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{{Infobox_gene|FLT1}}
{{Infobox gene|FLT1}}
'''Vascular endothelial growth factor receptor 1''' is a [[protein]] that in humans is encoded by the ''FLT1'' [[gene]].<ref name="pmid2158038">{{cite journal | vauthors = Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M | title = Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family | journal = Oncogene | volume = 5 | issue = 4 | pages = 519–24 | date = Apr 1990 | pmid = 2158038 | pmc =  | doi =  }}</ref>
'''Vascular endothelial growth factor receptor 1''' is a [[protein]] that in humans is encoded by the ''FLT1'' [[gene]].<ref name="pmid2158038">{{cite journal | vauthors = Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M | title = Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family | journal = Oncogene | volume = 5 | issue = 4 | pages = 519–24 | date = Apr 1990 | pmid = 2158038 | pmc =  | doi =  }}</ref>


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Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2321| accessdate = }}</ref>
Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2321| accessdate = }}</ref>
The ablation of VEGFR1 by chemical and genetic means has also recently been found to augment the conversion of white adipose tissue to brown adipose tissue as well as increase brown adipose angiogenesis in mice.<ref>{{cite journal | vauthors = Seki T, Hosaka K, Fischer C, Lim S, Andersson P, Abe M, Iwamoto H, Gao Y, Wang X, Fong GH, Cao Y | title = Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning | journal = The Journal of Experimental Medicine | volume = 215 | issue = 2 | pages = 611–626 | date = January 2018 | pmid = 29305395 | pmc = 5789413 | doi = 10.1084/jem.20171012 }}</ref>
Functional genetic variation in ''FLT1'' (rs9582036) has been found to affect [[Non-small-cell lung carcinoma|non-small cell lung cancer]] survival.<ref>{{Cite journal|last=Glubb|first=Dylan M.|last2=Paré-Brunet|first2=Laia|last3=Jantus-Lewintre|first3=Eloisa|last4=Jiang|first4=Chen|last5=Crona|first5=Daniel|last6=Etheridge|first6=Amy S.|last7=Mirza|first7=Osman|last8=Zhang|first8=Wei|last9=Seiser|first9=Eric L.|date=2015-7|title=Functional FLT1 Genetic Variation is a Prognostic Factor for Recurrence in Stage I-III Non-Small-Cell Lung Cancer|journal=Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer|volume=10|issue=7|pages=1067–1075|doi=10.1097/JTO.0000000000000549|issn=1556-1380|pmc=4494119|pmid=26134224}}</ref>


== Interactions ==
== Interactions ==
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* {{cite journal | vauthors = Shibuya M | title = Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis | journal = Angiogenesis | volume = 9 | issue = 4 | pages = 225–30; discussion 231 | year = 2007 | pmid = 17109193 | doi = 10.1007/s10456-006-9055-8 }}
* {{cite journal | vauthors = Shibuya M | title = Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis | journal = Angiogenesis | volume = 9 | issue = 4 | pages = 225–30; discussion 231 | year = 2007 | pmid = 17109193 | doi = 10.1007/s10456-006-9055-8 }}
* {{cite journal | vauthors = Widmer M, Villar J, Benigni A, Conde-Agudelo A, Karumanchi SA, Lindheimer M | title = Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review | journal = Obstetrics and Gynecology | volume = 109 | issue = 1 | pages = 168–80  | date = Jan 2007 | pmid = 17197602 | doi = 10.1097/01.AOG.0000249609.04831.7c }}
* {{cite journal | vauthors = Widmer M, Villar J, Benigni A, Conde-Agudelo A, Karumanchi SA, Lindheimer M | title = Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review | journal = Obstetrics and Gynecology | volume = 109 | issue = 1 | pages = 168–80  | date = Jan 2007 | pmid = 17197602 | doi = 10.1097/01.AOG.0000249609.04831.7c }}
* {{cite journal | vauthors = López-Novoa JM | title = Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia | journal = Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association | volume = 22 | issue = 3 | pages = 712–4  | date = Mar 2007 | pmid = 17210583 | doi = 10.1093/ndt/gfl768 }}
* {{cite journal | vauthors = López-Novoa JM | title = Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia | journal = Nephrology, Dialysis, Transplantation | volume = 22 | issue = 3 | pages = 712–4  | date = Mar 2007 | pmid = 17210583 | doi = 10.1093/ndt/gfl768 }}
* {{cite journal | vauthors = Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P | title = Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration | journal = The Journal of Neuroscience | volume = 28 | issue = 42 | pages = 10451–9  | date = Oct 2008 | pmid = 18923022 | doi = 10.1523/JNEUROSCI.1092-08.2008 | first3 = P. }}
* {{cite journal | vauthors = Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P | title = Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration | journal = The Journal of Neuroscience | volume = 28 | issue = 42 | pages = 10451–9  | date = Oct 2008 | pmid = 18923022 | doi = 10.1523/JNEUROSCI.1092-08.2008 | first3 = P. }}
* {{cite journal | vauthors = Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V, Eriksson U, Alitalo K | title = Vascular endothelial growth factors VEGF-B and VEGF-C | journal = Journal of Cellular Physiology | volume = 173 | issue = 2 | pages = 211–5  | date = Nov 1997 | pmid = 9365524 | doi = 10.1002/(SICI)1097-4652(199711)173:2<211::AID-JCP23>3.0.CO;2-H }}
* {{cite journal | vauthors = Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V, Eriksson U, Alitalo K | title = Vascular endothelial growth factors VEGF-B and VEGF-C | journal = Journal of Cellular Physiology | volume = 173 | issue = 2 | pages = 211–5  | date = Nov 1997 | pmid = 9365524 | doi = 10.1002/(SICI)1097-4652(199711)173:2<211::AID-JCP23>3.0.CO;2-H }}

