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{{Peutz-Jeghers syndrome}}
{{Peutz-Jeghers syndrome}}
{{CMG}} {{AE}} {{MJK}}
{{CMG}}; {{AE}} {{HQ}}
==Overview==
==Overview==
Secondary prevention strategies to detect intestinal and extraintestinal malignancies in Peutz-Jeghers syndrome include [[genetic testing]], [[enteroscopy]] and [[colonoscopy]].<ref>{{Cite web | title = Peutz-Jeghers syndrome | url = https://online.epocrates.com/u/29441128/Peutz-Jeghers+syndrome }}</ref>
Secondary prevention strategies to detect intestinal and extraintestinal malignancies in Peutz-Jeghers syndrome include performing [[enteroscopy]] and [[colonoscopy]] at periodic intervals.
 
==Secondary Prevention==
==Secondary Prevention==
If there is a family history of Peutz-Jeghers syndrome, the following is recommended:<ref>{{Cite web | title = Peutz-Jeghers syndrome | url = https://www.nlm.nih.gov/medlineplus/ency/article/000244.htm }}</ref>
At time of diagnosis, screening for cancerous lesions among patients with Peutz-Jeghers syndrome include the following:<ref name="SyngalBrand2015">{{cite journal|last1=Syngal|first1=Sapna|last2=Brand|first2=Randall E|last3=Church|first3=James M|last4=Giardiello|first4=Francis M|last5=Hampel|first5=Heather L|last6=Burt|first6=Randall W|title=ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes|journal=The American Journal of Gastroenterology|volume=110|issue=2|year=2015|pages=223–262|issn=0002-9270|doi=10.1038/ajg.2014.435}}</ref><ref>Peutz-Jeghers syndrome https://online.epocrates.com/u/29441128/Peutz-Jeghers+syndrome</ref>
*[[Genetic testing]]
 
*[[Enteroscopy]]
*[[Small bowel]] video [[capsule endoscopy]] (every 3 years)
*[[Colonoscopy]]
*[[Stomach]] [[esophagogastroduodenoscopy]] (every 3 years)
*[[Colonoscopy]] (every 3 years)
*[[Pancreas]] (every 1-2 years)
**[[Endoscopic ultrasound]] OR
**[[Magnetic resonance cholangiopancreatography]] (MRCP)
*Abdominal [[CT]]
*[[Pelvic ultrasound]] (annually)
*[[Testicular]] exam (annually)
**If abnormalities palpable perform an [[ultrasound]]
*[[Mammography]] starting at age 25 (annually)
*[[Endometrial]] [[pelvic exam]] and [[ultrasound]] (annually)
*[[Cervical]] [[Pap test|Papanicolaou test]] ([[Pap test]]) (annually)
*Physical examination that includes evaluation of the [[breasts]], [[abdomen]], [[pelvis]], and [[testes]] should be performed by a physician (annually)
*[[Complete blood count]] ([[CBC]]) to check for [[anemia]] should be done (annually)


== References ==
== References ==
{{reflist|2}}
{{reflist|2}}


{{Phakomatoses}}
{{Digestive system neoplasia}}
[[Category:Dental disorders]]
[[Category:Gastroenterology]]
[[Category:Genetic disorders]]
[[Category:Syndromes]]
{{WH}}
{{WH}}
{{WS}}
{{WS}}
[[Category:Gastroenterology]]
[[Category:Surgery]]
[[Category:Oncology]]
[[Category:Disease]]
[[Category:Pediatrics]]
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Latest revision as of 15:09, 21 December 2017

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Hamid Qazi, MD, BSc [2]

Overview

Secondary prevention strategies to detect intestinal and extraintestinal malignancies in Peutz-Jeghers syndrome include performing enteroscopy and colonoscopy at periodic intervals.

Secondary Prevention

At time of diagnosis, screening for cancerous lesions among patients with Peutz-Jeghers syndrome include the following:[1][2]

References

  1. Syngal, Sapna; Brand, Randall E; Church, James M; Giardiello, Francis M; Hampel, Heather L; Burt, Randall W (2015). "ACG Clinical Guideline: Genetic Testing and Management of Hereditary Gastrointestinal Cancer Syndromes". The American Journal of Gastroenterology. 110 (2): 223–262. doi:10.1038/ajg.2014.435. ISSN 0002-9270.
  2. Peutz-Jeghers syndrome https://online.epocrates.com/u/29441128/Peutz-Jeghers+syndrome

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