Atopic dermatitis laboratory findings: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Atopic dermatitis}} | {{Atopic dermatitis}} | ||
{{CMG}}; {{AE}} | {{CMG}}; {{AE}}{{S.S}} | ||
{{S.S}} | |||
==Overview== | ==Overview== | ||
There diagnosis of atopic dermatitis remains clinical as there is no reliable [[Biomarker|bio-marker]] that can differentiate atopic dermatitis from other [[skin]] [[diseases]]. | |||
[ | |||
==Laboratory Findings== | ==Laboratory Findings== | ||
* There are no reliable diagnostic laboratory findings associated with atopic dermatitis. | *There are no reliable diagnostic laboratory findings associated with atopic dermatitis. | ||
* The most common laborotory finding in atopic dermatitis is an elevated total and/or allergen-specific serum IgE level, which is not present in about 20% of affected individuals | *The most common laborotory finding in atopic dermatitis is an elevated total and/or allergen-specific serum [[IgE]] level, which is not present in about 20% of affected individuals.<ref name="pmid234738562">{{cite journal |vauthors=Kabashima K |title=New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity |journal=J. Dermatol. Sci. |volume=70 |issue=1 |pages=3–11 |date=April 2013 |pmid=23473856 |doi=10.1016/j.jdermsci.2013.02.001 |url=}}</ref> | ||
*Monitoring of [[IgE]] levels is not recommended for the assessment of atopic dermatitis severity. | |||
*Higher serum levels of some of the new biomarkers using the [[SCORAD|SCORing Atopic Dermatitis]] ([[SCORAD]]) index and other severity scales:<ref name="pmid170472942">{{cite journal |vauthors=Aral M, Arican O, Gul M, Sasmaz S, Kocturk SA, Kastal U, Ekerbicer HC |title=The relationship between serum levels of total IgE, IL-18, IL-12, IFN-gamma and disease severity in children with atopic dermatitis |journal=Mediators Inflamm. |volume=2006 |issue=4 |pages=73098 |date=2006 |pmid=17047294 |pmc=1618943 |doi=10.1155/MI/2006/73098 |url=}}</ref><ref name="pmid127753632">{{cite journal |vauthors=Di Lorenzo G, Gangemi S, Merendino RA, Minciullo PL, Cannavò SP, Martinelli N, Mansueto P, Rini GB, Corrocher R, Pacor ML |title=Serum levels of soluble CD30 in adult patients affected by atopic dermatitis and its relation to age, duration of disease and Scoring Atopic Dermatitis index |journal=Mediators Inflamm. |volume=12 |issue=2 |pages=123–5 |date=April 2003 |pmid=12775363 |pmc=1781600 |doi=10.1080/0962935031000097736 |url=}}</ref><ref name="pmid20306677">{{cite journal |vauthors=El Mongy S, Metwaly SS, Arafat MS, Hady HA |title=Serum levels of soluble CD30 in patients with atopic dermatitis: correlations with age, disease duration and severity |journal=Egypt J Immunol |volume=15 |issue=1 |pages=123–9 |date=2008 |pmid=20306677 |doi= |url=}}</ref><ref name="pmid21294778">{{cite journal |vauthors=Ezzat MH, Hasan ZE, Shaheen KY |title=Serum measurement of interleukin-31 (IL-31) in paediatric atopic dermatitis: elevated levels correlate with severity scoring |journal=J Eur Acad Dermatol Venereol |volume=25 |issue=3 |pages=334–9 |date=March 2011 |pmid=21294778 |doi=10.1111/j.1468-3083.2010.03794.x |url=}}</ref><ref name="pmid15813816">{{cite journal |vauthors=Jahnz-Rozyk K, Targowski T, Paluchowska E, Owczarek W, Kucharczyk A |title=Serum thymus and activation-regulated chemokine, macrophage-derived chemokine and eotaxin as markers of severity of atopic dermatitis |journal=Allergy |volume=60 |issue=5 |pages=685–8 |date=May 2005 |pmid=15813816 |doi=10.1111/j.1398-9995.2005.00774.x |url=}}</ref><ref name="pmid18266834">{{cite journal |vauthors=Nakazato J, Kishida M, Kuroiwa R, Fujiwara J, Shimoda M, Shinomiya N |title=Serum levels of Th2 chemokines, CCL17, CCL22, and CCL27, were the important markers of severity in infantile atopic dermatitis |journal=Pediatr Allergy Immunol |volume=19 |issue=7 |pages=605–13 |date=November 2008 |pmid=18266834 |doi=10.1111/j.1399-3038.2007.00692.x |url=}}</ref><ref name="StänderRopper2021">{{cite journal|last1=Ständer|first1=Sonja|last2=Ropper|first2=Allan H.|title=Atopic Dermatitis|journal=New England Journal of Medicine|volume=384|issue=12|year=2021|pages=1136–1143|issn=0028-4793|doi=10.1056/NEJMra2023911}}</ref> | |||
**Serum levels of [[CD30]] | |||
**Macrophage-derived chemoattractant (MDC) | |||
**[[Interleukin 12|Interleukins (IL)-12]] | |||
**[[Interleukin 16|Interleukins (IL)-16]] | |||
**[[Interleukin 18|Interleukins (IL)-18]] | |||
**[[Interleukin 31|Interleukins (IL)-31]] | |||
**Thymus and activation-regulated [[chemokine]] (TARC) | |||
*[ | |||
*[ | |||
*[ | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
[[Category:Autoimmune diseases]] | [[Category:Autoimmune diseases]] | ||
[[Category:Dermatology]] | [[Category:Dermatology]] | ||
Latest revision as of 03:11, 26 April 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shalinder Singh, M.B.B.S.[2]
Overview
There diagnosis of atopic dermatitis remains clinical as there is no reliable bio-marker that can differentiate atopic dermatitis from other skin diseases.
