SEC23A: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''Sec23 homolog A (S. cerevisiae)''', also known as '''SEC23A''', is a [[protein]] which in humans is encoded by the ''SEC23A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SEC23A Sec23 homolog A (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10484| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_SEC23A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2nup.
| PDB = {{PDB2|2nup}}, {{PDB2|2nut}}
| Name = Sec23 homolog A (S. cerevisiae)
| HGNCid = 10701
| Symbol = SEC23A
| AltSymbols =; CLSD; MGC26267
| OMIM = 610511
| ECnumber = 
| Homologene = 4642
| MGIid = 1349635
| GeneAtlas_image1 = PBB_GE_SEC23A_204344_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SEC23A_212887_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008270 |text = zinc ion binding}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005783 |text = endoplasmic reticulum}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0030127 |text = COPII vesicle coat}} {{GNF_GO|id=GO:0048471 |text = perinuclear region of cytoplasm}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006888 |text = ER to Golgi vesicle-mediated transport}} {{GNF_GO|id=GO:0016192 |text = vesicle-mediated transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10484
    | Hs_Ensembl = ENSG00000100934
    | Hs_RefseqProtein = NP_006355
    | Hs_RefseqmRNA = NM_006364
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 38570874
    | Hs_GenLoc_end = 38642190
    | Hs_Uniprot = Q15436
    | Mm_EntrezGene = 20334
    | Mm_Ensembl = ENSMUSG00000020986
    | Mm_RefseqmRNA = NM_009147
    | Mm_RefseqProtein = NP_033173
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 12
    | Mm_GenLoc_start = 59876396
    | Mm_GenLoc_end = 59930029
    | Mm_Uniprot = Q8C1E4
  }}
}}
'''Sec23 homolog A (S. cerevisiae)''', also known as '''SEC23A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SEC23A Sec23 homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10484| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It contains a [[gelsolin]] domain.<ref>{{Cite journal
{{PBB_Summary
| pmid = 24155256
| section_title =
| year = 2013
| summary_text = The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.<ref name="entrez">{{cite web | title = Entrez Gene: SEC23A Sec23 homolog A (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10484| accessdate = }}</ref>
| author1 = Ghoshdastider
}}
| first1 = U
| title = The expanding superfamily of gelsolin homology domain proteins
| journal = Cytoskeleton
| volume = 70
| issue = 11
| pages = 775–95
| last2 = Popp
| first2 = D
| last3 = Burtnick
| first3 = L. D.
| last4 = Robinson
| first4 = R. C.
| doi = 10.1002/cm.21149
}}</ref> It is part of a protein complex and found in the [[ribosome]]-free transitional face of the [[endoplasmic reticulum]] (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of [[COPII]]. COPII is the coat protein complex responsible for [[vesicle (biology)|vesicle]] budding from the ER. The encoded protein is suggested to play a role in the ER-[[Golgi apparatus|Golgi]] protein trafficking.<ref name="entrez"/>


==References==
SEC23 interacts with both [[SEC16A]] and [[SEC16B]].{{Citation needed|date=July 2009}}
{{reflist|2}}
 
==Further reading==
== Interactions ==
 
SEC23A has been shown to [[Protein-protein interaction|interact]] with [[SEC24C]],<ref name=pmid10075675>{{cite journal | vauthors = Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP | title = Sec24 proteins and sorting at the endoplasmic reticulum | journal = J. Biol. Chem. | volume = 274 | issue = 12 | pages = 7833–40  | date = Mar 1999 | pmid = 10075675 | doi = 10.1074/jbc.274.12.7833 }}</ref> [[Sec16A]]/p250 and iPLA<sub>1</sub>β/p125.<ref>p125 is localized in endoplasmic reticulum exit sites and involved in their organization.</ref>
 
