GLUT5: Difference between revisions

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Latest revision as of 01:00, 12 June 2017

GLUT5 is a fructose transporter expressed on the apical border of enterocytes in the small intestine.^[1] GLUT5 allows for fructose to be transported from the intestinal lumen into the enterocyte by facilitated diffusion due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in skeletal muscle,^[2] testis, kidney, fat tissue (adipocytes), and brain.^[3]

Fructose malabsorption or Dietary Fructose Intolerance is a dietary disability of the small intestine, where the amount of fructose carrier in enterocytes is deficient.^[4]

In humans the GLUT5 protein is encoded by the SLC2A5 gene.^[5]

Regulation

Fructose uptake rate by GLUT5 is significantly affected by diabetes mellitus, hypertension, obesity, fructose malabsorption, and inflammation. However, age-related changes in fructose intake capability are not explained by the rate of expression of GLUT5.^[6]^[7]^[8] The absorption of fructose in the simultaneous presence of glucose is improved, while sorbitol is inhibitory.^[9]

Interactive pathway map

Click on genes, proteins and metabolites below to link to respective articles. ^{[§ 1]}

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<imagemap> Image:WP534.png

|{{{bSize}}}px|alt=Glycolysis and Gluconeogenesis edit]]

Glycolysis and Gluconeogenesis edit

↑ The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

References

↑ Uldry M, Thorens B (February 2004). "The SLC2 family of facilitated hexose and polyol transporters". Pflügers Archiv : European Journal of Physiology. 447 (5): 480–9. doi:10.1007/s00424-003-1085-0. PMID 12750891.
↑ Hundal HS, Darakhshan F, Kristiansen S, Blakemore SJ, Richter EA (1998). "GLUT5 expression and fructose transport in human skeletal muscle". Advances in Experimental Medicine and Biology. 441: 35–45. doi:10.1007/978-1-4899-1928-1_4. PMID 9781312.
↑ Douard V, Ferraris RP (August 2008). "Regulation of the fructose transporter GLUT5 in health and disease". American Journal of Physiology. Endocrinology and Metabolism. 295 (2): E227–37. doi:10.1152/ajpendo.90245.2008. PMC 2652499. PMID 18398011.
↑ Barone S, Fussell SL, Singh AK, Lucas F, Xu J, Kim C, Wu X, Yu Y, Amlal H, Seidler U, Zuo J, Soleimani M (February 2009). "Slc2a5 (Glut5) Is Essential for the Absorption of Fructose in the Intestine and Generation of Fructose-induced Hypertension". The Journal of Biological Chemistry. 284 (8): 5056–66. doi:10.1074/jbc.M808128200. PMC 2643499. PMID 19091748.
↑ White PS, Jensen SJ, Rajalingam V, Stairs D, Sulman EP, Maris JM, Biegel JA, Wooster R, Brodeur GM (1998). "Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2". Cytogenetics and Cell Genetics. 81 (1): 60–4. doi:10.1159/000014989. PMID 9691177.
↑ Douard V, Ferraris RP (August 2008). "Regulation of the fructose transporter GLUT5 in health and disease". Am. J. Physiol. Endocrinol. Metab. 295 (2): E227–37. doi:10.1152/ajpendo.90245.2008. PMC 2652499. PMID 18398011.
↑ Litherland GJ, Hajduch E, Gould GW, Hundal HS (June 2004). "Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance" (PDF). Mol. Cell. Biochem. 261 (1–2): 23–33. doi:10.1023/b:mcbi.0000028734.77867.d2. PMID 15362482.
↑ Drozdowski LA, Woudstra TD, Wild GE, Clandinin MT, Thomson AB (October 2004). "Age-associated changes in intestinal fructose uptake are not explained by alterations in the abundance of GLUT5 or GLUT2". J. Nutr. Biochem. 15 (10): 630–7. doi:10.1016/j.jnutbio.2004.06.003. PMID 15542355.
↑ Heinrich Kasper: Ernährungsmedizin und Diätetik. 11. Auflage, Elsevier, Urban&Fischer-Verlag, 2009, ISBN 9783437420122, S. 208

External links

GLUT5+Protein at the US National Library of Medicine Medical Subject Headings (MeSH)

Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[WikiPathways-10] The interactive pathway map can be edited at WikiPathways: "GlycolysisGluconeogenesis_WP534".

[pmid12750891-1] Uldry M, Thorens B (February 2004). "The SLC2 family of facilitated hexose and polyol transporters". Pflügers Archiv : European Journal of Physiology. 447 (5): 480–9. doi:10.1007/s00424-003-1085-0. PMID 12750891.

