Spina bifida natural history, complications and prognosis: Difference between revisions
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==Overview== | ==Overview== | ||
If left untreated, [ | Prognosis of patients with spina bifida is generally poor. Early clinical features of spina bifida include: Weakness or [[paralysis]] in the legs, [[Urinary incontinence]], [[Bowel]] incontinence, [[Sensation]] problems in the [[lower extremity]], [[Motor]] problems in the [[lower extrimity]] and [[Hydrocephalus]]. If left untreated, 50% of patients with congenital anomalies, especially spina bifida may die soon after birth in the underdeveloped countries. [[Renal failure]] is the commonest cause of death in patients with spina bifida. Common complications of [disease name] include: [[Cardiac]] disease, [[Respiratory disease]], [[Suicidality]] and [[Cancer]]. | ||
== Natural History, Complications and Prognosis== | |||
*Prognosis of patients with spina bifida is generally poor. | |||
*Early clinical features include:<ref name="pmid10350196">{{cite journal |vauthors=Soonawala N, Overweg-Plandsoen WC, Brouwer OF |title=Early clinical signs and symptoms in occult spinal dysraphism: a retrospective case study of 47 patients |journal=Clin Neurol Neurosurg |volume=101 |issue=1 |pages=11–4 |date=March 1999 |pmid=10350196 |doi= |url=}}</ref><ref name="pmid4898641">{{cite journal |vauthors=Bannur BB, Purandare GM |title=Microbial production of L-lysine |journal=Hindustan Antibiot Bull |volume=11 |issue=3 |pages=191–205 |date=February 1969 |pmid=4898641 |doi= |url=}}</ref><ref name="pmid2647936">{{cite journal |vauthors=Horton D, Barnes P, Pendleton BD, Pollay M |title=Spina bifida occulta: early clinical and radiographic diagnosis |journal=J Okla State Med Assoc |volume=82 |issue=1 |pages=15–9 |date=January 1989 |pmid=2647936 |doi= |url=}}</ref> | |||
**Weakness or [[paralysis]] in the legs. | |||
**[[Urinary incontinence]] | |||
**[[Bowel]] incontinence | |||
Prognosis is generally | **[[Sensation]] problems in the [[lower extremity]] | ||
== | **[[Motor]] problems in the [[lower extrimity]] | ||
**[[Hydrocephalus]] | |||
=== | *If left untreated, 50% of patients with congenital anomalies, especially spina bifida may die soon after birth in the underdeveloped countries.<ref name="pmid2441590">{{cite journal |vauthors=Kozlowski BW, Taylor ML, Baer MT, Blyler EM, Trahms C |title=Anticonvulsant medication use and circulating levels of total thyroxine, retinol binding protein, and vitamin A in children with delayed cognitive development |journal=Am. J. Clin. Nutr. |volume=46 |issue=2 |pages=360–8 |date=August 1987 |pmid=2441590 |doi=10.1093/ajcn/46.2.360 |url=}}</ref> | ||
* | *[[Renal failure]] is the commonest cause of death in patients with spina bifida.<ref name="pmid2441590">{{cite journal |vauthors=Kozlowski BW, Taylor ML, Baer MT, Blyler EM, Trahms C |title=Anticonvulsant medication use and circulating levels of total thyroxine, retinol binding protein, and vitamin A in children with delayed cognitive development |journal=Am. J. Clin. Nutr. |volume=46 |issue=2 |pages=360–8 |date=August 1987 |pmid=2441590 |doi=10.1093/ajcn/46.2.360 |url=}}</ref> | ||
* | *Common complications of [disease name] include:<ref name="pmid2441590">{{cite journal |vauthors=Kozlowski BW, Taylor ML, Baer MT, Blyler EM, Trahms C |title=Anticonvulsant medication use and circulating levels of total thyroxine, retinol binding protein, and vitamin A in children with delayed cognitive development |journal=Am. J. Clin. Nutr. |volume=46 |issue=2 |pages=360–8 |date=August 1987 |pmid=2441590 |doi=10.1093/ajcn/46.2.360 |url=}}</ref> | ||
* | **[[Cardiac]] disease | ||
**[[Respiratory disease]] | |||
**[[Suicidality]] | |||
* | **[[Cancer]] | ||
**[ | |||
**[ | |||
=== | |||
* | |||
* | |||
* | |||
*[ | |||
* | |||
==References== | ==References== | ||
Latest revision as of 18:26, 6 February 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Prognosis of patients with spina bifida is generally poor. Early clinical features of spina bifida include: Weakness or paralysis in the legs, Urinary incontinence, Bowel incontinence, Sensation problems in the lower extremity, Motor problems in the lower extrimity and Hydrocephalus. If left untreated, 50% of patients with congenital anomalies, especially spina bifida may die soon after birth in the underdeveloped countries. Renal failure is the commonest cause of death in patients with spina bifida. Common complications of [disease name] include: Cardiac disease, Respiratory disease, Suicidality and Cancer.
Natural History, Complications and Prognosis
- Prognosis of patients with spina bifida is generally poor.
- Early clinical features include:[1][2][3]
- Weakness or paralysis in the legs.
- Urinary incontinence
- Bowel incontinence
- Sensation problems in the lower extremity
- Motor problems in the lower extrimity
- Hydrocephalus
- If left untreated, 50% of patients with congenital anomalies, especially spina bifida may die soon after birth in the underdeveloped countries.[4]
- Renal failure is the commonest cause of death in patients with spina bifida.[4]
- Common complications of [disease name] include:[4]
- Cardiac disease
- Respiratory disease
- Suicidality
- Cancer
References
- ↑ Soonawala N, Overweg-Plandsoen WC, Brouwer OF (March 1999). "Early clinical signs and symptoms in occult spinal dysraphism: a retrospective case study of 47 patients". Clin Neurol Neurosurg. 101 (1): 11–4. PMID 10350196.
- ↑ Bannur BB, Purandare GM (February 1969). "Microbial production of L-lysine". Hindustan Antibiot Bull. 11 (3): 191–205. PMID 4898641.
- ↑ Horton D, Barnes P, Pendleton BD, Pollay M (January 1989). "Spina bifida occulta: early clinical and radiographic diagnosis". J Okla State Med Assoc. 82 (1): 15–9. PMID 2647936.
- ↑ 4.0 4.1 4.2 Kozlowski BW, Taylor ML, Baer MT, Blyler EM, Trahms C (August 1987). "Anticonvulsant medication use and circulating levels of total thyroxine, retinol binding protein, and vitamin A in children with delayed cognitive development". Am. J. Clin. Nutr. 46 (2): 360–8. doi:10.1093/ajcn/46.2.360. PMID 2441590.