Follicular lymphoma causes: Difference between revisions
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{{CMG}}; {{AE}} {{AS}} | {{CMG}}; {{AE}} {{AS}} | ||
==Overview== | ==Overview== | ||
Follicular lymphoma may be caused by [[translocation]] between [[chromosome]] 14 and 18 that results in the overexpression of the ''[[BCL-2]]'' gene. | Follicular lymphoma may be caused by a [[translocation]] between [[chromosome]] 14 and 18 that results in the overexpression of the ''[[BCL-2]]'' gene. | ||
==Causes== | ==Causes== | ||
*A [[Chromosomal translocation|translocation]] between [[chromosome]] 14 and 18 results in the overexpression of the ''[[BCL-2]]'' gene.<ref name="pmid12529293">{{cite journal |author=Bosga-Bouwer AG, van Imhoff GW, Boonstra R, ''et al.'' |title=Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive |journal=Blood |volume=101 |issue=3 |pages=1149–54 |date=February 2003 |pmid=12529293 |doi=10.1182/blood.V101.3.1149 |url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=12529293}}</ref> | *A [[Chromosomal translocation|translocation]] between [[chromosome]] 14 and 18 results in the overexpression of the ''[[BCL-2]]'' gene.<ref name="pmid12529293">{{cite journal |author=Bosga-Bouwer AG, van Imhoff GW, Boonstra R, ''et al.'' |title=Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive |journal=Blood |volume=101 |issue=3 |pages=1149–54 |date=February 2003 |pmid=12529293 |doi=10.1182/blood.V101.3.1149 |url=http://www.bloodjournal.org/cgi/pmidlookup?view=long&pmid=12529293}}</ref> | ||
*As the bcl-2 protein is normally involved in preventing [[apoptosis]], cells with | *As the bcl-2 protein is normally involved in preventing [[apoptosis]], cells with overexpression of this protein are basically immortal. | ||
*The ''BCL-2 gene'' is normally found on chromosome 18, and the translocation moves the gene near to the site of the immunoglobulin heavy chain enhancer element on chromosome 14. | *The ''BCL-2 gene'' is normally found on chromosome 18, and the translocation moves the gene near to the site of the [[immunoglobulin]] heavy chain enhancer element on [[chromosome 14]]. | ||
*[[Translocations]] of ''BCL6'' at 3q27 may also be involved.<ref name="pmid16075463">{{cite journal |author=Bosga-Bouwer AG, Haralambieva E, Booman M, ''et al.'' |title=BCL6 alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B |journal=Genes Chromosomes Cancer |volume=44 |issue=3 |pages=301–4 |date=November 2005 |pmid=16075463 |doi=10.1002/gcc.20246}}</ref> | *[[Translocations]] of ''BCL6'' at 3q27 may also be involved.<ref name="pmid16075463">{{cite journal |author=Bosga-Bouwer AG, Haralambieva E, Booman M, ''et al.'' |title=BCL6 alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B |journal=Genes Chromosomes Cancer |volume=44 |issue=3 |pages=301–4 |date=November 2005 |pmid=16075463 |doi=10.1002/gcc.20246}}</ref> | ||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
Latest revision as of 16:28, 22 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Follicular lymphoma may be caused by a translocation between chromosome 14 and 18 that results in the overexpression of the BCL-2 gene.
Causes
- A translocation between chromosome 14 and 18 results in the overexpression of the BCL-2 gene.[1]
- As the bcl-2 protein is normally involved in preventing apoptosis, cells with overexpression of this protein are basically immortal.
- The BCL-2 gene is normally found on chromosome 18, and the translocation moves the gene near to the site of the immunoglobulin heavy chain enhancer element on chromosome 14.
- Translocations of BCL6 at 3q27 may also be involved.[2]
References
- ↑ Bosga-Bouwer AG, van Imhoff GW, Boonstra R; et al. (February 2003). "Follicular lymphoma grade 3B includes 3 cytogenetically defined subgroups with primary t(14;18), 3q27, or other translocations: t(14;18) and 3q27 are mutually exclusive". Blood. 101 (3): 1149–54. doi:10.1182/blood.V101.3.1149. PMID 12529293.
- ↑ Bosga-Bouwer AG, Haralambieva E, Booman M; et al. (November 2005). "BCL6 alternative translocation breakpoint cluster region associated with follicular lymphoma grade 3B". Genes Chromosomes Cancer. 44 (3): 301–4. doi:10.1002/gcc.20246. PMID 16075463.