Alzheimer's disease ultrasound: Difference between revisions
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{{Alzheimer's disease}} | {{Alzheimer's disease}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}} {{ARK}} | ||
==Overview== | ==Overview== | ||
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==Echocardiography/Ultrasound== | ==Echocardiography/Ultrasound== | ||
'''Focused Ultrasound Therapy:''' <ref name="pmid28159329">{{cite journal| author=Miller DB, O'Callaghan JP| title=New horizons for focused ultrasound (FUS) - therapeutic applications in neurodegenerative diseases. | journal=Metabolism | year= 2017 | volume= 69S | issue= | pages= S3-S7 | pmid=28159329 | doi=10.1016/j.metabol.2017.01.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28159329 }} </ref> <ref name="pmid27331236">{{cite journal| author=Galkin MV| title=[The use of transcranial focused ultrasound in CNS diseases]. | journal=Zh Vopr Neirokhir Im N N Burdenko | year= 2016 | volume= 80 | issue= 2 | pages= 108-118 | pmid=27331236 | doi=10.17116/neiro2016802108-118 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27331236 }} </ref> <ref name="pmid25420161">{{cite journal| author=Jolesz FA| title=Science to practice: opening the blood-brain barrier with focused ultrasound-a potential treatment for Alzheimer disease? | journal=Radiology | year= 2014 | volume= 273 | issue= 3 | pages= 631-3 | pmid=25420161 | doi=10.1148/radiol.14142033 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25420161 }} </ref> <ref name="pmid25107692">{{cite journal| author=Burgess A, Nhan T, Moffatt C, Klibanov AL, Hynynen K| title=Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy. | journal=J Control Release | year= 2014 | volume= 192 | issue= | pages= 243-8 | pmid=25107692 | doi=10.1016/j.jconrel.2014.07.051 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25107692 }} </ref> | '''Focused Ultrasound Therapy:''' <ref name="pmid28159329">{{cite journal| author=Miller DB, O'Callaghan JP| title=New horizons for focused ultrasound (FUS) - therapeutic applications in neurodegenerative diseases. | journal=Metabolism | year= 2017 | volume= 69S | issue= | pages= S3-S7 | pmid=28159329 | doi=10.1016/j.metabol.2017.01.012 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28159329 }} </ref> <ref name="pmid27331236">{{cite journal| author=Galkin MV| title=[The use of transcranial focused ultrasound in CNS diseases]. | journal=Zh Vopr Neirokhir Im N N Burdenko | year= 2016 | volume= 80 | issue= 2 | pages= 108-118 | pmid=27331236 | doi=10.17116/neiro2016802108-118 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27331236 }} </ref> <ref name="pmid25420161">{{cite journal| author=Jolesz FA| title=Science to practice: opening the blood-brain barrier with focused ultrasound-a potential treatment for Alzheimer disease? | journal=Radiology | year= 2014 | volume= 273 | issue= 3 | pages= 631-3 | pmid=25420161 | doi=10.1148/radiol.14142033 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25420161 }} </ref> <ref name="pmid25107692">{{cite journal| author=Burgess A, Nhan T, Moffatt C, Klibanov AL, Hynynen K| title=Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy. | journal=J Control Release | year= 2014 | volume= 192 | issue= | pages= 243-8 | pmid=25107692 | doi=10.1016/j.jconrel.2014.07.051 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25107692 }} </ref> | ||
*[[Non-invasive (medical)|Non-invasive]], [[therapeutic]] technology aiming to improve the [[quality of life]] with lower costs for [[patients]] with Alzheimer’s disease. | |||
*Beams of ultrasonic energy focus precisely and accurately on targets deep in the brain without damaging surrounding normal tissue. | *Beams of [[ultrasonic]] energy focus precisely and accurately on targets deep in the [[brain]] without damaging surrounding normal tissue. | ||
*Ultrasound produces a variety of therapeutic effects eliminating the need for incisions or radiation at the focus where beams converge. | *[[Ultrasound]] produces a variety of [[therapeutic]] effects eliminating the need for incisions or [[radiation]] at the focus where beams converge. | ||
*Preclinical studies have have shown promising results with the potential of focused ultrasound in enhancing the delivery of therapeutic drugs or antibodies to the brain. | *Preclinical studies have have shown promising results with the potential of focused [[ultrasound]] in enhancing the delivery of [[therapeutic]] [[drugs]] or [[antibodies]] to the [[brain]]. | ||
*Focused ultrasound in combination with microbubbles can safely open the blood-brain barrier (BBB) thereby enabling enhanced delivery of anti-amyloid antibodies to the brain. This method may reduce the number of plaques and improve cognition in Alzheimer’s disease subjects. | *Focused [[ultrasound]] in combination with microbubbles can safely open the [[blood-brain barrier]] (BBB) thereby enabling enhanced delivery of anti-amyloid antibodies to the [[brain]]. This method may reduce the number of [[plaques]] and improve [[cognition]] in Alzheimer’s disease subjects. | ||
==References== | ==References== | ||
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{{WS}} | {{WS}} | ||
[[Category: (name of the system)]] | [[Category: (name of the system)]] | ||
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Latest revision as of 19:47, 21 September 2017
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Alzheimer's disease Microchapters |
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Diagnosis |
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Treatment |
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Alzheimer's disease ultrasound On the Web |
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American Roentgen Ray Society Images of Alzheimer's disease ultrasound |
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Risk calculators and risk factors for Alzheimer's disease ultrasound |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Focused ultrasound is a non-invasive, therapeutic technology aiming to improve the quality of life at lower costs for patients with Alzheimer’s disease.
Echocardiography/Ultrasound
Focused Ultrasound Therapy: [1] [2] [3] [4]
- Non-invasive, therapeutic technology aiming to improve the quality of life with lower costs for patients with Alzheimer’s disease.
- Beams of ultrasonic energy focus precisely and accurately on targets deep in the brain without damaging surrounding normal tissue.
- Ultrasound produces a variety of therapeutic effects eliminating the need for incisions or radiation at the focus where beams converge.
- Preclinical studies have have shown promising results with the potential of focused ultrasound in enhancing the delivery of therapeutic drugs or antibodies to the brain.
- Focused ultrasound in combination with microbubbles can safely open the blood-brain barrier (BBB) thereby enabling enhanced delivery of anti-amyloid antibodies to the brain. This method may reduce the number of plaques and improve cognition in Alzheimer’s disease subjects.
References
- ↑ Miller DB, O'Callaghan JP (2017). "New horizons for focused ultrasound (FUS) - therapeutic applications in neurodegenerative diseases". Metabolism. 69S: S3–S7. doi:10.1016/j.metabol.2017.01.012. PMID 28159329.
- ↑ Galkin MV (2016). "[The use of transcranial focused ultrasound in CNS diseases]". Zh Vopr Neirokhir Im N N Burdenko. 80 (2): 108–118. doi:10.17116/neiro2016802108-118. PMID 27331236.
- ↑ Jolesz FA (2014). "Science to practice: opening the blood-brain barrier with focused ultrasound-a potential treatment for Alzheimer disease?". Radiology. 273 (3): 631–3. doi:10.1148/radiol.14142033. PMID 25420161.
- ↑ Burgess A, Nhan T, Moffatt C, Klibanov AL, Hynynen K (2014). "Analysis of focused ultrasound-induced blood-brain barrier permeability in a mouse model of Alzheimer's disease using two-photon microscopy". J Control Release. 192: 243–8. doi:10.1016/j.jconrel.2014.07.051. PMID 25107692.