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{{other uses|Christian Leaders Training College}}
{{PBB_Controls
{{Infobox_gene}}
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'''Clathrin heavy chain 1''' is a [[protein]] that in humans is encoded by the ''CLTC'' [[gene]].<ref name="pmid1765375">{{cite journal | vauthors = Dodge GR, Kovalszky I, McBride OW, Yi HF, Chu ML, Saitta B, Stokes DG, Iozzo RV | title = Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter | journal = Genomics | volume = 11 | issue = 1 | pages = 174–8 |date=Feb 1992 | pmid = 1765375 | pmc =  | doi =10.1016/0888-7543(91)90115-U }}</ref><ref name="pmid7584026">{{cite journal | vauthors = Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S | title = Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 | journal = DNA Res | volume = 1 | issue = 1 | pages = 27–35 |date=Dec 1995 | pmid = 7584026 | pmc =  | doi =10.1093/dnares/1.1.27 }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_CLTC_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1b89.
| PDB = {{PDB2|1b89}}, {{PDB2|1bpo}}, {{PDB2|1c9i}}, {{PDB2|1c9l}}, {{PDB2|1utc}}, {{PDB2|1xi4}}, {{PDB2|1xi5}}
| Name = Clathrin, heavy chain (Hc)
| HGNCid = 2092
| Symbol = CLTC
| AltSymbols =; CHC17; CLH-17; CLTCL2; Hc; KIAA0034
| OMIM = 118955
| ECnumber =
| Homologene = 3572
| MGIid = 2388633
  | GeneAtlas_image1 = PBB_GE_CLTC_200614_at_tn.png
  | Function = {{GNF_GO|id=GO:0005198 |text = structural molecule activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005739 |text = mitochondrion}} {{GNF_GO|id=GO:0005905 |text = coated pit}} {{GNF_GO|id=GO:0030125 |text = clathrin vesicle coat}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1213
    | Hs_Ensembl = ENSG00000141367
    | Hs_RefseqProtein = NP_004850
    | Hs_RefseqmRNA = NM_004859
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 55052038
    | Hs_GenLoc_end = 55127254
    | Hs_Uniprot = Q00610
    | Mm_EntrezGene = 67300
    | Mm_Ensembl = ENSMUSG00000047126
    | Mm_RefseqmRNA = NM_001003908
    | Mm_RefseqProtein = NP_001003908
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 86510546
    | Mm_GenLoc_end = 86573760
    | Mm_Uniprot = Q3TJ98
  }}
}}
'''Clathrin, heavy chain (Hc)''', also known as '''CLTC''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules.  The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.<ref>{{cite web | title = Entrez Gene: CLTC clathrin, heavy chain (Hc)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1213| accessdate = }}</ref>
| summary_text = Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules.  The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.<ref>{{cite web | title = Entrez Gene: CLTC clathrin, heavy chain (Hc)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1213| accessdate = }}</ref>
}}
}}


==Interactions==
CLTC has been shown to [[Protein-protein interaction|interact]] with [[PICALM]]<ref name=pmid10436022>{{cite journal |last=Tebar |first=F |author2=Bohlander S K|author3=Sorkin A |date=Aug 1999 |title=Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic |journal=Mol. Biol. Cell |volume=10 |issue=8 |pages=2687–702 |publisher= |location = UNITED STATES| issn = 1059-1524| pmid = 10436022 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=25500 | doi=10.1091/mbc.10.8.2687}}</ref> and [[HGS (gene)|HGS]].<ref name=pmid11532964>{{cite journal |last=Raiborg |first=C |author2=Bache K G|author3=Mehlum A|author4=Stang E|author5=Stenmark H |date=Sep 2001 |title=Hrs recruits clathrin to early endosomes |journal=EMBO J. |volume=20 |issue=17 |pages=5008–21 |publisher= |location = England| issn = 0261-4189| pmid = 11532964 |doi = 10.1093/emboj/20.17.5008 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=125612 }}</ref>


==See also==
==See also==
Line 59: Line 16:


