Syndrome of inappropriate antidiuretic hormone pathophysiology: Difference between revisions
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==Overview== | ==Overview== | ||
[[SIADH|Syndrome of inappropriate antidiuretic hormone production]] is a condition in which the body develops an excess of [[water]] and a decrease in the concentration of [[electrolytes]]. [[SIADH]] may be caused by a [[central nervous system]] [[diseases]], [[cancers]], | [[SIADH|Syndrome of inappropriate antidiuretic hormone production]] is a condition in which the body develops an excess of [[water]] and a decrease in the concentration of [[electrolytes]]. [[SIADH]] may be caused by a [[central nervous system]] [[diseases]], [[cancers]], pulmonary diseases, or some [[drugs]]. [[ADH]] is normally produced by the posterior [[pituitary]] gland to prevent water loss in the [[kidneys]]. In [[SIADH]], [[ADH]] level rises above the normal level. [[Aquaporins]] are localized on storage [[vesicles]] in the [[cytoplasm]] of the [[epithelial cells]] which make up the [[collecting ducts]] of the [[kidneys]]. High [[ADH]] level stimulates mass fusion of [[aquaporin]]-carrying storage vesicles with the [[plasma membrane]]. High [[aquaporin]] density facilitates high diffusion of water across the [[plasma]] membrane. Excess [[water]] is reabsorbed from the [[nephrons]] and is returned to the [[blood]]. A [[mutation]] affecting the [[gene]] for the [[renal]] [[V2 receptor]] might cause SIADH. | ||
==Pathophysiology== | ==Pathophysiology== | ||
The normal function of [[ADH|antidiuretic hormone (ADH)]] on the [[kidney]]s is to control the amount of [[water]] reabsorbed by kidney [[nephron]]s. [[ADH]] acts | The normal function of [[ADH|antidiuretic hormone (ADH)]] on the [[kidney]]s is to control the amount of [[water]] reabsorbed by kidney [[nephron]]s. [[ADH]] acts on the distal portion of the [[renal tubule]] ([[distal convoluted tubule]]) as well as the [[collecting duct]] and causes the retention of [[water]]. Owing to the water retention, dilution of the [[blood]] and [[hyponatremia]] occurs. | ||
===Pathogenesis=== | ===Pathogenesis=== | ||
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*This dilution, otherwise described as a reduction in [[plasma osmolality]] is detected by [[osmoreceptor]]s in the [[hypothalamus]] of the [[brain]]. Then, these switch off the release of [[ADH]]. | *This dilution, otherwise described as a reduction in [[plasma osmolality]] is detected by [[osmoreceptor]]s in the [[hypothalamus]] of the [[brain]]. Then, these switch off the release of [[ADH]]. | ||
*The decreasing concentration of [[ADH]] effectively inhibits the [[aquaporin]]s in the [[collecting ducts]] and [[distal convoluted tubule]]s in the [[nephron]]s of the [[kidney]]. | *The decreasing concentration of [[ADH]] effectively inhibits the [[aquaporin]]s in the [[collecting ducts]] and [[distal convoluted tubule]]s in the [[nephron]]s of the [[kidney]]. | ||
*This leads to less water reabsorption, thereby increasing [[urine]] output, decreasing urine osmolality, and increasing (normalization of) [[blood]] [[osmolality]]. | *This leads to less water reabsorption, thereby increasing [[urine]] output, decreasing urine [[osmolality]], and increasing (normalization of) [[blood]] [[osmolality]]. | ||
*In general, the plasma [[sodium]] concentration is the primary osmotic determinant of [[AVP]] release. In [[SIADH]], there is non [[physiological]] secretion of [[AVP]]. There is enhanced water reabsorption, leading to dilutional [[hyponatremia]]. | *In general, the plasma [[sodium]] concentration is the primary osmotic determinant of [[AVP]] release. In [[SIADH]], there is non [[physiological]] secretion of [[AVP]]. There is enhanced water reabsorption, leading to dilutional [[hyponatremia]]. | ||
