SLC35A2: Difference between revisions

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{{Infobox_gene}}
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'''UDP-galactose translocator''' is a [[protein]] that in humans is encoded by the ''SLC35A2'' [[gene]].<ref name="pmid8128316">{{cite journal | vauthors = Hara T, Yamauchi M, Takahashi E, Hoshino M, Aoki K, Ayusawa D, Kawakita M | title = The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus | journal = Somat Cell Mol Genet | volume = 19 | issue = 6 | pages = 571–5 |date=Apr 1994 | pmid = 8128316 | pmc =  | doi =10.1007/BF01233383 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7355| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Solute carrier family 35 (UDP-galactose transporter), member A2
| HGNCid = 11022
| Symbol = SLC35A2
| AltSymbols =; UGAT; UGALT; UGT; UGT1; UGT2; UGTL
| OMIM = 314375
| ECnumber = 
| Homologene = 38085
| MGIid = 1345297
| GeneAtlas_image1 = PBB_GE_SLC35A2_207439_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_SLC35A2_207440_at_tn.png
| GeneAtlas_image3 = PBB_GE_SLC35A2_209326_at_tn.png
| Function = {{GNF_GO|id=GO:0005338 |text = nucleotide-sugar transmembrane transporter activity}} {{GNF_GO|id=GO:0005351 |text = sugar:hydrogen ion symporter activity}} {{GNF_GO|id=GO:0005459 |text = UDP-galactose transmembrane transporter activity}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0006012 |text = galactose metabolic process}} {{GNF_GO|id=GO:0008643 |text = carbohydrate transport}} {{GNF_GO|id=GO:0015780 |text = nucleotide-sugar transport}} {{GNF_GO|id=GO:0015785 |text = UDP-galactose transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7355
    | Hs_Ensembl = ENSG00000102100
    | Hs_RefseqProtein = NP_001027460
    | Hs_RefseqmRNA = NM_001032289
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = X
    | Hs_GenLoc_start = 48645403
    | Hs_GenLoc_end = 48654179
    | Hs_Uniprot = P78381
    | Mm_EntrezGene = 22232
    | Mm_Ensembl = ENSMUSG00000031156
    | Mm_RefseqmRNA = NM_078484
    | Mm_RefseqProtein = NP_511039
    | Mm_GenLoc_db =   
    | Mm_GenLoc_chr = X
    | Mm_GenLoc_start = 7041203
    | Mm_GenLoc_end = 7051364
    | Mm_Uniprot = Q3U1S3
  }}
}}
'''Solute carrier family 35 (UDP-galactose transporter), member A2''', also known as '''SLC35A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7355| accessdate = }}</ref>


