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{{Syndrome of inappropriate antidiuretic hormone}} | {{Syndrome of inappropriate antidiuretic hormone}} | ||
{{CMG}}; {{AE}}{{Vbe}} | {{CMG}}; {{AE}}{{Vbe}} | ||
==Overview== | ==Overview== | ||
SIADH can occur at any age. | Syndrome of inappropriate antidiuretic hormone (SIADH) can occur at any age. Its [[incidence]] depends upon various possible [[etiologies]]. [[Prevalence]] of [[SIADH]] was estimated to be 2500-3000 cases per 100,000 individuals. The [[incidence]] and [[prevalence]] of [[SIADH]] in particular is less thoroughly studied in the literature. Hospitalized patients with plasma [[sodium]] concentration <125 mmol/l show an overall mortality of 28000 per 100,000 patients. The [[incidence]] of [[SIADH]] increases with [[age]]. The [[prevalence]] and [[incidence]] of [[SIADH]] does not vary by gender. There is no racial predilection to [[SIADH]]. | ||
Prevalence of | |||
==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
=== Incidence === | |||
* SIADH is the most common cause of [[hyponatremia]].<ref name="pmid19881931">{{cite journal |vauthors=O'Donoghue D, Trehan A |title=SIADH and hyponatraemia: foreword |journal=NDT Plus |volume=2 |issue=Suppl_3 |pages=iii1–iii4 |year=2009 |pmid=19881931 |pmc=2762825 |doi=10.1093/ndtplus/sfp152 |url=}}</ref> | |||
* [[Incidence]] of moderate and severe [[hyponatraemia]] in the United States ranges from a low of 1000 to 7000 per 100,000 among hospitalized patients.<ref name="pmid198819312">{{cite journal |vauthors=O'Donoghue D, Trehan A |title=SIADH and hyponatraemia: foreword |journal=NDT Plus |volume=2 |issue=Suppl_3 |pages=iii1–iii4 |year=2009 |pmid=19881931 |pmc=2762825 |doi=10.1093/ndtplus/sfp152 |url=}}</ref> | |||
===Prevalence=== | |||
*[[Prevalence]] of [[SIADH]] was estimated to be 2500-3000 cases per 100,000 individuals. | |||
*Prevalence of [[hyponatremia]] in the United States has been estimated to be 1720 per 100,000 individuals.<ref name="pmid24262726">{{cite journal |vauthors=Mohan S, Gu S, Parikh A, Radhakrishnan J |title=Prevalence of hyponatremia and association with mortality: results from NHANES |journal=Am. J. Med. |volume=126 |issue=12 |pages=1127–37.e1 |year=2013 |pmid=24262726 |pmc=3933395 |doi=10.1016/j.amjmed.2013.07.021 |url=}}</ref> | |||
=== Mortality === | |||
* Hospitalized patients with plasma [[sodium]] concentration <125 mmol/l show an overall mortality of 28000 per 100,000 patients.<ref name="GillHuda2006">{{cite journal|last1=Gill|first1=Geoffrey|last2=Huda|first2=Bobby|last3=Boyd|first3=Alice|last4=Skagen|first4=Karolina|last5=Wile|first5=David|last6=Watson|first6=Ian|last7=van Heyningen|first7=Charles|title=Characteristics and mortality of severe hyponatraemia ? a hospital-based study|journal=Clinical Endocrinology|volume=65|issue=2|year=2006|pages=246–249|issn=0300-0664|doi=10.1111/j.1365-2265.2006.02583.x}}</ref> | |||
===Age=== | |||
*The [[incidence]] of [[SIADH]] increases with [[age]].<ref name="pmid27812063">{{cite journal |vauthors=Tarif N, Sabir O, Niaz A, Akhtar R, Rafique K, Rizvi N |title=Hyponatraemia: Epidemiology and aetiology in a tertiary care centre in Pakistan |journal=J Pak Med Assoc |volume=66 |issue=11 |pages=1436–1439 |year=2016 |pmid=27812063 |doi= |url=}}</ref><ref name="pmid6113402">{{cite journal |vauthors=Flear CT, Gill GV, Burn J |title=Hyponatraemia: mechanisms and management |journal=Lancet |volume=2 |issue=8236 |pages=26–31 |year=1981 |pmid=6113402 |doi= |url=}}</ref> | |||
===Gender=== | |||
