GNA12: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Guanine nucleotide-binding protein subunit alpha-12''' is a [[protein]] that in humans is encoded by the ''GNA12'' [[gene]].<ref name="pmid8423800">{{cite journal | vauthors = Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA | title = Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product | journal = Molecular and Cellular Biology | volume = 13 | issue = 2 | pages = 762–8 | date = February 1993 | pmid = 8423800 | pmc = 358958 | doi = 10.1128/mcb.13.2.762}}</ref><ref name="pmid16247467">{{cite journal | vauthors = Kumar RN, Shore SK, Dhanasekaran N | title = Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3 | journal = Oncogene | volume = 25 | issue = 6 | pages = 899–906 | date = February 2006 | pmid = 16247467 | pmc =  | doi = 10.1038/sj.onc.1209132 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2768| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->{{GNF_Protein_box
| image = PBB_Protein_GNA12_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1zca.
| PDB = {{PDB2|1zca}}
| Name = Guanine nucleotide binding protein (G protein) alpha 12
| HGNCid = 4380
| Symbol = GNA12
| AltSymbols =; RMP; MGC104623; MGC99644; NNX3; gep
| OMIM = 604394
| ECnumber =
| Homologene = 22398
| MGIid = 95767
| GeneAtlas_image1 = PBB_GE_GNA12_221737_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}} {{GNF_GO|id=GO:0019001 |text = guanyl nucleotide binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}}
  | Process = {{GNF_GO|id=GO:0001701 |text = in utero embryonic development}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}} {{GNF_GO|id=GO:0007266 |text = Rho protein signal transduction}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}} {{GNF_GO|id=GO:0030154 |text = cell differentiation}} {{GNF_GO|id=GO:0042733 |text = embryonic digit morphogenesis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2768
    | Hs_Ensembl = ENSG00000146535
    | Hs_RefseqProtein = NP_031379
    | Hs_RefseqmRNA = NM_007353
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 2734271
    | Hs_GenLoc_end = 2850485
    | Hs_Uniprot = Q03113
    | Mm_EntrezGene = 14673
    | Mm_Ensembl = ENSMUSG00000000149
    | Mm_RefseqmRNA = XM_001001104
    | Mm_RefseqProtein = XP_001001104
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 141012418
    | Mm_GenLoc_end = 141082905
    | Mm_Uniprot = Q2NKI3
  }}
}}
{{SI}}




'''Guanine nucleotide binding protein (G protein) alpha 12''', also known as '''GNA12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2768| accessdate = }}</ref>
== Interactions ==


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
GNA12 has been shown to [[Protein-protein interaction|interact]] with [[ARHGEF1]],<ref name=pmid14634662>{{cite journal | vauthors = Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM | title = RGS16 inhibits signalling through the G alpha 13-Rho axis | journal = Nature Cell Biology | volume = 5 | issue = 12 | pages = 1095–103 | date = December 2003 | pmid = 14634662 | doi = 10.1038/ncb1065 }}</ref> [[PPP5C]],<ref name=pmid12176367>{{cite journal | vauthors = Yamaguchi Y, Katoh H, Mori K, Negishi M | title = Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity | journal = Current Biology | volume = 12 | issue = 15 | pages = 1353–8 | date = August 2002 | pmid = 12176367 | doi = 10.1016/S0960-9822(02)01034-5 }}</ref> [[ARHGEF12]],<ref name=pmid11094164>{{cite journal | vauthors = Fukuhara S, Chikumi H, Gutkind JS | title = Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho | journal = FEBS Letters | volume = 485 | issue = 2–3 | pages = 183–8 | date = November 2000 | pmid = 11094164 | doi = 10.1016/S0014-5793(00)02224-9 }}</ref><ref name=pmid12515866>{{cite journal | vauthors = Suzuki N, Nakamura S, Mano H, Kozasa T | title = Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 2 | pages = 733–8 | date = January 2003 | pmid = 12515866 | pmc = 141065 | doi = 10.1073/pnas.0234057100 }}</ref> [[HSP90]]<ref name=pmid11598136>{{cite journal | vauthors = Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA | title = Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling | journal = The Journal of Biological Chemistry | volume = 276 | issue = 49 | pages = 46088–93 | date = December 2001 | pmid = 11598136 | doi = 10.1074/jbc.M108711200 }}</ref>, Resistance to inhibitors of cholinesterase-8A (Ric-8A) <ref name=pmid21771786>{{cite journal | vauthors = Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY | title = Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization | journal = The Journal of Biological Chemistry | volume = 286 | issue = 35 | pages = 31055–61 | date = September 2011 | pmid = 21771786 | doi = 10.1074/jbc.M111.253427 | pmc=3162464}}</ref> and [[TEC (gene)|TEC]].<ref name=pmid12515866/>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== See also ==
{{Reflist}}
 
