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{{Infobox_gene}}
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'''MAP kinase-interacting serine/threonine-protein kinase 1''' is an [[enzyme]] that in humans is encoded by the ''MKNK1'' [[gene]].<ref name="pmid9155018">{{cite journal |vauthors=Fukunaga R, Hunter T | title = MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates | journal = EMBO J | volume = 16 | issue = 8 | pages = 1921–33 |date=Jun 1997 | pmid = 9155018 | pmc = 1169795 | doi = 10.1093/emboj/16.8.1921 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MKNK1 MAP kinase interacting serine/threonine kinase 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8569| accessdate = }}</ref>
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| image = PBB_Protein_MKNK1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2hw6.
| PDB = {{PDB2|2hw6}}
| Name = MAP kinase interacting serine/threonine kinase 1
| HGNCid = 7110
| Symbol = MKNK1
| AltSymbols =; MNK1
| OMIM = 606724
| ECnumber = 
| Homologene = 37838
| MGIid = 894316
| GeneAtlas_image1 = PBB_GE_MKNK1_209467_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006417 |text = regulation of translation}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 8569
    | Hs_Ensembl = ENSG00000079277
    | Hs_RefseqProtein = NP_003675
    | Hs_RefseqmRNA = NM_003684
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 46795677
    | Hs_GenLoc_end = 46842497
    | Hs_Uniprot = Q9BUB5
    | Mm_EntrezGene = 17346
    | Mm_Ensembl = ENSMUSG00000028708
    | Mm_RefseqmRNA = NM_021461
    | Mm_RefseqProtein = NP_067436
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 115337178
    | Mm_GenLoc_end = 115377180
    | Mm_Uniprot = Q3TDV2
  }}
}}
'''MAP kinase interacting serine/threonine kinase 1''', also known as '''MKNK1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MKNK1 MAP kinase interacting serine/threonine kinase 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8569| accessdate = }}</ref>
 
