Lung mass laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
Laboratory findings associated with lung mass varies with underlying presentation. The findings may range from normal to | [[Medical laboratory|Laboratory]] findings associated with lung mass varies with the underlying presentation. The findings may range from normal to severely elevated. In general, a thorough [[Medical laboratory|laboratory]] evaluation is necessary to accurately assess, [[Diagnosis|diagnose]] and [[Cancer staging|stage]] the severity of lung mass. [[Medical laboratory|Laboratory]] evaluations include [[complete blood count]], [[Electrolyte|electrolytes]], [[serum]] [[calcium]], [[alkaline phosphatase|alkaline phosphatase (ALP)]], [[alanine aminotransferase|alanine aminotransferase (ALT)]], [[aspartate aminotransferase|aspartate aminotransferase (AST)]], [[Bilirubin|total bilirubin]], [[serum]] [[creatinine]], [[albumin]], and [[lactate dehydrogenase]]. | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
[[Medical laboratory|Laboratory]] findings associated with lung mass include:<ref name="pmid14736930">{{cite journal |vauthors=Spira A, Ettinger DS |title=Multidisciplinary management of lung cancer |journal=N. Engl. J. Med. |volume=350 |issue=4 |pages=379–92 |year=2004 |pmid=14736930 |doi=10.1056/NEJMra035536 |url=}}</ref> | |||
:*[[ | |||
:*[[Electrolyte|Electrolytes]] | :*[[Anemia]] on [[complete blood count]]<ref>{{Cite journal | ||
| author = [[Katarzyna A. Zablocka-Slowinska]], [[Monika Kosacka]], [[Irena Porebska]], [[Konrad Pawelczyk]], [[Marcin Golecki]], [[Jadwiga Biernat]] & [[Halina Grajeta]] | |||
:*[[ | | title = The usefulness of routinely used malnutrition screening tools in predicting anemia in lung cancer patients | ||
:*[[ | | journal = [[Advances in clinical and experimental medicine : official organ Wroclaw Medical University]] | ||
:* | | volume = 26 | ||
: | | issue = 9 | ||
:*[[ | | pages = 1383–1389 | ||
| year = 2017 | |||
| month = December | |||
| doi = 10.17219/acem/65785 | |||
| pmid = 29442459 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[Qianjun Zhou]], [[Guangzhong Lu]], [[Aiqun Liu]] & [[Tadasu Kohno]] | |||
| title = Extraskeletal myxoid chondrosarcoma in the lung: asymptomatic lung mass with severe anemia | |||
| journal = [[Diagnostic pathology]] | |||
| volume = 7 | |||
| pages = 112 | |||
| year = 2012 | |||
| month = August | |||
| doi = 10.1186/1746-1596-7-112 | |||
| pmid = 22925697 | |||
}}</ref> | |||
:*[[Electrolyte|Electrolytes]] imbalance<ref>{{Cite journal | |||
| author = [[S. G. Cunningham]] | |||
| title = Fluid and electrolyte disturbances associated with cancer and its treatment | |||
| journal = [[The Nursing clinics of North America]] | |||
| volume = 17 | |||
| issue = 4 | |||
| pages = 579–593 | |||
| year = 1982 | |||
| month = December | |||
| pmid = 6757872 | |||
}}</ref><ref name="Bowman2018">{{cite journal|last1=Bowman|first1=Brendan T.|title=Electrolyte Disorders Associated with Cancer|journal=Journal of Onco-Nephrology|volume=1|issue=1|year=2018|pages=30–35|issn=2399-3693|doi=10.5301/jo-n.5000004}}</ref> | |||
:*Raised [[serum]] [[alkaline phosphatase]]<ref>{{Cite journal | |||
| author = [[Fusun Alatas]], [[Ozkan Alatas]], [[Muzaffer Metintas]], [[Omer Colak]], [[Sinan Erginel]] & [[Emel Harmanci]] | |||
