MYH14: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
m (Robot: Automated text replacement (-{{WikiDoc Cardiology Network Infobox}} +, -<references /> +{{reflist|2}}, -{{reflist}} +{{reflist|2}}))
 
imported>Veryproicelandic
m (Disambiguated: superfamily → Protein superfamily)
 
(One intermediate revision by one other user not shown)
Line 1: Line 1:
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Myosin-14''' is a [[protein]] that in humans is encoded by the ''MYH14'' [[gene]].<ref name="pmid12909352">{{cite journal |vauthors=Leal A, Endele S, Stengel C, Huehne K, Loetterle J, Barrantes R, Winterpacht A, Rautenstrauss B | title = A novel myosin heavy chain gene in human chromosome 19q13.3 | journal = Gene | volume = 312 | issue =  | pages = 165–71 |date=Aug 2003 | pmid = 12909352 | pmc =  | doi =10.1016/S0378-1119(03)00613-9 }}</ref><ref name="pmid15015131">{{cite journal |vauthors=Donaudy F, Snoeckx R, Pfister M, Zenner HP, Blin N, Di Stazio M, Ferrara A, Lanzara C, Ficarella R, Declau F, Pusch CM, Nurnberg P, Melchionda S, Zelante L, Ballana E, Estivill X, Van Camp G, Gasparini P, Savoia A | title = Nonmuscle Myosin Heavy-Chain Gene MYH14 Is Expressed in Cochlea and Mutated in Patients Affected by Autosomal Dominant Hearing Impairment (DFNA4) | journal = Am J Hum Genet | volume = 74 | issue = 4 | pages = 770–6 |date=Mar 2004 | pmid = 15015131 | pmc = 1181955 | doi = 10.1086/383285 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: MYH14 myosin, heavy chain 14| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79784| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Myosin, heavy chain 14
| HGNCid = 23212
| Symbol = MYH14
| AltSymbols =; DFNA4; DKFZp667A1311; FLJ13881; FLJ43092; FP17425; KIAA2034; NMHC-II-C
  | OMIM = 608568
| ECnumber = 
| Homologene = 23480
| MGIid = 1919210
| GeneAtlas_image1 = PBB_GE_MYH14_217545_at_tn.png
  | GeneAtlas_image2 = PBB_GE_MYH14_217660_at_tn.png
| GeneAtlas_image3 = PBB_GE_MYH14_219946_x_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003774 |text = motor activity}} {{GNF_GO|id=GO:0003779 |text = actin binding}} {{GNF_GO|id=GO:0005516 |text = calmodulin binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}}
| Component = {{GNF_GO|id=GO:0016459 |text = myosin complex}}
| Process = {{GNF_GO|id=GO:0007605 |text = sensory perception of sound}} {{GNF_GO|id=GO:0008360 |text = regulation of cell shape}}  
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 79784
    | Hs_Ensembl = ENSG00000105357
    | Hs_RefseqProtein = NP_001070654
    | Hs_RefseqmRNA = NM_001077186
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 55398697
    | Hs_GenLoc_end = 55505610
    | Hs_Uniprot = Q7Z406
    | Mm_EntrezGene = 71960
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = NM_028021
    | Mm_RefseqProtein = NP_082297
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Myosin, heavy chain 14''', also known as '''MYH14''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: MYH14 myosin, heavy chain 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79784| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the myosin superfamily. Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: MYH14 myosin, heavy chain 14| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79784| accessdate = }}</ref>
| summary_text = This gene encodes a member of the [[myosin]] [[Protein superfamily|superfamily]]. Myosins are [[actin]]-dependent [[motor protein]]s with diverse functions, including regulation of [[cytokinesis]], [[cell motility]], and [[cell polarity]]. [[Mutation]]s in this gene result in one form of [[autosomal dominant]] [[hearing impairment]]. Multiple [[genetic transcription|transcript]] variants encoding different [[isoform]]s have been found for this gene.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Chen AH, Ni L, Fukushima K, ''et al.'' |title=Linkage of a gene for dominant non-syndromic deafness to chromosome 19. |journal=Hum. Mol. Genet. |volume=4 |issue= 6 |pages= 1073-6 |year= 1995 |pmid= 7655461 |doi=  }}
*{{cite journal   |vauthors=Chen AH, Ni L, Fukushima K, etal |title=Linkage of a gene for dominant non-syndromic deafness to chromosome 19 |journal=Hum. Mol. Genet. |volume=4 |issue= 6 |pages= 1073–6 |year= 1995 |pmid= 7655461 |doi=10.1093/hmg/4.6.1073 }}
*{{cite journal | author=Shoeman RL, Sachse C, Höner B, ''et al.'' |title=Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin. |journal=Am. J. Pathol. |volume=142 |issue= 1 |pages= 221-30 |year= 1993 |pmid= 8424456 |doi=  }}
*{{cite journal   |vauthors=Shoeman RL, Sachse C, Höner B, etal |title=Cleavage of human and mouse cytoskeletal and sarcomeric proteins by human immunodeficiency virus type 1 protease. Actin, desmin, myosin, and tropomyosin |journal=Am. J. Pathol. |volume=142 |issue= 1 |pages= 221–30 |year= 1993 |pmid= 8424456 |doi= | pmc=1886840 }}
*{{cite journal | author=Xu XR, Huang J, Xu ZG, ''et al.'' |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089-94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398 }}
*{{cite journal   |vauthors=Xu XR, Huang J, Xu ZG, etal |title=Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 26 |pages= 15089–94 |year= 2002 |pmid= 11752456 |doi= 10.1073/pnas.241522398 | pmc=64988 }}
*{{cite journal | author=Desjardins PR, Burkman JM, Shrager JB, ''et al.'' |title=Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family. |journal=Mol. Biol. Evol. |volume=19 |issue= 4 |pages= 375-93 |year= 2002 |pmid= 11919279 |doi=  }}
*{{cite journal   |vauthors=Desjardins PR, Burkman JM, Shrager JB, etal |title=Evolutionary implications of three novel members of the human sarcomeric myosin heavy chain gene family |journal=Mol. Biol. Evol. |volume=19 |issue= 4 |pages= 375–93 |year= 2002 |pmid= 11919279 |doi=  10.1093/oxfordjournals.molbev.a004093}}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
*{{cite journal | author=Leal A, Endele S, Stengel C, ''et al.'' |title=A novel myosin heavy chain gene in human chromosome 19q13.3. |journal=Gene |volume=312 |issue=  |pages= 165-71 |year= 2003 |pmid= 12909352 |doi=  }}
*{{cite journal   |vauthors=Golomb E, Ma X, Jana SS, etal |title=Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family |journal=J. Biol. Chem. |volume=279 |issue= 4 |pages= 2800–8 |year= 2004 |pmid= 14594953 |doi= 10.1074/jbc.M309981200 }}
*{{cite journal | author=Golomb E, Ma X, Jana SS, ''et al.'' |title=Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family. |journal=J. Biol. Chem. |volume=279 |issue= 4 |pages= 2800-8 |year= 2004 |pmid= 14594953 |doi= 10.1074/jbc.M309981200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Bouwmeester T, Bauch A, Ruffner H, etal |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97–105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal | author=Bouwmeester T, Bauch A, Ruffner H, ''et al.'' |title=A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. |journal=Nat. Cell Biol. |volume=6 |issue= 2 |pages= 97-105 |year= 2004 |pmid= 14743216 |doi= 10.1038/ncb1086 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Donaudy F, Snoeckx R, Pfister M, ''et al.'' |title=Nonmuscle myosin heavy-chain gene MYH14 is expressed in cochlea and mutated in patients affected by autosomal dominant hearing impairment (DFNA4). |journal=Am. J. Hum. Genet. |volume=74 |issue= 4 |pages= 770-6 |year= 2004 |pmid= 15015131 |doi= 10.1086/383285 }}
*{{cite journal   |vauthors=Wan D, Gong Y, Qin W, etal |title=Large-scale cDNA transfection screening for genes related to cancer development and progression |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724–9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101 | pmc=524842 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Kim KY, Kovács M, Kawamoto S, etal |title=Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C |journal=J. Biol. Chem. |volume=280 |issue= 24 |pages= 22769–75 |year= 2005 |pmid= 15845534 |doi= 10.1074/jbc.M503488200 }}
*{{cite journal | author=Wan D, Gong Y, Qin W, ''et al.'' |title=Large-scale cDNA transfection screening for genes related to cancer development and progression. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 44 |pages= 15724-9 |year= 2004 |pmid= 15498874 |doi= 10.1073/pnas.0404089101 }}
*{{cite journal   |vauthors=Lim J, Hao T, Shaw C, etal |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
*{{cite journal | author=Kim KY, Kovács M, Kawamoto S, ''et al.'' |title=Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C. |journal=J. Biol. Chem. |volume=280 |issue= 24 |pages= 22769-75 |year= 2005 |pmid= 15845534 |doi= 10.1074/jbc.M503488200 }}
*{{cite journal | author=Lim J, Hao T, Shaw C, ''et al.'' |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801-14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* [https://www.ncbi.nlm.nih.gov/books/NBK1434/  GeneReviews/NCBI/NIH/UW entry on Deafness and Hereditary Hearing Loss Overview]
 
