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{{Infobox_gene}}
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'''MAP kinase-interacting serine/threonine-protein kinase 2''' is an [[enzyme]] that in humans is encoded by the ''MKNK2'' [[gene]].<ref name="pmid11013076">{{cite journal |vauthors=Slentz-Kesler K, Moore JT, Lombard M, Zhang J, Hollingsworth R, Weiner MP | title = Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta | journal = Genomics | volume = 69 | issue = 1 | pages = 63–71 |date=Oct 2000 | pmid = 11013076 | pmc =  | doi = 10.1006/geno.2000.6299 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2872| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_MKNK2_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2ac3.
| PDB = {{PDB2|2ac3}}, {{PDB2|2ac5}}, {{PDB2|2hw7}}
| Name = MAP kinase interacting serine/threonine kinase 2
| HGNCid = 7111
| Symbol = MKNK2
| AltSymbols =; GPRK7; MNK2
| OMIM = 605069
| ECnumber = 
| Homologene = 49674
| MGIid = 894279
| GeneAtlas_image1 = PBB_GE_MKNK2_218205_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0000287 |text = magnesium ion binding}} {{GNF_GO|id=GO:0004674 |text = protein serine/threonine kinase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006417 |text = regulation of translation}} {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007166 |text = cell surface receptor linked signal transduction}} {{GNF_GO|id=GO:0007243 |text = protein kinase cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2872
    | Hs_Ensembl = ENSG00000099875
    | Hs_RefseqProtein = NP_060042
    | Hs_RefseqmRNA = NM_017572
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 1988481
    | Hs_GenLoc_end = 2002233
    | Hs_Uniprot = Q9HBH9
    | Mm_EntrezGene = 17347
    | Mm_Ensembl = ENSMUSG00000020190
    | Mm_RefseqmRNA = NM_021462
    | Mm_RefseqProtein = NP_067437
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = 10
    | Mm_GenLoc_start = 80068456
    | Mm_GenLoc_end = 80079003
    | Mm_Uniprot = Q3TPM2
  }}
}}
'''MAP kinase interacting serine/threonine kinase 2''', also known as '''MKNK2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2872| accessdate = }}</ref>


