PRKACG: Difference between revisions

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Latest revision as of 07:37, 10 January 2019

cAMP-dependent protein kinase catalytic subunit gamma is an enzyme that in humans is encoded by the PRKACG gene.^[1]^[2]^[3]

Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.^[3]

Interactions

PRKACG has been shown to interact with Ryanodine receptor 2.^[4]

References

↑ Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T (June 1990). "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase". Mol Endocrinol. 4 (3): 465–75. doi:10.1210/mend-4-3-465. PMID 2342480.
↑ Reinton N, Haugen TB, Orstavik S, Skalhegg BS, Hansson V, Jahnsen T, Tasken K (August 1998). "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon". Genomics. 49 (2): 290–7. doi:10.1006/geno.1998.5240. PMID 9598317.
↑ ^3.0 ^3.1 "Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma".
↑ Marx, S O; Reiken S; Hisamatsu Y; Jayaraman T; Burkhoff D; Rosemblit N; Marks A R (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. UNITED STATES. 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. ISSN 0092-8674. PMID 10830164.

Foss KB, Simard J, Bérubé D, et al. (1992). "Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13". Cytogenet. Cell Genet. 60 (1): 22–5. doi:10.1159/000133286. PMID 1339328.
Hofmann B, Nishanian P, Baldwin RL, et al. (1991). "HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism". J. Immunol. 145 (11): 3699–705. PMID 1978848.
Hofmann B, Nishanian P, Nguyen T, et al. (1993). "Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 90 (14): 6676–80. Bibcode:1993PNAS...90.6676H. doi:10.1073/pnas.90.14.6676. PMC 46995. PMID 7688126.
Hofmann B, Nishanian P, Fan J, et al. (1994). "HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro". AIDS. 8 (7): 1016–7. doi:10.1097/00002030-199407000-00025. PMID 7946090.
Swingler S, Gallay P, Camaur D, et al. (1997). "The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix". J. Virol. 71 (6): 4372–7. PMC 191654. PMID 9151826.
Chen P, Mayne M, Power C, Nath A (1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". J. Biol. Chem. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
Liapi C, Takahashi N, Raynaud F, et al. (1998). "Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts". J. Invest. Dermatol. 110 (4): 332–7. doi:10.1046/j.1523-1747.1998.00149.x. PMID 9540970.
Zidovetzki R, Wang JL, Chen P, et al. (1998). "Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways". AIDS Res. Hum. Retroviruses. 14 (10): 825–33. doi:10.1089/aid.1998.14.825. PMID 9671211.
Mayne M, Bratanich AC, Chen P, et al. (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685.
Bodnar RJ, Xi X, Li Z, et al. (2003). "Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta)". J. Biol. Chem. 277 (49): 47080–7. doi:10.1074/jbc.M208329200. PMID 12361948.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Cartier C, Hemonnot B, Gay B, et al. (2003). "Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein". J. Biol. Chem. 278 (37): 35211–9. doi:10.1074/jbc.M301257200. PMID 12842892.
Masci AM, Galgani M, Cassano S, et al. (2004). "HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling". J. Leukoc. Biol. 74 (6): 1117–24. doi:10.1189/jlb.0503239. PMID 12972513.
Zhang W, Morris GZ, Beebe SJ (2004). "Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells". Protein Expr. Purif. 35 (1): 156–69. doi:10.1016/j.pep.2004.01.006. PMID 15039079.
Stevanin G, Hahn V, Lohmann E, et al. (2004). "Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14". Arch. Neurol. 61 (8): 1242–8. doi:10.1001/archneur.61.8.1242. PMID 15313841.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by expanding it.

[pmid2342480-1] Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T (June 1990). "Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase". Mol Endocrinol. 4 (3): 465–75. doi:10.1210/mend-4-3-465. PMID 2342480.

[pmid9598317-2] Reinton N, Haugen TB, Orstavik S, Skalhegg BS, Hansson V, Jahnsen T, Tasken K (August 1998). "The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon". Genomics. 49 (2): 290–7. doi:10.1006/geno.1998.5240. PMID 9598317.

