Follicular lymphoma laboratory findings: Difference between revisions

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{{CMG}}; {{AE}} {{AS}}
{{CMG}}; {{AE}} {{AS}}
==Overview==
==Overview==
Laboratory tests in the diagnosis of follicular lymphoma include histological confirmation, immunophenotyping, immunohistochemistry, molecular genetic analysis and cytogenetics.
Laboratory tests for follicular lymphoma include [[complete blood count]] (CBC), blood chemistry studies, bone marrow biopsy and aspiration, lymph node biopsy, cytogenetics studies, [[flow cytometry]], [[immunohistochemistry]], [[FISH]], [[genetic testing]], and [[immunophenotyping]].
==Laboratory Findings==
 
Laboratory findings consistent with the diagnosis of follicular lymphoma includes<ref>{{cite web | title = Non-Hodgkin's Lymphomas (NCCN.org) | url = http://www.nccn.org/professionals/physician_gls/PDF/nhl.pdf }}</ref>
==Laboratory tests==
* Histological confirmation by centroblasts and centrocytes
Laboratory tests for follicular lymphoma include the following
* Immunophenotyping using flow cytometry to detect immunophenotypes like CD20+, CD10+, BCL2+, CD23+/-, CD43-, CD5-, CCND1-, CD10-, BCL2- and BCL6+
* [[Complete blood count]] (CBC)
* Immunohistochemistry for Ki-67,Aggressive clinical behavior is in association with low-grade follicular lymphoma with a high proliferation index. ( determined by Ki-67 immunostaining)
* Complete metabolic panel
* Molecular genetic analysis for BCL2 rearrangement
* HBV, HCV and HIV testing
* Cytogenetics or FISH for t(14;18)
* Serum LDH levels and serum β<sub>2</sub>-microglobulin levels.
* Bone marrow biopsy and aspiration
* Lymph node biopsy
* Chest x ray and abdominal ultrasound
* [[CT scan]]
* [[PET scan]]
* Cytogenetics studies
* [[Flow cytometry]]
* [[Immunohistochemistry]]
* [[FISH]]
* [[Genetic testing]]
* [[Immunophenotyping]]: [[BCL-2]]+, BCL6+, [[CD5]]-, CD10+, [[CD19]], [[CD20]], [[CD22]], [[CD43]], [[CD79a]], heavy and light chains rearranged, t(14;18)(q32:q21)-85% with rearrangement of ''[[BCL-2]]'' gene.
* [[Endoscopy]] for gastrointestinal lymphoma


==References==
==References==
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[[Category:Hematology]]
[[Category:Hematology]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Up-To-Date]]
[[Category:Oncology]]
[[Category:Medicine]]
[[Category:Hematology]]
[[Category:Immunology]]

Latest revision as of 22:41, 22 January 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]

Overview

Laboratory tests for follicular lymphoma include complete blood count (CBC), blood chemistry studies, bone marrow biopsy and aspiration, lymph node biopsy, cytogenetics studies, flow cytometry, immunohistochemistry, FISH, genetic testing, and immunophenotyping.

Laboratory tests

Laboratory tests for follicular lymphoma include the following

References