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{{Infobox_gene}}
{{PBB_Controls
'''Guanine nucleotide-binding protein G(k) subunit alpha''' is a [[protein]] that in humans is encoded by the ''GNAI3'' [[gene]].<ref name="pmid3109953">{{cite journal | vauthors = Didsbury JR, Snyderman R | title = Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families | journal = FEBS Letters | volume = 219 | issue = 1 | pages = 259–63 | date = Jul 1987 | pmid = 3109953 | pmc =  | doi = 10.1016/0014-5793(87)81228-0 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2773| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_GNAI3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1agr.
| Name = Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3
| HGNCid = 4387
| Symbol = GNAI3
| AltSymbols =; 87U6; FLJ26559
| OMIM = 139370
| ECnumber = 
| Homologene = 55975
| MGIid = 95773
| GeneAtlas_image1 = PBB_GE_GNAI3_201180_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_GNAI3_201179_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_GNAI3_201181_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005794 |text = Golgi apparatus}}
| Process = {{GNF_GO|id=GO:0006810 |text = transport}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007194 |text = negative regulation of adenylate cyclase activity}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2773
    | Hs_Ensembl = ENSG00000065135
    | Hs_RefseqProtein = NP_006487
    | Hs_RefseqmRNA = NM_006496
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 109892756
    | Hs_GenLoc_end = 109938498
    | Hs_Uniprot = P08754
    | Mm_EntrezGene = 14679
    | Mm_Ensembl = ENSMUSG00000000001
    | Mm_RefseqmRNA = NM_010306
    | Mm_RefseqProtein = NP_034436
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 108235337
    | Mm_GenLoc_end = 108274202
    | Mm_Uniprot = Q3TJH1
  }}
}}
{{SI}}


GNAI3 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[RGS10]]<ref name = pmid8774883>{{cite journal | vauthors = Hunt TW, Fields TA, Casey PJ, Peralta EG | title = RGS10 is a selective activator of G alpha i GTPase activity | journal = Nature | volume = 383 | issue = 6596 | pages = 175–7 | date = Sep 1996 | pmid = 8774883 | doi = 10.1038/383175a0 }}</ref>
* [[RGS12]],<ref name = pmid11387333/>
* [[RGS14]],<ref name = pmid11387333>{{cite journal | vauthors = Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP | title = RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity | journal = The Journal of Biological Chemistry | volume = 276 | issue = 31 | pages = 29275–81 | date = Aug 2001 | pmid = 11387333 | doi = 10.1074/jbc.M103208200 }}</ref>
* [[RGS16]],<ref name = pmid9079700>{{cite journal | vauthors = Chen C, Zheng B, Han J, Lin SC | title = Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast | journal = The Journal of Biological Chemistry | volume = 272 | issue = 13 | pages = 8679–85 | date = Mar 1997 | pmid = 9079700 | doi =  10.1074/jbc.272.13.8679}}</ref><ref name = pmid10072511>{{cite journal | vauthors = Beadling C, Druey KM, Richter G, Kehrl JH, Smith KA | title = Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes | journal = Journal of Immunology | volume = 162 | issue = 5 | pages = 2677–82 | date = Mar 1999 | pmid = 10072511 | doi =  }}</ref>
* [[RGS18]],<ref name = pmid11563974>{{cite journal | vauthors = Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR | title = RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes | journal = The Biochemical Journal | volume = 359 | issue = Pt 1 | pages = 109–18 | date = Oct 2001 | pmid = 11563974 | pmc = 1222126 | doi =  10.1042/bj3590109}}</ref><ref name = pmid11955952>{{cite journal | vauthors = Gagnon AW, Murray DL, Leadley RJ | title = Cloning and characterization of a novel regulator of G protein signalling in human platelets | journal = Cellular Signalling | volume = 14 | issue = 7 | pages = 595–606 | date = Jul 2002 | pmid = 11955952 | doi =  10.1016/s0898-6568(02)00012-8}}</ref>
* [[RGS19]],<ref name = pmid8986788>{{cite journal | vauthors = De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG | title = GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 26 | pages = 15203–8 | date = Dec 1996 | pmid = 8986788 | pmc = 26381 | doi =  10.1073/pnas.93.26.15203}}</ref><ref name = pmid10364213>{{cite journal | vauthors = Woulfe DS, Stadel JM | title = Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP | journal = The Journal of Biological Chemistry | volume = 274 | issue = 25 | pages = 17718–24 | date = Jun 1999 | pmid = 10364213 | doi =  10.1074/jbc.274.25.17718}}</ref><ref name = pmid8524874>{{cite journal | vauthors = De Vries L, Mousli M, Wurmser A, Farquhar MG | title = GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 25 | pages = 11916–20 | date = Dec 1995 | pmid = 8524874 | pmc = 40514 | doi =  10.1073/pnas.92.25.11916}}</ref>
* [[RGS5]],<ref name = pmid9079700/><ref name = pmid11253162>{{cite journal | vauthors = Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S | title = Characterization of RGS5 in regulation of G protein-coupled receptor signaling | journal = Life Sciences | volume = 68 | issue = 13 | pages = 1457–69 | date = Feb 2001 | pmid = 11253162 | doi =  10.1016/s0024-3205(01)00939-0}}</ref>
* [[RIC8A]],<ref name = pmid12509430>{{cite journal | vauthors = Tall GG, Krumins AM, Gilman AG | title = Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor | journal = The Journal of Biological Chemistry | volume = 278 | issue = 10 | pages = 8356–62 | date = Mar 2003 | pmid = 12509430 | doi = 10.1074/jbc.M211862200 }}</ref>  and
* [[S1PR1]].<ref name = pmid8626678>{{cite journal | vauthors = Lee MJ, Evans M, Hla T | title = The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway | journal = The Journal of Biological Chemistry | volume = 271 | issue = 19 | pages = 11272–9 | date = May 1996 | pmid = 8626678 | doi =  10.1074/jbc.271.19.11272}}</ref>
{{Div col end}}


