EPHA7: Difference between revisions

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{{Infobox_gene}}
{{GNF_Protein_box
'''Ephrin type-A receptor 7''' is a [[protein]] that in humans is encoded by the ''EPHA7'' [[gene]].<ref name="pmid9267020">{{cite journal | title = Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee | journal = Cell | volume = 90 | issue = 3 | pages = 403–4 |date=Sep 1997 | pmid = 9267020 | pmc =  | doi =10.1016/S0092-8674(00)80500-0 | last1 =  Ephnomenclaturecommittee }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EPHA7 EPH receptor A7| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2045| accessdate = }}</ref>
| image = 
| image_source = 
| PDB =
| Name = EPH receptor A7
| HGNCid = 3390
| Symbol = EPHA7
| AltSymbols =; EHK3; HEK11
| OMIM = 602190
| ECnumber = 
| Homologene = 20935
| MGIid = 95276
| GeneAtlas_image1 = PBB_GE_EPHA7_206852_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005003 |text = ephrin receptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0045499 |text = chemorepellant activity}}
  | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007169 |text = transmembrane receptor protein tyrosine kinase signaling pathway}} {{GNF_GO|id=GO:0031290 |text = retinal ganglion cell axon guidance}} {{GNF_GO|id=GO:0048755 |text = branching morphogenesis of a nerve}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2045
    | Hs_Ensembl = ENSG00000135333
    | Hs_RefseqProtein = NP_004431
    | Hs_RefseqmRNA = NM_004440
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 94006459
    | Hs_GenLoc_end = 94185986
    | Hs_Uniprot = Q15375
    | Mm_EntrezGene = 13841
    | Mm_Ensembl = ENSMUSG00000028289
    | Mm_RefseqmRNA = NM_010141
    | Mm_RefseqProtein = NP_034271
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 28981919
    | Mm_GenLoc_end = 29133870
    | Mm_Uniprot = Q3V3T7
  }}
}}
'''EPH receptor A7''', also known as '''EPHA7''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EPHA7 EPH receptor A7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2045| accessdate = }}</ref>


