CDC2L5: Difference between revisions

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Latest revision as of 00:27, 22 June 2018

Cell division cycle 2-like protein kinase 5 is an enzyme that in humans is encoded by the CDC2L5 gene.^[1]^[2]

The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. Some of the cell cycle control kinases are able to phosphorylate proteins that are important for cell differentiation and apoptosis, thus provide connections between cell proliferation, differentiation, and apoptosis. Proteins of this family may also be involved in non-cell cycle-related functions, such as neurocytoskeleton dynamics. The exact function of this protein has not yet been determined. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced variants are described.^[2]

A 2017 study of children with rare developmental disorders^[3] found 11 children in the United Kingdom who had a fault in their CDK13 gene. This fault affected the children's communication and language skills as well as causing learning difficulties.^[4]

References

↑ Lapidot-Lifson Y, Patinkin D, Prody CA, Ehrlich G, Seidman S, Ben-Aziz R, Benseler F, Eckstein F, Zakut H, Soreq H (Feb 1992). "Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis". Proc Natl Acad Sci U S A. 89 (2): 579–83. doi:10.1073/pnas.89.2.579. PMC 48282. PMID 1731328.
↑ ^2.0 ^2.1 "Entrez Gene: CDC2L5 cell division cycle 2-like 5 (cholinesterase-related cell division controller)".
↑ McRae, Jeremy F.; Clayton, Stephen; Fitzgerald, Tomas W.; Kaplanis, Joanna; Prigmore, Elena; Rajan, Diana; Sifrim, Alejandro; Aitken, Stuart; Akawi, Nadia. "Prevalence and architecture of de novo mutations in developmental disorders". Nature. doi:10.1038/nature21062.
↑ Walsh, Fergus (2017-01-25). "Child gene study identifies new developmental disorders". BBC News. Retrieved 2017-01-27.

External links

Human CDK13 genome location and CDK13 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Mackenzie LF, Brooke GS, Cutfield JF, et al. (1997). "Identification of Glu-330 as the catalytic nucleophile of Candida albicans exo-beta-(1,3)-glucanase". J. Biol. Chem. 272 (6): 3161–7. doi:10.1074/jbc.272.6.3161. PMID 9013549.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
<Please add first missing authors to populate metadata.> (1999). "Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Marqués F, Moreau JL, Peaucellier G, et al. (2001). "A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE motifs". Biochem. Biophys. Res. Commun. 279 (3): 832–7. doi:10.1006/bbrc.2000.4042. PMID 11162436.
Nagase T, Nakayama M, Nakajima D, et al. (2001). "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 8 (2): 85–95. doi:10.1093/dnares/8.2.85. PMID 11347906.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. doi:10.1038/nature01782. PMID 12853948.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–72. doi:10.1021/ac035352d. PMID 15144186.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. doi:10.1038/nature03207. PMID 15635413.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Even Y, Durieux S, Escande ML, et al. (2007). "CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo". J. Cell. Biochem. 99 (3): 890–904. doi:10.1002/jcb.20986. PMID 16721827.
Tsang HT, Connell JW, Brown SE, et al. (2006). "A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex". Genomics. 88 (3): 333–46. doi:10.1016/j.ygeno.2006.04.003. PMID 16730941.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.

[pmid1731328-1] Lapidot-Lifson Y, Patinkin D, Prody CA, Ehrlich G, Seidman S, Ben-Aziz R, Benseler F, Eckstein F, Zakut H, Soreq H (Feb 1992). "Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis". Proc Natl Acad Sci U S A. 89 (2): 579–83. doi:10.1073/pnas.89.2.579. PMC 48282. PMID 1731328.

[entrez-2] 2.0 ^2.1 "Entrez Gene: CDC2L5 cell division cycle 2-like 5 (cholinesterase-related cell division controller)".

[3] McRae, Jeremy F.; Clayton, Stephen; Fitzgerald, Tomas W.; Kaplanis, Joanna; Prigmore, Elena; Rajan, Diana; Sifrim, Alejandro; Aitken, Stuart; Akawi, Nadia. "Prevalence and architecture of de novo mutations in developmental disorders". Nature. doi:10.1038/nature21062.

[4] Walsh, Fergus (2017-01-25). "Child gene study identifies new developmental disorders". BBC News. Retrieved 2017-01-27.