[entrez-3] 3.0 ^3.1 "Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma".

[pmid10830164-4] Marx, S O; Reiken S; Hisamatsu Y; Jayaraman T; Burkhoff D; Rosemblit N; Marks A R (May 2000). "PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts". Cell. UNITED STATES. 101 (4): 365–76. doi:10.1016/S0092-8674(00)80847-8. ISSN 0092-8674. PMID 10830164.

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-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''cAMP-dependent protein kinase catalytic subunit gamma''' is an [[enzyme]] that in humans is encoded by the ''PRKACG'' [[gene]].<ref name="pmid2342480">{{cite journal |vauthors=Beebe SJ, Oyen O, Sandberg M, Froysa A, Hansson V, Jahnsen T | title = Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase | journal = Mol Endocrinol | volume = 4 | issue = 3 | pages = 465–75 |date=June 1990 | pmid = 2342480 | pmc =  | doi =10.1210/mend-4-3-465  }}</ref><ref name="pmid9598317">{{cite journal |vauthors=Reinton N, Haugen TB, Orstavik S, Skalhegg BS, Hansson V, Jahnsen T, Tasken K | title = The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon | journal = Genomics | volume = 49 | issue = 2 | pages = 290–7 |date=August 1998 | pmid = 9598317 | pmc =  | doi = 10.1006/geno.1998.5240 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5568| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Protein kinase, cAMP-dependent, catalytic, gamma
- | HGNCid = 9382
- | Symbol = PRKACG
- | AltSymbols =; KAPG
- | OMIM = 176893
- | ECnumber =
- | Homologene = 55677
- | MGIid =
-  | GeneAtlas_image1 = PBB_GE_PRKACG_207228_at_tn.png
-  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0004691 |text = cAMP-dependent protein kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0031594 |text = neuromuscular junction}}
-  | Process = {{GNF_GO|id=GO:0001707 |text = mesoderm formation}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007283 |text = spermatogenesis}} {{GNF_GO|id=GO:0008584 |text = male gonad development}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 5568
-    | Hs_Ensembl = ENSG00000165059
-    | Hs_RefseqProtein = NP_002723
-    | Hs_RefseqmRNA = NM_002732
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 9
-    | Hs_GenLoc_start = 70817241
-    | Hs_GenLoc_end = 70818849
-    | Hs_Uniprot = P22612
-    | Mm_EntrezGene =
-    | Mm_Ensembl =
-    | Mm_RefseqmRNA =
-    | Mm_RefseqProtein =
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr =
-    | Mm_GenLoc_start =
-    | Mm_GenLoc_end =
-    | Mm_Uniprot =
-  }}
-}}
-'''Protein kinase, cAMP-dependent, catalytic, gamma''', also known as '''PRKACG''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5568| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = Cyclic AMP-dependent protein kinase (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is intronless and is thought to be a retrotransposon derived from the gene for the alpha form of the PKA catalytic subunit.<ref name="entrez">{{cite web | title = Entrez Gene: PRKACG protein kinase, cAMP-dependent, catalytic, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5568| accessdate = }}</ref>
+| summary_text = [[Protein kinase A|Cyclic AMP-dependent protein kinase]] (PKA) consists of two catalytic subunits and a regulatory subunit dimer. This gene encodes the gamma form of its catalytic subunit. The gene is [[Intron|intronless]] and is thought to be a [[retrotransposon]] derived from the gene for the alpha form of the PKA catalytic subunit.<ref name="entrez" />
 }}
+==Interactions==
