UBE2H: Difference between revisions
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'''Ubiquitin-conjugating enzyme E2 H''' is a [[protein]] that in humans is encoded by the ''UBE2H'' [[gene]].<ref name="pmid8132613">{{cite journal | vauthors = Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R | title = A human ubiquitin-conjugating enzyme homologous to yeast UBC8 | journal = J Biol Chem | volume = 269 | issue = 12 | pages = 8797–802 |date=Apr 1994 | pmid = 8132613 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7328| accessdate = }}</ref> | '''Ubiquitin-conjugating enzyme E2 H''' is a [[protein]] that in humans is encoded by the ''UBE2H'' [[gene]].<ref name="pmid8132613">{{cite journal | vauthors = Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R | title = A human ubiquitin-conjugating enzyme homologous to yeast UBC8 | journal = J Biol Chem | volume = 269 | issue = 12 | pages = 8797–802 |date=Apr 1994 | pmid = 8132613 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7328| accessdate = }}</ref> | ||
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| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7328| accessdate = }}</ref> | | summary_text = The modification of proteins with [[ubiquitin]] is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. [[Ubiquitination]] involves at least three classes of [[enzymes]]: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and [[ubiquitin-protein ligases]], or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded [[protein sequence]] is 100% identical to the mouse [[homolog]] and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct [[isoforms]].<ref name="entrez">{{cite web | title = Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7328| accessdate = }}</ref> | ||
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Latest revision as of 18:57, 15 February 2018
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Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.[1][2]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.[2]
References
- ↑ Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R (Apr 1994). "A human ubiquitin-conjugating enzyme homologous to yeast UBC8". J Biol Chem. 269 (12): 8797–802. PMID 8132613.
- ↑ 2.0 2.1 "Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)".
Further reading
- Wefes I, Mastrandrea LD, Haldeman M, et al. (1995). "Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation". Proc. Natl. Acad. Sci. U.S.A. 92 (11): 4982–6. doi:10.1073/pnas.92.11.4982. PMC 41831. PMID 7761435.
- Kaiser P, Mandl S, Schweiger M, Schneider R (1996). "Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2". FEBS Lett. 377 (2): 193–6. doi:10.1016/0014-5793(95)01323-7. PMID 8543049.
- Hayashida S, Yamasaki K, Asada Y, et al. (2000). "Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32". Genomics. 66 (2): 221–5. doi:10.1006/geno.2000.6206. PMID 10860668.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
- Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
- Vourc'h P, Martin I, Bonnet-Brilhault F, et al. (2005). "Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder". Psychiatr. Genet. 13 (4): 221–5. doi:10.1097/01.ypg.0000084946.07075.37. PMID 14639049.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Bartee E, Mansouri M, Hovey Nerenberg BT, et al. (2004). "Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins". J. Virol. 78 (3): 1109–20. doi:10.1128/JVI.78.3.1109-1120.2004. PMC 321412. PMID 14722266.
- Chuang TH, Ulevitch RJ (2004). "Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors". Nat. Immunol. 5 (5): 495–502. doi:10.1038/ni1066. PMID 15107846.
- Kim HJ, Chong KH, Kang SW, et al. (2005). "Identification of cyclophilin A as a CD99-binding protein by yeast two-hybrid screening". Immunol. Lett. 95 (2): 155–9. doi:10.1016/j.imlet.2004.07.001. PMID 15388255.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
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