SGK2: Difference between revisions

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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not  induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described.<ref name="entrez" />
| summary_text = This gene encodes a [[serine/threonine protein kinase]]. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase ([[SGK]]), this gene is not  induced by [[Serum (blood)|serum]] or [[glucocorticoids]]. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase ([[PI3K]]), which is also true for SGK. Two [[Alternative splicing|alternate transcripts]] encoding two different [[Protein isoform|isoforms]] have been described.<ref name="entrez" />
}}
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*{{cite journal  |vauthors=Lang F, Cohen P |title=Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms |journal=Sci. STKE |volume=2001 |issue= 108 |pages= RE17 |year= 2002 |pmid= 11707620 |doi= 10.1126/stke.2001.108.re17 }}
*{{cite journal  |vauthors=Lang F, Cohen P |title=Regulation and physiological roles of serum- and glucocorticoid-induced protein kinase isoforms |journal=Sci. STKE |volume=2001 |issue= 108 |pages= RE17 |year= 2002 |pmid= 11707620 |doi= 10.1126/stke.2001.108.re17 }}
*{{cite journal  | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a  |name-list-format=vanc| author2=Matthews LH  | author3=Ashurst J  | display-authors=3  | last4=Burton  | first4=J.  | last5=Gilbert  | first5=J. G. R.  | last6=Jones  | first6=M.  | last7=Stavrides  | first7=G.  | last8=Almeida  | first8=J. P.  | last9=Babbage  | first9=A. K. }}
*{{cite journal  | author=Deloukas P |title=The DNA sequence and comparative analysis of human chromosome 20 |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a  |name-list-format=vanc| author2=Matthews LH  | author3=Ashurst J  | display-authors=3  | last4=Burton  | first4=J.  | last5=Gilbert  | first5=J. G. R.  | last6=Jones  | first6=M.  | last7=Stavrides  | first7=G.  | last8=Almeida  | first8=J. P.  | last9=Babbage  | first9=A. K. }}
*{{cite journal  | author=Gamper N |title=K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK |journal=Pflugers Arch. |volume=445 |issue= 1 |pages= 60–6 |year= 2003 |pmid= 12397388 |doi= 10.1007/s00424-002-0873-2  |name-list-format=vanc| author2=Fillon S  | author3=Feng Y  | display-authors=3  | last4=b.  | first4=Friedrich  | last5=p.  | first5=Lang  | last6=g.  | first6=Henke  | last7=s.  | first7=Huber  | last8=t.  | first8=Kobayashi  | last9=p.  | first9=Cohen }}
*{{cite journal  | author=Gamper N |title=K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK |journal=Pflügers Arch. |volume=445 |issue= 1 |pages= 60–6 |year= 2003 |pmid= 12397388 |doi= 10.1007/s00424-002-0873-2  |name-list-format=vanc| author2=Fillon S  | author3=Feng Y  | display-authors=3  | last4=b.  | first4=Friedrich  | last5=p.  | first5=Lang  | last6=g.  | first6=Henke  | last7=s.  | first7=Huber  | last8=t.  | first8=Kobayashi  | last9=p.  | first9=Cohen }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
*{{cite journal  | author=Friedrich B |title=The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC |journal=Pflugers Arch. |volume=445 |issue= 6 |pages= 693–6 |year= 2003 |pmid= 12632189 |doi= 10.1007/s00424-002-0993-8  |name-list-format=vanc| author2=Feng Y  | author3=Cohen P  | display-authors=3  | last4=Risler  | first4=T  | last5=Vandewalle  | first5=A  | last6=Bröer  | first6=S  | last7=Wang  | first7=J  | last8=Pearce  | first8=D  | last9=Lang  | first9=F }}
*{{cite journal  | author=Friedrich B |title=The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC |journal=Pflügers Arch. |volume=445 |issue= 6 |pages= 693–6 |year= 2003 |pmid= 12632189 |doi= 10.1007/s00424-002-0993-8  |name-list-format=vanc| author2=Feng Y  | author3=Cohen P  | display-authors=3  | last4=Risler  | first4=T  | last5=Vandewalle  | first5=A  | last6=Bröer  | first6=S  | last7=Wang  | first7=J  | last8=Pearce  | first8=D  | last9=Lang  | first9=F }}
