EIF4H: Difference between revisions

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{{Infobox_gene}}
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'''Eukaryotic translation initiation factor 4H''' is a [[protein]] that in humans is encoded by the ''EIF4H'' [[gene]].<ref name="pmid9516461">{{cite journal | vauthors = Richter-Cook NJ, Dever TE, Hensold JO, Merrick WC | title = Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H | journal = J Biol Chem | volume = 273 | issue = 13 | pages = 7579–87 |date=Apr 1998 | pmid = 9516461 | pmc =  | doi =10.1074/jbc.273.13.7579 }}</ref><ref name="pmid15078951">{{cite journal | vauthors = Doepker RC, Hsu WL, Saffran HA, Smiley JR | title = Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H | journal = J Virol | volume = 78 | issue = 9 | pages = 4684–99 |date=Apr 2004 | pmid = 15078951 | pmc = 387725 | doi =10.1128/JVI.78.9.4684-4699.2004 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: EIF4H eukaryotic translation initiation factor 4H| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7458| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_EIF4H_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dng.
| PDB = {{PDB2|2dng}}
| Name = Eukaryotic translation initiation factor 4H
| HGNCid = 12741
| Symbol = EIF4H
| AltSymbols =; KIAA0038; WBSCR1; WSCR1
| OMIM = 603431
| ECnumber =
| Homologene = 32536
| MGIid = 1341822
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0003743 |text = translation initiation factor activity}}
  | Component = {{GNF_GO|id=GO:0016281 |text = eukaryotic translation initiation factor 4F complex}}  
| Process = {{GNF_GO|id=GO:0006412 |text = translation}} {{GNF_GO|id=GO:0006446 |text = regulation of translational initiation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7458
    | Hs_Ensembl =
    | Hs_RefseqProtein = NP_071496
    | Hs_RefseqmRNA = NM_022170
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start = 
    | Hs_GenLoc_end = 
    | Hs_Uniprot = 
    | Mm_EntrezGene = 22384
    | Mm_Ensembl = ENSMUSG00000040731
    | Mm_RefseqmRNA = NM_033561
    | Mm_RefseqProtein = NP_291039
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 134904507
    | Mm_GenLoc_end = 134923966
    | Mm_Uniprot = Q3V244
  }}
}}
'''Eukaryotic translation initiation factor 4H''', also known as '''EIF4H''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: EIF4H eukaryotic translation initiation factor 4H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7458| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes one of the translation initiation factors, which functions to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: EIF4H eukaryotic translation initiation factor 4H| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7458| accessdate = }}</ref>
| summary_text = This gene encodes one of the [[eukaryotic initiation factor|translation initiation factor]]s, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization.  
This gene is deleted in [[Williams syndrome]], a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.<ref name="entrez">{{cite web | title = Entrez Gene: EIF4H eukaryotic translation initiation factor 4H| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7458| accessdate = }}</ref>
}}
}}
EIF4H appears analogous to [[drr-2]] in [[Caenorhabditis elegans|C. elegans]] which regulates the [[mTOR pathway]] and affects longevity.<ref>{{cite web |url=http://www2.med.umich.edu/prmc/media/newsroom/details.cfm?ID=1689 |title=Early discovery may aid search for anti-aging drugs |year=2010 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27-35 |year= 1995 |pmid= 7584026 |doi=  }}
*{{cite journal  | vauthors=Nomura N, Miyajima N, Sazuka T |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=10.1093/dnares/1.1.27 |display-authors=etal}}
*{{cite journal  | author=Nomura N, Miyajima N, Sazuka T, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47-56 |year= 1995 |pmid= 7584028 |doi=  }}
*{{cite journal  | vauthors=Nomura N, Miyajima N, Sazuka T |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=10.1093/dnares/1.1.47 |display-authors=etal}}
*{{cite journal  | author=Osborne LR, Martindale D, Scherer SW, ''et al.'' |title=Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. |journal=Genomics |volume=36 |issue= 2 |pages= 328-36 |year= 1997 |pmid= 8812460 |doi= 10.1006/geno.1996.0469 }}
*{{cite journal  | vauthors=Osborne LR, Martindale D, Scherer SW |title=Identification of genes from a 500-kb region at 7q11.23 that is commonly deleted in Williams syndrome patients. |journal=Genomics |volume=36 |issue= 2 |pages= 328–36 |year= 1997 |pmid= 8812460 |doi= 10.1006/geno.1996.0469 |display-authors=etal}}
*{{cite journal  | author=Richter-Cook NJ, Dever TE, Hensold JO, Merrick WC |title=Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H. |journal=J. Biol. Chem. |volume=273 |issue= 13 |pages= 7579-87 |year= 1998 |pmid= 9516461 |doi=  }}
*{{cite journal  | vauthors=Richter NJ, Rogers GW, Hensold JO, Merrick WC |title=Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35415–24 |year= 2000 |pmid= 10585411 |doi=10.1074/jbc.274.50.35415 }}
*{{cite journal  | author=Richter NJ, Rogers GW, Hensold JO, Merrick WC |title=Further biochemical and kinetic characterization of human eukaryotic initiation factor 4H. |journal=J. Biol. Chem. |volume=274 |issue= 50 |pages= 35415-24 |year= 2000 |pmid= 10585411 |doi=  }}
*{{cite journal  | vauthors=Martindale DW, Wilson MD, Wang D |title=Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 890–8 |year= 2000 |pmid= 11003705 |doi=10.1007/s003350010166 |display-authors=etal}}
*{{cite journal  | author=Martindale DW, Wilson MD, Wang D, ''et al.'' |title=Comparative genomic sequence analysis of the Williams syndrome region (LIMK1-RFC2) of human chromosome 7q11.23. |journal=Mamm. Genome |volume=11 |issue= 10 |pages= 890-8 |year= 2000 |pmid= 11003705 |doi=  }}
*{{cite journal  | vauthors=Rogers GW, Richter NJ, Lima WF, Merrick WC |title=Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 30914–22 |year= 2001 |pmid= 11418588 |doi= 10.1074/jbc.M100157200 }}
*{{cite journal  | author=Rogers GW, Richter NJ, Lima WF, Merrick WC |title=Modulation of the helicase activity of eIF4A by eIF4B, eIF4H, and eIF4F. |journal=J. Biol. Chem. |volume=276 |issue= 33 |pages= 30914-22 |year= 2001 |pmid= 11418588 |doi= 10.1074/jbc.M100157200 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Gevaert K, Goethals M, Martens L |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566–9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 |display-authors=etal}}
*{{cite journal  | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
*{{cite journal  | vauthors=Scherer SW, Cheung J, MacDonald JR |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 | pmc=2882961 |doi= 10.1126/science.1083423 |display-authors=etal}}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | vauthors=Hillier LW, Fulton RS, Fulton LA |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 |display-authors=etal}}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Doepker RC, Hsu WL, Saffran HA, Smiley JR |title=Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H. |journal=J. Virol. |volume=78 |issue= 9 |pages= 4684-99 |year= 2004 |pmid= 15078951 |doi=  }}
*{{cite journal  | vauthors=Rush J, Moritz A, Lee KA |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Feng P, Everly DN, Read GS |title=mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. |journal=J. Virol. |volume=79 |issue= 15 |pages= 9651–64 |year= 2005 |pmid= 16014927 |doi= 10.1128/JVI.79.15.9651-9664.2005 | pmc=1181552 }}
*{{cite journal  | author=Rush J, Moritz A, Lee KA, ''et al.'' |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94-101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046 }}
*{{cite journal  | vauthors=Tao WA, Wollscheid B, O'Brien R |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591–8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776 |display-authors=etal}}
*{{cite journal  | author=Feng P, Everly DN, Read GS |title=mRNA decay during herpes simplex virus (HSV) infections: protein-protein interactions involving the HSV virion host shutoff protein and translation factors eIF4H and eIF4A. |journal=J. Virol. |volume=79 |issue= 15 |pages= 9651-64 |year= 2005 |pmid= 16014927 |doi= 10.1128/JVI.79.15.9651-9664.2005 }}
*{{cite journal  | vauthors=Rual JF, Venkatesan K, Hao T |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |display-authors=etal}}
*{{cite journal  | author=Tao WA, Wollscheid B, O'Brien R, ''et al.'' |title=Quantitative phosphoproteome analysis using a dendrimer conjugation chemistry and tandem mass spectrometry. |journal=Nat. Methods |volume=2 |issue= 8 |pages= 591-8 |year= 2005 |pmid= 16094384 |doi= 10.1038/nmeth776 }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
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{{PDB Gallery|geneid=7458}}
{{Initiation factors}}
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Latest revision as of 00:26, 31 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Eukaryotic translation initiation factor 4H is a protein that in humans is encoded by the EIF4H gene.[1][2][3]

