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{{for|the aerodrome using the TC LID, CCL3|Christina Lake Aerodrome}}
{{Infobox_gene}}
'''Chemokine (C-C motif) ligand 3''' (CCL3) also known as '''macrophage inflammatory protein 1-alpha''' (MIP-1-alpha) is a [[protein]] that in humans is encoded by the ''CCL3'' [[gene]].<ref name = "entrez"/>


== Function ==


<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
CCL3 is a [[cytokine]] belonging to the CC [[chemokine]] family that is involved in the acute inflammatory state in the recruitment and activation of [[polymorphonuclear leukocyte]]s<ref name="pmid3279154">{{cite journal | vauthors = Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A | title = Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties | journal = The Journal of Experimental Medicine | volume = 167 | issue = 2 | pages = 570–81 | year = 1988 | pmid = 3279154 | pmc = 2188834 | doi = 10.1084/jem.167.2.570 }}</ref> through binding to the receptors [[CCR1]], [[CCR4]] and [[CCR5]].<ref name = "entrez"/>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta ([[CCL4]]).<ref name="pmid3058856">{{cite journal | vauthors = Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A | title = Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta | journal = The Journal of Experimental Medicine | volume = 168 | issue = 6 | pages = 2251–9 | year = 1988 | pmid = 3058856 | pmc = 2189160 | doi = 10.1084/jem.168.6.2251 }}</ref><ref name = "entrez">{{cite web | title = Entrez Gene: CCL3 chemokine (C-C motif) ligand 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6348| accessdate = }}</ref>
{{GNF_Protein_box
| image = PBB_Protein_CCL3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b50.
| PDB = {{PDB2|1b50}}, {{PDB2|1b53}}
| Name = Chemokine (C-C motif) ligand 3
| HGNCid = 10627
| Symbol = CCL3
| AltSymbols =; G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3
| OMIM = 182283
| ECnumber =
| Homologene = 88430
| MGIid =
| GeneAtlas_image1 = PBB_GE_CCL3_205114_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0008009 |text = chemokine activity}} {{GNF_GO|id=GO:0042056 |text = chemoattractant activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}}
| Process = {{GNF_GO|id=GO:0006874 |text = cellular calcium ion homeostasis}} {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0006935 |text = chemotaxis}} {{GNF_GO|id=GO:0006954 |text = inflammatory response}} {{GNF_GO|id=GO:0006955 |text = immune response}} {{GNF_GO|id=GO:0007010 |text = cytoskeleton organization and biogenesis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007267 |text = cell-cell signaling}} {{GNF_GO|id=GO:0019735 |text = antimicrobial humoral response}} {{GNF_GO|id=GO:0045069 |text = regulation of viral genome replication}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6348
    | Hs_Ensembl = ENSG00000006075
    | Hs_RefseqProtein = NP_002974
    | Hs_RefseqmRNA = NM_002983
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 31439737
    | Hs_GenLoc_end = 31441517
    | Hs_Uniprot = P10147
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end =
    | Mm_Uniprot = 
  }}
}}
'''Chemokine (C-C motif) ligand 3''', also known as '''CCL3''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human [[tumor necrosis factor]] or recombinant human [[interleukin-1]]. However, in contrast to these two endogenous [[pyrogen (fever)|pyrogen]]s, the fever induced by MIP-1 is not inhibited by the [[cyclooxygenase]] inhibitor [[ibuprofen]] and CCL3 may participate in the [[febrile response]] that is not mediated through [[prostaglandin]] synthesis and clinically cannot be ablated by cyclooxygenase.<ref name="pmid2646711">{{cite journal | vauthors = Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A | title = Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen | journal = Science  | volume = 243 | issue = 4894 Pt 1 | pages = 1066–8 | year = 1989 | pmid = 2646711 | doi = 10.1126/science.2646711 }}</ref>
{{PBB_Summary
 
| section_title =  
== Interactions ==
| summary_text = Macrophage inflammatory protein-1 is a so-called monokine that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes (Wolpe et al., 1988). Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha and beta.[supplied by OMIM]<ref>{{cite web | title = Entrez Gene: CCL3 chemokine (C-C motif) ligand 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6348| accessdate = }}</ref>
 
}}
CCL3 has been shown to [[Protein-protein interaction|interact]] with [[CCL4]].<ref name=pmid11278300>{{cite journal | vauthors = Guan E, Wang J, Norcross MA | title = Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer | journal = The Journal of Biological Chemistry | volume = 276 | issue = 15 | pages = 12404–9 | date = Apr 2001 | pmid = 11278300 | doi = 10.1074/jbc.M006327200 }}</ref>
==See also==
Attracts macrophages, monocytes and neutrophils.
 
