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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Eukaryotic translation initiation factor 4B''' is a [[protein]] that in humans is encoded by the ''EIF4B'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF4B eukaryotic translation initiation factor 4B| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1975| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_EIF4B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1wi8.
| PDB = {{PDB2|1wi8}}
| Name = Eukaryotic translation initiation factor 4B
| HGNCid = 3285
| Symbol = EIF4B
| AltSymbols =; EIF-4B
| OMIM = 603928
| ECnumber = 
| Homologene = 83162
| MGIid = 95304
| GeneAtlas_image1 = PBB_GE_EIF4B_211937_at_tn.png
| GeneAtlas_image2 = PBB_GE_EIF4B_211938_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003676 |text = nucleic acid binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}}
| Component = {{GNF_GO|id=GO:0016281 |text = eukaryotic translation initiation factor 4F complex}}
| Process = {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0006446 |text = regulation of translational initiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 1975
    | Hs_Ensembl = ENSG00000063046
    | Hs_RefseqProtein = NP_001408
    | Hs_RefseqmRNA = NM_001417
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 12
    | Hs_GenLoc_start = 51696514
    | Hs_GenLoc_end = 51720363
    | Hs_Uniprot = P23588
    | Mm_EntrezGene = 75705
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_001005455
    | Mm_RefseqProtein = XP_001005455
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Eukaryotic translation initiation factor 4B''', also known as '''EIF4B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF4B eukaryotic translation initiation factor 4B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1975| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
EIF4B has been shown to [[Protein-protein interaction|interact]] and stimulate the activity of [[EIF4A]] and binds the [[eIF3]] complex through the [[eIF3A]] subunit.<ref name="Merrick">{{cite journal | vauthors = Merrick WC | title = eIF4F: a retrospective | journal = The Journal of Biological Chemistry | volume = 290 | issue = 40 | pages = 24091–9 | date = Oct 2015 | pmid = 26324716 | doi = 10.1074/jbc.R115.675280 | pmc = 4591800 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}


==External links==
== External links ==
* [http://www.nature.com/nrmicro/journal/v5/n1/box/nrmicro1558_BX1.html Cap-dependent translation initiation] from Nature Reviews Microbiology. A good image and overview of the function of initiation factors
* [http://www.nature.com/nrmicro/journal/v5/n1/box/nrmicro1558_BX1.html Cap-dependent translation initiation] from Nature Reviews Microbiology. A good image and overview of the function of initiation factors