*The [[prevalence]] and [[incidence]] of [[SIADH]] does not vary by gender. | |||
*The [[prevalence]] of hyponatremia is higher in females than males.<ref name="pmid17679119">{{cite journal |vauthors=Lien YH, Shapiro JI |title=Hyponatremia: clinical diagnosis and management |journal=Am. J. Med. |volume=120 |issue=8 |pages=653–8 |year=2007 |pmid=17679119 |doi=10.1016/j.amjmed.2006.09.031 |url=}}</ref> | |||
===Race=== | |||
*There is no racial predilection to [[SIADH]]. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category: | [[Category:Medicine]] | ||
[[Category:Endocrinology]] | [[Category:Endocrinology]] | ||
[[Category:Nephrology]] | |||
[[Category:Neurology]] | [[Category:Neurology]] | ||
[[Category: | [[Category:Up-To-Date]] | ||
Latest revision as of 00:22, 30 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Vindhya BellamKonda, M.B.B.S [2]
Overview
Syndrome of inappropriate antidiuretic hormone (SIADH) can occur at any age. Its incidence depends upon various possible etiologies. Prevalence of SIADH was estimated to be 2500-3000 cases per 100,000 individuals. The incidence and prevalence of SIADH in particular is less thoroughly studied in the literature. Hospitalized patients with plasma sodium concentration <125 mmol/l show an overall mortality of 28000 per 100,000 patients. The incidence of SIADH increases with age. The prevalence and incidence of SIADH does not vary by gender. There is no racial predilection to SIADH.
Epidemiology and Demographics
Incidence
- SIADH is the most common cause of hyponatremia.[1]
- Incidence of moderate and severe hyponatraemia in the United States ranges from a low of 1000 to 7000 per 100,000 among hospitalized patients.[2]
Prevalence
- Prevalence of SIADH was estimated to be 2500-3000 cases per 100,000 individuals.
- Prevalence of hyponatremia in the United States has been estimated to be 1720 per 100,000 individuals.[3]
Mortality
- Hospitalized patients with plasma sodium concentration <125 mmol/l show an overall mortality of 28000 per 100,000 patients.[4]
Age
Gender
- The prevalence and incidence of SIADH does not vary by gender.
- The prevalence of hyponatremia is higher in females than males.[7]
Race
- There is no racial predilection to SIADH.
References
- ↑ O'Donoghue D, Trehan A (2009). "SIADH and hyponatraemia: foreword". NDT Plus. 2 (Suppl_3): iii1–iii4. doi:10.1093/ndtplus/sfp152. PMC 2762825. PMID 19881931.
- ↑ O'Donoghue D, Trehan A (2009). "SIADH and hyponatraemia: foreword". NDT Plus. 2 (Suppl_3): iii1–iii4. doi:10.1093/ndtplus/sfp152. PMC 2762825. PMID 19881931.
- ↑ Mohan S, Gu S, Parikh A, Radhakrishnan J (2013). "Prevalence of hyponatremia and association with mortality: results from NHANES". Am. J. Med. 126 (12): 1127–37.e1. doi:10.1016/j.amjmed.2013.07.021. PMC 3933395. PMID 24262726.
- ↑ Gill, Geoffrey; Huda, Bobby; Boyd, Alice; Skagen, Karolina; Wile, David; Watson, Ian; van Heyningen, Charles (2006). "Characteristics and mortality of severe hyponatraemia ? a hospital-based study". Clinical Endocrinology. 65 (2): 246–249. doi:10.1111/j.1365-2265.2006.02583.x. ISSN 0300-0664.
- ↑ Tarif N, Sabir O, Niaz A, Akhtar R, Rafique K, Rizvi N (2016). "Hyponatraemia: Epidemiology and aetiology in a tertiary care centre in Pakistan". J Pak Med Assoc. 66 (11): 1436–1439. PMID 27812063.
- ↑ Flear CT, Gill GV, Burn J (1981). "Hyponatraemia: mechanisms and management". Lancet. 2 (8236): 26–31. PMID 6113402.
- ↑ Lien YH, Shapiro JI (2007). "Hyponatremia: clinical diagnosis and management". Am. J. Med. 120 (8): 653–8. doi:10.1016/j.amjmed.2006.09.031. PMID 17679119.