Sec23 has also been shown to [[Protein-protein interaction|interact]] with TRAPPⅠ, Grh1p also known as GRASP65 and Dynactin. Because they are involved in anterograde vesicle transport from ER to Golgi, Sec23 is involved in vesicle transport.<ref>Coordination of COPII vesicle trafficking by Sec23.</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Paccaud JP, Reith W, Carpentier JL, Ravazzola M, Amherdt M, Schekman R, Orci L | title = Cloning and functional characterization of mammalian homologues of the COPII component Sec23 | journal = Mol. Biol. Cell | volume = 7 | issue = 10 | pages = 1535–46 | year = 1996 | pmid = 8898360 | pmc = 276004 | doi = 10.1091/mbc.7.10.1535 }}
| citations =
* {{cite journal | vauthors = Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP | title = Sec24 proteins and sorting at the endoplasmic reticulum | journal = J. Biol. Chem. | volume = 274 | issue = 12 | pages = 7833–40 | year = 1999 | pmid = 10075675 | doi = 10.1074/jbc.274.12.7833 }}
*{{cite journal | author=Paccaud JP, Reith W, Carpentier JL, ''et al.'' |title=Cloning and functional characterization of mammalian homologues of the COPII component Sec23. |journal=Mol. Biol. Cell |volume=7 |issue= 10 |pages= 1535-46 |year= 1997 |pmid= 8898360 |doi= }}
* {{cite journal | vauthors = Tang BL, Kausalya J, Low DY, Lock ML, Hong W | title = A family of mammalian proteins homologous to yeast Sec24p | journal = Biochem. Biophys. Res. Commun. | volume = 258 | issue = 3 | pages = 679–84 | year = 1999 | pmid = 10329445 | doi = 10.1006/bbrc.1999.0574 }}
*{{cite journal | author=Pagano A, Letourneur F, Garcia-Estefania D, ''et al.'' |title=Sec24 proteins and sorting at the endoplasmic reticulum. |journal=J. Biol. Chem. |volume=274 |issue= 12 |pages= 7833-40 |year= 1999 |pmid= 10075675 |doi= }}
* {{cite journal | vauthors = Boyadjiev SA, Justice CM, Eyaid W, McKusick VA, Lachman RS, Chowdry AB, Jabak M, Zwaan J, Wilson AF, Jabs EW | title = A novel dysmorphic syndrome with open calvarial sutures and sutural cataracts maps to chromosome 14q13-q21 | journal = Hum. Genet. | volume = 113 | issue = 1 | pages = 1–9 | year = 2003 | pmid = 12677423 | doi = 10.1007/s00439-003-0932-6 }}
*{{cite journal | author=Tang BL, Kausalya J, Low DY, ''et al.'' |title=A family of mammalian proteins homologous to yeast Sec24p. |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 3 |pages= 679-84 |year= 1999 |pmid= 10329445 |doi= 10.1006/bbrc.1999.0574 }}
* {{cite journal | vauthors = Dudognon P, Maeder-Garavaglia C, Carpentier JL, Paccaud JP | title = Regulation of a COPII component by cytosolic O-glycosylation during mitosis | journal = FEBS Lett. | volume = 561 | issue = 1-3 | pages = 44–50 | year = 2004 | pmid = 15013749 | doi = 10.1016/S0014-5793(04)00109-7 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Watson P, Forster R, Palmer KJ, Pepperkok R, Stephens DJ | title = Coupling of ER exit to microtubules through direct interaction of COPII with dynactin | journal = Nat. Cell Biol. | volume = 7 | issue = 1 | pages = 48–55 | year = 2005 | pmid = 15580264 | pmc = 1592520 | doi = 10.1038/ncb1206 }}
*{{cite journal  | author=Heilig R, Eckenberg R, Petit JL, ''et al.'' |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601-7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
* {{cite journal | vauthors = Palmer KJ, Konkel JE, Stephens DJ | title = PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport | journal = J. Cell Sci. | volume = 118 | issue = Pt 17 | pages = 3839–47 | year = 2005 | pmid = 16091426 | doi = 10.1242/jcs.02496 }}
*{{cite journal  | author=Boyadjiev SA, Justice CM, Eyaid W, ''et al.'' |title=A novel dysmorphic syndrome with open calvarial sutures and sutural cataracts maps to chromosome 14q13-q21. |journal=Hum. Genet. |volume=113 |issue= 1 |pages= 1-9 |year= 2003 |pmid= 12677423 |doi= 10.1007/s00439-003-0932-6 }}
* {{cite journal | vauthors = Boyadjiev SA, Fromme JC, Ben J, Chong SS, Nauta C, Hur DJ, Zhang G, Hamamoto S, Schekman R, Ravazzola M, Orci L, Eyaid W | title = Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking | journal = Nat. Genet. | volume = 38 | issue = 10 | pages = 1192–7 | year = 2006 | pmid = 16980979 | doi = 10.1038/ng1876 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Tu LC, Yan X, Hood L, Lin B | title = Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells | journal = Mol. Cell. Proteomics | volume = 6 | issue = 4 | pages = 575–88 | year = 2007 | pmid = 17220478 | doi = 10.1074/mcp.M600249-MCP200 }}
*{{cite journal  | author=Dudognon P, Maeder-Garavaglia C, Carpentier JL, Paccaud JP |title=Regulation of a COPII component by cytosolic O-glycosylation during mitosis. |journal=FEBS Lett. |volume=561 |issue= 1-3 |pages= 44-50 |year= 2004 |pmid= 15013749 |doi= 10.1016/S0014-5793(04)00109-7 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Watson P, Forster R, Palmer KJ, ''et al.'' |title=Coupling of ER exit to microtubules through direct interaction of COPII with dynactin. |journal=Nat. Cell Biol. |volume=7 |issue= 1 |pages= 48-55 |year= 2005 |pmid= 15580264 |doi= 10.1038/ncb1206 }}
*{{cite journal | author=Palmer KJ, Konkel JE, Stephens DJ |title=PCTAIRE protein kinases interact directly with the COPII complex and modulate secretory cargo transport. |journal=J. Cell. Sci. |volume=118 |issue= Pt 17 |pages= 3839-47 |year= 2005 |pmid= 16091426 |doi= 10.1242/jcs.02496 }}
*{{cite journal | author=Boyadjiev SA, Fromme JC, Ben J, ''et al.'' |title=Cranio-lenticulo-sutural dysplasia is caused by a SEC23A mutation leading to abnormal endoplasmic-reticulum-to-Golgi trafficking. |journal=Nat. Genet. |volume=38 |issue= 10 |pages= 1192-7 |year= 2006 |pmid= 16980979 |doi= 10.1038/ng1876 }}
*{{cite journal | author=Tu LC, Yan X, Hood L, Lin B |title=Proteomics analysis of the interactome of N-myc downstream regulated gene 1 and its interactions with the androgen response program in prostate cancer cells. |journal=Mol. Cell Proteomics |volume=6 |issue= 4 |pages= 575-88 |year= 2007 |pmid= 17220478 |doi= 10.1074/mcp.M600249-MCP200 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=10484}}
{{Vesicular transport proteins}}