| title = Usefulness of bone markers for detection of bone metastases in lung cancer patients | |||
| journal = [[Clinical biochemistry]] | |||
| volume = 35 | |||
| issue = 4 | |||
| pages = 293–296 | |||
| year = 2002 | |||
| month = June | |||
| pmid = 12135691 | |||
}}</ref> | |||
:*Deranged levels of [[alanine aminotransferase|alanine aminotransferase (ALT)]] and [[aspartate aminotransferase|aspartate aminotransferase (AST)]] | |||
:*[[Serum]] [[bilirubin]] has a negative association with the decline in [[FEV1]] and [[FVC]] and a positive association with the decline in [[FEV1/FVC ratio|FEV1/FVC]]<ref>{{Cite journal | |||
| author = [[Ah Young Leem]], [[Ha Yan Kim]], [[Young Sam Kim]], [[Moo Suk Park]], [[Joon Chang]] & [[Ji Ye Jung]] | |||
| title = Association of serum bilirubin level with lung function decline: a Korean community-based cohort study | |||
| journal = [[Respiratory research]] | |||
| volume = 19 | |||
| issue = 1 | |||
| pages = 99 | |||
| year = 2018 | |||
| month = May | |||
| doi = 10.1186/s12931-018-0814-z | |||
| pmid = 29792214 | |||
}}</ref><ref>{{Cite journal | |||
| author = [[Ivan Curjuric]], [[Medea Imboden]], [[Martin Adam]], [[Robert W. Bettschart]], [[Margaret W. Gerbase]], [[Nino Kunzli]], [[Thierry Rochat]], [[Lucia Rohrer]], [[Thomas B. Rothe]], [[Joel Schwartz]], [[Daiana Stolz]], [[Jean-Marie Tschopp]], [[Arnold von Eckardstein]], [[Florian Kronenberg]] & [[Nicole M. Probst-Hensch]] | |||
| title = Serum bilirubin is associated with lung function in a Swiss general population sample | |||
| journal = [[The European respiratory journal]] | |||
| volume = 43 | |||
| issue = 5 | |||
| pages = 1278–1288 | |||
| year = 2014 | |||
| month = May | |||
| doi = 10.1183/09031936.00055813 | |||
| pmid = 24177000 | |||
}}</ref> | |||
:*Elevated [[serum]] [[Lactate dehydrogenase|lactate dehydrogenase (LDH)]]<ref>{{Cite journal | |||
| author = [[P. Ray]], [[X. Quantin]], [[J. Grenier]] & [[J. L. Pujol]] | |||
| title = Predictive factors of tumor response and prognostic factors of survival during lung cancer chemotherapy | |||
| journal = [[Cancer detection and prevention]] | |||
| volume = 22 | |||
| issue = 4 | |||
| pages = 293–304 | |||
| year = 1998 | |||
| month = | |||
| pmid = 9674872 | |||
}}</ref> | |||
:*Elevated [[serum]] tissue polypeptide-specific antigen (TPS)<ref>{{Cite journal | |||
| author = [[P. Ray]], [[X. Quantin]], [[J. Grenier]] & [[J. L. Pujol]] | |||
| title = Predictive factors of tumor response and prognostic factors of survival during lung cancer chemotherapy | |||
| journal = [[Cancer detection and prevention]] | |||
| volume = 22 | |||
| issue = 4 | |||
| pages = 293–304 | |||
| year = 1998 | |||
| month = | |||
| pmid = 9674872 | |||
}}</ref> | |||
==References== | ==References== | ||
Latest revision as of 19:43, 24 June 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Maria Fernanda Villarreal, M.D. [2] Akshun Kalia M.B.B.S.[3]
Overview
Laboratory findings associated with lung mass varies with the underlying presentation. The findings may range from normal to severely elevated. In general, a thorough laboratory evaluation is necessary to accurately assess, diagnose and stage the severity of lung mass. Laboratory evaluations include complete blood count, electrolytes, serum calcium, alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin, serum creatinine, albumin, and lactate dehydrogenase.
