SLC9A2: Difference between revisions

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Latest revision as of 06:36, 11 September 2017

Sodium–hydrogen exchanger 2 is a protein that in humans is encoded by the SLC9A2 gene.^[1]

References

↑ "Entrez Gene: SLC9A2 solute carrier family 9 (sodium/hydrogen exchanger), member 2".

Chow CW (1999). "Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3". Clinical and investigative medicine. Médecine clinique et experimentale. 22 (5): 195–206. PMID 10579058.
Kulanthaivel P, Furesz TC, Moe AJ, et al. (1992). "Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane". Biochem. J. 284 (1): 33–8. PMC 1132693. PMID 1318024.
Collins JF, Honda T, Knobel S, et al. (1993). "Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2)". Proc. Natl. Acad. Sci. U.S.A. 90 (9): 3938–42. doi:10.1073/pnas.90.9.3938. PMC 46421. PMID 7683411.
Ghishan FK, Knobel SM, Summar M (1996). "Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2)". Genomics. 30 (1): 25–30. doi:10.1006/geno.1995.0004. PMID 8595899.
Dudeja PK, Rao DD, Syed I, et al. (1996). "Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA". Am. J. Physiol. 271 (3 Pt 1): G483–93. PMID 8843774.
Lin X, Barber DL (1996). "A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange". Proc. Natl. Acad. Sci. U.S.A. 93 (22): 12631–6. doi:10.1073/pnas.93.22.12631. PMC 38044. PMID 8901634.
"Toward a complete human genome sequence". Genome Res. 8 (11): 1097–108. 1999. doi:10.1101/gr.8.11.1097. PMID 9847074.
Chow CW, Woodside M, Demaurex N, et al. (1999). "Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia". J. Biol. Chem. 274 (15): 10481–8. doi:10.1074/jbc.274.15.10481. PMID 10187839.
Malakooti J, Dahdal RY, Schmidt L, et al. (1999). "Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2". Am. J. Physiol. 277 (2 Pt 1): G383–90. PMID 10444453.
Malakooti J, Dahdal RY, Dudeja PK, et al. (2001). "The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization". Am. J. Physiol. Gastrointest. Liver Physiol. 280 (4): G763–73. PMID 11254504.
Pang T, Su X, Wakabayashi S, Shigekawa M (2001). "Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers". J. Biol. Chem. 276 (20): 17367–72. doi:10.1074/jbc.M100296200. PMID 11350981.
Repishti M, Hogan DL, Pratha V, et al. (2001). "Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement". Am. J. Physiol. Gastrointest. Liver Physiol. 281 (1): G159–63. PMID 11408268.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Lacey HA, Nolan T, Greenwood SL, et al. (2005). "Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR". Placenta. 26 (1): 93–8. doi:10.1016/j.placenta.2004.05.005. PMID 15664417.
Hillier LW, Graves TA, Fulton RS, et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature. 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621.
Pearse I, Zhu YX, Murray EJ, et al. (2007). "Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site". Biochem. J. 407 (1): 101–11. doi:10.1042/BJ20070364. PMC 2267401. PMID 17561809.

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This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[entrez-1] "Entrez Gene: SLC9A2 solute carrier family 9 (sodium/hydrogen exchanger), member 2".

[1]