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==Interactions==
MKNK2 has been shown to [[Protein-protein interaction|interact]] with [[MAPK1]]<ref name=pmid12897141>{{cite journal |last=Scheper |first=Gert C |authorlink= |author2=Parra Josep L |author3=Wilson Mary |author4=Van Kollenburg Barbara |author5=Vertegaal Alfred C O |author6=Han Ze-Guang |author7=Proud Christopher G  |date=Aug 2003 |title=The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization |journal=Mol. Cell. Biol. |volume=23 |issue=16 |pages=5692–705 |publisher= |location = United States| issn = 0270-7306| pmid = 12897141 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |doi=10.1128/MCB.23.16.5692-5705.2003 |pmc=166352 }}</ref><ref name=pmid9155017>{{cite journal |last=Waskiewicz |first=A J |authorlink= |author2=Flynn A |author3=Proud C G |author4=Cooper J A  |date=Apr 1997 |title=Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2 |journal=EMBO J. |volume=16 |issue=8 |pages=1909–20 |publisher= |location = ENGLAND| issn = 0261-4189| pmid = 9155017 |doi = 10.1093/emboj/16.8.1909 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=1169794 }}</ref> and [[Eukaryotic translation initiation factor 4 gamma]].<ref name=pmid12897141/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Haribabu B, Snyderman R |title=Identification of additional members of human G-protein-coupled receptor kinase multigene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 20 |pages= 9398-402 |year= 1993 |pmid= 8415712 |doi=  }}
*{{cite journal  |vauthors=Haribabu B, Snyderman R |title=Identification of additional members of human G-protein-coupled receptor kinase multigene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 20 |pages= 9398–402 |year= 1993 |pmid= 8415712 |doi=10.1073/pnas.90.20.9398 | pmc=47575  |bibcode=1993PNAS...90.9398H }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Waskiewicz AJ, Flynn A, Proud CG, Cooper JA |title=Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. |journal=EMBO J. |volume=16 |issue= 8 |pages= 1909-20 |year= 1997 |pmid= 9155017 |doi= 10.1093/emboj/16.8.1909 }}
*{{cite journal  |vauthors=Waskiewicz AJ, Flynn A, Proud CG, Cooper JA |title=Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2. |journal=EMBO J. |volume=16 |issue= 8 |pages= 1909–20 |year= 1997 |pmid= 9155017 |doi= 10.1093/emboj/16.8.1909  | pmc=1169794 }}
*{{cite journal | author=Slentz-Kesler K, Moore JT, Lombard M, ''et al.'' |title=Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta. |journal=Genomics |volume=69 |issue= 1 |pages= 63-71 |year= 2001 |pmid= 11013076 |doi= 10.1006/geno.2000.6299 }}
*{{cite journal  |vauthors=Scheper GC, Morrice NA, Kleijn M, Proud CG |title=The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. |journal=Mol. Cell. Biol. |volume=21 |issue= 3 |pages= 743–54 |year= 2001 |pmid= 11154262 |doi= 10.1128/MCB.21.3.743-754.2001 | pmc=86666 }}
*{{cite journal  | author=Scheper GC, Morrice NA, Kleijn M, Proud CG |title=The mitogen-activated protein kinase signal-integrating kinase Mnk2 is a eukaryotic initiation factor 4E kinase with high levels of basal activity in mammalian cells. |journal=Mol. Cell. Biol. |volume=21 |issue= 3 |pages= 743-54 |year= 2001 |pmid= 11154262 |doi= 10.1128/MCB.21.3.743-754.2001 }}
*{{cite journal  |vauthors=Knauf U, Tschopp C, Gram H |title=Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. |journal=Mol. Cell. Biol. |volume=21 |issue= 16 |pages= 5500–11 |year= 2001 |pmid= 11463832 |doi= 10.1128/MCB.21.16.5500-5511.2001 | pmc=87272 }}
*{{cite journal  | author=Knauf U, Tschopp C, Gram H |title=Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2. |journal=Mol. Cell. Biol. |volume=21 |issue= 16 |pages= 5500-11 |year= 2001 |pmid= 11463832 |doi= 10.1128/MCB.21.16.5500-5511.2001 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Scheper GC, Parra JL, Wilson M, etal |title=The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization. |journal=Mol. Cell. Biol. |volume=23 |issue= 16 |pages= 5692–705 |year= 2003 |pmid= 12897141 |doi=10.1128/MCB.23.16.5692-5705.2003  | pmc=166352 }}
*{{cite journal | author=Scheper GC, Parra JL, Wilson M, ''et al.'' |title=The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization. |journal=Mol. Cell. Biol. |volume=23 |issue= 16 |pages= 5692-705 |year= 2003 |pmid= 12897141 |doi=  }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Grimwood J, Gordon LA, Olsen A, etal |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 |bibcode=2004Natur.428..529G }}
*{{cite journal | author=Grimwood J, Gordon LA, Olsen A, ''et al.'' |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529-35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |vauthors=Yoshizuka N, Yoshizuka-Chadani Y, Krishnan V, Zeichner SL |title=Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway. |journal=J. Virol. |volume=79 |issue= 17 |pages= 11366–81 |year= 2005 |pmid= 16103188 |doi= 10.1128/JVI.79.17.11366-11381.2005 | pmc=1193619 }}
*{{cite journal  | author=Yoshizuka N, Yoshizuka-Chadani Y, Krishnan V, Zeichner SL |title=Human immunodeficiency virus type 1 Vpr-dependent cell cycle arrest through a mitogen-activated protein kinase signal transduction pathway. |journal=J. Virol. |volume=79 |issue= 17 |pages= 11366-81 |year= 2005 |pmid= 16103188 |doi= 10.1128/JVI.79.17.11366-11381.2005 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal   |vauthors=Jauch R, Jäkel S, Netter C, etal |title=Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site. |journal=Structure |volume=13 |issue= 10 |pages= 1559–68 |year= 2006 |pmid= 16216586 |doi= 10.1016/j.str.2005.07.013 }}
*{{cite journal | author=Jauch R, Jäkel S, Netter C, ''et al.'' |title=Crystal structures of the Mnk2 kinase domain reveal an inhibitory conformation and a zinc binding site. |journal=Structure |volume=13 |issue= 10 |pages= 1559-68 |year= 2006 |pmid= 16216586 |doi= 10.1016/j.str.2005.07.013 }}
*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
*{{cite journal   |vauthors=Wang P, Wang X, Wang F, etal |title=Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex. |journal=Sci. China, C, Life Sci. |volume=49 |issue= 3 |pages= 265–73 |year= 2006 |pmid= 16856496 |doi=10.1007/s11427-006-0265-5 }}
*{{cite journal | author=Wang P, Wang X, Wang F, ''et al.'' |title=Interaction between Mnk2 and CBC(VHL) ubiquitin ligase E3 complex. |journal=Sci. China, C, Life Sci. |volume=49 |issue= 3 |pages= 265-73 |year= 2006 |pmid= 16856496 |doi=  }}
}}
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{{Serine/threonine-specific protein kinases}}
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[[Category:EC 2.7.11]]


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{{gene-19-stub}}
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Latest revision as of 03:42, 25 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

MAP kinase-interacting serine/threonine-protein kinase 2 is an enzyme that in humans is encoded by the MKNK2 gene.[1][2]


Interactions

MKNK2 has been shown to interact with MAPK1[3][4] and Eukaryotic translation initiation factor 4 gamma.[3]

References

  1. ↑ Slentz-Kesler K, Moore JT, Lombard M, Zhang J, Hollingsworth R, Weiner MP (Oct 2000). "Identification of the human Mnk2 gene (MKNK2) through protein interaction with estrogen receptor beta". Genomics. 69 (1): 63–71. doi:10.1006/geno.2000.6299. PMID 11013076.
  2. ↑ "Entrez Gene: MKNK2 MAP kinase interacting serine/threonine kinase 2".
  3. ↑ 3.0 3.1 Scheper, Gert C; Parra Josep L; Wilson Mary; Van Kollenburg Barbara; Vertegaal Alfred C O; Han Ze-Guang; Proud Christopher G (Aug 2003). "The N and C termini of the splice variants of the human mitogen-activated protein kinase-interacting kinase Mnk2 determine activity and localization". Mol. Cell. Biol. United States. 23 (16): 5692–705. doi:10.1128/MCB.23.16.5692-5705.2003. ISSN 0270-7306. PMC 166352. PMID 12897141.
  4. ↑ Waskiewicz, A J; Flynn A; Proud C G; Cooper J A (Apr 1997). "Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2". EMBO J. ENGLAND. 16 (8): 1909–20. doi:10.1093/emboj/16.8.1909. ISSN 0261-4189. PMC 1169794. PMID 9155017.

Further reading


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