[1]

[2]

[3]

[4]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Underlinked|date=May 2016}}
-{{PBB_Controls
+{{Infobox_gene}}
-| update_page = yes
+'''Cell division cycle 2-like protein kinase 5''' is an [[enzyme]] that in humans is encoded by the ''CDC2L5'' [[gene]].<ref name="pmid1731328">{{cite journal | vauthors = Lapidot-Lifson Y, Patinkin D, Prody CA, Ehrlich G, Seidman S, Ben-Aziz R, Benseler F, Eckstein F, Zakut H, Soreq H | title = Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis | journal = Proc Natl Acad Sci U S A | volume = 89 | issue = 2 | pages = 579–83 |date=Feb 1992 | pmid = 1731328 | pmc = 48282 | doi =10.1073/pnas.89.2.579  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CDC2L5 cell division cycle 2-like 5 (cholinesterase-related cell division controller)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8621| accessdate = }}</ref>
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Cell division cycle 2-like 5 (cholinesterase-related cell division controller)
- | HGNCid = 1733
- | Symbol = CDC2L5
- | AltSymbols =; CHED; CDC2L; FLJ35215; KIAA1791
- | OMIM = 603309
- | ECnumber =
- | Homologene = 68359
- | MGIid = 1916812
- | GeneAtlas_image1 = PBB_GE_CDC2L5_210965_x_at_tn.png
- | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
- | Component =
- | Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007088 |text = regulation of mitosis}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 8621
-    | Hs_Ensembl = ENSG00000065883
-    | Hs_RefseqProtein = NP_003709
-    | Hs_RefseqmRNA = NM_003718
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 7
-    | Hs_GenLoc_start = 39956634
-    | Hs_GenLoc_end = 40101668
-    | Hs_Uniprot = Q14004
-    | Mm_EntrezGene = 69562
-    | Mm_Ensembl = ENSMUSG00000041297
-    | Mm_RefseqmRNA = XM_127221
-    | Mm_RefseqProtein = XP_127221
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 13
-    | Mm_GenLoc_start = 17502624
-    | Mm_GenLoc_end = 17590239
-    | Mm_Uniprot = Q3UF50
-  }}
-}}
-'''Cell division cycle 2-like 5 (cholinesterase-related cell division controller)''', also known as '''CDC2L5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CDC2L5 cell division cycle 2-like 5 (cholinesterase-related cell division controller)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8621| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
 | section_title =
-| summary_text = The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. Some of the cell cycle control kinases are able to phosphorylate proteins that are important for cell differentiation and apoptosis, thus provide connections between cell proliferation, differentiation, and apoptosis. Proteins of this family may also be involved in non-cell cycle-related functions, such as neurocytoskeleton dynamics. The exact function of this protein has not yet been determined. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced variants are described.<ref name="entrez">{{cite web | title = Entrez Gene: CDC2L5 cell division cycle 2-like 5 (cholinesterase-related cell division controller)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8621| accessdate = }}</ref>
+| summary_text = The protein encoded by this gene is a member of the cyclin-dependent serine/threonine protein kinase family. Members of this family are well known for their essential roles as master switches in cell cycle control. Some of the cell cycle control kinases are able to phosphorylate proteins that are important for cell differentiation and apoptosis, thus provide connections between cell proliferation, differentiation, and apoptosis. Proteins of this family may also be involved in non-cell cycle-related functions, such as neurocytoskeleton dynamics. The exact function of this protein has not yet been determined. It has unusually large N- and C-termini and is ubiquitously expressed in many tissues. Two alternatively spliced variants are described.<ref name="entrez"/>
 }}
+A 2017 study of children with rare [[Developmental disorder|developmental disorders]]<ref>{{Cite journal|last=McRae|first=Jeremy F.|last2=Clayton|first2=Stephen|last3=Fitzgerald|first3=Tomas W.|last4=Kaplanis|first4=Joanna|last5=Prigmore|first5=Elena|last6=Rajan|first6=Diana|last7=Sifrim|first7=Alejandro|last8=Aitken|first8=Stuart|last9=Akawi|first9=Nadia|title=Prevalence and architecture of de novo mutations in developmental disorders|url=http://www.nature.com/doifinder/10.1038/nature21062|journal=Nature|doi=10.1038/nature21062}}</ref> found 11 children in the United Kingdom who had a fault in their CDK13 gene.  This fault affected the children's communication and language skills as well as causing learning difficulties.<ref>{{Cite news|url=https://www.bbc.co.uk/news/health-38691622|title=Child gene study identifies new developmental disorders|last=Walsh|first=Fergus|date=2017-01-25|newspaper=BBC News|language=en-GB|access-date=2017-01-27}}</ref>