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = van Heugten HA, Kasperaitis MA, Thomas AA, Voorma HO | title = Evidence that eukaryotic initiation factor (eIF) 2 is a cap-binding protein that stimulates cap recognition by eIF-4B and eIF-4F | journal = J. Biol. Chem. | volume = 266 | issue = 11 | pages = 7279–84 | year = 1991 | pmid = 2016328 | doi =  }}
| citations =
* {{cite journal | vauthors = Milburn SC, Hershey JW, Davies MV, Kelleher K, Kaufman RJ | title = Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif | journal = EMBO J. | volume = 9 | issue = 9 | pages = 2783–90 | year = 1990 | pmid = 2390971 | pmc = 551988 | doi =  }}
*{{cite journal | author=van Heugten HA, Kasperaitis MA, Thomas AA, Voorma HO |title=Evidence that eukaryotic initiation factor (eIF) 2 is a cap-binding protein that stimulates cap recognition by eIF-4B and eIF-4F. |journal=J. Biol. Chem. |volume=266 |issue= 11 |pages= 7279-84 |year= 1991 |pmid= 2016328 |doi=  }}
* {{cite journal | vauthors = Howe JG, Hershey JW | title = Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells | journal = Cell | volume = 37 | issue = 1 | pages = 85–93 | year = 1984 | pmid = 6722878 | doi = 10.1016/0092-8674(84)90303-9 }}
*{{cite journal | author=Milburn SC, Hershey JW, Davies MV, ''et al.'' |title=Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif. |journal=EMBO J. |volume=9 |issue= 9 |pages= 2783-90 |year= 1990 |pmid= 2390971 |doi=  }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal | author=Howe JG, Hershey JW |title=Translational initiation factor and ribosome association with the cytoskeletal framework fraction from HeLa cells. |journal=Cell |volume=37 |issue= 1 |pages= 85-93 |year= 1984 |pmid= 6722878 |doi= }}
* {{cite journal | vauthors = Méthot N, Pause A, Hershey JW, Sonenberg N | title = The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence | journal = Mol. Cell. Biol. | volume = 14 | issue = 4 | pages = 2307–16 | year = 1994 | pmid = 8139536 | pmc = 358597 | doi = 10.1128/mcb.14.4.2307 }}
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
* {{cite journal | vauthors = Naranda T, Strong WB, Menaya J, Fabbri BJ, Hershey JW | title = Two structural domains of initiation factor eIF-4B are involved in binding to RNA | journal = J. Biol. Chem. | volume = 269 | issue = 20 | pages = 14465–72 | year = 1994 | pmid = 8182051 | doi =  }}
*{{cite journal | author=Méthot N, Pause A, Hershey JW, Sonenberg N |title=The translation initiation factor eIF-4B contains an RNA-binding region that is distinct and independent from its ribonucleoprotein consensus sequence. |journal=Mol. Cell. Biol. |volume=14 |issue= 4 |pages= 2307-16 |year= 1994 |pmid= 8139536 |doi= }}
* {{cite journal | vauthors = Méthot N, Song MS, Sonenberg N | title = A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3 | journal = Mol. Cell. Biol. | volume = 16 | issue = 10 | pages = 5328–34 | year = 1996 | pmid = 8816444 | pmc = 231531 | doi =  }}
*{{cite journal | author=Naranda T, Strong WB, Menaya J, ''et al.'' |title=Two structural domains of initiation factor eIF-4B are involved in binding to RNA. |journal=J. Biol. Chem. |volume=269 |issue= 20 |pages= 14465-72 |year= 1994 |pmid= 8182051 |doi=  }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Méthot N, Song MS, Sonenberg N |title=A region rich in aspartic acid, arginine, tyrosine, and glycine (DRYG) mediates eukaryotic initiation factor 4B (eIF4B) self-association and interaction with eIF3. |journal=Mol. Cell. Biol. |volume=16 |issue= 10 |pages= 5328-34 |year= 1996 |pmid= 8816444 |doi=  }}
* {{cite journal | vauthors = Richter NJ, Rogers GW, Hensold JO, Merrick WC | title = Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H | journal = J. Biol. Chem. | volume = 274 | issue = 50 | pages = 35415–24 | year = 1999 | pmid = 10585411 | doi = 10.1074/jbc.274.50.35415 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
* {{cite journal | vauthors = Bushell M, Wood W, Clemens MJ, Morley SJ | title = Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis | journal = Eur. J. Biochem. | volume = 267 | issue = 4 | pages = 1083–91 | year = 2000 | pmid = 10672017 | doi = 10.1046/j.1432-1327.2000.01101.x }}
*{{cite journal | author=Richter NJ, Rogers GW, Hensold JO, Merrick WC |title=Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35415-24 |year= 2000 |pmid= 10585411 |doi= }}
* {{cite journal | vauthors = Bushell M, Wood W, Carpenter G, Pain VM, Morley SJ, Clemens MJ | title = Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages | journal = J. Biol. Chem. | volume = 276 | issue = 26 | pages = 23922–8 | year = 2001 | pmid = 11274152 | doi = 10.1074/jbc.M100384200 }}