==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Murphy JE, Keen JH |title=Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia. |journal=J. Biol. Chem. |volume=267 |issue= 15 |pages= 10850-5 |year= 1992 |pmid= 1587861 |doi=  }}
*{{cite journal  | vauthors=Murphy JE, Keen JH |title=Recognition sites for clathrin-associated proteins AP-2 and AP-3 on clathrin triskelia. |journal=J. Biol. Chem. |volume=267 |issue= 15 |pages= 10850–5 |year= 1992 |pmid= 1587861 |doi=  }}
*{{cite journal  | author=Dodge GR, Kovalszky I, McBride OW, ''et al.'' |title=Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter. |journal=Genomics |volume=11 |issue= 1 |pages= 174-8 |year= 1992 |pmid= 1765375 |doi=  }}
*{{cite journal  | author=Corvera S |title=Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes. |journal=J. Biol. Chem. |volume=265 |issue= 5 |pages= 2413–6 |year= 1990 |pmid= 2154445 |doi=  }}
*{{cite journal  | author=Corvera S |title=Insulin stimulates the assembly of cytosolic clathrin onto adipocyte plasma membranes. |journal=J. Biol. Chem. |volume=265 |issue= 5 |pages= 2413-6 |year= 1990 |pmid= 2154445 |doi=  }}
*{{cite journal  | vauthors=Scarmato P, Kirchhausen T |title=Analysis of clathrin light chain-heavy chain interactions using truncated mutants of rat liver light chain LCB3. |journal=J. Biol. Chem. |volume=265 |issue= 7 |pages= 3661–8 |year= 1990 |pmid= 2406259 |doi=  }}
*{{cite journal  | author=Scarmato P, Kirchhausen T |title=Analysis of clathrin light chain-heavy chain interactions using truncated mutants of rat liver light chain LCB3. |journal=J. Biol. Chem. |volume=265 |issue= 7 |pages= 3661-8 |year= 1990 |pmid= 2406259 |doi=  }}
*{{cite journal  | vauthors=Hanspal M, Luna E, Branton D |title=The association of clathrin fragments with coated vesicle membranes. |journal=J. Biol. Chem. |volume=259 |issue= 17 |pages= 11075–82 |year= 1984 |pmid= 6147350 |doi=  }}
*{{cite journal  | author=Hanspal M, Luna E, Branton D |title=The association of clathrin fragments with coated vesicle membranes. |journal=J. Biol. Chem. |volume=259 |issue= 17 |pages= 11075-82 |year= 1984 |pmid= 6147350 |doi= }}
*{{cite journal  | vauthors=Nomura N, Miyajima N, Sazuka T |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=10.1093/dnares/1.1.47  |display-authors=etal}}
*{{cite journal  | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27-35 |year= 1995 |pmid= 7584026 |doi=  }}
*{{cite journal  | vauthors=Fausser JL, Ungewickell E, Ruch JV, Lesot H |title=Interaction of vinculin with the clathrin heavy chain. |journal=J. Biochem. |volume=114 |issue= 4 |pages= 498–503 |year= 1994 |pmid= 8276759 |doi=  }}
*{{cite journal  | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47-56 |year= 1995 |pmid= 7584028 |doi=  }}
*{{cite journal  | vauthors=Kedra D, Peyrard M, Fransson I |title=Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 625–31 |year= 1997 |pmid= 8733129 |doi=10.1093/hmg/5.5.625 |display-authors=etal}}
*{{cite journal  | author=Fausser JL, Ungewickell E, Ruch JV, Lesot H |title=Interaction of vinculin with the clathrin heavy chain. |journal=J. Biochem. |volume=114 |issue= 4 |pages= 498-503 |year= 1994 |pmid= 8276759 |doi=  }}
*{{cite journal  | vauthors=Goodman OB, Krupnick JG, Gurevich VV |title=Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 15017–22 |year= 1997 |pmid= 9169477 |doi=10.1074/jbc.272.23.15017 |display-authors=etal}}
*{{cite journal  | author=Kedra D, Peyrard M, Fransson I, ''et al.'' |title=Characterization of a second human clathrin heavy chain polypeptide gene (CLH-22) from chromosome 22q11. |journal=Hum. Mol. Genet. |volume=5 |issue= 5 |pages= 625-31 |year= 1997 |pmid= 8733129 |doi=  }}
*{{cite journal  | vauthors=Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS |title=Identification and characterization of a nerve terminal-enriched amphiphysin isoform. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16700–6 |year= 1997 |pmid= 9195986 |doi=10.1074/jbc.272.26.16700 }}
*{{cite journal  | author=Goodman OB, Krupnick JG, Gurevich VV, ''et al.'' |title=Arrestin/clathrin interaction. Localization of the arrestin binding locus to the clathrin terminal domain. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 15017-22 |year= 1997 |pmid= 9169477 |doi=  }}
*{{cite journal  | vauthors=McMahon HT, Wigge P, Smith C |title=Clathrin interacts specifically with amphiphysin and is displaced by dynamin. |journal=FEBS Lett. |volume=413 |issue= 2 |pages= 319–22 |year= 1997 |pmid= 9280305 |doi=10.1016/S0014-5793(97)00928-9 }}