+PRKACG has been shown to [[Protein-protein interaction|interact]] with [[Ryanodine receptor 2]].<ref name=pmid10830164>{{cite journal |last=Marx |first=S O |authorlink= |author2=Reiken S |author3=Hisamatsu Y |author4=Jayaraman T |author5=Burkhoff D |author6=Rosemblit N |author7=Marks A R  |date=May 2000 |title=PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts |journal=Cell |volume=101 |issue=4 |pages=365–76 |publisher= |location = UNITED STATES| issn = 0092-8674| pmid = 10830164 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1016/S0092-8674(00)80847-8 }}</ref>
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Foss KB, Simard J, Bérubé D, ''et al.'' |title=Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13. |journal=Cytogenet. Cell Genet. |volume=60 |issue= 1 |pages= 22-5 |year= 1992 |pmid= 1339328 |doi=  }}
+*{{cite journal  | author=Foss KB |title=Localization of the catalytic subunit C gamma of the cAMP-dependent protein kinase gene (PRKACG) to human chromosome region 9q13 |journal=Cytogenet. Cell Genet. |volume=60 |issue= 1 |pages= 22–5 |year= 1992 |pmid= 1339328 |doi=10.1159/000133286  |name-list-format=vanc| author2=Simard J  | author3=Bérubé D  | display-authors=3  | last4=Beebe  | first4=S.J.  | last5=Sandberg  | first5=M.  | last6=Grzeschik  | first6=K.-H.  | last7=Gagn&Eacute;  | first7=R.  | last8=Hansson  | first8=V.  | last9=Jahnsen  | first9=T.  }}
-*{{cite journal  | author=Hofmann B, Nishanian P, Baldwin RL, ''et al.'' |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism. |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699-705 |year= 1991 |pmid= 1978848 |doi=  }}
+*{{cite journal  | author=Hofmann B |title=HIV inhibits the early steps of lymphocyte activation, including initiation of inositol phospholipid metabolism |journal=J. Immunol. |volume=145 |issue= 11 |pages= 3699–705 |year= 1991 |pmid= 1978848 |doi=  |name-list-format=vanc| author2=Nishanian P  | author3=Baldwin RL  | display-authors=3  | last4=Insixiengmay  | first4=P  | last5=Nel  | first5=A  | last6=Fahey  | first6=JL  }}
-*{{cite journal  | author=Beebe SJ, Oyen O, Sandberg M, ''et al.'' |title=Molecular cloning of a tissue-specific protein kinase (C gamma) from human testis--representing a third isoform for the catalytic subunit of cAMP-dependent protein kinase. |journal=Mol. Endocrinol. |volume=4 |issue= 3 |pages= 465-75 |year= 1990 |pmid= 2342480 |doi=  }}
+*{{cite journal  | author=Hofmann B |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676–80 |year= 1993 |pmid= 7688126 |doi=10.1073/pnas.90.14.6676  | pmc=46995  |name-list-format=vanc| author2=Nishanian P  | author3=Nguyen T  | display-authors=3  | last4=Insixiengmay  | first4=P  | last5=Fahey  | first5=JL  |bibcode=1993PNAS...90.6676H}}
-*{{cite journal  | author=Hofmann B, Nishanian P, Nguyen T, ''et al.'' |title=Human immunodeficiency virus proteins induce the inhibitory cAMP/protein kinase A pathway in normal lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 14 |pages= 6676-80 |year= 1993 |pmid= 7688126 |doi=  }}
+*{{cite journal  | author=Hofmann B |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro |journal=AIDS |volume=8 |issue= 7 |pages= 1016–7 |year= 1994 |pmid= 7946090 |doi=10.1097/00002030-199407000-00025  |name-list-format=vanc| author2=Nishanian P  | author3=Fan J  | display-authors=3  | last4=Nguyen  | first4=T.  | last5=Fahey  | first5=J. L.  }}
-*{{cite journal  | author=Hofmann B, Nishanian P, Fan J, ''et al.'' |title=HIV Gag p17 protein impairs proliferation of normal lymphocytes in vitro. |journal=AIDS |volume=8 |issue= 7 |pages= 1016-7 |year= 1994 |pmid= 7946090 |doi=  }}
+*{{cite journal  | author=Swingler S |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372–7 |year= 1997 |pmid= 9151826 |doi=  | pmc=191654  |name-list-format=vanc| author2=Gallay P  | author3=Camaur D  | display-authors=3  | last4=Song  | first4=J  | last5=Abo  | first5=A  | last6=Trono  | first6=D  }}
