SLC34A2: Difference between revisions

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Latest revision as of 21:51, 7 October 2017

Sodium-dependent phosphate transport protein 2B (NaPi2b) is a protein that in humans is encoded by the SLC34A2 gene.^[1]^[2]^[3]

Clinical significance

Sodium-dependent phosphate transport protein 2b (NaPi2b) is a tumor-associated antigen.^[4]

References

↑ Feild JA, Zhang L, Brun KA, Brooks DP, Edwards RM (Jun 1999). "Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine". Biochem Biophys Res Commun. 258 (3): 578–82. doi:10.1006/bbrc.1999.0666. PMID 10329428.
↑ Xu H, Bai L, Collins JF, Ghishan FK (Feb 2000). "Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)". Genomics. 62 (2): 281–4. doi:10.1006/geno.1999.6009. PMID 10610722.
↑ "Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2".
↑ Yin BW, Kiyamova R, Chua R, Caballero OL, Gout I, Gryshkova V, Bhaskaran N, Souchelnytskyi S, Hellman U, Filonenko V, Jungbluth AA, Odunsi K, Lloyd KO, Old LJ, Ritter G. "Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas". Cancer Immun. 8: 3. PMC 2935786. PMID 18251464.

Xu H, Collins JF, Bai L, et al. (2001). "Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb gene promoter by epidermal growth factor". Am. J. Physiol., Cell Physiol. 280 (3): C628–36. PMID 11171583.
Segawa H, Kaneko I, Takahashi A, et al. (2002). "Growth-related renal type II Na/Pi cotransporter". J. Biol. Chem. 277 (22): 19665–72. doi:10.1074/jbc.M200943200. PMID 11880379.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Xu H, Uno JK, Inouye M, et al. (2005). "NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene". Am. J. Physiol. Gastrointest. Liver Physiol. 288 (2): G175–81. doi:10.1152/ajpgi.00396.2004. PMID 15458926.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Corut A, Senyigit A, Ugur SA, et al. (2006). "Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis". Am. J. Hum. Genet. 79 (4): 650–6. doi:10.1086/508263. PMC 1592565. PMID 16960801.
Huqun, Izumi S, Miyazawa H, et al. (2007). "Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis". Am. J. Respir. Crit. Care Med. 175 (3): 263–8. doi:10.1164/rccm.200609-1274OC. PMID 17095743.

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[pmid10329428-1] Feild JA, Zhang L, Brun KA, Brooks DP, Edwards RM (Jun 1999). "Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine". Biochem Biophys Res Commun. 258 (3): 578–82. doi:10.1006/bbrc.1999.0666. PMID 10329428.

[pmid10610722-2] Xu H, Bai L, Collins JF, Ghishan FK (Feb 2000). "Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2)". Genomics. 62 (2): 281–4. doi:10.1006/geno.1999.6009. PMID 10610722.

[entrez-3] "Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2".

[4] Yin BW, Kiyamova R, Chua R, Caballero OL, Gout I, Gryshkova V, Bhaskaran N, Souchelnytskyi S, Hellman U, Filonenko V, Jungbluth AA, Odunsi K, Lloyd KO, Old LJ, Ritter G. "Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas". Cancer Immun. 8: 3. PMC 2935786. PMID 18251464.

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[2]

[3]