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
*{{cite journal  | vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Hara T, Yamauchi M, Takahashi E, ''et al.'' |title=The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus. |journal=Somat. Cell Mol. Genet. |volume=19 |issue= 6 |pages= 571-5 |year= 1994 |pmid= 8128316 |doi= }}
*{{cite journal   |vauthors=Miura N, Ishida N, Hoshino M, etal |title=Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator. |journal=J. Biochem. |volume=120 |issue= 2 |pages= 236–41 |year= 1997 |pmid= 8889805 |doi=  10.1093/oxfordjournals.jbchem.a021404}}
*{{cite journal | author=Miura N, Ishida N, Hoshino M, ''et al.'' |title=Human UDP-galactose translocator: molecular cloning of a complementary DNA that complements the genetic defect of a mutant cell line deficient in UDP-galactose translocator. |journal=J. Biochem. |volume=120 |issue= 2 |pages= 236-41 |year= 1997 |pmid= 8889805 |doi=  }}
*{{cite journal  | vauthors=Ishida N, Miura N, Yoshioka S, Kawakita M |title=Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family. |journal=J. Biochem. |volume=120 |issue= 6 |pages= 1074–8 |year= 1997 |pmid= 9010752 |doi=  10.1093/oxfordjournals.jbchem.a021523}}
*{{cite journal  | author=Ishida N, Miura N, Yoshioka S, Kawakita M |title=Molecular cloning and characterization of a novel isoform of the human UDP-galactose transporter, and of related complementary DNAs belonging to the nucleotide-sugar transporter gene family. |journal=J. Biochem. |volume=120 |issue= 6 |pages= 1074-8 |year= 1997 |pmid= 9010752 |doi=  }}
*{{cite journal   |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | vauthors=Yoshioka S, Sun-Wada GH, Ishida N, Kawakita M |title=Expression of the human UDP-galactose transporter in the Golgi membranes of murine Had-1 cells that lack the endogenous transporter. |journal=J. Biochem. |volume=122 |issue= 4 |pages= 691–5 |year= 1998 |pmid= 9399569 |doi=  10.1093/oxfordjournals.jbchem.a021810}}
*{{cite journal  | author=Yoshioka S, Sun-Wada GH, Ishida N, Kawakita M |title=Expression of the human UDP-galactose transporter in the Golgi membranes of murine Had-1 cells that lack the endogenous transporter. |journal=J. Biochem. |volume=122 |issue= 4 |pages= 691-5 |year= 1998 |pmid= 9399569 |doi=  }}
*{{cite journal  | vauthors=Aoki K, Ishida N, Kawakita M |title=Substrate recognition by UDP-galactose and CMP-sialic acid transporters. Different sets of transmembrane helices are utilized for the specific recognition of UDP-galactose and CMP-sialic acid. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21555–61 |year= 2001 |pmid= 11279205 |doi= 10.1074/jbc.M101462200 }}
*{{cite journal  | author=Aoki K, Ishida N, Kawakita M |title=Substrate recognition by UDP-galactose and CMP-sialic acid transporters. Different sets of transmembrane helices are utilized for the specific recognition of UDP-galactose and CMP-sialic acid. |journal=J. Biol. Chem. |volume=276 |issue= 24 |pages= 21555-61 |year= 2001 |pmid= 11279205 |doi= 10.1074/jbc.M101462200 }}
*{{cite journal   |vauthors=Kumamoto K, Goto Y, Sekikawa K, etal |title=Increased expression of UDP-galactose transporter messenger RNA in human colon cancer tissues and its implication in synthesis of Thomsen-Friedenreich antigen and sialyl Lewis A/X determinants. |journal=Cancer Res. |volume=61 |issue= 11 |pages= 4620–7 |year= 2001 |pmid= 11389099 |doi=  }}
*{{cite journal | author=Kumamoto K, Goto Y, Sekikawa K, ''et al.'' |title=Increased expression of UDP-galactose transporter messenger RNA in human colon cancer tissues and its implication in synthesis of Thomsen-Friedenreich antigen and sialyl Lewis A/X determinants. |journal=Cancer Res. |volume=61 |issue= 11 |pages= 4620-7 |year= 2001 |pmid= 11389099 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Sprong H, Degroote S, Nilsson T, etal |title=Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum. |journal=Mol. Biol. Cell |volume=14 |issue= 8 |pages= 3482–93 |year= 2004 |pmid= 12925779 |doi= 10.1091/mbc.E03-03-0130 | pmc=181583 }}
*{{cite journal | author=Sprong H, Degroote S, Nilsson T, ''et al.'' |title=Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum. |journal=Mol. Biol. Cell |volume=14 |issue= 8 |pages= 3482-93 |year= 2004 |pmid= 12925779 |doi= 10.1091/mbc.E03-03-0130 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}


{{membrane-protein-stub}}
{{Membrane transport proteins}}
{{Membrane transport proteins}}
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[[Category:Solute carrier family]]
[[Category:Solute carrier family]]
{{WikiDoc Sources}}
 
 
{{membrane-protein-stub}}

Latest revision as of 06:32, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

UDP-galactose translocator is a protein that in humans is encoded by the SLC35A2 gene.[1][2]


See also

References

  1. Hara T, Yamauchi M, Takahashi E, Hoshino M, Aoki K, Ayusawa D, Kawakita M (Apr 1994). "The UDP-galactose translocator gene is mapped to band Xp11.23-p11.22 containing the Wiskott-Aldrich syndrome locus". Somat Cell Mol Genet. 19 (6): 571–5. doi:10.1007/BF01233383. PMID 8128316.
  2. "Entrez Gene: SLC35A2 solute carrier family 35 (UDP-galactose transporter), member A2".

Further reading