*{{cite journal  | author=Ramjaun AR, Micheva KD, Bouchelet I, McPherson PS |title=Identification and characterization of a nerve terminal-enriched amphiphysin isoform. |journal=J. Biol. Chem. |volume=272 |issue= 26 |pages= 16700-6 |year= 1997 |pmid= 9195986 |doi=  }}
*{{cite journal  | vauthors=Foti M, Mangasarian A, Piguet V |title=Nef-mediated clathrin-coated pit formation. |journal=J. Cell Biol. |volume=139 |issue= 1 |pages= 37–47 |year= 1998 |pmid= 9314527 |doi=10.1083/jcb.139.1.37  | pmc=2139808 |display-authors=etal}}
*{{cite journal  | author=McMahon HT, Wigge P, Smith C |title=Clathrin interacts specifically with amphiphysin and is displaced by dynamin. |journal=FEBS Lett. |volume=413 |issue= 2 |pages= 319-22 |year= 1997 |pmid= 9280305 |doi= }}
*{{cite journal  | vauthors=Dell'Angelica EC, Klumperman J, Stoorvogel W, Bonifacino JS |title=Association of the AP-3 adaptor complex with clathrin. |journal=Science |volume=280 |issue= 5362 |pages= 431–4 |year= 1998 |pmid= 9545220 |doi=10.1126/science.280.5362.431  |bibcode=1998Sci...280..431D }}
*{{cite journal  | author=Foti M, Mangasarian A, Piguet V, ''et al.'' |title=Nef-mediated clathrin-coated pit formation. |journal=J. Cell Biol. |volume=139 |issue= 1 |pages= 37-47 |year= 1998 |pmid= 9314527 |doi=  }}
*{{cite journal  | vauthors=Ramjaun AR, McPherson PS |title=Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites. |journal=J. Neurochem. |volume=70 |issue= 6 |pages= 2369–76 |year= 1998 |pmid= 9603201 |doi=10.1046/j.1471-4159.1998.70062369.x }}
*{{cite journal  | author=Dell'Angelica EC, Klumperman J, Stoorvogel W, Bonifacino JS |title=Association of the AP-3 adaptor complex with clathrin. |journal=Science |volume=280 |issue= 5362 |pages= 431-4 |year= 1998 |pmid= 9545220 |doi=  }}
*{{cite journal  | vauthors=ter Haar E, Musacchio A, Harrison SC, Kirchhausen T |title=Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker. |journal=Cell |volume=95 |issue= 4 |pages= 563–73 |year= 1998 |pmid= 9827808 |doi=10.1016/S0092-8674(00)81623-2 }}
*{{cite journal  | author=Ramjaun AR, McPherson PS |title=Multiple amphiphysin II splice variants display differential clathrin binding: identification of two distinct clathrin-binding sites. |journal=J. Neurochem. |volume=70 |issue= 6 |pages= 2369-76 |year= 1998 |pmid= 9603201 |doi= }}
*{{cite journal  | vauthors=Laporte SA, Oakley RH, Zhang J |title=The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3712–7 |year= 1999 |pmid= 10097102 |doi=10.1073/pnas.96.7.3712  | pmc=22359  |display-authors=etal|bibcode=1999PNAS...96.3712L}}
*{{cite journal  | author=ter Haar E, Musacchio A, Harrison SC, Kirchhausen T |title=Atomic structure of clathrin: a beta propeller terminal domain joins an alpha zigzag linker. |journal=Cell |volume=95 |issue= 4 |pages= 563-73 |year= 1998 |pmid= 9827808 |doi=  }}
*{{cite journal  | vauthors=Turner CE, Brown MC, Perrotta JA |title=Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. |journal=J. Cell Biol. |volume=145 |issue= 4 |pages= 851–63 |year= 1999 |pmid= 10330411 |doi=10.1083/jcb.145.4.851 | pmc=2133183  |display-authors=etal}}
*{{cite journal  | author=Laporte SA, Oakley RH, Zhang J, ''et al.'' |title=The beta2-adrenergic receptor/betaarrestin complex recruits the clathrin adaptor AP-2 during endocytosis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 7 |pages= 3712-7 |year= 1999 |pmid= 10097102 |doi=  }}
*{{cite journal  | vauthors=Hussain NK, Yamabhai M, Ramjaun AR |title=Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15671–7 |year= 1999 |pmid= 10336464 |doi=10.1074/jbc.274.22.15671 |display-authors=etal}}
*{{cite journal  | author=Turner CE, Brown MC, Perrotta JA, ''et al.'' |title=Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. |journal=J. Cell Biol. |volume=145 |issue= 4 |pages= 851-63 |year= 1999 |pmid= 10330411 |doi= }}
*{{cite journal  | vauthors=Ybe JA, Brodsky FM, Hofmann K |title=Clathrin self-assembly is mediated by a tandemly repeated superhelix. |journal=Nature |volume=399 |issue= 6734 |pages= 371–5 |year= 1999 |pmid= 10360576 |doi= 10.1038/20708 |display-authors=etal|bibcode=1999Natur.399..371Y }}
*{{cite journal  | author=Hussain NK, Yamabhai M, Ramjaun AR, ''et al.'' |title=Splice variants of intersectin are components of the endocytic machinery in neurons and nonneuronal cells. |journal=J. Biol. Chem. |volume=274 |issue= 22 |pages= 15671-7 |year= 1999 |pmid= 10336464 |doi=  }}
*{{cite journal  | author=Ybe JA, Brodsky FM, Hofmann K, ''et al.'' |title=Clathrin self-assembly is mediated by a tandemly repeated superhelix. |journal=Nature |volume=399 |issue= 6734 |pages= 371-5 |year= 1999 |pmid= 10360576 |doi= 10.1038/20708 }}
}}
}}
{{refend}}
{{refend}}
==External links==
* {{UCSC gene info|CLTC}}
{{PDB Gallery|geneid=1213}}