@@ Line 1: / Line 1: @@
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+{{Infobox_gene}}
-{{PBB_Controls
+'''Sodium–hydrogen exchanger 2''' is a [[protein]] that in humans is encoded by the ''SLC9A2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC9A2 solute carrier family 9 (sodium/hydrogen exchanger), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6549| accessdate = }}</ref>
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- | image =
- | image_source =
- | PDB =
- | Name = Solute carrier family 9 (sodium/hydrogen exchanger), member 2
- | HGNCid = 11072
- | Symbol = SLC9A2
- | AltSymbols =; NHE2
- | OMIM = 600530
- | ECnumber =
- | Homologene = 20661
- | MGIid = 105075
- | Function = {{GNF_GO|id=GO:0015297 |text = antiporter activity}} {{GNF_GO|id=GO:0015299 |text = solute:hydrogen antiporter activity}} {{GNF_GO|id=GO:0015385 |text = sodium:hydrogen antiporter activity}} {{GNF_GO|id=GO:0031402 |text = sodium ion binding}}
- | Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
- | Process = {{GNF_GO|id=GO:0006811 |text = ion transport}} {{GNF_GO|id=GO:0006814 |text = sodium ion transport}} {{GNF_GO|id=GO:0006885 |text = regulation of pH}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 6549
-    | Hs_Ensembl = ENSG00000115616
-    | Hs_RefseqProtein = NP_003039
-    | Hs_RefseqmRNA = NM_003048
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr = 2
-    | Hs_GenLoc_start = 102602598
-    | Hs_GenLoc_end = 102694239
-    | Hs_Uniprot = Q9UBY0
-    | Mm_EntrezGene = 226999
-    | Mm_Ensembl = ENSMUSG00000026062
-    | Mm_RefseqmRNA = NM_001033289
-    | Mm_RefseqProtein = NP_001028461
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 1
-    | Mm_GenLoc_start = 40626171
-    | Mm_GenLoc_end = 40713812
-    | Mm_Uniprot =
-  }}
-}}
-'''Solute carrier family 9 (sodium/hydrogen exchanger), member 2''', also known as '''SLC9A2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SLC9A2 solute carrier family 9 (sodium/hydrogen exchanger), member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6549| accessdate = }}</ref>
 <!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
@@ Line 57: / Line 12: @@
 ==References==
-{{reflist|2}}
+{{reflist}}
 ==Further reading==
@@ Line 63: / Line 18: @@
 {{PBB_Further_reading
 | citations =
-*{{cite journal  | author=Chow CW |title=Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3. |journal=Clinical and investigative medicine. Médecine clinique et experimentale |volume=22 |issue= 5 |pages= 195-206 |year= 1999 |pmid= 10579058 |doi=  }}
+*{{cite journal  | author=Chow CW |title=Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3. |journal=Clinical and investigative medicine. Médecine clinique et experimentale |volume=22 |issue= 5 |pages= 195–206 |year= 1999 |pmid= 10579058 |doi=  }}
-*{{cite journal  | author=Kulanthaivel P, Furesz TC, Moe AJ, ''et al.'' |title=Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane. |journal=Biochem. J. |volume=284 ( Pt 1) |issue=  |pages= 33-8 |year= 1992 |pmid= 1318024 |doi=  }}
+*{{cite journal   |vauthors=Kulanthaivel P, Furesz TC, Moe AJ, etal |title=Human placental syncytiotrophoblast expresses two pharmacologically distinguishable types of Na(+)-H+ exchangers, NHE-1 in the maternal-facing (brush border) membrane and NHE-2 in the fetal-facing (basal) membrane. |journal=Biochem. J. |volume=284 |issue=  1|pages= 33–8 |year= 1992 |pmid= 1318024 |doi=  | pmc=1132693  }}
-*{{cite journal  | author=Collins JF, Honda T, Knobel S, ''et al.'' |title=Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 9 |pages= 3938-42 |year= 1993 |pmid= 7683411 |doi=  }}
+*{{cite journal   |vauthors=Collins JF, Honda T, Knobel S, etal |title=Molecular cloning, sequencing, tissue distribution, and functional expression of a Na+/H+ exchanger (NHE-2). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 9 |pages= 3938–42 |year= 1993 |pmid= 7683411 |doi=10.1073/pnas.90.9.3938  | pmc=46421  }}
-*{{cite journal  | author=Ghishan FK, Knobel SM, Summar M |title=Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2). |journal=Genomics |volume=30 |issue= 1 |pages= 25-30 |year= 1996 |pmid= 8595899 |doi= 10.1006/geno.1995.0004 }}
+*{{cite journal  | vauthors=Ghishan FK, Knobel SM, Summar M |title=Molecular cloning, sequencing, chromosomal localization, and tissue distribution of the human Na+/H+ exchanger (SLC9A2). |journal=Genomics |volume=30 |issue= 1 |pages= 25–30 |year= 1996 |pmid= 8595899 |doi= 10.1006/geno.1995.0004 }}
-*{{cite journal  | author=Dudeja PK, Rao DD, Syed I, ''et al.'' |title=Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA. |journal=Am. J. Physiol. |volume=271 |issue= 3 Pt 1 |pages= G483-93 |year= 1996 |pmid= 8843774 |doi=  }}
+*{{cite journal   |vauthors=Dudeja PK, Rao DD, Syed I, etal |title=Intestinal distribution of human Na+/H+ exchanger isoforms NHE-1, NHE-2, and NHE-3 mRNA. |journal=Am. J. Physiol. |volume=271 |issue= 3 Pt 1 |pages= G483–93 |year= 1996 |pmid= 8843774 |doi=  }}
-*{{cite journal  | author=Lin X, Barber DL |title=A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 22 |pages= 12631-6 |year= 1996 |pmid= 8901634 |doi=  }}