[pmid9781312-2] Hundal HS, Darakhshan F, Kristiansen S, Blakemore SJ, Richter EA (1998). "GLUT5 expression and fructose transport in human skeletal muscle". Advances in Experimental Medicine and Biology. 441: 35–45. doi:10.1007/978-1-4899-1928-1_4. PMID 9781312.

[pmid18398011-3] Douard V, Ferraris RP (August 2008). "Regulation of the fructose transporter GLUT5 in health and disease". American Journal of Physiology. Endocrinology and Metabolism. 295 (2): E227–37. doi:10.1152/ajpendo.90245.2008. PMC 2652499. PMID 18398011.

[pmid19091748-4] Barone S, Fussell SL, Singh AK, Lucas F, Xu J, Kim C, Wu X, Yu Y, Amlal H, Seidler U, Zuo J, Soleimani M (February 2009). "Slc2a5 (Glut5) Is Essential for the Absorption of Fructose in the Intestine and Generation of Fructose-induced Hypertension". The Journal of Biological Chemistry. 284 (8): 5056–66. doi:10.1074/jbc.M808128200. PMC 2643499. PMID 19091748.

[pmid9691177-5] White PS, Jensen SJ, Rajalingam V, Stairs D, Sulman EP, Maris JM, Biegel JA, Wooster R, Brodeur GM (1998). "Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2". Cytogenetics and Cell Genetics. 81 (1): 60–4. doi:10.1159/000014989. PMID 9691177.

[6] Douard V, Ferraris RP (August 2008). "Regulation of the fructose transporter GLUT5 in health and disease". Am. J. Physiol. Endocrinol. Metab. 295 (2): E227–37. doi:10.1152/ajpendo.90245.2008. PMC 2652499. PMID 18398011.

[7] Litherland GJ, Hajduch E, Gould GW, Hundal HS (June 2004). "Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance" (PDF). Mol. Cell. Biochem. 261 (1–2): 23–33. doi:10.1023/b:mcbi.0000028734.77867.d2. PMID 15362482.

[8] Drozdowski LA, Woudstra TD, Wild GE, Clandinin MT, Thomson AB (October 2004). "Age-associated changes in intestinal fructose uptake are not explained by alterations in the abundance of GLUT5 or GLUT2". J. Nutr. Biochem. 15 (10): 630–7. doi:10.1016/j.jnutbio.2004.06.003. PMID 15542355.

[9] Heinrich Kasper: Ernährungsmedizin und Diätetik. 11. Auflage, Elsevier, Urban&Fischer-Verlag, 2009, ISBN 9783437420122, S. 208

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[§ 1]