Latest revision as of 11:30, 9 January 2019

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Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.[1]

Function

Oncogene FLT belongs to the src gene family and is related to oncogene ROS (MIM 165020). Like other members of this family, it shows tyrosine protein kinase activity that is important for the control of cell proliferation and differentiation. The sequence structure of the FLT gene resembles that of the FMS gene (MIM 164770); hence, Yoshida et al. (1987) proposed the name FLT as an acronym for FMS-like tyrosine kinase.[supplied by OMIM][2]

The ablation of VEGFR1 by chemical and genetic means has also recently been found to augment the conversion of white adipose tissue to brown adipose tissue as well as increase brown adipose angiogenesis in mice.[3]

Functional genetic variation in FLT1 (rs9582036) has been found to affect non-small cell lung cancer survival.[4]

Interactions

FLT1 has been shown to interact with PLCG1[5] and vascular endothelial growth factor B (VEGF-B).[6][7]

See also

References

  1. ↑ Shibuya M, Yamaguchi S, Yamane A, Ikeda T, Tojo A, Matsushime H, Sato M (Apr 1990). "Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family". Oncogene. 5 (4): 519–24. PMID 2158038.
  2. ↑ "Entrez Gene: FLT1 fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)".
  3. ↑ Seki T, Hosaka K, Fischer C, Lim S, Andersson P, Abe M, Iwamoto H, Gao Y, Wang X, Fong GH, Cao Y (January 2018). "Ablation of endothelial VEGFR1 improves metabolic dysfunction by inducing adipose tissue browning". The Journal of Experimental Medicine. 215 (2): 611–626. doi:10.1084/jem.20171012. PMC 5789413. PMID 29305395.
  4. ↑ Glubb, Dylan M.; Paré-Brunet, Laia; Jantus-Lewintre, Eloisa; Jiang, Chen; Crona, Daniel; Etheridge, Amy S.; Mirza, Osman; Zhang, Wei; Seiser, Eric L. (2015-7). "Functional FLT1 Genetic Variation is a Prognostic Factor for Recurrence in Stage I-III Non-Small-Cell Lung Cancer". Journal of Thoracic Oncology: Official Publication of the International Association for the Study of Lung Cancer. 10 (7): 1067–1075. doi:10.1097/JTO.0000000000000549. ISSN 1556-1380. PMC 4494119. PMID 26134224. Check date values in: |date= (help)
  5. ↑ Cunningham SA, Arrate MP, Brock TA, Waxham MN (Nov 1997). "Interactions of FLT-1 and KDR with phospholipase C gamma: identification of the phosphotyrosine binding sites". Biochemical and Biophysical Research Communications. 240 (3): 635–9. doi:10.1006/bbrc.1997.7719. PMID 9398617.
  6. ↑ Olofsson B, Korpelainen E, Pepper MS, Mandriota SJ, Aase K, Kumar V, Gunji Y, Jeltsch MM, Shibuya M, Alitalo K, Eriksson U (Sep 1998). "Vascular endothelial growth factor B (VEGF-B) binds to VEGF receptor-1 and regulates plasminogen activator activity in endothelial cells". Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11709–14. doi:10.1073/pnas.95.20.11709. PMC 21705. PMID 9751730.
  7. ↑ Makinen T, Olofsson B, Karpanen T, Hellman U, Soker S, Klagsbrun M, Eriksson U, Alitalo K (Jul 1999). "Differential binding of vascular endothelial growth factor B splice and proteolytic isoforms to neuropilin-1". The Journal of Biological Chemistry. 274 (30): 21217–22. doi:10.1074/jbc.274.30.21217. PMID 10409677.

