SGK2: Difference between revisions
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| summary_text = This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described.<ref name="entrez" /> | | summary_text = This gene encodes a [[serine/threonine protein kinase]]. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase ([[SGK]]), this gene is not induced by [[Serum (blood)|serum]] or [[glucocorticoids]]. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase ([[PI3K]]), which is also true for SGK. Two [[Alternative splicing|alternate transcripts]] encoding two different [[Protein isoform|isoforms]] have been described.<ref name="entrez" /> | ||
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*{{cite journal |vauthors=Lang F, Cohen P |title=Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms |journal=Sci. STKE |volume=2001 |issue= 108 |pages= RE17 |year= 2002 |pmid= 11707620 |doi= 10.1126/stke.2001.108.re17 }} | *{{cite journal |vauthors=Lang F, Cohen P |title=Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms |journal=Sci. STKE |volume=2001 |issue= 108 |pages= RE17 |year= 2002 |pmid= 11707620 |doi= 10.1126/stke.2001.108.re17 }} | ||
*{{cite journal | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |name-list-format=vanc| author2=Matthews LH | author3=Ashurst J | display-authors=3 | last4=Burton | first4=J. | last5=Gilbert | first5=J. G. R. | last6=Jones | first6=M. | last7=Stavrides | first7=G. | last8=Almeida | first8=J. P. | last9=Babbage | first9=A. K. }} | *{{cite journal | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a |name-list-format=vanc| author2=Matthews LH | author3=Ashurst J | display-authors=3 | last4=Burton | first4=J. | last5=Gilbert | first5=J. G. R. | last6=Jones | first6=M. | last7=Stavrides | first7=G. | last8=Almeida | first8=J. P. | last9=Babbage | first9=A. K. }} | ||
*{{cite journal | author=Gamper N |title=K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK |journal= | *{{cite journal | author=Gamper N |title=K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK |journal=Pflügers Arch. |volume=445 |issue= 1 |pages= 60–6 |year= 2003 |pmid= 12397388 |doi= 10.1007/s00424-002-0873-2 |name-list-format=vanc| author2=Fillon S | author3=Feng Y | display-authors=3 | last4=b. | first4=Friedrich | last5=p. | first5=Lang | last6=g. | first6=Henke | last7=s. | first7=Huber | last8=t. | first8=Kobayashi | last9=p. | first9=Cohen }} | ||
*{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }} | ||
*{{cite journal | author=Friedrich B |title=The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC |journal= | *{{cite journal | author=Friedrich B |title=The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC |journal=Pflügers Arch. |volume=445 |issue= 6 |pages= 693–6 |year= 2003 |pmid= 12632189 |doi= 10.1007/s00424-002-0993-8 |name-list-format=vanc| author2=Feng Y | author3=Cohen P | display-authors=3 | last4=Risler | first4=T | last5=Vandewalle | first5=A | last6=Bröer | first6=S | last7=Wang | first7=J | last8=Pearce | first8=D | last9=Lang | first9=F }} | ||
*{{cite journal | author=Embark HM |title=Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms |journal= | *{{cite journal | author=Embark HM |title=Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms |journal=Pflügers Arch. |volume=445 |issue= 5 |pages= 601–6 |year= 2003 |pmid= 12634932 |doi= 10.1007/s00424-002-0982-y |name-list-format=vanc| author2=Böhmer C | author3=Vallon V | display-authors=3 | last4=Luft | first4=F | last5=Lang | first5=F }} | ||
*{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | *{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | ||
*{{cite journal | author=Baltaev R |title=Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes |journal= | *{{cite journal | author=Baltaev R |title=Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes |journal=Pflügers Arch. |volume=450 |issue= 1 |pages= 26–33 |year= 2005 |pmid= 15578212 |doi= 10.1007/s00424-004-1369-z |name-list-format=vanc| author2=Strutz-Seebohm N | author3=Korniychuk G | display-authors=3 | last4=Myssina | first4=Svetlana | last5=Lang | first5=Florian | last6=Seebohm | first6=Guiscard }} | ||
*{{cite journal | author=Cheng J |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution |journal=Science |volume=308 |issue= 5725 |pages= 1149–54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625 |name-list-format=vanc| author2=Kapranov P | author3=Drenkow J | display-authors=3 | last4=Dike | first4=S | last5=Brubaker | first5=S | last6=Patel | first6=S | last7=Long | first7=J | last8=Stern | first8=D | last9=Tammana | first9=H }} | *{{cite journal | author=Cheng J |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution |journal=Science |volume=308 |issue= 5725 |pages= 1149–54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625 |name-list-format=vanc| author2=Kapranov P | author3=Drenkow J | display-authors=3 | last4=Dike | first4=S | last5=Brubaker | first5=S | last6=Patel | first6=S | last7=Long | first7=J | last8=Stern | first8=D | last9=Tammana | first9=H }} | ||
}} | }} | ||
Latest revision as of 07:19, 10 January 2019
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| External IDs | GeneCards: [1] | ||||||
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| Species | Human | Mouse | |||||
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| RefSeq (mRNA) |
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| Location (UCSC) | n/a | n/a | |||||
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Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene.[1][2]
This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase (PI3K), which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described.[2]
References
- ↑ Kobayashi T, Deak M, Morrice N, Cohen P (Jan 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 (1): 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550.
- ↑ 2.0 2.1 "Entrez Gene: SGK2 serum/glucocorticoid regulated kinase 2".
Further reading
- Lang F, Cohen P (2002). "Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms". Sci. STKE. 2001 (108): RE17. doi:10.1126/stke.2001.108.re17. PMID 11707620.
- Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.
- Gamper N, Fillon S, Feng Y, et al. (2003). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflügers Arch. 445 (1): 60–6. doi:10.1007/s00424-002-0873-2. PMID 12397388.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Friedrich B, Feng Y, Cohen P, et al. (2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC". Pflügers Arch. 445 (6): 693–6. doi:10.1007/s00424-002-0993-8. PMID 12632189.
- Embark HM, Böhmer C, Vallon V, et al. (2003). "Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms". Pflügers Arch. 445 (5): 601–6. doi:10.1007/s00424-002-0982-y. PMID 12634932.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Baltaev R, Strutz-Seebohm N, Korniychuk G, et al. (2005). "Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes". Pflügers Arch. 450 (1): 26–33. doi:10.1007/s00424-004-1369-z. PMID 15578212.
- Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. doi:10.1126/science.1108625. PMID 15790807.
External links
- SGK2 human gene location in the UCSC Genome Browser.
- SGK2 human gene details in the UCSC Genome Browser.
 | This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by expanding it. |