+*{{cite journal  | vauthors=Lin X, Barber DL |title=A calcineurin homologous protein inhibits GTPase-stimulated Na-H exchange. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 22 |pages= 12631–6 |year= 1996 |pmid= 8901634 |doi=10.1073/pnas.93.22.12631  | pmc=38044  }}
-*{{cite journal  | author= |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097-108 |year= 1999 |pmid= 9847074 |doi=  }}
+*{{cite journal  |title=Toward a complete human genome sequence. |journal=Genome Res. |volume=8 |issue= 11 |pages= 1097–108 |year= 1999 |pmid= 9847074 |doi=  10.1101/gr.8.11.1097}}
-*{{cite journal  | author=Chow CW, Woodside M, Demaurex N, ''et al.'' |title=Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10481-8 |year= 1999 |pmid= 10187839 |doi=  }}
+*{{cite journal   |vauthors=Chow CW, Woodside M, Demaurex N, etal |title=Proline-rich motifs of the Na+/H+ exchanger 2 isoform. Binding of Src homology domain 3 and role in apical targeting in epithelia. |journal=J. Biol. Chem. |volume=274 |issue= 15 |pages= 10481–8 |year= 1999 |pmid= 10187839 |doi=10.1074/jbc.274.15.10481  }}
-*{{cite journal  | author=Malakooti J, Dahdal RY, Schmidt L, ''et al.'' |title=Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2. |journal=Am. J. Physiol. |volume=277 |issue= 2 Pt 1 |pages= G383-90 |year= 1999 |pmid= 10444453 |doi=  }}
+*{{cite journal   |vauthors=Malakooti J, Dahdal RY, Schmidt L, etal |title=Molecular cloning, tissue distribution, and functional expression of the human Na(+)/H(+) exchanger NHE2. |journal=Am. J. Physiol. |volume=277 |issue= 2 Pt 1 |pages= G383–90 |year= 1999 |pmid= 10444453 |doi=  }}
-*{{cite journal  | author=Malakooti J, Dahdal RY, Dudeja PK, ''et al.'' |title=The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=280 |issue= 4 |pages= G763-73 |year= 2001 |pmid= 11254504 |doi=  }}
+*{{cite journal   |vauthors=Malakooti J, Dahdal RY, Dudeja PK, etal |title=The human Na(+)/H(+) exchanger NHE2 gene: genomic organization and promoter characterization. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=280 |issue= 4 |pages= G763–73 |year= 2001 |pmid= 11254504 |doi=  }}
-*{{cite journal  | author=Pang T, Su X, Wakabayashi S, Shigekawa M |title=Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17367-72 |year= 2001 |pmid= 11350981 |doi= 10.1074/jbc.M100296200 }}
+*{{cite journal  | vauthors=Pang T, Su X, Wakabayashi S, Shigekawa M |title=Calcineurin homologous protein as an essential cofactor for Na+/H+ exchangers. |journal=J. Biol. Chem. |volume=276 |issue= 20 |pages= 17367–72 |year= 2001 |pmid= 11350981 |doi= 10.1074/jbc.M100296200 }}
-*{{cite journal  | author=Repishti M, Hogan DL, Pratha V, ''et al.'' |title=Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=281 |issue= 1 |pages= G159-63 |year= 2001 |pmid= 11408268 |doi=  }}
+*{{cite journal   |vauthors=Repishti M, Hogan DL, Pratha V, etal |title=Human duodenal mucosal brush border Na(+)/H(+) exchangers NHE2 and NHE3 alter net bicarbonate movement. |journal=Am. J. Physiol. Gastrointest. Liver Physiol. |volume=281 |issue= 1 |pages= G159–63 |year= 2001 |pmid= 11408268 |doi=  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899  | pmc=139241 }}
-*{{cite journal  | author=Lacey HA, Nolan T, Greenwood SL, ''et al.'' |title=Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR. |journal=Placenta |volume=26 |issue= 1 |pages= 93-8 |year= 2005 |pmid= 15664417 |doi= 10.1016/j.placenta.2004.05.005 }}
+*{{cite journal   |vauthors=Lacey HA, Nolan T, Greenwood SL, etal |title=Gestational profile of Na+/H+ exchanger and Cl-/HCO3- anion exchanger mRNA expression in placenta using real-time QPCR. |journal=Placenta |volume=26 |issue= 1 |pages= 93–8 |year= 2005 |pmid= 15664417 |doi= 10.1016/j.placenta.2004.05.005 }}
-*{{cite journal  | author=Hillier LW, Graves TA, Fulton RS, ''et al.'' |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724-31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
+*{{cite journal   |vauthors=Hillier LW, Graves TA, Fulton RS, etal |title=Generation and annotation of the DNA sequences of human chromosomes 2 and 4. |journal=Nature |volume=434 |issue= 7034 |pages= 724–31 |year= 2005 |pmid= 15815621 |doi= 10.1038/nature03466 }}
-*{{cite journal  | author=Pearse I, Zhu YX, Murray EJ, ''et al.'' |title=Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site. |journal=Biochem. J. |volume=407 |issue= 1 |pages= 101-11 |year= 2007 |pmid= 17561809 |doi= 10.1042/BJ20070364 }}
+*{{cite journal   |vauthors=Pearse I, Zhu YX, Murray EJ, etal |title=Sp1 and Sp3 control constitutive expression of the human NHE2 promoter by interactions with the proximal promoter and the transcription initiation site. |journal=Biochem. J. |volume=407 |issue= 1 |pages= 101–11 |year= 2007 |pmid= 17561809 |doi= 10.1042/BJ20070364  | pmc=2267401 }}
 }}
 {{refend}}
-{{membrane-protein-stub}}
 {{Membrane transport proteins}}
+<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{PBB_Controls
+| update_page = yes
+| require_manual_inspection = no
+| update_protein_box = yes
+| update_summary = yes
+| update_citations = yes
+}}
 [[Category:Solute carrier family]]
-{{WikiDoc Sources}}
+{{membrane-protein-stub}}

SLC9A2: Difference between revisions

Latest revision as of 06:36, 11 September 2017

See also

References

Further reading

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