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|CDK13}}
 ==Further reading==
 {{refbegin | 2}}
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Lapidot-Lifson Y, Patinkin D, Prody CA, ''et al.'' |title=Cloning and antisense oligodeoxynucleotide inhibition of a human homolog of cdc2 required in hematopoiesis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 2 |pages= 579-83 |year= 1992 |pmid= 1731328 |doi=  }}
+*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8  }}
-*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
+*{{cite journal  | author=Mackenzie LF |title=Identification of Glu-330 as the catalytic nucleophile of Candida albicans exo-beta-(1,3)-glucanase |journal=J. Biol. Chem. |volume=272 |issue= 6 |pages= 3161–7 |year= 1997 |pmid= 9013549 |doi=10.1074/jbc.272.6.3161  |name-list-format=vanc| author2=Brooke GS  | author3=Cutfield JF  | display-authors=3  | last4=Sullivan  | first4=PA  | last5=Withers  | first5=SG  }}
-*{{cite journal  | author=Mackenzie LF, Brooke GS, Cutfield JF, ''et al.'' |title=Identification of Glu-330 as the catalytic nucleophile of Candida albicans exo-beta-(1,3)-glucanase. |journal=J. Biol. Chem. |volume=272 |issue= 6 |pages= 3161-7 |year= 1997 |pmid= 9013549 |doi=  }}
+*{{cite journal  | author=Suzuki Y |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3  |name-list-format=vanc| author2=Yoshitomo-Nakagawa K  | author3=Maruyama K  | display-authors=3  | last4=Suyama  | first4=A  | last5=Sugano  | first5=S  }}
-*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
+*{{cite journal  |title=Toward a complete human genome sequence |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097  | author1= <Please add first missing authors to populate metadata.>}}
-*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
+*{{cite journal  | author=Marqués F |title=A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE motifs |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 832–7 |year= 2001 |pmid= 11162436 |doi= 10.1006/bbrc.2000.4042  |name-list-format=vanc| author2=Moreau JL  | author3=Peaucellier G  | display-authors=3  | last4=Lozano  | first4=JC  | last5=Schatt  | first5=P  | last6=Picard  | first6=A  | last7=Callebaut  | first7=I  | last8=Perret  | first8=E  | last9=Genevière  | first9=AM }}
-*{{cite journal  | author=Marqués F, Moreau JL, Peaucellier G, ''et al.'' |title=A new subfamily of high molecular mass CDC2-related kinases with PITAI/VRE motifs. |journal=Biochem. Biophys. Res. Commun. |volume=279 |issue= 3 |pages= 832-7 |year= 2001 |pmid= 11162436 |doi= 10.1006/bbrc.2000.4042 }}
+*{{cite journal  | author=Nagase T |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro |journal=DNA Res. |volume=8 |issue= 2 |pages= 85–95 |year= 2001 |pmid= 11347906 |doi=10.1093/dnares/8.2.85  |name-list-format=vanc| author2=Nakayama M  | author3=Nakajima D  | display-authors=3  | last4=Kikuno  | first4=R  | last5=Ohara  | first5=O  }}
-*{{cite journal  | author=Nagase T, Nakayama M, Nakajima D, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=8 |issue= 2 |pages= 85-95 |year= 2001 |pmid= 11347906 |doi=  }}
+*{{cite journal  | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241  |name-list-format=vanc| author2=Feingold EA  | author3=Grouse LH  | display-authors=3  | last4=Derge  | first4=JG  | last5=Klausner  | first5=RD  | last6=Collins  | first6=FS  | last7=Wagner  | first7=L  | last8=Shenmen  | first8=CM  | last9=Schuler  | first9=GD }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | author=Hillier LW |title=The DNA sequence of human chromosome 7 |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782  |name-list-format=vanc| author2=Fulton RS  | author3=Fulton LA  | display-authors=3  | last4=Graves  | first4=Tina A.  | last5=Pepin  | first5=Kymberlie H.  | last6=Wagner-Mcpherson  | first6=Caryn  | last7=Layman  | first7=Dan  | last8=Maas  | first8=Jason  | last9=Jaeger  | first9=Sara }}
-*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
+*{{cite journal  | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285  |name-list-format=vanc| author2=Suzuki Y  | author3=Nishikawa T  | display-authors=3  | last4=Otsuki  | first4=Tetsuji  | last5=Sugiyama  | first5=Tomoyasu  | last6=Irie  | first6=Ryotaro  | last7=Wakamatsu  | first7=Ai  | last8=Hayashi  | first8=Koji  | last9=Sato  | first9=Hiroyuki }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal  | author=Brill LM |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763–72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d  |name-list-format=vanc| author2=Salomon AR  | author3=Ficarro SB  | display-authors=3  | last4=Mukherji  | first4=Mridul  | last5=Stettler-Gill  | first5=Michelle  | last6=Peters  | first6=Eric C. }}