== See also ==
*[[Macrophage inflammatory protein]]s
*[[Macrophage inflammatory protein]]s


==References==
== References ==
{{reflist}}
{{reflist}}
==Further reading==
 
{{refbegin | 2}}
==External links==
{{PBB_Further_reading
* {{UCSC gene info|CCL3}}
| citations =
 
*{{cite journal | author=Menten P, Wuyts A, Van Damme J |title=Macrophage inflammatory protein-1. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 6 |pages= 455–81 |year= 2003 |pmid= 12401480 |doi= }}
== Further reading ==
*{{cite journal | author=Muthumani K, Desai BM, Hwang DS, ''et al.'' |title=HIV-1 Vpr and anti-inflammatory activity. |journal=DNA Cell Biol. |volume=23 |issue= 4 |pages= 239–47 |year= 2004 |pmid= 15142381 |doi= 10.1089/104454904773819824 }}
{{refbegin|35em}}
*{{cite journal | author=Joseph AM, Kumar M, Mitra D |title=Nef: "necessary and enforcing factor" in HIV infection. |journal=Curr. HIV Res. |volume=3 |issue= 1 |pages= 87–94 |year= 2005 |pmid= 15638726 |doi= }}
* {{cite journal | vauthors = Menten P, Wuyts A, Van Damme J | title = Macrophage inflammatory protein-1 | journal = Cytokine & Growth Factor Reviews | volume = 13 | issue = 6 | pages = 455–81 | date = Dec 2002 | pmid = 12401480 | doi = 10.1016/S1359-6101(02)00045-X }}
*{{cite journal | author=Zhao RY, Elder RT |title=Viral infections and cell cycle G2/M regulation. |journal=Cell Res. |volume=15 |issue= 3 |pages= 143–9 |year= 2005 |pmid= 15780175 |doi= 10.1038/sj.cr.7290279 }}
* {{cite journal | vauthors = Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB | title = HIV-1 Vpr and anti-inflammatory activity | journal = DNA and Cell Biology | volume = 23 | issue = 4 | pages = 239–47 | date = Apr 2004 | pmid = 15142381 | doi = 10.1089/104454904773819824 }}
*{{cite journal | author=Zhao RY, Bukrinsky M, Elder RT |title=HIV-1 viral protein R (Vpr) & host cellular responses. |journal=Indian J. Med. Res. |volume=121 |issue= 4 |pages= 270–86 |year= 2005 |pmid= 15817944 |doi=  }}
* {{cite journal | vauthors = Joseph AM, Kumar M, Mitra D | title = Nef: "necessary and enforcing factor" in HIV infection | journal = Current HIV Research | volume = 3 | issue = 1 | pages = 87–94 | date = Jan 2005 | pmid = 15638726 | doi = 10.2174/1570162052773013 }}
*{{cite journal | author=Li L, Li HS, Pauza CD, ''et al.'' |title=Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions. |journal=Cell Res. |volume=15 |issue= 11-12 |pages= 923–34 |year= 2006 |pmid= 16354571 |doi= 10.1038/sj.cr.7290370 }}
* {{cite journal | vauthors = Zhao RY, Elder RT | title = Viral infections and cell cycle G2/M regulation | journal = Cell Research | volume = 15 | issue = 3 | pages = 143–9 | date = Mar 2005 | pmid = 15780175 | doi = 10.1038/sj.cr.7290279 }}
}}
* {{cite journal | vauthors = Zhao RY, Bukrinsky M, Elder RT | title = HIV-1 viral protein R (Vpr) & host cellular responses | journal = The Indian Journal of Medical Research | volume = 121 | issue = 4 | pages = 270–86 | date = Apr 2005 | pmid = 15817944 | doi =  }}
* {{cite journal | vauthors = Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY | title = Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions | journal = Cell Research | volume = 15 | issue = 11–12 | pages = 923–34 | year = 2006 | pmid = 16354571 | doi = 10.1038/sj.cr.7290370 }}
{{refend}}
{{refend}}