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==Interactions==
MKNK1 has been shown to [[Protein-protein interaction|interact]] with [[MAPK1]]<ref name=pmid9155017>{{cite journal |last=Waskiewicz |first=A J |authorlink= |author2=Flynn A |author3=Proud C G |author4=Cooper J A  |date=Apr 1997 |title=Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 |journal=EMBO J. |volume=16 |issue=8 |pages=1909–20 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 9155017 |doi = 10.1093/emboj/16.8.1909 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1169794 }}</ref> and [[Eukaryotic translation initiation factor 4 gamma]].<ref name=pmid9878069>{{cite journal |last=Pyronnet |first=S |authorlink= |author2=Imataka H |author3=Gingras A C |author4=Fukunaga R |author5=Hunter T |author6=Sonenberg N  |date=Jan 1999 |title=Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E |journal=EMBO J. |volume=18 |issue=1 |pages=270–9 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 9878069 |doi = 10.1093/emboj/18.1.270 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1171121 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=de Carvalho MG, McCormack AL, Olson E, ''et al.'' |title=Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 6987-97 |year= 1996 |pmid= 8636128 |doi=  }}
*{{cite journal   |vauthors=de Carvalho MG, McCormack AL, Olson E, etal |title=Identification of phosphorylation sites of human 85-kDa cytosolic phospholipase A2 expressed in insect cells and present in human monocytes. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 6987–97 |year= 1996 |pmid= 8636128 |doi=10.1074/jbc.271.12.6987 }}
*{{cite journal  | author=Waskiewicz AJ, Flynn A, Proud CG, Cooper JA |title=Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. |journal=EMBO J. |volume=16 |issue= 8 |pages= 1909-20 |year= 1997 |pmid= 9155017 |doi= 10.1093/emboj/16.8.1909 }}
*{{cite journal  |vauthors=Waskiewicz AJ, Flynn A, Proud CG, Cooper JA |title=Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. |journal=EMBO J. |volume=16 |issue= 8 |pages= 1909–20 |year= 1997 |pmid= 9155017 |doi= 10.1093/emboj/16.8.1909 | pmc=1169794 }}
*{{cite journal | author=Fukunaga R, Hunter T |title=MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates. |journal=EMBO J. |volume=16 |issue= 8 |pages= 1921-33 |year= 1997 |pmid= 9155018 |doi= 10.1093/emboj/16.8.1921 }}
*{{cite journal   |vauthors=Börsch-Haubold AG, Bartoli F, Asselin J, etal |title=Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. |journal=J. Biol. Chem. |volume=273 |issue= 8 |pages= 4449–58 |year= 1998 |pmid= 9468497 |doi=10.1074/jbc.273.8.4449  }}
*{{cite journal | author=Börsch-Haubold AG, Bartoli F, Asselin J, ''et al.'' |title=Identification of the phosphorylation sites of cytosolic phospholipase A2 in agonist-stimulated human platelets and HeLa cells. |journal=J. Biol. Chem. |volume=273 |issue= 8 |pages= 4449-58 |year= 1998 |pmid= 9468497 |doi=  }}
*{{cite journal   |vauthors=Pyronnet S, Imataka H, Gingras AC, etal |title=Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. |journal=EMBO J. |volume=18 |issue= 1 |pages= 270–9 |year= 1999 |pmid= 9878069 |doi= 10.1093/emboj/18.1.270 | pmc=1171121 }}
*{{cite journal | author=Pyronnet S, Imataka H, Gingras AC, ''et al.'' |title=Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E. |journal=EMBO J. |volume=18 |issue= 1 |pages= 270-9 |year= 1999 |pmid= 9878069 |doi= 10.1093/emboj/18.1.270 }}
*{{cite journal   |vauthors=Waskiewicz AJ, Johnson JC, Penn B, etal |title=Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1871–80 |year= 1999 |pmid= 10022874 |doi= | pmc=83980  }}
*{{cite journal  | author=Waskiewicz AJ, Johnson JC, Penn B, ''et al.'' |title=Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo. |journal=Mol. Cell. Biol. |volume=19 |issue= 3 |pages= 1871-80 |year= 1999 |pmid= 10022874 |doi=  }}
*{{cite journal  |vauthors=Cuesta R, Laroia G, Schneider RJ |title=Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes. |journal=Genes Dev. |volume=14 |issue= 12 |pages= 1460–70 |year= 2000 |pmid= 10859165 |doi= | pmc=316692 }}
*{{cite journal | author=Cuesta R, Laroia G, Schneider RJ |title=Chaperone hsp27 inhibits translation during heat shock by binding eIF4G and facilitating dissociation of cap-initiation complexes. |journal=Genes Dev. |volume=14 |issue= 12 |pages= 1460-70 |year= 2000 |pmid= 10859165 |doi= }}
*{{cite journal   |vauthors=Hefner Y, Borsch-Haubold AG, Murakami M, etal |title=Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37542–51 |year= 2001 |pmid= 10978317 |doi= 10.1074/jbc.M003395200 }}
*{{cite journal  | author=Hefner Y, Borsch-Haubold AG, Murakami M, ''et al.'' |title=Serine 727 phosphorylation and activation of cytosolic phospholipase A2 by MNK1-related protein kinases. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37542-51 |year= 2001 |pmid= 10978317 |doi= 10.1074/jbc.M003395200 }}
*{{cite journal  |vauthors=Scheper GC, Morrice NA, Kleijn M, Proud CG |title=The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. |journal=Mol. Cell. Biol. |volume=21 |issue= 3 |pages= 743–54 |year= 2001 |pmid= 11154262 |doi= 10.1128/MCB.21.3.743-754.2001  | pmc=86666 }}
*{{cite journal  | author=Scheper GC, Morrice NA, Kleijn M, Proud CG |title=The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. |journal=Mol. Cell. Biol. |volume=21 |issue= 3 |pages= 743-54 |year= 2001 |pmid= 11154262 |doi= 10.1128/MCB.21.3.743-754.2001 }}
*{{cite journal  |vauthors=Knauf U, Tschopp C, Gram H |title=Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. |journal=Mol. Cell. Biol. |volume=21 |issue= 16 |pages= 5500–11 |year= 2001 |pmid= 11463832 |doi= 10.1128/MCB.21.16.5500-5511.2001 | pmc=87272 }}