'''Guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3''', also known as '''GNAI3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2773| accessdate = }}</ref>
== See also ==
 
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{{PBB_Summary
| section_title =
| summary_text =
}}
 
==See also==
* [[Gi alpha subunit]]
* [[Gi alpha subunit]]


==References==
== References ==
{{reflist}}
{{reflist}}
==Further reading==
{{clear}}
{{refbegin | 2}}
 
{{PBB_Further_reading
== Further reading ==
| citations =
{{refbegin|33em}}
*{{cite journal | author=Downes GB, Gautam N |title=The G protein subunit gene families. |journal=Genomics |volume=62 |issue= 3 |pages= 544–52 |year= 2000 |pmid= 10644457 |doi= 10.1006/geno.1999.5992 }}
* {{cite journal | vauthors = Downes GB, Gautam N | title = The G protein subunit gene families | journal = Genomics | volume = 62 | issue = 3 | pages = 544–52 | date = Dec 1999 | pmid = 10644457 | doi = 10.1006/geno.1999.5992 }}
*{{cite journal | author=Sidhu A, Niznik HB |title=Coupling of dopamine receptor subtypes to multiple and diverse G proteins. |journal=Int. J. Dev. Neurosci. |volume=18 |issue= 7 |pages= 669–77 |year= 2000 |pmid= 10978845 |doi= }}
* {{cite journal | vauthors = Sidhu A, Niznik HB | title = Coupling of dopamine receptor subtypes to multiple and diverse G proteins | journal = International Journal of Developmental Neuroscience | volume = 18 | issue = 7 | pages = 669–77 | date = Nov 2000 | pmid = 10978845 | doi = 10.1016/S0736-5748(00)00033-2 }}
*{{cite journal | author=Jiang M, Pandey S, Tran VT, Fong HK |title=Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 9 |pages= 3907–11 |year= 1991 |pmid= 1902575 |doi= }}
* {{cite journal | vauthors = Jiang M, Pandey S, Tran VT, Fong HK | title = Guanine nucleotide-binding regulatory proteins in retinal pigment epithelial cells | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 88 | issue = 9 | pages = 3907–11 | date = May 1991 | pmid = 1902575 | pmc = 51562 | doi = 10.1073/pnas.88.9.3907 }}
*{{cite journal | author=Carty DJ, Padrell E, Codina J, ''et al.'' |title=Distinct guanine nucleotide binding and release properties of the three Gi proteins. |journal=J. Biol. Chem. |volume=265 |issue= 11 |pages= 6268–73 |year= 1990 |pmid= 2108158 |doi=  }}
* {{cite journal | vauthors = Carty DJ, Padrell E, Codina J, Birnbaumer L, Hildebrandt JD, Iyengar R | title = Distinct guanine nucleotide binding and release properties of the three Gi proteins | journal = The Journal of Biological Chemistry | volume = 265 | issue = 11 | pages = 6268–73 | date = Apr 1990 | pmid = 2108158 | doi =  }}
*{{cite journal | author=Suki WN, Abramowitz J, Mattera R, ''et al.'' |title=The human genome encodes at least three non-allellic G proteins with alpha i-type subunits. |journal=FEBS Lett. |volume=220 |issue= 1 |pages= 187–92 |year= 1987 |pmid= 2440724 |doi= }}
* {{cite journal | vauthors = Suki WN, Abramowitz J, Mattera R, Codina J, Birnbaumer L | title = The human genome encodes at least three non-allellic G proteins with alpha i-type subunits | journal = FEBS Letters | volume = 220 | issue = 1 | pages = 187–92 | date = Aug 1987 | pmid = 2440724 | doi = 10.1016/0014-5793(87)80900-6 }}
*{{cite journal | author=Codina J, Olate J, Abramowitz J, ''et al.'' |title=Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels. |journal=J. Biol. Chem. |volume=263 |issue= 14 |pages= 6746–50 |year= 1988 |pmid= 2452165 |doi=  }}
* {{cite journal | vauthors = Codina J, Olate J, Abramowitz J, Mattera R, Cook RG, Birnbaumer L | title = Alpha i-3 cDNA encodes the alpha subunit of Gk, the stimulatory G protein of receptor-regulated K+ channels | journal = The Journal of Biological Chemistry | volume = 263 | issue = 14 | pages = 6746–50 | date = May 1988 | pmid = 2452165 | doi =  }}