[4]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Sodium-dependent phosphate transport protein 2B''' (NaPi2b) is a [[protein]] that in humans is encoded by the ''SLC34A2'' [[gene]].<ref name="pmid10329428">{{cite journal | vauthors = Feild JA, Zhang L, Brun KA, Brooks DP, Edwards RM | title = Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine | journal = Biochem Biophys Res Commun | volume = 258 | issue = 3 | pages = 578–82 |date=Jun 1999 | pmid = 10329428 | pmc =  | doi = 10.1006/bbrc.1999.0666 }}</ref><ref name="pmid10610722">{{cite journal | vauthors = Xu H, Bai L, Collins JF, Ghishan FK | title = Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2) | journal = Genomics | volume = 62 | issue = 2 | pages = 281–4 |date=Feb 2000 | pmid = 10610722 | pmc =  | doi = 10.1006/geno.1999.6009 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10568| accessdate = }}</ref>
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-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 34 (sodium phosphate), member 2
- | HGNCid = 11020
- | Symbol = SLC34A2
- | AltSymbols =; FLJ90534; NAPI-3B; NAPI-IIb; NPTIIb
- | OMIM = 604217
- | ECnumber =
- | Homologene = 2297
- | MGIid = 1342284
- | GeneAtlas_image1 = PBB_GE_SLC34A2_204124_at_tn.png
- | Function = {{GNF_GO|id=GO:0015293 |text = symporter activity}} {{GNF_GO|id=GO:0015321 |text = sodium-dependent phosphate transmembrane transporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
- | Component = {{GNF_GO|id=GO:0005624 |text = membrane fraction}} {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016324 |text = apical plasma membrane}}
-  | Process = {{GNF_GO|id=GO:0006796 |text = phosphate metabolic process}} {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006817 |text = phosphate transport}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 10568
-    | Hs_Ensembl = ENSG00000157765
-    | Hs_RefseqProtein = NP_006415
-    | Hs_RefseqmRNA = NM_006424
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 4
-    | Hs_GenLoc_start = 25266564
-    | Hs_GenLoc_end = 25289468
-    | Hs_Uniprot = O95436
-    | Mm_EntrezGene = 20531
-    | Mm_Ensembl = ENSMUSG00000029188
-    | Mm_RefseqmRNA = NM_011402
-    | Mm_RefseqProtein = NP_035532
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 53337605
-    | Mm_GenLoc_end = 53359912
-    | Mm_Uniprot = Q9DBP0
-  }}
-}}
-'''Solute carrier family 34 (sodium phosphate), member 2''', also known as '''SLC34A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC34A2 solute carrier family 34 (sodium phosphate), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10568| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
 {{PBB_Summary
@@ Line 53: / Line 6: @@
 | summary_text =
 }}
+==Clinical significance==
+Sodium-dependent phosphate transport protein 2b (NaPi2b) is a [[tumor-associated antigen]].<ref>{{cite journal | pmc = 2935786 | pmid=18251464 | volume=8 | title=Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas | journal=Cancer Immun | pages=3 | vauthors=Yin BW, Kiyamova R, Chua R, Caballero OL, Gout I, Gryshkova V, Bhaskaran N, Souchelnytskyi S, Hellman U, Filonenko V, Jungbluth AA, Odunsi K, Lloyd KO, Old LJ, Ritter G}}</ref>
 ==See also==
 * [[Solute carrier family]]
+* [[Pulmonary alveolar microlithiasis]]
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 64: / Line 20: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Feild JA, Zhang L, Brun KA, ''et al.'' |title=Cloning and functional characterization of a sodium-dependent phosphate transporter expressed in human lung and small intestine. |journal=Biochem. Biophys. Res. Commun. |volume=258 |issue= 3 |pages= 578-82 |year= 1999 |pmid= 10329428 |doi= 10.1006/bbrc.1999.0666 }}
+*{{cite journal   |vauthors=Xu H, Collins JF, Bai L, etal |title=Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb gene promoter by epidermal growth factor. |journal=Am. J. Physiol., Cell Physiol. |volume=280 |issue= 3 |pages= C628–36 |year= 2001 |pmid= 11171583 |doi=  }}
-*{{cite journal  | author=Xu H, Bai L, Collins JF, Ghishan FK |title=Molecular cloning, functional characterization, tissue distribution, and chromosomal localization of a human, small intestinal sodium-phosphate (Na+-Pi) transporter (SLC34A2). |journal=Genomics |volume=62 |issue= 2 |pages= 281-4 |year= 2000 |pmid= 10610722 |doi= 10.1006/geno.1999.6009 }}
+*{{cite journal   |vauthors=Segawa H, Kaneko I, Takahashi A, etal |title=Growth-related renal type II Na/Pi cotransporter. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19665–72 |year= 2002 |pmid= 11880379 |doi= 10.1074/jbc.M200943200 }}
-*{{cite journal  | author=Xu H, Collins JF, Bai L, ''et al.'' |title=Regulation of the human sodium-phosphate cotransporter NaP(i)-IIb gene promoter by epidermal growth factor. |journal=Am. J. Physiol., Cell Physiol. |volume=280 |issue= 3 |pages= C628-36 |year= 2001 |pmid= 11171583 |doi=  }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Segawa H, Kaneko I, Takahashi A, ''et al.'' |title=Growth-related renal type II Na/Pi cotransporter. |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19665-72 |year= 2002 |pmid= 11880379 |doi= 10.1074/jbc.M200943200 }}
+*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Xu H, Uno JK, Inouye M, etal |title=NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=288 |issue= 2 |pages= G175–81 |year= 2005 |pmid= 15458926 |doi= 10.1152/ajpgi.00396.2004 }}
-*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
+*{{cite journal   |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
-*{{cite journal  | author=Xu H, Uno JK, Inouye M, ''et al.'' |title=NF1 transcriptional factor(s) is required for basal promoter activation of the human intestinal NaPi-IIb cotransporter gene. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=288 |issue= 2 |pages= G175-81 |year= 2005 |pmid= 15458926 |doi= 10.1152/ajpgi.00396.2004 }}
+*{{cite journal   |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406  | pmc=1356129 }}
-*{{cite journal  | author=Otsuki T, Ota T, Nishikawa T, ''et al.'' |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. |journal=DNA Res. |volume=12 |issue= 2 |pages= 117-26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
+*{{cite journal   |vauthors=Corut A, Senyigit A, Ugur SA, etal |title=Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis. |journal=Am. J. Hum. Genet. |volume=79 |issue= 4 |pages= 650–6 |year= 2006 |pmid= 16960801 |doi= 10.1086/508263  | pmc=1592565 }}
-*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
+*{{cite journal  | vauthors=((Huqun)), Izumi S, Miyazawa H, et al.|title=Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. |journal=Am. J. Respir. Crit. Care Med. |volume=175 |issue= 3 |pages= 263–8 |year= 2007 |pmid= 17095743 |doi= 10.1164/rccm.200609-1274OC |display-authors=etal}}
-*{{cite journal  | author=Corut A, Senyigit A, Ugur SA, ''et al.'' |title=Mutations in SLC34A2 cause pulmonary alveolar microlithiasis and are possibly associated with testicular microlithiasis. |journal=Am. J. Hum. Genet. |volume=79 |issue= 4 |pages= 650-6 |year= 2006 |pmid= 16960801 |doi= 10.1086/508263 }}
-*{{cite journal  | author=Huqun , Izumi S, Miyazawa H, ''et al.'' |title=Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis. |journal=Am. J. Respir. Crit. Care Med. |volume=175 |issue= 3 |pages= 263-8 |year= 2007 |pmid= 17095743 |doi= 10.1164/rccm.200609-1274OC }}
 }}
 {{refend}}
-{{membrane-protein-stub}}
 {{Membrane transport proteins}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 [[Category:Solute carrier family]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

SLC34A2: Difference between revisions

Latest revision as of 21:51, 7 October 2017

Contents

Clinical significance

See also

References

Further reading

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