*{{cite journal | author=Knauf U, Tschopp C, Gram H |title=Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. |journal=Mol. Cell. Biol. |volume=21 |issue= 16 |pages= 5500-11 |year= 2001 |pmid= 11463832 |doi= 10.1128/MCB.21.16.5500-5511.2001 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Reuter TY, Medhurst AL, Waisfisz Q, etal |title=Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. |journal=Exp. Cell Res. |volume=289 |issue= 2 |pages= 211–21 |year= 2003 |pmid= 14499622 |doi=10.1016/S0014-4827(03)00261-1  }}
*{{cite journal | author=Reuter TY, Medhurst AL, Waisfisz Q, ''et al.'' |title=Yeast two-hybrid screens imply involvement of Fanconi anemia proteins in transcription regulation, cell signaling, oxidative metabolism, and cellular transport. |journal=Exp. Cell Res. |volume=289 |issue= 2 |pages= 211-21 |year= 2003 |pmid= 14499622 |doi= }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Cuesta R, Xi Q, Schneider RJ |title=Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein. |journal=J. Virol. |volume=78 |issue= 14 |pages= 7707–16 |year= 2004 |pmid= 15220445 |doi= 10.1128/JVI.78.14.7707-7716.2004  | pmc=434077 }}
*{{cite journal | author=Cuesta R, Xi Q, Schneider RJ |title=Structural basis for competitive inhibition of eIF4G-Mnk1 interaction by the adenovirus 100-kilodalton protein. |journal=J. Virol. |volume=78 |issue= 14 |pages= 7707-16 |year= 2004 |pmid= 15220445 |doi= 10.1128/JVI.78.14.7707-7716.2004 }}
*{{cite journal   |vauthors=Orton KC, Ling J, Waskiewicz AJ, etal |title=Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. |journal=J. Biol. Chem. |volume=279 |issue= 37 |pages= 38649–57 |year= 2004 |pmid= 15234964 |doi= 10.1074/jbc.M407337200 }}
*{{cite journal | author=Orton KC, Ling J, Waskiewicz AJ, ''et al.'' |title=Phosphorylation of Mnk1 by caspase-activated Pak2/gamma-PAK inhibits phosphorylation and interaction of eIF4G with Mnk. |journal=J. Biol. Chem. |volume=279 |issue= 37 |pages= 38649-57 |year= 2004 |pmid= 15234964 |doi= 10.1074/jbc.M407337200 }}
*{{cite journal   |vauthors=O'Loghlen A, González VM, Piñeiro D, etal |title=Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1. |journal=Exp. Cell Res. |volume=299 |issue= 2 |pages= 343–55 |year= 2004 |pmid= 15350534 |doi= 10.1016/j.yexcr.2004.06.006 }}
*{{cite journal | author=O'Loghlen A, González VM, Piñeiro D, ''et al.'' |title=Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1. |journal=Exp. Cell Res. |volume=299 |issue= 2 |pages= 343-55 |year= 2004 |pmid= 15350534 |doi= 10.1016/j.yexcr.2004.06.006 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Worch J, Tickenbrock L, Schwäble J, etal |title=The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells. |journal=Oncogene |volume=23 |issue= 57 |pages= 9162–72 |year= 2005 |pmid= 15516979 |doi= 10.1038/sj.onc.1208164 }}
*{{cite journal | author=Worch J, Tickenbrock L, Schwäble J, ''et al.'' |title=The serine-threonine kinase MNK1 is post-translationally stabilized by PML-RARalpha and regulates differentiation of hematopoietic cells. |journal=Oncogene |volume=23 |issue= 57 |pages= 9162-72 |year= 2005 |pmid= 15516979 |doi= 10.1038/sj.onc.1208164 }}
*{{cite journal  |vauthors=Grund EM, Spyropoulos DD, Watson DK, Muise-Helmericks RC |title=Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells. |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 4772–8 |year= 2005 |pmid= 15563472 |doi= 10.1074/jbc.M408356200 }}
*{{cite journal  | author=Grund EM, Spyropoulos DD, Watson DK, Muise-Helmericks RC |title=Interleukins 2 and 15 regulate Ets1 expression via ERK1/2 and MNK1 in human natural killer cells. |journal=J. Biol. Chem. |volume=280 |issue= 6 |pages= 4772-8 |year= 2005 |pmid= 15563472 |doi= 10.1074/jbc.M408356200 }}
*{{cite journal  |vauthors=O'Loghlen A, González VM, Salinas M, Martín ME |title=Suppression of human Mnk1 by small interfering RNA increases the eukaryotic initiation factor 4F activity in HEK293T cells. |journal=FEBS Lett. |volume=578 |issue= 1-2 |pages= 31–5 |year= 2005 |pmid= 15581611 |doi= 10.1016/j.febslet.2004.10.063 }}
*{{cite journal  | author=O'Loghlen A, González VM, Salinas M, Martín ME |title=Suppression of human Mnk1 by small interfering RNA increases the eukaryotic initiation factor 4F activity in HEK293T cells. |journal=FEBS Lett. |volume=578 |issue= 1-2 |pages= 31-5 |year= 2005 |pmid= 15581611 |doi= 10.1016/j.febslet.2004.10.063 }}
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{{PDB Gallery|geneid=8569}}
{{Serine/threonine-specific protein kinases}}
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[[Category:EC 2.7.11]]


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Latest revision as of 03:41, 25 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MAP kinase-interacting serine/threonine-protein kinase 1 is an enzyme that in humans is encoded by the MKNK1 gene.[1][2]

Interactions

MKNK1 has been shown to interact with MAPK1[3] and Eukaryotic translation initiation factor 4 gamma.[4]

References

  1. ↑ Fukunaga R, Hunter T (Jun 1997). "MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates". EMBO J. 16 (8): 1921–33. doi:10.1093/emboj/16.8.1921. PMC 1169795. PMID 9155018.
  2. ↑ "Entrez Gene: MKNK1 MAP kinase interacting serine/threonine kinase 1".
  3. ↑ Waskiewicz, A J; Flynn A; Proud C G; Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. ENGLAND. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. ISSN 0261-4189. PMC 1169794. PMID 9155017.
  4. ↑ Pyronnet, S; Imataka H; Gingras A C; Fukunaga R; Hunter T; Sonenberg N (Jan 1999). "Human eukaryotic translation initiation factor 4G (eIF4G) recruits mnk1 to phosphorylate eIF4E". EMBO J. ENGLAND. 18 (1): 270–9. doi:10.1093/emboj/18.1.270. ISSN 0261-4189. PMC 1171121. PMID 9878069.

Further reading


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