*{{cite journal | author=Itoh H, Toyama R, Kozasa T, ''et al.'' |title=Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs. |journal=J. Biol. Chem. |volume=263 |issue= 14 |pages= 6656–64 |year= 1988 |pmid= 2834384 |doi=  }}
* {{cite journal | vauthors = Itoh H, Toyama R, Kozasa T, Tsukamoto T, Matsuoka M, Kaziro Y | title = Presence of three distinct molecular species of Gi protein alpha subunit. Structure of rat cDNAs and human genomic DNAs | journal = The Journal of Biological Chemistry | volume = 263 | issue = 14 | pages = 6656–64 | date = May 1988 | pmid = 2834384 | doi =  }}
*{{cite journal | author=Didsbury JR, Snyderman R |title=Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families. |journal=FEBS Lett. |volume=219 |issue= 1 |pages= 259–63 |year= 1987 |pmid= 3109953 |doi= }}
* {{cite journal | vauthors = Beals CR, Wilson CB, Perlmutter RM | title = A small multigene family encodes Gi signal-transduction proteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 84 | issue = 22 | pages = 7886–90 | date = Nov 1987 | pmid = 3120178 | pmc = 299440 | doi = 10.1073/pnas.84.22.7886 }}
*{{cite journal | author=Beals CR, Wilson CB, Perlmutter RM |title=A small multigene family encodes Gi signal-transduction proteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=84 |issue= 22 |pages= 7886–90 |year= 1987 |pmid= 3120178 |doi= }}
* {{cite journal | vauthors = Kim SY, Ang SL, Bloch DB, Bloch KD, Kawahara Y, Tolman C, Lee R, Seidman JG, Neer EJ | title = Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 85 | issue = 12 | pages = 4153–7 | date = Jun 1988 | pmid = 3132707 | pmc = 280384 | doi = 10.1073/pnas.85.12.4153 }}
*{{cite journal | author=Kim SY, Ang SL, Bloch DB, ''et al.'' |title=Identification of cDNA encoding an additional alpha subunit of a human GTP-binding protein: expression of three alpha i subtypes in human tissues and cell lines. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 12 |pages= 4153–7 |year= 1988 |pmid= 3132707 |doi= }}
* {{cite journal | vauthors = Migeon JC, Thomas SL, Nathanson NM | title = Differential coupling of m2 and m4 muscarinic receptors to inhibition of adenylyl cyclase by Gi alpha and G(o)alpha subunits | journal = The Journal of Biological Chemistry | volume = 270 | issue = 27 | pages = 16070–4 | date = Jul 1995 | pmid = 7608168 | doi = 10.1074/jbc.270.27.16070 }}
*{{cite journal | author=Migeon JC, Thomas SL, Nathanson NM |title=Differential coupling of m2 and m4 muscarinic receptors to inhibition of adenylyl cyclase by Gi alpha and G(o)alpha subunits. |journal=J. Biol. Chem. |volume=270 |issue= 27 |pages= 16070–4 |year= 1995 |pmid= 7608168 |doi= }}
* {{cite journal | vauthors = Raymond JR, Olsen CL, Gettys TW | title = Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gs alpha | journal = Biochemistry | volume = 32 | issue = 41 | pages = 11064–73 | date = Oct 1993 | pmid = 8218170 | doi = 10.1021/bi00092a016 }}
*{{cite journal | author=Raymond JR, Olsen CL, Gettys TW |title=Cell-specific physical and functional coupling of human 5-HT1A receptors to inhibitory G protein alpha-subunits and lack of coupling to Gs alpha. |journal=Biochemistry |volume=32 |issue= 41 |pages= 11064–73 |year= 1993 |pmid= 8218170 |doi= }}
* {{cite journal | vauthors = Wu D, LaRosa GJ, Simon MI | title = G protein-coupled signal transduction pathways for interleukin-8 | journal = Science | volume = 261 | issue = 5117 | pages = 101–3 | date = Jul 1993 | pmid = 8316840 | doi = 10.1126/science.8316840 }}