==See also==
* [[G12/G13 alpha subunits]]
* [[G12/G13 alpha subunits]]


{{refbegin | 2}}
{{refbegin | 2}}
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{{refend}}


==External links==
== References ==
{{Reflist}}
 
== External links ==
* {{MeshName|GNA12+protein,+human}}
* {{MeshName|GNA12+protein,+human}}
{{PDB Gallery|geneid=2768}}
{{Intracellular signaling peptides and proteins}}
{{GTPases}}


{{gene-7-stub}}
{{gene-7-stub}}
{{GTPases}}
{{WikiDoc Help Menu}}
{{WS}}

Latest revision as of 13:01, 5 March 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.[1][2][3]


Interactions

GNA12 has been shown to interact with ARHGEF1,[4] PPP5C,[5] ARHGEF12,[6][7] HSP90[8], Resistance to inhibitors of cholinesterase-8A (Ric-8A) [9] and TEC.[7]

See also

References

  1. ↑ Chan AM, Fleming TP, McGovern ES, Chedid M, Miki T, Aaronson SA (February 1993). "Expression cDNA cloning of a transforming gene encoding the wild-type G alpha 12 gene product". Molecular and Cellular Biology. 13 (2): 762–8. doi:10.1128/mcb.13.2.762. PMC 358958. PMID 8423800.
  2. ↑ Kumar RN, Shore SK, Dhanasekaran N (February 2006). "Neoplastic transformation by the gep oncogene, Galpha12, involves signaling by STAT3". Oncogene. 25 (6): 899–906. doi:10.1038/sj.onc.1209132. PMID 16247467.
  3. ↑ "Entrez Gene: GNA12 guanine nucleotide binding protein (G protein) alpha 12".
  4. ↑ Johnson EN, Seasholtz TM, Waheed AA, Kreutz B, Suzuki N, Kozasa T, Jones TL, Brown JH, Druey KM (December 2003). "RGS16 inhibits signalling through the G alpha 13-Rho axis". Nature Cell Biology. 5 (12): 1095–103. doi:10.1038/ncb1065. PMID 14634662.
  5. ↑ Yamaguchi Y, Katoh H, Mori K, Negishi M (August 2002). "Galpha(12) and Galpha(13) interact with Ser/Thr protein phosphatase type 5 and stimulate its phosphatase activity". Current Biology. 12 (15): 1353–8. doi:10.1016/S0960-9822(02)01034-5. PMID 12176367.
  6. ↑ Fukuhara S, Chikumi H, Gutkind JS (November 2000). "Leukemia-associated Rho guanine nucleotide exchange factor (LARG) links heterotrimeric G proteins of the G(12) family to Rho". FEBS Letters. 485 (2–3): 183–8. doi:10.1016/S0014-5793(00)02224-9. PMID 11094164.
  7. ↑ 7.0 7.1 Suzuki N, Nakamura S, Mano H, Kozasa T (January 2003). "Galpha 12 activates Rho GTPase through tyrosine-phosphorylated leukemia-associated RhoGEF". Proceedings of the National Academy of Sciences of the United States of America. 100 (2): 733–8. doi:10.1073/pnas.0234057100. PMC 141065. PMID 12515866.
  8. ↑ Vaiskunaite R, Kozasa T, Voyno-Yasenetskaya TA (December 2001). "Interaction between the G alpha subunit of heterotrimeric G(12) protein and Hsp90 is required for G alpha(12) signaling". The Journal of Biological Chemistry. 276 (49): 46088–93. doi:10.1074/jbc.M108711200. PMID 11598136.
  9. ↑ Wang L, Guo D, Xing B, Zhang JJ, Shu HB, Guo L, Huang XY (September 2011). "Resistance to inhibitors of cholinesterase-8A (Ric-8A) is critical for growth factor receptor-induced actin cytoskeletal reorganization". The Journal of Biological Chemistry. 286 (35): 31055–61. doi:10.1074/jbc.M111.253427. PMC 3162464. PMID 21771786.

External links


Retrieved from "https://www.wikidoc.org/index.php?title=GNA12&oldid=1533864"