== Genetics== | == Genetics== | ||
*A [[mutation]] affecting the [[gene]] for the [[renal]] [[V2 receptor]] | *A [[mutation]] affecting the [[gene]] for the [[renal]] [[V2 receptor]] might cause SIADH. | ||
*[[Congenital]] [[nephrogenic diabetes insipidus]] is characterized by a [[resistance]] of the renal [[collecting duct]] to the action of the [[arginine vasopressin]] [[hormone]] responsible for the inability of the [[kidney]] to [[concentrate]] [[urine]]. | *[[Congenital]] [[nephrogenic diabetes insipidus]] is characterized by a [[resistance]] of the renal [[collecting duct]] to the action of the [[arginine vasopressin]] [[hormone]] responsible for the inability of the [[kidney]] to [[concentrate]] [[urine]]. | ||
* Inactivating [[mutations]] of the [[V2 receptor]] gene leading to a loss of function of the mutated receptors are implicated in the [[X-linked]] form.<ref name="pmid22029026">{{cite journal |vauthors=Pillai BP, Unnikrishnan AG, Pavithran PV |title=Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder |journal=Indian J Endocrinol Metab |volume=15 Suppl 3 |issue= |pages=S208–15 |year=2011 |pmid=22029026 |pmc=3183532 |doi=10.4103/2230-8210.84870 |url=}}</ref> | * Inactivating [[mutations]] of the [[V2 receptor]] gene leading to a loss of function of the mutated receptors are implicated in the [[X-linked]] form.<ref name="pmid22029026">{{cite journal |vauthors=Pillai BP, Unnikrishnan AG, Pavithran PV |title=Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder |journal=Indian J Endocrinol Metab |volume=15 Suppl 3 |issue= |pages=S208–15 |year=2011 |pmid=22029026 |pmc=3183532 |doi=10.4103/2230-8210.84870 |url=}}</ref> | ||
* SIADH due to lesion in the [[hypothalamus]] is secondary to [[mutation]] in the transient receptor potential vanilloid type 4 ([[TRPV4]]) [[gene]].<ref name="pmid19666518">{{cite journal |vauthors=Tian W, Fu Y, Garcia-Elias A, Fernández-Fernández JM, Vicente R, Kramer PL, Klein RF, Hitzemann R, Orwoll ES, Wilmot B, McWeeney S, Valverde MA, Cohen DM |title=A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=106 |issue=33 |pages=14034–9 |year=2009 |pmid=19666518 |pmc=2729015 |doi=10.1073/pnas.0904084106 |url=}}</ref> | |||
== Associated conditions== | == Associated conditions== | ||
*[[SIADH]] is most commonly associated with: | *[[SIADH]] is most commonly associated with:<ref name="pmid18086907">{{cite journal |vauthors=Onitilo AA, Kio E, Doi SA |title=Tumor-related hyponatremia |journal=Clin Med Res |volume=5 |issue=4 |pages=228–37 |year=2007 |pmid=18086907 |pmc=2275758 |doi=10.3121/cmr.2007.762 |url=}}</ref><ref name="pmid22618570">{{cite journal |vauthors=Castillo JJ, Vincent M, Justice E |title=Diagnosis and management of hyponatremia in cancer patients |journal=Oncologist |volume=17 |issue=6 |pages=756–65 |year=2012 |pmid=22618570 |pmc=3380874 |doi=10.1634/theoncologist.2011-0400 |url=}}</ref><ref name="pmid7110540">{{cite journal |vauthors=Dóczi T, Tarjányi J, Huszka E, Kiss J |title=Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after head injury |journal=Neurosurgery |volume=10 |issue=6 Pt 1 |pages=685–8 |year=1982 |pmid=7110540 |doi= |url=}}</ref> | ||
** [[Malignancies]] | ** [[Malignancies]] | ||
** [[CNS disease|Central nervous system disorders]] | ** [[CNS disease|Central nervous system disorders]] | ||
| Line 43: | Line 43: | ||
== Gross pathology== | == Gross pathology== | ||
There are no [[gross]] [[pathology]] findings associated with [[SIADH]], | There are no [[gross]] [[pathology]] findings associated with [[SIADH]]. However, SIADH may be associated with [[squamous cell carcinoma of the lung]], which exhibits the following [[gross pathology]] findings: | ||
* Cavitations | * Cavitations | ||
* Tissue [[necrosis]] | * Tissue [[necrosis]] | ||