*{{cite journal  | author=Embark HM |title=Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms |journal=Pflugers Arch. |volume=445 |issue= 5 |pages= 601–6 |year= 2003 |pmid= 12634932 |doi= 10.1007/s00424-002-0982-y  |name-list-format=vanc| author2=Böhmer C  | author3=Vallon V  | display-authors=3  | last4=Luft  | first4=F  | last5=Lang  | first5=F }}
*{{cite journal  | author=Embark HM |title=Regulation of KCNE1-dependent K(+) current by the serum and glucocorticoid-inducible kinase (SGK) isoforms |journal=Pflügers Arch. |volume=445 |issue= 5 |pages= 601–6 |year= 2003 |pmid= 12634932 |doi= 10.1007/s00424-002-0982-y  |name-list-format=vanc| author2=Böhmer C  | author3=Vallon V  | display-authors=3  | last4=Luft  | first4=F  | last5=Lang  | first5=F }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928  |name-list-format=vanc| author2=Wagner L  | author3=Feingold EA  | display-authors=3  | last4=Shenmen  | first4=CM  | last5=Grouse  | first5=LH  | last6=Schuler  | first6=G  | last7=Klein  | first7=SL  | last8=Old  | first8=S  | last9=Rasooly  | first9=R }}
*{{cite journal  | author=Baltaev R |title=Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes |journal=Pflugers Arch. |volume=450 |issue= 1 |pages= 26–33 |year= 2005 |pmid= 15578212 |doi= 10.1007/s00424-004-1369-z  |name-list-format=vanc| author2=Strutz-Seebohm N  | author3=Korniychuk G  | display-authors=3  | last4=Myssina  | first4=Svetlana  | last5=Lang  | first5=Florian  | last6=Seebohm  | first6=Guiscard }}
*{{cite journal  | author=Baltaev R |title=Regulation of cardiac shal-related potassium channel Kv 4.3 by serum- and glucocorticoid-inducible kinase isoforms in Xenopus oocytes |journal=Pflügers Arch. |volume=450 |issue= 1 |pages= 26–33 |year= 2005 |pmid= 15578212 |doi= 10.1007/s00424-004-1369-z  |name-list-format=vanc| author2=Strutz-Seebohm N  | author3=Korniychuk G  | display-authors=3  | last4=Myssina  | first4=Svetlana  | last5=Lang  | first5=Florian  | last6=Seebohm  | first6=Guiscard }}
*{{cite journal  | author=Cheng J |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution |journal=Science |volume=308 |issue= 5725 |pages= 1149–54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625  |name-list-format=vanc| author2=Kapranov P  | author3=Drenkow J  | display-authors=3  | last4=Dike  | first4=S  | last5=Brubaker  | first5=S  | last6=Patel  | first6=S  | last7=Long  | first7=J  | last8=Stern  | first8=D  | last9=Tammana  | first9=H }}
*{{cite journal  | author=Cheng J |title=Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution |journal=Science |volume=308 |issue= 5725 |pages= 1149–54 |year= 2005 |pmid= 15790807 |doi= 10.1126/science.1108625  |name-list-format=vanc| author2=Kapranov P  | author3=Drenkow J  | display-authors=3  | last4=Dike  | first4=S  | last5=Brubaker  | first5=S  | last6=Patel  | first6=S  | last7=Long  | first7=J  | last8=Stern  | first8=D  | last9=Tammana  | first9=H }}
}}
}}

Latest revision as of 07:19, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene.[1][2]

This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase (PI3K), which is also true for SGK. Two alternate transcripts encoding two different isoforms have been described.[2]

References

  1. Kobayashi T, Deak M, Morrice N, Cohen P (Jan 2000). "Characterization of the structure and regulation of two novel isoforms of serum- and glucocorticoid-induced protein kinase". Biochem J. 344 (1): 189–97. doi:10.1042/0264-6021:3440189. PMC 1220630. PMID 10548550.
  2. 2.0 2.1 "Entrez Gene: SGK2 serum/glucocorticoid regulated kinase 2".

Further reading

External links