Further reading

  • Petrova TV, Makinen T, Alitalo K (Nov 1999). "Signaling via vascular endothelial growth factor receptors". Experimental Cell Research. 253 (1): 117–30. doi:10.1006/excr.1999.4707. PMID 10579917.
  • Sato Y, Kanno S, Oda N, Abe M, Ito M, Shitara K, Shibuya M (May 2000). "Properties of two VEGF receptors, Flt-1 and KDR, in signal transduction". Annals of the New York Academy of Sciences. 902 (1): 201–5, discussion 205–7. doi:10.1111/j.1749-6632.2000.tb06314.x. PMID 10865839.
  • Boyd AW, Lackmann M (Dec 2001). "Signals from Eph and ephrin proteins: a developmental tool kit". Science's STKE : Signal Transduction Knowledge Environment. 2001 (112): RE20. doi:10.1126/stke.2001.112.re20. PMID 11741094.
  • Luttun A, Tjwa M, Carmeliet P (Dec 2002). "Placental growth factor (PlGF) and its receptor Flt-1 (VEGFR-1): novel therapeutic targets for angiogenic disorders". Annals of the New York Academy of Sciences. 979: 80–93. doi:10.1111/j.1749-6632.2002.tb04870.x. PMID 12543719.
  • Maynard SE, Venkatesha S, Thadhani R, Karumanchi SA (May 2005). "Soluble Fms-like tyrosine kinase 1 and endothelial dysfunction in the pathogenesis of preeclampsia". Pediatric Research. 57 (5 Pt 2): 1R–7R. doi:10.1203/01.PDR.0000159567.85157.B7. PMID 15817508.
  • Shibuya M (2007). "Vascular endothelial growth factor receptor-1 (VEGFR-1/Flt-1): a dual regulator for angiogenesis". Angiogenesis. 9 (4): 225–30, discussion 231. doi:10.1007/s10456-006-9055-8. PMID 17109193.
  • Widmer M, Villar J, Benigni A, Conde-Agudelo A, Karumanchi SA, Lindheimer M (Jan 2007). "Mapping the theories of preeclampsia and the role of angiogenic factors: a systematic review". Obstetrics and Gynecology. 109 (1): 168–80. doi:10.1097/01.AOG.0000249609.04831.7c. PMID 17197602.
  • López-Novoa JM (Mar 2007). "Soluble endoglin is an accurate predictor and a pathogenic molecule in pre-eclampsia". Nephrology, Dialysis, Transplantation. 22 (3): 712–4. doi:10.1093/ndt/gfl768. PMID 17210583.
  • Poesen K, Lambrechts D, Van Damme P, Dhondt J, Bender F, Frank N, Bogaert E, Claes B, Heylen L, Verheyen A, Raes K, Tjwa M, Eriksson U, Shibuya M, Nuydens R, Van Den Bosch L, Meert T, D'Hooge R, Sendtner M, Robberecht W, Carmeliet P (Oct 2008). "Novel role for vascular endothelial growth factor (VEGF) receptor-1 and its ligand VEGF-B in motor neuron degeneration". The Journal of Neuroscience. 28 (42): 10451–9. doi:10.1523/JNEUROSCI.1092-08.2008. PMID 18923022.
  • Joukov V, Kaipainen A, Jeltsch M, Pajusola K, Olofsson B, Kumar V, Eriksson U, Alitalo K (Nov 1997). "Vascular endothelial growth factors VEGF-B and VEGF-C". Journal of Cellular Physiology. 173 (2): 211–5. doi:10.1002/(SICI)1097-4652(199711)173:2<211::AID-JCP23>3.0.CO;2-H. PMID 9365524.
  • Kaplan RN, Riba RD, Zacharoulis S, Bramley AH, Vincent L, Costa C, MacDonald DD, Jin DK, Shido K, Kerns SA, Zhu Z, Hicklin D, Wu Y, Port JL, Altorki N, Port ER, Ruggero D, Shmelkov SV, Jensen KK, Rafii S, Lyden D (Dec 2005). "VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche". Nature. 438 (7069): 820–7. doi:10.1038/nature04186. PMC 2945882. PMID 16341007.


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