*{{cite journal | author=Wu D, LaRosa GJ, Simon MI |title=G protein-coupled signal transduction pathways for interleukin-8. |journal=Science |volume=261 |issue= 5117 |pages= 101–3 |year= 1993 |pmid= 8316840 |doi= }}
* {{cite journal | vauthors = Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A | title = Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy | journal = Endocrinology | volume = 132 | issue = 6 | pages = 2484–90 | date = Jun 1993 | pmid = 8504751 | doi = 10.1210/en.132.6.2484 }}
*{{cite journal | author=Europe-Finner GN, Phaneuf S, Watson SP, López Bernal A |title=Identification and expression of G-proteins in human myometrium: up-regulation of G alpha s in pregnancy. |journal=Endocrinology |volume=132 |issue= 6 |pages= 2484–90 |year= 1993 |pmid= 8504751 |doi= }}
* {{cite journal | vauthors = De Vries L, Mousli M, Wurmser A, Farquhar MG | title = GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 25 | pages = 11916–20 | date = Dec 1995 | pmid = 8524874 | pmc = 40514 | doi = 10.1073/pnas.92.25.11916 }}
*{{cite journal | author=De Vries L, Mousli M, Wurmser A, Farquhar MG |title=GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11916–20 |year= 1996 |pmid= 8524874 |doi= }}
* {{cite journal | vauthors = Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G | title = The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 1 | pages = 116–20 | date = Jan 1996 | pmid = 8552586 | pmc = 40189 | doi = 10.1073/pnas.93.1.116 }}
*{{cite journal | author=Laugwitz KL, Allgeier A, Offermanns S, ''et al.'' |title=The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 1 |pages= 116–20 |year= 1996 |pmid= 8552586 |doi= }}
* {{cite journal | vauthors = Lee MJ, Evans M, Hla T | title = The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway | journal = The Journal of Biological Chemistry | volume = 271 | issue = 19 | pages = 11272–9 | date = May 1996 | pmid = 8626678 | doi = 10.1074/jbc.271.19.11272 }}
*{{cite journal | author=Lee MJ, Evans M, Hla T |title=The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway. |journal=J. Biol. Chem. |volume=271 |issue= 19 |pages= 11272–9 |year= 1996 |pmid= 8626678 |doi= }}
* {{cite journal | vauthors = Solomon KR, Rudd CE, Finberg RW | title = The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 93 | issue = 12 | pages = 6053–8 | date = Jun 1996 | pmid = 8650218 | pmc = 39187 | doi = 10.1073/pnas.93.12.6053 }}
*{{cite journal | author=Solomon KR, Rudd CE, Finberg RW |title=The association between glycosylphosphatidylinositol-anchored proteins and heterotrimeric G protein alpha subunits in lymphocytes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 12 |pages= 6053–8 |year= 1996 |pmid= 8650218 |doi= }}
* {{cite journal | vauthors = Zhang J, Pratt RE | title = The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus | journal = The Journal of Biological Chemistry | volume = 271 | issue = 25 | pages = 15026–33 | date = Jun 1996 | pmid = 8663053 | doi = 10.1074/jbc.271.25.15026 }}
*{{cite journal  | author=Zhang J, Pratt RE |title=The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetus. |journal=J. Biol. Chem. |volume=271 |issue= 25 |pages= 15026–33 |year= 1996 |pmid= 8663053 |doi=  }}
* {{cite journal | vauthors = Hunt TW, Fields TA, Casey PJ, Peralta EG | title = RGS10 is a selective activator of G alpha i GTPase activity | journal = Nature | volume = 383 | issue = 6596 | pages = 175–7 | date = Sep 1996 | pmid = 8774883 | doi = 10.1038/383175a0 }}
*{{cite journal | author=Hunt TW, Fields TA, Casey PJ, Peralta EG |title=RGS10 is a selective activator of G alpha i GTPase activity. |journal=Nature |volume=383 |issue= 6596 |pages= 175–7 |year= 1996 |pmid= 8774883 |doi= 10.1038/383175a0 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=2773}}