@@ Line 1: / Line 1: @@
-{{protein
+{{infobox gene}}
-| Name = solute carrier family 2 (facilitated glucose/fructose transporter), member 5
+'''GLUT5''' is a [[fructose]] transporter expressed on the apical border of [[enterocytes]] in the [[small intestine]].<ref name="pmid12750891">{{cite journal |vauthors=Uldry M, Thorens B | title = The SLC2 family of facilitated hexose and polyol transporters | journal = Pflügers Archiv : European Journal of Physiology | volume = 447 | issue = 5 | pages = 480–9 |date=February 2004 | pmid = 12750891 | doi = 10.1007/s00424-003-1085-0 | url =  }}</ref> GLUT5 allows for fructose to be transported from the [[intestinal lumen]] into the enterocyte by [[facilitated diffusion]] due to fructose's high concentration in the intestinal lumen. GLUT5 is also expressed in [[skeletal muscle]],<ref name="pmid9781312">{{cite journal |vauthors=Hundal HS, Darakhshan F, Kristiansen S, Blakemore SJ, Richter EA | title = GLUT5 expression and fructose transport in human skeletal muscle | journal = Advances in Experimental Medicine and Biology | volume = 441 | issue = | pages = 35–45 | year = 1998 | pmid = 9781312 | doi = 10.1007/978-1-4899-1928-1_4| url =  }}</ref> testis, kidney, fat tissue (adipocytes), and brain.<ref name="pmid18398011">{{cite journal |vauthors=Douard V, Ferraris RP | title = Regulation of the fructose transporter GLUT5 in health and disease | journal = American Journal of Physiology. Endocrinology and Metabolism | volume = 295 | issue = 2 | pages = E227–37 |date=August 2008 | pmid = 18398011 | doi = 10.1152/ajpendo.90245.2008 | url = | pmc = 2652499 }}</ref>
-| image =
-| width =
-| caption =
-| Symbol = SLC2A5
-| AltSymbols =
-| ATC_prefix=
-| ATC_suffix=
-| ATC_supplemental=
-| CAS_number=
-| CAS_supplemental=
-| DrugBank=
-| EntrezGene = 6518
-| HGNCid =SLC2A5
-| OMIM = 138230
-| PDB =
-| RefSeq = NM_003039
-| UniProt = P22732
-| ECnumber =
-| Chromosome = 1
-| Arm = p
-| Band = 36.2
-| LocusSupplementaryData =
-}}
-{{CMG}}
+[[Fructose malabsorption]] or Dietary Fructose Intolerance is a dietary disability of the [[small intestine]], where the amount of fructose carrier in [[enterocyte]]s is deficient.<ref name="pmid19091748">{{cite journal |vauthors=Barone S, Fussell SL, Singh AK, Lucas F, Xu J, Kim C, Wu X, Yu Y, Amlal H, Seidler U, Zuo J, Soleimani M | title = Slc2a5 (Glut5) Is Essential for the Absorption of Fructose in the Intestine and Generation of Fructose-induced Hypertension | journal = The Journal of Biological Chemistry | volume = 284 | issue = 8 | pages = 5056–66 |date=February 2009 | pmid = 19091748 | doi = 10.1074/jbc.M808128200 | url = | pmc = 2643499 }}</ref>
+In humans the GLUT5 protein is encoded by the ''SLC2A5'' [[gene]].<ref name="pmid9691177">{{cite journal |vauthors=White PS, Jensen SJ, Rajalingam V, Stairs D, Sulman EP, Maris JM, Biegel JA, Wooster R, Brodeur GM | title = Physical mapping of the CA6, ENO1, and SLC2A5 (GLUT5) genes and reassignment of SLC2A5 to 1p36.2 | journal = Cytogenetics and Cell Genetics | volume = 81 | issue = 1 | pages = 60–4 | year = 1998 | pmid = 9691177 | doi = 10.1159/000014989 | url =   }}</ref>
+== Regulation ==
+Fructose uptake rate by GLUT5 is significantly affected by [[diabetes mellitus]], [[hypertension]], [[obesity]], [[fructose malabsorption]], and [[inflammation]]. However, age-related changes in fructose intake capability are not explained by the rate of expression of GLUT5.<ref>{{cite journal |vauthors=Douard V, Ferraris RP |title=Regulation of the fructose transporter GLUT5 in health and disease |journal=Am. J. Physiol. Endocrinol. Metab. |volume=295 |issue=2 |pages=E227–37 |date=August 2008  |pmid=18398011 |doi=10.1152/ajpendo.90245.2008 |url= |pmc=2652499}}</ref><ref>{{cite journal |vauthors=Litherland GJ, Hajduch E, Gould GW, Hundal HS |title=Fructose transport and metabolism in adipose tissue of Zucker rats: diminished GLUT5 activity during obesity and insulin resistance |journal=Mol. Cell. Biochem. |volume=261 |issue=1-2 |pages=23–33 |date=June 2004  |pmid=15362482 |doi= 10.1023/b:mcbi.0000028734.77867.d2|url=http://www.kluweronline.com/art.pdf?issn=0300-8177&volume=261&page=23}}</ref><ref>{{cite journal |vauthors=Drozdowski LA, Woudstra TD, Wild GE, Clandinin MT, Thomson AB |title=Age-associated changes in intestinal fructose uptake are not explained by alterations in the abundance of GLUT5 or GLUT2 |journal=J. Nutr. Biochem. |volume=15 |issue=10 |pages=630–7 |date=October 2004  |pmid=15542355 |doi=10.1016/j.jnutbio.2004.06.003 |url=}}</ref> The absorption of fructose in the simultaneous presence of [[glucose]] is improved, while [[sorbitol]] is inhibitory.<ref>Heinrich Kasper: ''Ernährungsmedizin und Diätetik.'' 11. Auflage, Elsevier, Urban&Fischer-Verlag, 2009, {{ISBN|9783437420122}}, S.&nbsp;208</ref>
-'''GLUT5''' is a [[fructose]] transporter.
+==Interactive pathway map==
+{{GlycolysisGluconeogenesis_WP534|highlight=GLUT5}}
-[[Fructose malabsorption]] or Dietary Fructose Intolerance is a dietary disability of the [[small intestine]], where the amount of fructose carrier in [[enterocyte]]s is deficient.
+== References ==
+{{Reflist}}
-==External links==
+== External links ==
 * {{MeshName|GLUT5+Protein}}
-{{Membrane transport proteins}}
+{{Solute carrier family|bg|bg0}}
-[[es:GLUT5]]
+[[Category:Solute carrier family]]
-{{WH}}
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}