-*{{cite journal  | author=Swingler S, Gallay P, Camaur D, ''et al.'' |title=The Nef protein of human immunodeficiency virus type 1 enhances serine phosphorylation of the viral matrix. |journal=J. Virol. |volume=71 |issue= 6 |pages= 4372-7 |year= 1997 |pmid= 9151826 |doi=  }}
+*{{cite journal  |vauthors=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385–8 |year= 1997 |pmid= 9278385 |doi=10.1074/jbc.272.36.22385  }}
-*{{cite journal  | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385-8 |year= 1997 |pmid= 9278385 |doi=  }}
+*{{cite journal  | author=Liapi C |title=Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts |journal=J. Invest. Dermatol. |volume=110 |issue= 4 |pages= 332–7 |year= 1998 |pmid= 9540970 |doi= 10.1046/j.1523-1747.1998.00149.x  |name-list-format=vanc| author2=Takahashi N  | author3=Raynaud F  | display-authors=3  | last4=Evain-Brion  | first4=Daniele  | last5=Anderson  | first5=Wayne B. }}
-*{{cite journal  | author=Liapi C, Takahashi N, Raynaud F, ''et al.'' |title=Effects of [D-Ala1] peptide T-NH2 and HIV envelope glycoprotein gp120 on cyclic AMP dependent protein kinases in normal and psoriatic human fibroblasts. |journal=J. Invest. Dermatol. |volume=110 |issue= 4 |pages= 332-7 |year= 1998 |pmid= 9540970 |doi= 10.1046/j.1523-1747.1998.00149.x }}
+*{{cite journal  | author=Zidovetzki R |title=Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways |journal=AIDS Res. Hum. Retroviruses |volume=14 |issue= 10 |pages= 825–33 |year= 1998 |pmid= 9671211 |doi=10.1089/aid.1998.14.825  |name-list-format=vanc| author2=Wang JL  | author3=Chen P  | display-authors=3  | last4=Jeyaseelan  | first4=Raju  | last5=Hofman  | first5=Florence  }}
-*{{cite journal  | author=Reinton N, Haugen TB, Orstavik S, ''et al.'' |title=The gene encoding the C gamma catalytic subunit of cAMP-dependent protein kinase is a transcribed retroposon. |journal=Genomics |volume=49 |issue= 2 |pages= 290-7 |year= 1998 |pmid= 9598317 |doi= 10.1006/geno.1998.5240 }}
+*{{cite journal  | author=Mayne M |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease |journal=Neuroimmunomodulation |volume=5 |issue= 3–4 |pages= 184–92 |year= 1998 |pmid= 9730685 |doi=10.1159/000026336  |name-list-format=vanc| author2=Bratanich AC  | author3=Chen P  | display-authors=3  | last4=Rana  | first4=Farazana  | last5=Nath  | first5=Avindra  | last6=Power  | first6=Christopher  }}
-*{{cite journal  | author=Zidovetzki R, Wang JL, Chen P, ''et al.'' |title=Human immunodeficiency virus Tat protein induces interleukin 6 mRNA expression in human brain endothelial cells via protein kinase C- and cAMP-dependent protein kinase pathways. |journal=AIDS Res. Hum. Retroviruses |volume=14 |issue= 10 |pages= 825-33 |year= 1998 |pmid= 9671211 |doi=  }}
+*{{cite journal  | author=Bodnar RJ |title=Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta) |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47080–7 |year= 2003 |pmid= 12361948 |doi= 10.1074/jbc.M208329200  |name-list-format=vanc| author2=Xi X  | author3=Li Z  | display-authors=3  | last4=Berndt  | first4=MC  | last5=Du  | first5=X }}
-*{{cite journal  | author=Mayne M, Bratanich AC, Chen P, ''et al.'' |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184-92 |year= 1998 |pmid= 9730685 |doi=  }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD |bibcode=2002PNAS...9916899M}}
-*{{cite journal  | author=Bodnar RJ, Xi X, Li Z, ''et al.'' |title=Regulation of glycoprotein Ib-IX-von Willebrand factor interaction by cAMP-dependent protein kinase-mediated phosphorylation at Ser 166 of glycoprotein Ib(beta). |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47080-7 |year= 2003 |pmid= 12361948 |doi= 10.1074/jbc.M208329200 }}