Laboratory Findings
Laboratory findings associated with lung mass include:[1]
- Anemia on complete blood count[2][3]
- Electrolytes imbalance[4][5]
- Raised serum alkaline phosphatase[6]
- Deranged levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST)
- Serum bilirubin has a negative association with the decline in FEV1 and FVC and a positive association with the decline in FEV1/FVC[7][8]
- Elevated serum lactate dehydrogenase (LDH)[9]
- Elevated serum tissue polypeptide-specific antigen (TPS)[10]
References
- ↑ Spira A, Ettinger DS (2004). "Multidisciplinary management of lung cancer". N. Engl. J. Med. 350 (4): 379–92. doi:10.1056/NEJMra035536. PMID 14736930.
- ↑ Katarzyna A. Zablocka-Slowinska, Monika Kosacka, Irena Porebska, Konrad Pawelczyk, Marcin Golecki, Jadwiga Biernat & Halina Grajeta (2017). "The usefulness of routinely used malnutrition screening tools in predicting anemia in lung cancer patients". Advances in clinical and experimental medicine : official organ Wroclaw Medical University. 26 (9): 1383–1389. doi:10.17219/acem/65785. PMID 29442459. Unknown parameter
|month=ignored (help) - ↑ Qianjun Zhou, Guangzhong Lu, Aiqun Liu & Tadasu Kohno (2012). "Extraskeletal myxoid chondrosarcoma in the lung: asymptomatic lung mass with severe anemia". Diagnostic pathology. 7: 112. doi:10.1186/1746-1596-7-112. PMID 22925697. Unknown parameter
|month=ignored (help) - ↑ S. G. Cunningham (1982). "Fluid and electrolyte disturbances associated with cancer and its treatment". The Nursing clinics of North America. 17 (4): 579–593. PMID 6757872. Unknown parameter
|month=ignored (help) - ↑ Bowman, Brendan T. (2018). "Electrolyte Disorders Associated with Cancer". Journal of Onco-Nephrology. 1 (1): 30–35. doi:10.5301/jo-n.5000004. ISSN 2399-3693.
- ↑ Fusun Alatas, Ozkan Alatas, Muzaffer Metintas, Omer Colak, Sinan Erginel & Emel Harmanci (2002). "Usefulness of bone markers for detection of bone metastases in lung cancer patients". Clinical biochemistry. 35 (4): 293–296. PMID 12135691. Unknown parameter
|month=ignored (help) - ↑ Ah Young Leem, Ha Yan Kim, Young Sam Kim, Moo Suk Park, Joon Chang & Ji Ye Jung (2018). "Association of serum bilirubin level with lung function decline: a Korean community-based cohort study". Respiratory research. 19 (1): 99. doi:10.1186/s12931-018-0814-z. PMID 29792214. Unknown parameter
|month=ignored (help) - ↑ Ivan Curjuric, Medea Imboden, Martin Adam, Robert W. Bettschart, Margaret W. Gerbase, Nino Kunzli, Thierry Rochat, Lucia Rohrer, Thomas B. Rothe, Joel Schwartz, Daiana Stolz, Jean-Marie Tschopp, Arnold von Eckardstein, Florian Kronenberg & Nicole M. Probst-Hensch (2014). "Serum bilirubin is associated with lung function in a Swiss general population sample". The European respiratory journal. 43 (5): 1278–1288. doi:10.1183/09031936.00055813. PMID 24177000. Unknown parameter
|month=ignored (help) - ↑ P. Ray, X. Quantin, J. Grenier & J. L. Pujol (1998). "Predictive factors of tumor response and prognostic factors of survival during lung cancer chemotherapy". Cancer detection and prevention. 22 (4): 293–304. PMID 9674872.
- ↑ P. Ray, X. Quantin, J. Grenier & J. L. Pujol (1998). "Predictive factors of tumor response and prognostic factors of survival during lung cancer chemotherapy". Cancer detection and prevention. 22 (4): 293–304. PMID 9674872.