*{{cite journal | author=Bushell M, Wood W, Clemens MJ, Morley SJ |title=Changes in integrity and association of eukaryotic protein synthesis initiation factors during apoptosis. |journal=Eur. J. Biochem. |volume=267 |issue= 4 |pages= 1083-91 |year= 2000 |pmid= 10672017 |doi= }}
* {{cite journal | vauthors = Fleming K, Ghuman J, Yuan X, Simpson P, Szendröi A, Matthews S, Curry S | title = Solution structure and RNA interactions of the RNA recognition motif from eukaryotic translation initiation factor 4B | journal = Biochemistry | volume = 42 | issue = 30 | pages = 8966–75 | year = 2003 | pmid = 12885229 | doi = 10.1021/bi034506g }}
*{{cite journal | author=Bushell M, Wood W, Carpenter G, ''et al.'' |title=Disruption of the interaction of mammalian protein synthesis eukaryotic initiation factor 4B with the poly(A)-binding protein by caspase- and viral protease-mediated cleavages. |journal=J. Biol. Chem. |volume=276 |issue= 26 |pages= 23922-8 |year= 2001 |pmid= 11274152 |doi= 10.1074/jbc.M100384200 }}
* {{cite journal | vauthors = Raught B, Peiretti F, Gingras AC, Livingstone M, Shahbazian D, Mayeur GL, Polakiewicz RD, Sonenberg N, Hershey JW | title = Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases | journal = EMBO J. | volume = 23 | issue = 8 | pages = 1761–9 | year = 2004 | pmid = 15071500 | pmc = 394247 | doi = 10.1038/sj.emboj.7600193 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Doepker RC, Hsu WL, Saffran HA, Smiley JR | title = Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H | journal = J. Virol. | volume = 78 | issue = 9 | pages = 4684–99 | year = 2004 | pmid = 15078951 | pmc = 387725 | doi = 10.1128/JVI.78.9.4684-4699.2004 }}
*{{cite journal | author=Fleming K, Ghuman J, Yuan X, ''et al.'' |title=Solution structure and RNA interactions of the RNA recognition motif from eukaryotic translation initiation factor 4B. |journal=Biochemistry |volume=42 |issue= 30 |pages= 8966-75 |year= 2003 |pmid= 12885229 |doi= 10.1021/bi034506g }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 101 | issue = 33 | pages = 12130–5 | year = 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Raught B, Peiretti F, Gingras AC, ''et al.'' |title=Phosphorylation of eucaryotic translation initiation factor 4B Ser422 is modulated by S6 kinases. |journal=EMBO J. |volume=23 |issue= 8 |pages= 1761-9 |year= 2005 |pmid= 15071500 |doi= 10.1038/sj.emboj.7600193 }}
* {{cite journal | vauthors = Suzuki Y, Yamashita R, Shirota M, Sakakibara Y, Chiba J, Mizushima-Sugano J, Nakai K, Sugano S | title = Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions | journal = Genome Res. | volume = 14 | issue = 9 | pages = 1711–8 | year = 2004 | pmid = 15342556 | pmc = 515316 | doi = 10.1101/gr.2435604 }}
*{{cite journal | author=Doepker RC, Hsu WL, Saffran HA, Smiley JR |title=Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H. |journal=J. Virol. |volume=78 |issue= 9 |pages= 4684-99 |year= 2004 |pmid= 15078951 |doi= }}
* {{cite journal | vauthors = Shahbazian D, Roux PP, Mieulet V, Cohen MS, Raught B, Taunton J, Hershey JW, Blenis J, Pende M, Sonenberg N | title = The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity | journal = EMBO J. | volume = 25 | issue = 12 | pages = 2781–91 | year = 2006 | pmid = 16763566 | pmc = 1500846 | doi = 10.1038/sj.emboj.7601166 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | year = 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Suzuki Y, Yamashita R, Shirota M, ''et al.'' |title=Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. |journal=Genome Res. |volume=14 |issue= 9 |pages= 1711-8 |year= 2004 |pmid= 15342556 |doi= 10.1101/gr.2435604 }}
*{{cite journal | author=Shahbazian D, Roux PP, Mieulet V, ''et al.'' |title=The mTOR/PI3K and MAPK pathways converge on eIF4B to control its phosphorylation and activity. |journal=EMBO J. |volume=25 |issue= 12 |pages= 2781-91 |year= 2006 |pmid= 16763566 |doi= 10.1038/sj.emboj.7601166 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=1975}}


{{Initiation factors}}
{{Initiation factors}}


{{protein-stub}}
 
{{WikiDoc Sources}}
{{gene-12-stub}}

Latest revision as of 08:24, 12 May 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Eukaryotic translation initiation factor 4B is a protein that in humans is encoded by the EIF4B gene.[1]

Interactions

EIF4B has been shown to interact and stimulate the activity of EIF4A and binds the eIF3 complex through the eIF3A subunit.[2]

References

  1. ↑ "Entrez Gene: EIF4B eukaryotic translation initiation factor 4B".
  2. ↑ Merrick WC (Oct 2015). "eIF4F: a retrospective". The Journal of Biological Chemistry. 290 (40): 24091–9. doi:10.1074/jbc.R115.675280. PMC 4591800. PMID 26324716.

External links

Further reading


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