This gene encodes one of the translation initiation factors, which function to stimulate the initiation of protein synthesis at the level of mRNA utilization. This gene is deleted in Williams syndrome, a multisystem developmental disorder caused by the deletion of contiguous genes at 7q11.23. Alternative splicing of this gene generates 2 transcript variants.[3]

EIF4H appears analogous to drr-2 in C. elegans which regulates the mTOR pathway and affects longevity.[4]

References

  1. ↑ Richter-Cook NJ, Dever TE, Hensold JO, Merrick WC (Apr 1998). "Purification and characterization of a new eukaryotic protein translation factor. Eukaryotic initiation factor 4H". J Biol Chem. 273 (13): 7579–87. doi:10.1074/jbc.273.13.7579. PMID 9516461.
  2. ↑ Doepker RC, Hsu WL, Saffran HA, Smiley JR (Apr 2004). "Herpes simplex virus virion host shutoff protein is stimulated by translation initiation factors eIF4B and eIF4H". J Virol. 78 (9): 4684–99. doi:10.1128/JVI.78.9.4684-4699.2004. PMC 387725. PMID 15078951.
  3. ↑ 3.0 3.1 "Entrez Gene: EIF4H eukaryotic translation initiation factor 4H".
  4. ↑ "Early discovery may aid search for anti-aging drugs". 2010.

Further reading



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