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{{Infobox_gene}}
{{PBB_Controls
'''Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ)''' is a [[protein]] that in humans is encoded by the ''EIF2S3'' [[gene]].<ref name="pmid8106381">{{cite journal | vauthors = Gaspar NJ, Kinzy TG, Scherer BJ, Humbelin M, Hershey JW, Merrick WC | title = Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit | journal = J Biol Chem | volume = 269 | issue = 5 | pages = 3415–22 |date=Mar 1994 | pmid = 8106381 | pmc =  | doi =  }}</ref><ref name="pmid8106381" /><ref name="pmid9736774">{{cite journal | vauthors = Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM | title = Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution | journal = Hum Mol Genet | volume = 7 | issue = 11 | pages = 1725–37 |date=Dec 1998 | pmid = 9736774 | pmc =  | doi =10.1093/hmg/7.11.1725  }}</ref><ref name="pmid9736774" /><ref name="entrez">{{cite web | title = Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1968| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Eukaryotic initiation factor|Eukaryotic translation initiation factor]] 2 ([[eIF2]]) functions in the early steps of [[protein synthesis]] by forming a ternary complex with [[Guanosine triphosphate|GTP]] and initiator [[Transfer RNA|tRNA]] and binding to a [[40S]] [[ribosome|ribosomal]] subunit. eIF2 is composed of three subunits, [[EIF2S1|alpha (α)]], [[EIF2S2|beta (β)]], and gamma (γ, this article), with the protein encoded by this gene representing the gamma subunit.<ref name="entrez"/>
{{GNF_Protein_box
| image = 
| image_source = 
| PDB =
| Name = Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
| HGNCid = 3267
| Symbol = EIF2S3
| AltSymbols =; EIF2; EIF2G; EIF2gamma
| OMIM = 300161
| ECnumber = 
| Homologene = 37475
| MGIid = 1349431
| GeneAtlas_image1 = PBB_GE_EIF2S3_205321_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005843 |text = cytosolic small ribosomal subunit (sensu Eukaryota)}} {{GNF_GO|id=GO:0005850 |text = eukaryotic translation initiation factor 2 complex}}
| Process = {{GNF_GO|id=GO:0006413 |text = translational initiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1968
    | Hs_Ensembl = ENSG00000130741
    | Hs_RefseqProtein = NP_001406
    | Hs_RefseqmRNA = NM_001415
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 23982986
    | Hs_GenLoc_end = 24006007
    | Hs_Uniprot = P41091
    | Mm_EntrezGene = 26905
    | Mm_Ensembl = ENSMUSG00000035150
    | Mm_RefseqmRNA = XM_980187
    | Mm_RefseqProtein = XP_985281
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 90441422
    | Mm_GenLoc_end = 90465370
    | Mm_Uniprot = Q3TML6
  }}
}}
'''Eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa''', also known as '''EIF2S3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1968| accessdate = }}</ref>


