Spina bifida primary prevention: Difference between revisions
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==Overview== | ==Overview== | ||
A protective effect of [[folate]] against the development of [[neural tube defect]]s (NTDs), specifically, spina bifida, is now well recognized, having been established by a lot of clinical research studies over the past half-century. Effective measures for the primary prevention of spina bifida include: Not drinking alcohol, not smoking, not taking drugs, taking [[Folic Acid]] and taking oral daily [[folate]] for all pregnant women. Neural tube closure is completed 28 days (four weeks) from conception, and the preventive effect of folic acid is not effective after that period. So, folate supplementation should start at least 4 weeks before conception and it should continue until at least two months after conception. The recommended intakes of [[folate]] are 4 mg/d for those at high-risk pregnancies(by virtue of a previous NTD pregnancy outcome) and 0.4 mg/d for all others. | |||
==Primary Prevention== | ==Primary Prevention== | ||
*A protective effect of [[folate]] against the development of [[neural tube defect]]s (NTDs), specifically, spina bifida, is now well recognized, having been established by a lot of clinical research studies over the past half-century.<ref name="pmid17209211">{{cite journal |vauthors=Pitkin RM |title=Folate and neural tube defects |journal=Am. J. Clin. Nutr. |volume=85 |issue=1 |pages=285S–288S |date=January 2007 |pmid=17209211 |doi=10.1093/ajcn/85.1.285S |url=}}</ref> | |||
*Effective measures for the primary prevention of spina bifida include:<ref name="pmid3504607">{{cite journal |vauthors=Srb V, Kubzová E |title=[Comparison of the effects of 1st and 3d generation platinum cytostatics on the chromosomes of lymphocytes in human peripheral blood in vitro] |language=Czech |journal=Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl |volume=30 |issue=4 |pages=475–83 |date=1987 |pmid=3504607 |doi= |url=}}</ref> | |||
**Not drinking alcohol | |||
**Not smoking | |||
**Not taking drugs | |||
**Taking [[Folic Acid]] | |||
*Taking oral daily [[folate]] is recommended for all pregnant women.<ref name="pmid17209211" /> | |||
*Neural tube closure is completed 28 days (four weeks) from conception, and the preventive effect of folic acid is not effective after that period.<ref name="pmid3279093">{{cite journal |vauthors=Alt TH |title=Aids to scalp reduction surgery |journal=J Dermatol Surg Oncol |volume=14 |issue=3 |pages=309–15 |date=March 1988 |pmid=3279093 |doi= |url=}}</ref> | |||
*So, folate supplementation should start at least 4 weeks before conception and it should continue until at least two months after conception.<ref name="pmid3279093" /> | |||
*The recommended intakes of [[folate]] are 4 mg/d for those at high-risk pregnancies(by virtue of a previous NTD pregnancy outcome) and 0.4 mg/d for all others.<ref name="pmid17209211" /> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
A protective effect of folate against the development of neural tube defects (NTDs), specifically, spina bifida, is now well recognized, having been established by a lot of clinical research studies over the past half-century. Effective measures for the primary prevention of spina bifida include: Not drinking alcohol, not smoking, not taking drugs, taking Folic Acid and taking oral daily folate for all pregnant women. Neural tube closure is completed 28 days (four weeks) from conception, and the preventive effect of folic acid is not effective after that period. So, folate supplementation should start at least 4 weeks before conception and it should continue until at least two months after conception. The recommended intakes of folate are 4 mg/d for those at high-risk pregnancies(by virtue of a previous NTD pregnancy outcome) and 0.4 mg/d for all others.
Primary Prevention
- A protective effect of folate against the development of neural tube defects (NTDs), specifically, spina bifida, is now well recognized, having been established by a lot of clinical research studies over the past half-century.[1]
- Effective measures for the primary prevention of spina bifida include:[2]
- Not drinking alcohol
- Not smoking
- Not taking drugs
- Taking Folic Acid
- Taking oral daily folate is recommended for all pregnant women.[1]
- Neural tube closure is completed 28 days (four weeks) from conception, and the preventive effect of folic acid is not effective after that period.[3]
- So, folate supplementation should start at least 4 weeks before conception and it should continue until at least two months after conception.[3]
- The recommended intakes of folate are 4 mg/d for those at high-risk pregnancies(by virtue of a previous NTD pregnancy outcome) and 0.4 mg/d for all others.[1]
References
- ↑ 1.0 1.1 1.2 Pitkin RM (January 2007). "Folate and neural tube defects". Am. J. Clin. Nutr. 85 (1): 285S–288S. doi:10.1093/ajcn/85.1.285S. PMID 17209211.
- ↑ Srb V, Kubzová E (1987). "[Comparison of the effects of 1st and 3d generation platinum cytostatics on the chromosomes of lymphocytes in human peripheral blood in vitro]". Sb Ved Pr Lek Fak Karlovy Univerzity Hradci Kralove Suppl (in Czech). 30 (4): 475–83. PMID 3504607.
- ↑ 3.0 3.1 Alt TH (March 1988). "Aids to scalp reduction surgery". J Dermatol Surg Oncol. 14 (3): 309–15. PMID 3279093.