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Latest revision as of 08:50, 31 August 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Guanine nucleotide-binding protein G(k) subunit alpha is a protein that in humans is encoded by the GNAI3 gene.[1][2]

Interactions

GNAI3 has been shown to interact with:

See also

References

  1. ↑ Didsbury JR, Snyderman R (Jul 1987). "Molecular cloning of a new human G protein. Evidence for two Gi alpha-like protein families". FEBS Letters. 219 (1): 259–63. doi:10.1016/0014-5793(87)81228-0. PMID 3109953.
  2. ↑ "Entrez Gene: GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3".
  3. ↑ Hunt TW, Fields TA, Casey PJ, Peralta EG (Sep 1996). "RGS10 is a selective activator of G alpha i GTPase activity". Nature. 383 (6596): 175–7. doi:10.1038/383175a0. PMID 8774883.
  4. ↑ 4.0 4.1 Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (Aug 2001). "RGS12 and RGS14 GoLoco motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological Chemistry. 276 (31): 29275–81. doi:10.1074/jbc.M103208200. PMID 11387333.
  5. ↑ 5.0 5.1 Chen C, Zheng B, Han J, Lin SC (Mar 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". The Journal of Biological Chemistry. 272 (13): 8679–85. doi:10.1074/jbc.272.13.8679. PMID 9079700.
  6. ↑ Beadling C, Druey KM, Richter G, Kehrl JH, Smith KA (Mar 1999). "Regulators of G protein signaling exhibit distinct patterns of gene expression and target G protein specificity in human lymphocytes". Journal of Immunology. 162 (5): 2677–82. PMID 10072511.
  7. ↑ Yowe D, Weich N, Prabhudas M, Poisson L, Errada P, Kapeller R, Yu K, Faron L, Shen M, Cleary J, Wilkie TM, Gutierrez-Ramos C, Hodge MR (Oct 2001). "RGS18 is a myeloerythroid lineage-specific regulator of G-protein-signalling molecule highly expressed in megakaryocytes". The Biochemical Journal. 359 (Pt 1): 109–18. doi:10.1042/bj3590109. PMC 1222126. PMID 11563974.
  8. ↑ Gagnon AW, Murray DL, Leadley RJ (Jul 2002). "Cloning and characterization of a novel regulator of G protein signalling in human platelets". Cellular Signalling. 14 (7): 595–606. doi:10.1016/s0898-6568(02)00012-8. PMID 11955952.
  9. ↑ De Vries L, Elenko E, Hubler L, Jones TL, Farquhar MG (Dec 1996). "GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of G alpha i subunits". Proceedings of the National Academy of Sciences of the United States of America. 93 (26): 15203–8. doi:10.1073/pnas.93.26.15203. PMC 26381. PMID 8986788.
  10. ↑ Woulfe DS, Stadel JM (Jun 1999). "Structural basis for the selectivity of the RGS protein, GAIP, for Galphai family members. Identification of a single amino acid determinant for selective interaction of Galphai subunits with GAIP". The Journal of Biological Chemistry. 274 (25): 17718–24. doi:10.1074/jbc.274.25.17718. PMID 10364213.
  11. ↑ De Vries L, Mousli M, Wurmser A, Farquhar MG (Dec 1995). "GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain". Proceedings of the National Academy of Sciences of the United States of America. 92 (25): 11916–20. doi:10.1073/pnas.92.25.11916. PMC 40514. PMID 8524874.
  12. ↑ Zhou J, Moroi K, Nishiyama M, Usui H, Seki N, Ishida J, Fukamizu A, Kimura S (Feb 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sciences. 68 (13): 1457–69. doi:10.1016/s0024-3205(01)00939-0. PMID 11253162.
  13. ↑ Tall GG, Krumins AM, Gilman AG (Mar 2003). "Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry. 278 (10): 8356–62. doi:10.1074/jbc.M211862200. PMID 12509430.
  14. ↑ Lee MJ, Evans M, Hla T (May 1996). "The inducible G protein-coupled receptor edg-1 signals via the G(i)/mitogen-activated protein kinase pathway". The Journal of Biological Chemistry. 271 (19): 11272–9. doi:10.1074/jbc.271.19.11272. PMID 8626678.

Further reading

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