{{protein-stub}}
{{gene-14-stub}}
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Latest revision as of 20:49, 8 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sec23 homolog A (S. cerevisiae), also known as SEC23A, is a protein which in humans is encoded by the SEC23A gene.[1]

Function

The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It contains a gelsolin domain.[2] It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking.[1]

SEC23 interacts with both SEC16A and SEC16B.[citation needed]

Interactions

SEC23A has been shown to interact with SEC24C,[3] Sec16A/p250 and iPLA1β/p125.[4]

Sec23 has also been shown to interact with TRAPPⅠ, Grh1p also known as GRASP65 and Dynactin. Because they are involved in anterograde vesicle transport from ER to Golgi, Sec23 is involved in vesicle transport.[5]

References

  1. ↑ 1.0 1.1 "Entrez Gene: SEC23A Sec23 homolog A (S. cerevisiae)".
  2. ↑ Ghoshdastider, U; Popp, D; Burtnick, L. D.; Robinson, R. C. (2013). "The expanding superfamily of gelsolin homology domain proteins". Cytoskeleton. 70 (11): 775–95. doi:10.1002/cm.21149. PMID 24155256.
  3. ↑ Pagano A, Letourneur F, Garcia-Estefania D, Carpentier JL, Orci L, Paccaud JP (Mar 1999). "Sec24 proteins and sorting at the endoplasmic reticulum". J. Biol. Chem. 274 (12): 7833–40. doi:10.1074/jbc.274.12.7833. PMID 10075675.
  4. ↑ p125 is localized in endoplasmic reticulum exit sites and involved in their organization.
  5. ↑ Coordination of COPII vesicle trafficking by Sec23.

Further reading


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