| Line 52: | Line 52: | ||
== Microscopic pathology== | == Microscopic pathology== | ||
There are no [[microscopic]] findings associated with SIADH, | There are no [[microscopic]] findings associated with SIADH. However, SIADH may be associated with [[squamous cell carcinoma of the lung]], which exhibits the following [[microscopic]] pathology findings:<ref name="urlwww.iarc.fr">{{cite web |url=https://www.iarc.fr/en/publications/pdfs-online/pat-gen/bb2/BB2.pdf |title=www.iarc.fr |format= |work= |accessdate=}}</ref><ref name="pmid24942260">{{cite journal |vauthors=Kadota K, Nitadori J, Woo KM, Sima CS, Finley DJ, Rusch VW, Adusumilli PS, Travis WD |title=Comprehensive pathological analyses in lung squamous cell carcinoma: single cell invasion, nuclear diameter, and tumor budding are independent prognostic factors for worse outcomes |journal=J Thorac Oncol |volume=9 |issue=8 |pages=1126–39 |year=2014 |pmid=24942260 |pmc=4806792 |doi=10.1097/JTO.0000000000000253 |url=}}</ref> | ||
* [[Keratin]] pearls | * [[Keratin]] pearls | ||
* Intercellular bridges | * Intercellular bridges | ||
* Prominent peripheral palisading of [[Tumor cell|tumor cells]] with scanty [[cytoplasm]] | * Prominent peripheral palisading of [[Tumor cell|tumor cells]] with scanty [[cytoplasm]] | ||
* [[Nuclear]] [[atypia]] | * [[Nuclear]] [[atypia]] | ||
[[Image: | [[Image: Aq.jpg|300px|thumb|left|Squamous cell carcinoma of the lung, source: librepathology.com]] | ||
<br style="clear:left"> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category: | [[Category:Medicine]] | ||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category:Nephrology]] | |||
[[Category:Neurology]] | [[Category:Neurology]] | ||
[[Category: | [[Category:Up-To-Date]] | ||
Latest revision as of 00:22, 30 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]
Overview
Syndrome of inappropriate antidiuretic hormone production is a condition in which the body develops an excess of water and a decrease in the concentration of electrolytes. SIADH may be caused by a central nervous system diseases, cancers, pulmonary diseases, or some drugs. ADH is normally produced by the posterior pituitary gland to prevent water loss in the kidneys. In SIADH, ADH level rises above the normal level. Aquaporins are localized on storage vesicles in the cytoplasm of the epithelial cells which make up the collecting ducts of the kidneys. High ADH level stimulates mass fusion of aquaporin-carrying storage vesicles with the plasma membrane. High aquaporin density facilitates high diffusion of water across the plasma membrane. Excess water is reabsorbed from the nephrons and is returned to the blood. A mutation affecting the gene for the renal V2 receptor might cause SIADH.
Pathophysiology
The normal function of antidiuretic hormone (ADH) on the kidneys is to control the amount of water reabsorbed by kidney nephrons. ADH acts on the distal portion of the renal tubule (distal convoluted tubule) as well as the collecting duct and causes the retention of water. Owing to the water retention, dilution of the blood and hyponatremia occurs.
Pathogenesis
| https://youtu.be/MR8BABoFTP8}} |
- ADH is normally produced by the posterior pituitary gland.
- In SIADH, ADH level rises above the normal level.
- Aquaporins are localized on storage vesicles in the cytoplasm of the epithelial cells which make up the collecting ducts of the kidneys.
- High ADH level stimulates mass fusion of aquaporin-carrying storage vesicles with the plasma membrane.
- High aquaporin density facilitates high diffusion of water across the plasma membrane.
- Excess water is reabsorbed from the nephrons and is returned to the blood.
Feedback inhibition
- Developmentally, Mammalian brain have evolved in times of water scarcity.