{{Cytoskeletal Proteins}}
 
<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{PBB_Controls
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}
 
 
{{gene-19-stub}}

Latest revision as of 09:46, 30 August 2018

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Myosin-14 is a protein that in humans is encoded by the MYH14 gene.[1][2][3]

This gene encodes a member of the myosin superfamily. Myosins are actin-dependent motor proteins with diverse functions, including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene.[3]

References

  1. ↑ Leal A, Endele S, Stengel C, Huehne K, Loetterle J, Barrantes R, Winterpacht A, Rautenstrauss B (Aug 2003). "A novel myosin heavy chain gene in human chromosome 19q13.3". Gene. 312: 165–71. doi:10.1016/S0378-1119(03)00613-9. PMID 12909352.
  2. ↑ Donaudy F, Snoeckx R, Pfister M, Zenner HP, Blin N, Di Stazio M, Ferrara A, Lanzara C, Ficarella R, Declau F, Pusch CM, Nurnberg P, Melchionda S, Zelante L, Ballana E, Estivill X, Van Camp G, Gasparini P, Savoia A (Mar 2004). "Nonmuscle Myosin Heavy-Chain Gene MYH14 Is Expressed in Cochlea and Mutated in Patients Affected by Autosomal Dominant Hearing Impairment (DFNA4)". Am J Hum Genet. 74 (4): 770–6. doi:10.1086/383285. PMC 1181955. PMID 15015131.
  3. ↑ 3.0 3.1 "Entrez Gene: MYH14 myosin, heavy chain 14".

Further reading

External links



Retrieved from "https://www.wikidoc.org/index.php?title=MYH14&oldid=1529889"