{{gene-17-stub}}
{{PDB Gallery|geneid=6348}}
{{Chemokines}}
{{Chemokines}}
{{Chemokine receptor modulators}}
[[Category:Cytokines]]


[[category:cytokines]]
{{gene-17-stub}}
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{{WS}}

Latest revision as of 00:30, 27 October 2017

For the aerodrome using the TC LID, CCL3, see Christina Lake Aerodrome.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene.[1]

Function

CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes[2] through binding to the receptors CCR1, CCR4 and CCR5.[1]

Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4).[3][1]

CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxygenase inhibitor ibuprofen and CCL3 may participate in the febrile response that is not mediated through prostaglandin synthesis and clinically cannot be ablated by cyclooxygenase.[4]

Interactions

CCL3 has been shown to interact with CCL4.[5] Attracts macrophages, monocytes and neutrophils.

See also

References

  1. ↑ 1.0 1.1 1.2 "Entrez Gene: CCL3 chemokine (C-C motif) ligand 3".
  2. ↑ Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A (1988). "Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties". The Journal of Experimental Medicine. 167 (2): 570–81. doi:10.1084/jem.167.2.570. PMC 2188834. PMID 3279154.
  3. ↑ Sherry B, Tekamp-Olson P, Gallegos C, Bauer D, Davatelis G, Wolpe SD, Masiarz F, Coit D, Cerami A (1988). "Resolution of the two components of macrophage inflammatory protein 1, and cloning and characterization of one of those components, macrophage inflammatory protein 1 beta". The Journal of Experimental Medicine. 168 (6): 2251–9. doi:10.1084/jem.168.6.2251. PMC 2189160. PMID 3058856.
  4. ↑ Davatelis G, Wolpe SD, Sherry B, Dayer JM, Chicheportiche R, Cerami A (1989). "Macrophage inflammatory protein-1: a prostaglandin-independent endogenous pyrogen". Science. 243 (4894 Pt 1): 1066–8. doi:10.1126/science.2646711. PMID 2646711.
  5. ↑ Guan E, Wang J, Norcross MA (Apr 2001). "Identification of human macrophage inflammatory proteins 1alpha and 1beta as a native secreted heterodimer". The Journal of Biological Chemistry. 276 (15): 12404–9. doi:10.1074/jbc.M006327200. PMID 11278300.

External links

Further reading

  • Menten P, Wuyts A, Van Damme J (Dec 2002). "Macrophage inflammatory protein-1". Cytokine & Growth Factor Reviews. 13 (6): 455–81. doi:10.1016/S1359-6101(02)00045-X. PMID 12401480.
  • Muthumani K, Desai BM, Hwang DS, Choo AY, Laddy DJ, Thieu KP, Rao RG, Weiner DB (Apr 2004). "HIV-1 Vpr and anti-inflammatory activity". DNA and Cell Biology. 23 (4): 239–47. doi:10.1089/104454904773819824. PMID 15142381.
  • Joseph AM, Kumar M, Mitra D (Jan 2005). "Nef: "necessary and enforcing factor" in HIV infection". Current HIV Research. 3 (1): 87–94. doi:10.2174/1570162052773013. PMID 15638726.
  • Zhao RY, Elder RT (Mar 2005). "Viral infections and cell cycle G2/M regulation". Cell Research. 15 (3): 143–9. doi:10.1038/sj.cr.7290279. PMID 15780175.
  • Zhao RY, Bukrinsky M, Elder RT (Apr 2005). "HIV-1 viral protein R (Vpr) & host cellular responses". The Indian Journal of Medical Research. 121 (4): 270–86. PMID 15817944.
  • Li L, Li HS, Pauza CD, Bukrinsky M, Zhao RY (2006). "Roles of HIV-1 auxiliary proteins in viral pathogenesis and host-pathogen interactions". Cell Research. 15 (11–12): 923–34. doi:10.1038/sj.cr.7290370. PMID 16354571.


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