+*{{cite journal  | author=Cartier C |title=Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35211–9 |year= 2003 |pmid= 12842892 |doi= 10.1074/jbc.M301257200  |name-list-format=vanc| author2=Hemonnot B  | author3=Gay B  | display-authors=3  | last4=Bardy  | first4=M  | last5=Sanchiz  | first5=C  | last6=Devaux  | first6=C  | last7=Briant  | first7=L }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | author=Masci AM |title=HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling |journal=J. Leukoc. Biol. |volume=74 |issue= 6 |pages= 1117–24 |year= 2004 |pmid= 12972513 |doi= 10.1189/jlb.0503239  |name-list-format=vanc| author2=Galgani M  | author3=Cassano S  | display-authors=3  | last4=De Simone  | first4=S  | last5=Gallo  | first5=A  | last6=De Rosa  | first6=V  | last7=Zappacosta  | first7=S  | last8=Racioppi  | first8=L }}
-*{{cite journal  | author=Cartier C, Hemonnot B, Gay B, ''et al.'' |title=Active cAMP-dependent protein kinase incorporated within highly purified HIV-1 particles is required for viral infectivity and interacts with viral capsid protein. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35211-9 |year= 2003 |pmid= 12842892 |doi= 10.1074/jbc.M301257200 }}
+*{{cite journal  |vauthors=Zhang W, Morris GZ, Beebe SJ |title=Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells |journal=Protein Expr. Purif. |volume=35 |issue= 1 |pages= 156–69 |year= 2004 |pmid= 15039079 |doi= 10.1016/j.pep.2004.01.006 }}
-*{{cite journal  | author=Masci AM, Galgani M, Cassano S, ''et al.'' |title=HIV-1 gp120 induces anergy in naive T lymphocytes through CD4-independent protein kinase-A-mediated signaling. |journal=J. Leukoc. Biol. |volume=74 |issue= 6 |pages= 1117-24 |year= 2004 |pmid= 12972513 |doi= 10.1189/jlb.0503239 }}
+*{{cite journal  | author=Stevanin G |title=Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14 |journal=Arch. Neurol. |volume=61 |issue= 8 |pages= 1242–8 |year= 2004 |pmid= 15313841 |doi= 10.1001/archneur.61.8.1242  |name-list-format=vanc| author2=Hahn V  | author3=Lohmann E  | display-authors=3  | last4=Bouslam  | first4=N  | last5=Gouttard  | first5=M  | last6=Soumphonphakdy  | first6=C  | last7=Welter  | first7=ML  | last8=Ollagnon-Roman  | first8=E  | last9=Lemainque  | first9=A }}
-*{{cite journal  | author=Zhang W, Morris GZ, Beebe SJ |title=Characterization of the cAMP-dependent protein kinase catalytic subunit Cgamma expressed and purified from sf9 cells. |journal=Protein Expr. Purif. |volume=35 |issue= 1 |pages= 156-69 |year= 2004 |pmid= 15039079 |doi= 10.1016/j.pep.2004.01.006 }}
+*{{cite journal  | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
-*{{cite journal  | author=Stevanin G, Hahn V, Lohmann E, ''et al.'' |title=Mutation in the catalytic domain of protein kinase C gamma and extension of the phenotype associated with spinocerebellar ataxia type 14. |journal=Arch. Neurol. |volume=61 |issue= 8 |pages= 1242-8 |year= 2004 |pmid= 15313841 |doi= 10.1001/archneur.61.8.1242 }}
-*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
 }}
 {{refend}}
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+{{Enzymes}}
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+{{PBB_Controls
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+[[Category:EC 2.7.11]]
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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

PRKACG: Difference between revisions

Latest revision as of 07:37, 10 January 2019

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