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{{Infobox_gene}}
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'''Protein kinase C gamma type''' is an [[enzyme]] that in humans is encoded by the ''PRKCG'' [[gene]].<ref name="pmid8432525">{{cite journal |vauthors=Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A | title = Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers | journal = Genomics | volume = 15 | issue = 1 | pages = 133–45 |date=Mar 1993 | pmid = 8432525 | pmc =  | doi =10.1006/geno.1993.1021 |display-authors=etal}}</ref><ref name="pmid3755548">{{cite journal |vauthors=Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A | title = Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways | journal = Science | volume = 233 | issue = 4766 | pages = 859–66 |date=Sep 1986 | pmid = 3755548 | pmc =  | doi =10.1126/science.3755548 | bibcode =1986Sci...233..859C }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_PRKCG_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1tbn.
| PDB = {{PDB2|1tbn}}, {{PDB2|1tbo}}, {{PDB2|2uzp}}
| Name = Protein kinase C, gamma
| HGNCid = 9402
| Symbol = PRKCG
| AltSymbols =; MGC57564; PKC-gamma; PKCC; PKCG; SCA14
| OMIM = 176980
| ECnumber =
| Homologene = 20602
| MGIid =
  | GeneAtlas_image1 = PBB_GE_PRKCG_206270_at_tn.png
  | Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0004697 |text = protein kinase C activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}} {{GNF_GO|id=GO:0016740 |text = transferase activity}} {{GNF_GO|id=GO:0019992 |text = diacylglycerol binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006468 |text = protein amino acid phosphorylation}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0008219 |text = cell death}} {{GNF_GO|id=GO:0031397 |text = negative regulation of protein ubiquitination}} {{GNF_GO|id=GO:0032425 |text = positive regulation of mismatch repair}} {{GNF_GO|id=GO:0042177 |text = negative regulation of protein catabolic process}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5582
    | Hs_Ensembl = ENSG00000126583
    | Hs_RefseqProtein = NP_002730
    | Hs_RefseqmRNA = NM_002739
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 19
    | Hs_GenLoc_start = 59077279
    | Hs_GenLoc_end = 59102713
    | Hs_Uniprot = P05129
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
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}}
'''Protein kinase C, gamma''', also known as '''PRKCG''', is a human [[gene]].


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{{PBB_Summary
{{PBB Summary
| section_title =  
| section_title =  
| summary_text = Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).<ref>{{cite web | title = Entrez Gene: PRKCG protein kinase C, gamma| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5582| accessdate = }}</ref>
| summary_text = Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).<ref>{{cite web | title = Entrez Gene: PRKCG protein kinase C, gamma| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5582| accessdate = }}</ref>
}}
}}
==Interactions==
PRKCG has been shown to [[Protein-protein interaction|interact]] with [[GRIA4]].<ref name=pmid12471040>{{cite journal |last=Correia |first=Susana Santos |authorlink= |author2=Duarte Carlos Bandeira |author3=Faro Carlos José |author4=Pires Euclides Vieira |author5=Carvalho Ana Luísa  |date=Feb 2003 |title=Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation |journal=J. Biol. Chem. |volume=278 |issue=8 |pages=6307–13 |publisher= |location = United States| issn = 0021-9258| pmid = 12471040 |doi = 10.1074/jbc.M205587200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref>
==See also==
==See also==
*[[Protein kinase C]]
*[[Protein kinase C]]


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Ali A, Hoeflich KP, Woodgett JR |title=Glycogen synthase kinase-3: properties, functions, and regulation. |journal=Chem. Rev. |volume=101 |issue= 8 |pages= 2527-40 |year= 2002 |pmid= 11749387 |doi=  }}
*{{cite journal  |vauthors=Ali A, Hoeflich KP, Woodgett JR |title=Glycogen synthase kinase-3: properties, functions, and regulation. |journal=Chem. Rev. |volume=101 |issue= 8 |pages= 2527–40 |year= 2002 |pmid= 11749387 |doi=10.1021/cr000110o }}
*{{cite journal  | author=Slater SJ, Ho C, Stubbs CD |title=The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions. |journal=Chem. Phys. Lipids |volume=116 |issue= 1-2 |pages= 75-91 |year= 2003 |pmid= 12093536 |doi=  }}
*{{cite journal  |vauthors=Slater SJ, Ho C, Stubbs CD |title=The use of fluorescent phorbol esters in studies of protein kinase C-membrane interactions. |journal=Chem. Phys. Lipids |volume=116 |issue= 1–2 |pages= 75–91 |year= 2003 |pmid= 12093536 |doi=10.1016/S0009-3084(02)00021-X }}
*{{cite journal  | author=Saito N, Shirai Y |title=Protein kinase C gamma (PKC gamma): function of neuron specific isotype. |journal=J. Biochem. |volume=132 |issue= 5 |pages= 683-7 |year= 2003 |pmid= 12417016 |doi=  }}
*{{cite journal  |vauthors=Saito N, Shirai Y |title=Protein kinase C gamma (PKC gamma): function of neuron specific isotype |journal=J. Biochem. |volume=132 |issue= 5 |pages= 683–7 |year= 2003 |pmid= 12417016 |doi=  10.1093/oxfordjournals.jbchem.a003274}}
}}
}}
{{refend}}
{{refend}}
==External links==
* [https://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part=sca14  GeneReviews/NCBI/NIH/UW entry on Spinocerebellar Ataxia Type 14]
{{PDB Gallery|geneid=5582}}
{{Serine/threonine-specific protein kinases}}
{{Enzymes}}
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Latest revision as of 19:51, 25 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Protein kinase C gamma type is an enzyme that in humans is encoded by the PRKCG gene.[1][2]

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons. It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase. Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development. Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).[3]

Interactions

PRKCG has been shown to interact with GRIA4.[4]

See also

References

  1. ↑ Trask B, Fertitta A, Christensen M, Youngblom J, Bergmann A, Copeland A, de Jong P, Mohrenweiser H, Olsen A, Carrano A, et al. (Mar 1993). "Fluorescence in situ hybridization mapping of human chromosome 19: cytogenetic band location of 540 cosmids and 70 genes or DNA markers". Genomics. 15 (1): 133–45. doi:10.1006/geno.1993.1021. PMID 8432525.
  2. ↑ Coussens L, Parker PJ, Rhee L, Yang-Feng TL, Chen E, Waterfield MD, Francke U, Ullrich A (Sep 1986). "Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways". Science. 233 (4766): 859–66. Bibcode:1986Sci...233..859C. doi:10.1126/science.3755548. PMID 3755548.
  3. ↑ "Entrez Gene: PRKCG protein kinase C, gamma".
  4. ↑ Correia, Susana Santos; Duarte Carlos Bandeira; Faro Carlos José; Pires Euclides Vieira; Carvalho Ana Luísa (Feb 2003). "Protein kinase C gamma associates directly with the GluR4 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor subunit. Effect on receptor phosphorylation". J. Biol. Chem. United States. 278 (8): 6307–13. doi:10.1074/jbc.M205587200. ISSN 0021-9258. PMID 12471040.

Further reading

External links


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