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{{Vesicular transport proteins}}
 
 
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Latest revision as of 01:16, 23 June 2018

For other uses, see Christian Leaders Training College.
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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Clathrin heavy chain 1 is a protein that in humans is encoded by the CLTC gene.[1][2]

Clathrin is a major protein component of the cytoplasmic face of intracellular organelles, called coated vesicles and coated pits. These specialized organelles are involved in the intracellular trafficking of receptors and endocytosis of a variety of macromolecules. The basic subunit of the clathrin coat is composed of three heavy chains and three light chains.[3]

Interactions

CLTC has been shown to interact with PICALM[4] and HGS.[5]

See also

References

  1. ↑ Dodge GR, Kovalszky I, McBride OW, Yi HF, Chu ML, Saitta B, Stokes DG, Iozzo RV (Feb 1992). "Human clathrin heavy chain (CLTC): partial molecular cloning, expression, and mapping of the gene to human chromosome 17q11-qter". Genomics. 11 (1): 174–8. doi:10.1016/0888-7543(91)90115-U. PMID 1765375.
  2. ↑ Nomura N, Miyajima N, Sazuka T, Tanaka A, Kawarabayasi Y, Sato S, Nagase T, Seki N, Ishikawa K, Tabata S (Dec 1995). "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1". DNA Res. 1 (1): 27–35. doi:10.1093/dnares/1.1.27. PMID 7584026.
  3. ↑ "Entrez Gene: CLTC clathrin, heavy chain (Hc)".
  4. ↑ Tebar, F; Bohlander S K; Sorkin A (Aug 1999). "Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic". Mol. Biol. Cell. UNITED STATES. 10 (8): 2687–702. doi:10.1091/mbc.10.8.2687. ISSN 1059-1524. PMC 25500. PMID 10436022.
  5. ↑ Raiborg, C; Bache K G; Mehlum A; Stang E; Stenmark H (Sep 2001). "Hrs recruits clathrin to early endosomes". EMBO J. England. 20 (17): 5008–21. doi:10.1093/emboj/20.17.5008. ISSN 0261-4189. PMC 125612. PMID 11532964.

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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