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{{PBB_Summary
{{PBB Summary
| section_title =  
| section_title =  
| summary_text = This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.<ref name="entrez">{{cite web | title = Entrez Gene: EPHA7 EPH receptor A7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2045| accessdate = }}</ref>
| summary_text = This gene belongs to the [[ephrin]] receptor subfamily of the [[protein-tyrosine kinase]] family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the [[nervous system]]. Receptors in the EPH subfamily typically have a single [[kinase]] domain and an extracellular region containing a Cys-rich domain and 2 [[fibronectin]] type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B [[ligands]].<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue=  |pages= 309-45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
*{{cite journal  | vauthors=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development |journal=Annu. Rev. Neurosci. |volume=21 |issue=  |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309 }}
*{{cite journal  | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151-81 |year= 1998 |pmid= 9576626 |doi=  }}
*{{cite journal  | author=Zhou R |title=The Eph family receptors and ligands |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=10.1016/S0163-7258(97)00112-5 }}
*{{cite journal  | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033-44 |year= 1999 |pmid= 10207129 |doi=  }}
*{{cite journal  | vauthors=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi=  }}
*{{cite journal  | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue=  |pages= 177-244 |year= 2000 |pmid= 10730216 |doi=  }}
*{{cite journal  | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly |journal=Int. Rev. Cytol. |volume=196 |issue=  |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=10.1016/S0074-7696(00)96005-4  | series=International Review of Cytology  | isbn=978-0-12-364600-2 }}
*{{cite journal  | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993-1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635 }}
*{{cite journal  | vauthors=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning |journal=Philos. Trans. R. Soc. Lond. B Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635 | pmc=1692797 }}
*{{cite journal  | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155-64 |year= 2001 |pmid= 11256076 |doi=  }}
*{{cite journal  | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=10.1038/35058515 }}
*{{cite journal  | author=Fox GM, Holst PL, Chute HT, ''et al.'' |title=cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases. |journal=Oncogene |volume=10 |issue= 5 |pages= 897-905 |year= 1995 |pmid= 7898931 |doi=  }}
*{{cite journal  | vauthors=Fox GM, Holst PL, Chute HT |title=cDNA cloning and tissue distribution of five human EPH-like receptor protein-tyrosine kinases |journal=Oncogene |volume=10 |issue= 5 |pages= 897–905 |year= 1995 |pmid= 7898931 |doi=  |display-authors=etal}}
*{{cite journal  | author=Gale NW, Holland SJ, Valenzuela DM, ''et al.'' |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis. |journal=Neuron |volume=17 |issue= 1 |pages= 9-19 |year= 1996 |pmid= 8755474 |doi=  }}
*{{cite journal  | vauthors=Gale NW, Holland SJ, Valenzuela DM |title=Eph receptors and ligands comprise two major specificity subclasses and are reciprocally compartmentalized during embryogenesis |journal=Neuron |volume=17 |issue= 1 |pages= 9–19 |year= 1996 |pmid= 8755474 |doi=10.1016/S0896-6273(00)80276-7 |display-authors=etal}}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Ciossek T, Ullrich A |title=Identification of Elf-1 and B61 as high affinity ligands for the receptor tyrosine kinase MDK1. |journal=Oncogene |volume=14 |issue= 1 |pages= 35-43 |year= 1997 |pmid= 9010230 |doi= 10.1038/sj.onc.1200800 }}
*{{cite journal  | vauthors=Ciossek T, Ullrich A |title=Identification of Elf-1 and B61 as high affinity ligands for the receptor tyrosine kinase MDK1 |journal=Oncogene |volume=14 |issue= 1 |pages= 35–43 |year= 1997 |pmid= 9010230 |doi= 10.1038/sj.onc.1200800 }}
*{{cite journal  | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403-4 |year= 1997 |pmid= 9267020 |doi=  }}
*{{cite journal  | vauthors=Hock B, Böhme B, Karn T |title=PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 9779–84 |year= 1998 |pmid= 9707552 |doi=10.1073/pnas.95.17.9779  | pmc=21413 |display-authors=etal}}
*{{cite journal  | author=Hock B, Böhme B, Karn T, ''et al.'' |title=PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 9779-84 |year= 1998 |pmid= 9707552 |doi=  }}
*{{cite journal  | vauthors=Bianchi LM, Liu H |title=Comparison of ephrin-A ligand and EphA receptor distribution in the developing inner ear |journal=Anat. Rec. |volume=254 |issue= 1 |pages= 127–34 |year= 1999 |pmid= 9892426 |doi=10.1002/(SICI)1097-0185(19990101)254:1<127::AID-AR16>3.0.CO;2-Q }}
*{{cite journal  | author=Bianchi LM, Liu H |title=Comparison of ephrin-A ligand and EphA receptor distribution in the developing inner ear. |journal=Anat. Rec. |volume=254 |issue= 1 |pages= 127-34 |year= 1999 |pmid= 9892426 |doi=  }}
*{{cite journal  | vauthors=Janis LS, Cassidy RM, Kromer LF |title=Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum |journal=J. Neurosci. |volume=19 |issue= 12 |pages= 4962–71 |year= 1999 |pmid= 10366629 |doi=  }}
*{{cite journal  | author=Janis LS, Cassidy RM, Kromer LF |title=Ephrin-A binding and EphA receptor expression delineate the matrix compartment of the striatum. |journal=J. Neurosci. |volume=19 |issue= 12 |pages= 4962-71 |year= 1999 |pmid= 10366629 |doi=  }}
*{{cite journal  | vauthors=Stubbs J, Palmer A, Vidovic M, Marotte LR |title=Graded expression of EphA3 in the retina and ephrin-A2 in the superior colliculus during initial development of coarse topography in the wallaby retinocollicular projection |journal=Eur. J. Neurosci. |volume=12 |issue= 10 |pages= 3626–36 |year= 2000 |pmid= 11029633 |doi=10.1046/j.1460-9568.2000.00251.x }}
*{{cite journal  | author=Stubbs J, Palmer A, Vidovic M, Marotte LR |title=Graded expression of EphA3 in the retina and ephrin-A2 in the superior colliculus during initial development of coarse topography in the wallaby retinocollicular projection. |journal=Eur. J. Neurosci. |volume=12 |issue= 10 |pages= 3626-36 |year= 2000 |pmid= 11029633 |doi=  }}
}}
}}
{{refend}}
{{refend}}


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[[Category:Tyrosine kinase receptors]]
 
 
{{gene-6-stub}}

Latest revision as of 17:34, 21 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ephrin type-A receptor 7 is a protein that in humans is encoded by the EPHA7 gene.[1][2]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands.[2]

References

  1. ↑ Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi:10.1016/S0092-8674(00)80500-0. PMID 9267020.
  2. ↑ 2.0 2.1 "Entrez Gene: EPHA7 EPH receptor A7".

Further reading


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