-*{{cite journal  | author=Brill LM, Salomon AR, Ficarro SB, ''et al.'' |title=Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry. |journal=Anal. Chem. |volume=76 |issue= 10 |pages= 2763-72 |year= 2004 |pmid= 15144186 |doi= 10.1021/ac035352d }}
+*{{cite journal  | author=Colland F |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104  | pmc=442148  |name-list-format=vanc| author2=Jacq X  | author3=Trouplin V  | display-authors=3  | last4=Mougin  | first4=C  | last5=Groizeleau  | first5=C  | last6=Hamburger  | first6=A  | last7=Meil  | first7=A  | last8=Wojcik  | first8=J  | last9=Legrain  | first9=P }}
-*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
+*{{cite journal  | author=Beausoleil SA |title=Large-scale characterization of HeLa cell nuclear phosphoproteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101  | pmc=514446  |name-list-format=vanc| author2=Jedrychowski M  | author3=Schwartz D  | display-authors=3  | last4=Elias  | first4=JE  | last5=Villén  | first5=J  | last6=Li  | first6=J  | last7=Cohn  | first7=MA  | last8=Cantley  | first8=LC  | last9=Gygi  | first9=SP }}
-*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
+*{{cite journal  | author=Andersen JS |title=Nucleolar proteome dynamics |journal=Nature |volume=433 |issue= 7021 |pages= 77–83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207  |name-list-format=vanc| author2=Lam YW  | author3=Leung AK  | display-authors=3  | last4=Ong  | first4=Shao-En  | last5=Lyon  | first5=Carol E.  | last6=Lamond  | first6=Angus I.  | last7=Mann  | first7=Matthias }}
-*{{cite journal  | author=Andersen JS, Lam YW, Leung AK, ''et al.'' |title=Nucleolar proteome dynamics. |journal=Nature |volume=433 |issue= 7021 |pages= 77-83 |year= 2005 |pmid= 15635413 |doi= 10.1038/nature03207 }}
+*{{cite journal  | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209  |name-list-format=vanc| author2=Venkatesan K  | author3=Hao T  | display-authors=3  | last4=Hirozane-Kishikawa  | first4=Tomoko  | last5=Dricot  | first5=Amélie  | last6=Li  | first6=Ning  | last7=Berriz  | first7=Gabriel F.  | last8=Gibbons  | first8=Francis D.  | last9=Dreze  | first9=Matija }}
-*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
+*{{cite journal  | author=Even Y |title=CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo |journal=J. Cell. Biochem. |volume=99 |issue= 3 |pages= 890–904 |year= 2007 |pmid= 16721827 |doi= 10.1002/jcb.20986  |name-list-format=vanc| author2=Durieux S  | author3=Escande ML  | display-authors=3  | last4=Lozano  | first4=Jean Claude  | last5=Peaucellier  | first5=Gérard  | last6=Weil  | first6=Dominique  | last7=Genevière  | first7=Anne-Marie }}
-*{{cite journal  | author=Even Y, Durieux S, Escande ML, ''et al.'' |title=CDC2L5, a Cdk-like kinase with RS domain, interacts with the ASF/SF2-associated protein p32 and affects splicing in vivo. |journal=J. Cell. Biochem. |volume=99 |issue= 3 |pages= 890-904 |year= 2007 |pmid= 16721827 |doi= 10.1002/jcb.20986 }}
+*{{cite journal  | author=Tsang HT |title=A systematic analysis of human CHMP protein interactions: additional MIT domain-containing proteins bind to multiple components of the human ESCRT III complex |journal=Genomics |volume=88 |issue= 3 |pages= 333–46 |year= 2006 |pmid= 16730941 |doi= 10.1016/j.ygeno.2006.04.003  |name-list-format=vanc| author2=Connell JW  | author3=Brown SE  | display-authors=3  | last4=Thompson  | first4=Amanda  | last5=Reid  | first5=Evan  | last6=Sanderson  | first6=Christopher M. }}
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+*{{cite journal  | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026  |name-list-format=vanc| author2=Blagoev B  | author3=Gnad F  | display-authors=3  | last4=Macek  | first4=Boris  | last5=Kumar  | first5=Chanchal  | last6=Mortensen  | first6=Peter  | last7=Mann  | first7=Matthias }}
-*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
 }}
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+[[Category:EC 2.7.11]]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Catalytically perfect enzyme Coenzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list)

CDC2L5: Difference between revisions

Latest revision as of 00:27, 22 June 2018

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