Ribosomal protein s6: Difference between revisions
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'''Ribosomal protein S6''' ('''rpS6''') is a component of the [[40S]] ribosomal subunit and is therefore thought to be involved in regulating [[Translation (biology)|translation]]. While the true function of rpS6 is currently under investigation, studies have shown that it is involved in the regulation of [[cell size]], [[cell proliferation]], and [[glucose homeostasis]].<ref name="pmid22168436">{{cite journal | | '''Ribosomal protein S6''' ('''rpS6''') is a component of the [[40S]] ribosomal subunit and is therefore thought to be involved in regulating [[Translation (biology)|translation]]. While the true function of rpS6 is currently under investigation, studies have shown that it is involved in the regulation of [[cell size]], [[cell proliferation]], and [[glucose homeostasis]].<ref name="pmid22168436">{{cite journal | vauthors = Magnuson B, Ekim B, Fingar DC | title = Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks | journal = The Biochemical Journal | volume = 441 | issue = 1 | pages = 1–21 | date = January 2012 | pmid = 22168436 | doi = 10.1042/BJ20110892 }}</ref> | ||
Studies show that the p70 ribosomal protein S6 kinases ([[S6K1]] and [[S6K2]]) and p90 ribosomal protein S6 kinases ([[Ribosomal s6 kinase|RSK]]) both phosphorylate rpS6 and that S6K1 and S6K2 predominate this function. | Studies show that the p70 ribosomal protein S6 kinases ([[S6K1]] and [[S6K2]]) and p90 ribosomal protein S6 kinases ([[Ribosomal s6 kinase|RSK]]) both phosphorylate rpS6 and that S6K1 and S6K2 predominate this function. | ||
==References== | == References == | ||
{{Reflist}} | {{Reflist}} | ||
==External links== | == External links == | ||
* {{MeshName|Ribosomal+Protein+S6}} | * {{MeshName|Ribosomal+Protein+S6}} | ||
Latest revision as of 07:28, 10 January 2019
| ribosomal protein S6 | |
|---|---|
| Identifiers | |
| Symbol | RPS6 |
| Entrez | 6194 |
| HUGO | 10429 |
| OMIM | 180460 |
| RefSeq | NM_001010 |
| UniProt | P62753 |
| Other data | |
| Locus | Chr. 9 p21 |
Ribosomal protein S6 (rpS6) is a component of the 40S ribosomal subunit and is therefore thought to be involved in regulating translation. While the true function of rpS6 is currently under investigation, studies have shown that it is involved in the regulation of cell size, cell proliferation, and glucose homeostasis.[1]
Studies show that the p70 ribosomal protein S6 kinases (S6K1 and S6K2) and p90 ribosomal protein S6 kinases (RSK) both phosphorylate rpS6 and that S6K1 and S6K2 predominate this function.
References
- ↑ Magnuson B, Ekim B, Fingar DC (January 2012). "Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks". The Biochemical Journal. 441 (1): 1–21. doi:10.1042/BJ20110892. PMID 22168436.
External links
- Ribosomal+Protein+S6 at the US National Library of Medicine Medical Subject Headings (MeSH)