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==See also==
{{PBB_Summary
* [[eIF2]]
| section_title =  
| summary_text =  
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ray MK, Chakraborty A, Datta B, ''et al.'' |title=Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide. |journal=Biochemistry |volume=32 |issue= 19 |pages= 5151-9 |year= 1993 |pmid= 8098621 |doi=  }}
*{{cite journal  | vauthors=Ray MK, Chakraborty A, Datta B |title=Characteristics of the eukaryotic initiation factor 2 associated 67-kDa polypeptide |journal=Biochemistry |volume=32 |issue= 19 |pages= 5151–9 |year= 1993 |pmid= 8098621 |doi=10.1021/bi00070a026 |display-authors=etal}}
*{{cite journal  | author=Gaspar NJ, Kinzy TG, Scherer BJ, ''et al.'' |title=Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit. |journal=J. Biol. Chem. |volume=269 |issue= 5 |pages= 3415-22 |year= 1994 |pmid= 8106381 |doi=  }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | vauthors=Brand SR, Kobayashi R, Mathews MB |title=The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8388–95 |year= 1997 |pmid= 9079663 |doi=10.1074/jbc.272.13.8388 }}
*{{cite journal  | author=Brand SR, Kobayashi R, Mathews MB |title=The Tat protein of human immunodeficiency virus type 1 is a substrate and inhibitor of the interferon-induced, virally activated protein kinase, PKR. |journal=J. Biol. Chem. |volume=272 |issue= 13 |pages= 8388-95 |year= 1997 |pmid= 9079663 |doi=  }}
*{{cite journal  | vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 |display-authors=etal}}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
*{{cite journal  | vauthors=Cai R, Carpick B, Chun RF |title=HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms |journal=Arch. Biochem. Biophys. |volume=373 |issue= 2 |pages= 361–7 |year= 2000 |pmid= 10620360 |doi= 10.1006/abbi.1999.1583 |display-authors=etal}}
*{{cite journal  | author=Ehrmann IE, Ellis PS, Mazeyrat S, ''et al.'' |title=Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. |journal=Hum. Mol. Genet. |volume=7 |issue= 11 |pages= 1725-37 |year= 1998 |pmid= 9736774 |doi=  }}
*{{cite journal  | vauthors=Ben-Asouli Y, Banai Y, Hauser H, Kaempfer R |title=Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2 |journal=Nucleic Acids Res. |volume=28 |issue= 4 |pages= 1011–8 |year= 2000 |pmid= 10648795 |doi=10.1093/nar/28.4.1011  | pmc=102579 }}
*{{cite journal  | author=Cai R, Carpick B, Chun RF, ''et al.'' |title=HIV-I TAT inhibits PKR activity by both RNA-dependent and RNA-independent mechanisms. |journal=Arch. Biochem. Biophys. |volume=373 |issue= 2 |pages= 361-7 |year= 2000 |pmid= 10620360 |doi= 10.1006/abbi.1999.1583 }}
*{{cite journal  | vauthors=Kruger M, Beger C, Li QX |title=Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8566–71 |year= 2000 |pmid= 10900014 |doi=10.1073/pnas.97.15.8566  | pmc=26988  |display-authors=etal}}
*{{cite journal  | author=Ben-Asouli Y, Banai Y, Hauser H, Kaempfer R |title=Recognition of 5'-terminal TAR structure in human immunodeficiency virus-1 mRNA by eukaryotic translation initiation factor 2. |journal=Nucleic Acids Res. |volume=28 |issue= 4 |pages= 1011-8 |year= 2000 |pmid= 10648795 |doi= }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Kruger M, Beger C, Li QX, ''et al.'' |title=Identification of eIF2Bgamma and eIF2gamma as cofactors of hepatitis C virus internal ribosome entry site-mediated translation using a functional genomics approach. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 15 |pages= 8566-71 |year= 2000 |pmid= 10900014 |doi= }}
*{{cite journal  | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | vauthors=Andersen JS, Lam YW, Leung AK |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Filippova GN, Cheng MK, Moore JM |title=Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development |journal=Dev. Cell |volume=8 |issue= 1 |pages= 31–42 |year= 2005 |pmid= 15669143 |doi=10.1016/j.devcel.2004.10.018  |display-authors=etal}}
*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