Laboratory Findings
- There are no reliable diagnostic laboratory findings associated with atopic dermatitis.
- The most common laborotory finding in atopic dermatitis is an elevated total and/or allergen-specific serum IgE level, which is not present in about 20% of affected individuals.[1]
- Monitoring of IgE levels is not recommended for the assessment of atopic dermatitis severity.
- Higher serum levels of some of the new biomarkers using the SCORing Atopic Dermatitis (SCORAD) index and other severity scales:[2][3][4][5][6][7][8]
- Serum levels of CD30
- Macrophage-derived chemoattractant (MDC)
- Interleukins (IL)-12
- Interleukins (IL)-16
- Interleukins (IL)-18
- Interleukins (IL)-31
- Thymus and activation-regulated chemokine (TARC)
References
- ↑ Kabashima K (April 2013). "New concept of the pathogenesis of atopic dermatitis: interplay among the barrier, allergy, and pruritus as a trinity". J. Dermatol. Sci. 70 (1): 3–11. doi:10.1016/j.jdermsci.2013.02.001. PMID 23473856.
- ↑ Aral M, Arican O, Gul M, Sasmaz S, Kocturk SA, Kastal U, Ekerbicer HC (2006). "The relationship between serum levels of total IgE, IL-18, IL-12, IFN-gamma and disease severity in children with atopic dermatitis". Mediators Inflamm. 2006 (4): 73098. doi:10.1155/MI/2006/73098. PMC 1618943. PMID 17047294.
- ↑ Di Lorenzo G, Gangemi S, Merendino RA, Minciullo PL, Cannavò SP, Martinelli N, Mansueto P, Rini GB, Corrocher R, Pacor ML (April 2003). "Serum levels of soluble CD30 in adult patients affected by atopic dermatitis and its relation to age, duration of disease and Scoring Atopic Dermatitis index". Mediators Inflamm. 12 (2): 123–5. doi:10.1080/0962935031000097736. PMC 1781600. PMID 12775363.
- ↑ El Mongy S, Metwaly SS, Arafat MS, Hady HA (2008). "Serum levels of soluble CD30 in patients with atopic dermatitis: correlations with age, disease duration and severity". Egypt J Immunol. 15 (1): 123–9. PMID 20306677.
- ↑ Ezzat MH, Hasan ZE, Shaheen KY (March 2011). "Serum measurement of interleukin-31 (IL-31) in paediatric atopic dermatitis: elevated levels correlate with severity scoring". J Eur Acad Dermatol Venereol. 25 (3): 334–9. doi:10.1111/j.1468-3083.2010.03794.x. PMID 21294778.
- ↑ Jahnz-Rozyk K, Targowski T, Paluchowska E, Owczarek W, Kucharczyk A (May 2005). "Serum thymus and activation-regulated chemokine, macrophage-derived chemokine and eotaxin as markers of severity of atopic dermatitis". Allergy. 60 (5): 685–8. doi:10.1111/j.1398-9995.2005.00774.x. PMID 15813816.
- ↑ Nakazato J, Kishida M, Kuroiwa R, Fujiwara J, Shimoda M, Shinomiya N (November 2008). "Serum levels of Th2 chemokines, CCL17, CCL22, and CCL27, were the important markers of severity in infantile atopic dermatitis". Pediatr Allergy Immunol. 19 (7): 605–13. doi:10.1111/j.1399-3038.2007.00692.x. PMID 18266834.
- ↑ Ständer, Sonja; Ropper, Allan H. (2021). "Atopic Dermatitis". New England Journal of Medicine. 384 (12): 1136–1143. doi:10.1056/NEJMra2023911. ISSN 0028-4793.