- ADH is secreted to prevent water loss in the kidneys.
- When water is ingested, it is taken up into the circulation and results in a dilution of the plasma.
- This dilution, otherwise described as a reduction in plasma osmolality is detected by osmoreceptors in the hypothalamus of the brain. Then, these switch off the release of ADH.
- The decreasing concentration of ADH effectively inhibits the aquaporins in the collecting ducts and distal convoluted tubules in the nephrons of the kidney.
- This leads to less water reabsorption, thereby increasing urine output, decreasing urine osmolality, and increasing (normalization of) blood osmolality.
- In general, the plasma sodium concentration is the primary osmotic determinant of AVP release. In SIADH, there is non physiological secretion of AVP. There is enhanced water reabsorption, leading to dilutional hyponatremia.
Genetics
- A mutation affecting the gene for the renal V2 receptor might cause SIADH.
- Congenital nephrogenic diabetes insipidus is characterized by a resistance of the renal collecting duct to the action of the arginine vasopressin hormone responsible for the inability of the kidney to concentrate urine.
- Inactivating mutations of the V2 receptor gene leading to a loss of function of the mutated receptors are implicated in the X-linked form.[1]
- SIADH due to lesion in the hypothalamus is secondary to mutation in the transient receptor potential vanilloid type 4 (TRPV4) gene.[2]
Associated conditions
Gross pathology
There are no gross pathology findings associated with SIADH. However, SIADH may be associated with squamous cell carcinoma of the lung, which exhibits the following gross pathology findings:
- Cavitations
- Tissue necrosis
- Fibrosis
- Keratinization
Microscopic pathology
There are no microscopic findings associated with SIADH. However, SIADH may be associated with squamous cell carcinoma of the lung, which exhibits the following microscopic pathology findings:[6][7]
- Keratin pearls
- Intercellular bridges
- Prominent peripheral palisading of tumor cells with scanty cytoplasm
- Nuclear atypia
References
- ↑ Pillai BP, Unnikrishnan AG, Pavithran PV (2011). "Syndrome of inappropriate antidiuretic hormone secretion: Revisiting a classical endocrine disorder". Indian J Endocrinol Metab. 15 Suppl 3: S208–15. doi:10.4103/2230-8210.84870. PMC 3183532. PMID 22029026.
- ↑ Tian W, Fu Y, Garcia-Elias A, Fernández-Fernández JM, Vicente R, Kramer PL, Klein RF, Hitzemann R, Orwoll ES, Wilmot B, McWeeney S, Valverde MA, Cohen DM (2009). "A loss-of-function nonsynonymous polymorphism in the osmoregulatory TRPV4 gene is associated with human hyponatremia". Proc. Natl. Acad. Sci. U.S.A. 106 (33): 14034–9. doi:10.1073/pnas.0904084106. PMC 2729015. PMID 19666518.
- ↑ Onitilo AA, Kio E, Doi SA (2007). "Tumor-related hyponatremia". Clin Med Res. 5 (4): 228–37. doi:10.3121/cmr.2007.762. PMC 2275758. PMID 18086907.
- ↑ Castillo JJ, Vincent M, Justice E (2012). "Diagnosis and management of hyponatremia in cancer patients". Oncologist. 17 (6): 756–65. doi:10.1634/theoncologist.2011-0400. PMC 3380874. PMID 22618570.
- ↑ Dóczi T, Tarjányi J, Huszka E, Kiss J (1982). "Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) after head injury". Neurosurgery. 10 (6 Pt 1): 685–8. PMID 7110540.
- ↑ "www.iarc.fr" (PDF).
- ↑ Kadota K, Nitadori J, Woo KM, Sima CS, Finley DJ, Rusch VW, Adusumilli PS, Travis WD (2014). "Comprehensive pathological analyses in lung squamous cell carcinoma: single cell invasion, nuclear diameter, and tumor budding are independent prognostic factors for worse outcomes". J Thorac Oncol. 9 (8): 1126–39. doi:10.1097/JTO.0000000000000253. PMC 4806792. PMID 24942260.