title=Clinical, biochemical and molecular findings in a patient with X-linked liver glycogenosis followed for 40 years. |journal=Eur. J. Pediatr. |volume=157 |issue= 11 |pages= 919–23 |year= 1999 |pmid= 9835437 |doi=10.1007/s004310050967  }}
-*{{cite journal  | author=Hendrickx J, Bosshard NU, Willems P, Gitzelmann R |title=Clinical, biochemical and molecular findings in a patient with X-linked liver glycogenosis followed for 40 years. |journal=Eur. J. Pediatr. |volume=157 |issue= 11 |pages= 919-23 |year= 1999 |pmid= 9835437 |doi=  }}
+*{{cite journal   |vauthors=Hendrickx J, Lee P, Keating JP, etal |title=Complete genomic structure and mutational spectrum of PHKA2 in patients with x-linked liver glycogenosis type I and II. |journal=Am. J. Hum. Genet. |volume=64 |issue= 6 |pages= 1541–9 |year= 1999 |pmid= 10330341 |doi=10.1086/302399  | pmc=1377897  }}
-*{{cite journal  | author=Hendrickx J, Lee P, Keating JP, ''et al.'' |title=Complete genomic structure and mutational spectrum of PHKA2 in patients with x-linked liver glycogenosis type I and II. |journal=Am. J. Hum. Genet. |volume=64 |issue= 6 |pages= 1541-9 |year= 1999 |pmid= 10330341 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Ban K, Sugiyama K, Goto K, etal |title=Detection of PHKA2 gene mutation in four Japanese patients with hepatic phosphorylase kinase deficiency. |journal=Tohoku J. Exp. Med. |volume=200 |issue= 1 |pages= 47–53 |year= 2004 |pmid= 12862311 |doi=10.1620/tjem.200.47  }}
-*{{cite journal  | author=Ban K, Sugiyama K, Goto K, ''et al.'' |title=Detection of PHKA2 gene mutation in four Japanese patients with hepatic phosphorylase kinase deficiency. |journal=Tohoku J. Exp. Med. |volume=200 |issue= 1 |pages= 47-53 |year= 2004 |pmid= 12862311 |doi=  }}
+*{{cite journal  | author=Pallen MJ |title=Glucoamylase-like domains in the alpha- and beta-subunits of phosphorylase kinase. |journal=Protein Sci. |volume=12 |issue= 8 |pages= 1804–7 |year= 2004 |pmid= 12876330 |doi=10.1110/ps.0371103  | pmc=2323967  }}
-*{{cite journal  | author=Pallen MJ |title=Glucoamylase-like domains in the alpha- and beta-subunits of phosphorylase kinase. |journal=Protein Sci. |volume=12 |issue= 8 |pages= 1804-7 |year= 2004 |pmid= 12876330 |doi=  }}
+*{{cite journal   |vauthors=Johnson JM, Castle J, Garrett-Engele P, etal |title=Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. |journal=Science |volume=302 |issue= 5653 |pages= 2141–4 |year= 2004 |pmid= 14684825 |doi= 10.1126/science.1090100 }}
-*{{cite journal  | author=Johnson JM, Castle J, Garrett-Engele P, ''et al.'' |title=Genome-wide survey of human alternative pre-mRNA splicing with exon junction microarrays. |journal=Science |volume=302 |issue= 5653 |pages= 2141-4 |year= 2004 |pmid= 14684825 |doi= 10.1126/science.1090100 }}
 }}
 {{refend}}
-{{protein-stub}}
+==External links==
-{{WikiDoc Sources}}
+* [https://www.ncbi.nlm.nih.gov/books/NBK55061/  GeneReviews/NCBI/NIH/UW entry on Phosphorylase Kinase Deficiency, Glycogen Storage Disease Type IX]
+{{Serine/threonine-specific protein kinases}}
+{{Enzymes}}
+{{Portal bar|Molecular and Cellular Biology|border=no}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
+[[Category:EC 2.7.11]]
+{{gene-X-stub}}

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

PHKA2: Difference between revisions

Latest revision as of 18:03, 7 September 2017

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