Alzheimer's disease MRI: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{ | {{Alzheimer's disease}} | ||
{{CMG}}; {{AE}} {{ARK}} | {{CMG}}; {{AE}} {{ARK}} | ||
==Overview== | ==Overview== | ||
Structural MRI of the brain may be helpful in the diagnosis of | Structural [[MRI]] of the brain may be helpful in the diagnosis of Alzheimer's disease. Characteristic findings on [[MRI]] suggestive of Alzheimer's disease include reduced [[hippocampal]] volume and [[medial temporal lobe]] [[atrophy]]. | ||
==MRI== | ==MRI== | ||
*Structural MRI of the brain may be helpful in the diagnosis of | *Structural [[MRI]] of the brain may be helpful in the diagnosis of Alzheimer's disease. Characteristic findings on [[MRI]] suggestive of Alzheimer's disease include: <ref name="pmid22951070">{{cite journal| author=Whitwell JL, Dickson DW, Murray ME, Weigand SD, Tosakulwong N, Senjem ML et al.| title=Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study. | journal=Lancet Neurol | year= 2012 | volume= 11 | issue= 10 | pages= 868-77 | pmid=22951070 | doi=10.1016/S1474-4422(12)70200-4 | pmc=3490201 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22951070 }} </ref> <ref name="pmid1643466">{{cite journal| author=Brook RH| title=Improving practice: the clinician's role. | journal=Br J Surg | year= 1992 | volume= 79 | issue= 7 | pages= 606-7 | pmid=1643466 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1643466 }} </ref> <ref name="pmid17923614">{{cite journal| author=Barkhof F, Polvikoski TM, van Straaten EC, Kalaria RN, Sulkava R, Aronen HJ et al.| title=The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old. | journal=Neurology | year= 2007 | volume= 69 | issue= 15 | pages= 1521-7 | pmid=17923614 | doi=10.1212/01.wnl.0000277459.83543.99 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17923614 }} </ref> | ||
**Reduced hippocampal volume | **Reduced [[hippocampal]] volume | ||
**Medial temporal lobe atrophy | **[[Medial temporal lobe|Medial temporal lob]]<nowiki/>e [[atrophy]] | ||
*Findings on MRI in an elderly patient with memory loss demonstrates cerebral volume loss, particularly pronounced in the temporal and parietal lobes, consistent with the clinical impression of Alzheimer disease. | *Findings on [[MRI]] in an elderly patient with [[memory]] loss demonstrates [[cerebral]] volume loss, particularly pronounced in the [[Temporal lobe|temporal]] and [[Parietal lobe|parietal lobes]], consistent with the clinical impression of Alzheimer disease. | ||
*Multiple white matter T2 hyperintense regions are suggestive of chronic small vessel ischemic change. | *Multiple white matter T2 hyperintense regions are suggestive of chronic small [[Blood vessel|vessel]] [[ischemic]] change. | ||
[[image:MRI_-_alzheimer-disease-T1.jpg|thumb|350px|center| | [[image:MRI_-_alzheimer-disease-T1.jpg|thumb|350px|center| Radiopaedia.org">{{cite web |url=https://radiopaedia.org/cases/10738 |title=Alzheimer disease | Radiology Case | Radiopaedia.org |format= |work= |accessdate=}}<nowiki></ref></nowiki>, rID: 10738]] | ||
[[image:MRI_-_alzheimer-disease-FLAIR.jpg|thumb|350px|center| | [[image:MRI_-_alzheimer-disease-FLAIR.jpg|thumb|350px|center| Radiopaedia.org">{{cite web |url=https://radiopaedia.org/cases/10738 |title=Alzheimer disease | Radiology Case | Radiopaedia.org |format= |work= |accessdate=}}<nowiki></ref></nowiki>, rID: 10738]] | ||
==References== | ==References== | ||
Latest revision as of 01:16, 7 December 2017
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aravind Reddy Kothagadi M.B.B.S[2]
Overview
Structural MRI of the brain may be helpful in the diagnosis of Alzheimer's disease. Characteristic findings on MRI suggestive of Alzheimer's disease include reduced hippocampal volume and medial temporal lobe atrophy.
MRI
- Structural MRI of the brain may be helpful in the diagnosis of Alzheimer's disease. Characteristic findings on MRI suggestive of Alzheimer's disease include: [1] [2] [3]
- Reduced hippocampal volume
- Medial temporal lobe atrophy
- Findings on MRI in an elderly patient with memory loss demonstrates cerebral volume loss, particularly pronounced in the temporal and parietal lobes, consistent with the clinical impression of Alzheimer disease.
- Multiple white matter T2 hyperintense regions are suggestive of chronic small vessel ischemic change.
References
- ↑ Whitwell JL, Dickson DW, Murray ME, Weigand SD, Tosakulwong N, Senjem ML; et al. (2012). "Neuroimaging correlates of pathologically defined subtypes of Alzheimer's disease: a case-control study". Lancet Neurol. 11 (10): 868–77. doi:10.1016/S1474-4422(12)70200-4. PMC 3490201. PMID 22951070.
- ↑ Brook RH (1992). "Improving practice: the clinician's role". Br J Surg. 79 (7): 606–7. PMID 1643466.
- ↑ Barkhof F, Polvikoski TM, van Straaten EC, Kalaria RN, Sulkava R, Aronen HJ; et al. (2007). "The significance of medial temporal lobe atrophy: a postmortem MRI study in the very old". Neurology. 69 (15): 1521–7. doi:10.1212/01.wnl.0000277459.83543.99. PMID 17923614.