*{{cite journal  | vauthors=Marques AC, Dupanloup I, Vinckenbosch N |title=Emergence of young human genes after a burst of retroposition in primates |journal=PLoS Biol. |volume=3 |issue= 11 |pages= e357 |year= 2006 |pmid= 16201836 |doi= 10.1371/journal.pbio.0030357  | pmc=1251493 |display-authors=etal}}
*{{cite journal  | author=Filippova GN, Cheng MK, Moore JM, ''et al.'' |title=Boundaries between chromosomal domains of X inactivation and escape bind CTCF and lack CpG methylation during early development. |journal=Dev. Cell |volume=8 |issue= 1 |pages= 31-42 |year= 2005 |pmid= 15669143 |doi= }}
*{{cite journal  | vauthors=Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV |title=Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 4 |pages= 1766–72 |year= 2006 |pmid= 16288713 |doi= 10.1016/j.bbrc.2005.10.150 }}
*{{cite journal  | author=Marques AC, Dupanloup I, Vinckenbosch N, ''et al.'' |title=Emergence of young human genes after a burst of retroposition in primates. |journal=PLoS Biol. |volume=3 |issue= 11 |pages= e357 |year= 2006 |pmid= 16201836 |doi= 10.1371/journal.pbio.0030357 }}
*{{cite journal  | vauthors=Mikami S, Masutani M, Sonenberg N |title=An efficient mammalian cell-free translation system supplemented with translation factors |journal=Protein Expr. Purif. |volume=46 |issue= 2 |pages= 348–57 |year= 2006 |pmid= 16289705 |doi= 10.1016/j.pep.2005.09.021 |display-authors=etal}}
*{{cite journal  | author=Suragani RN, Kamindla R, Ehtesham NZ, Ramaiah KV |title=Interaction of recombinant human eIF2 subunits with eIF2B and eIF2alpha kinases. |journal=Biochem. Biophys. Res. Commun. |volume=338 |issue= 4 |pages= 1766-72 |year= 2006 |pmid= 16288713 |doi= 10.1016/j.bbrc.2005.10.150 }}
*{{cite journal  | vauthors=Tu LC, Yan X, Hood L, Lin B |title=Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells |journal=Mol. Cell. Proteomics |volume=6 |issue= 4 |pages= 575–88 |year= 2007 |pmid= 17220478 |doi= 10.1074/mcp.M600249-MCP200 }}
*{{cite journal  | author=Mikami S, Masutani M, Sonenberg N, ''et al.'' |title=An efficient mammalian cell-free translation system supplemented with translation factors. |journal=Protein Expr. Purif. |volume=46 |issue= 2 |pages= 348-57 |year= 2006 |pmid= 16289705 |doi= 10.1016/j.pep.2005.09.021 }}
*{{cite journal  | vauthors=Ewing RM, Chu P, Elisma F |title=Large-scale mapping of human protein-protein interactions by mass spectrometry |journal=Mol. Syst. Biol. |volume=3 |issue= 1|pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 | pmc=1847948 |display-authors=etal}}
*{{cite journal  | author=Tu LC, Yan X, Hood L, Lin B |title=Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. |journal=Mol. Cell Proteomics |volume=6 |issue= 4 |pages= 575-88 |year= 2007 |pmid= 17220478 |doi= 10.1074/mcp.M600249-MCP200 }}
*{{cite journal  | author=Ewing RM, Chu P, Elisma F, ''et al.'' |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Initiation factors}}
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{{gene-X-stub}}

Latest revision as of 00:05, 6 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic translation initiation factor 2 subunit 3 (eIF2γ) is a protein that in humans is encoded by the EIF2S3 gene.[1][1][2][2][3]

Function

Eukaryotic translation initiation factor 2 (eIF2) functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA and binding to a 40S ribosomal subunit. eIF2 is composed of three subunits, alpha (α), beta (β), and gamma (γ, this article), with the protein encoded by this gene representing the gamma subunit.[3]

See also

References

  1. ↑ 1.0 1.1 Gaspar NJ, Kinzy TG, Scherer BJ, Humbelin M, Hershey JW, Merrick WC (Mar 1994). "Translation initiation factor eIF-2. Cloning and expression of the human cDNA encoding the gamma-subunit". J Biol Chem. 269 (5): 3415–22. PMID 8106381.
  2. ↑ 2.0 2.1 Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM (Dec 1998). "Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution". Hum Mol Genet. 7 (11): 1725–37. doi:10.1093/hmg/7.11.1725. PMID 9736774.
  3. ↑ 3.0 3.1 "Entrez Gene: EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa".

Further reading



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