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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Syntaxin-12''' is a [[protein]] that in humans is encoded by the ''STX12'' [[gene]].<ref name="pmid9507000">{{cite journal | vauthors = Tang BL, Tan AE, Lim LK, Lee SS, Low DY, Hong W | title = Syntaxin 12, a member of the syntaxin family localized to the endosome | journal = The Journal of Biological Chemistry | volume = 273 | issue = 12 | pages = 6944–50 | date = March 1998 | pmid = 9507000 | pmc = | doi = 10.1074/jbc.273.12.6944 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: STX12 syntaxin 12| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23673| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_STX12_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2dnx.
| PDB = {{PDB2|2dnx}}, {{PDB2|2nps}}
| Name = Syntaxin 12
| HGNCid = 11430
| Symbol = STX12
| AltSymbols =; MGC51957; STX13; STX14
| OMIM = 606892
| ECnumber = 
| Homologene = 41508
| MGIid = 1931027
| GeneAtlas_image1 = PBB_GE_STX12_212111_at_tn.png
| GeneAtlas_image2 = PBB_GE_STX12_212112_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008565 |text = protein transporter activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23673
    | Hs_Ensembl = ENSG00000117758
    | Hs_RefseqProtein = NP_803173
    | Hs_RefseqmRNA = NM_177424
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 27972281
    | Hs_GenLoc_end = 28023550
    | Hs_Uniprot = Q86Y82
    | Mm_EntrezGene = 100226
    | Mm_Ensembl = ENSMUSG00000028879
    | Mm_RefseqmRNA = NM_133887
    | Mm_RefseqProtein = NP_598648
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 132125579
    | Mm_GenLoc_end = 132156519
    | Mm_Uniprot = Q3TDG9
  }}
}}
'''Syntaxin 12''', also known as '''STX12''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: STX12 syntaxin 12| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23673| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
STX12 has been shown to [[Protein-protein interaction|interact]] with [[PLDN]].<ref name=pmid10610180>{{cite journal | vauthors = Huang L, Kuo YM, Gitschier J | title = The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency | journal = Nature Genetics | volume = 23 | issue = 3 | pages = 329–32 | date = November 1999 | pmid = 10610180 | doi = 10.1038/15507 }}</ref>
{{PBB_Summary
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| summary_text =  
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==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Falcón-Pérez JM, Dell'Angelica EC | title = The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis | journal = Pigment Cell Research | volume = 15 | issue = 2 | pages = 82–6 | date = April 2002 | pmid = 11936273 | doi = 10.1034/j.1600-0749.2002.1r082.x }}
| citations =
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction | journal = Analytical Biochemistry | volume = 236 | issue = 1 | pages = 107–13 | date = April 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Falcón-Pérez JM, Dell'Angelica EC |title=The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis. |journal=Pigment Cell Res. |volume=15 |issue= 2 |pages= 82-6 |year= 2002 |pmid= 11936273 |doi= }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing | journal = Genome Research | volume = 7 | issue = 4 | pages = 353–8 | date = April 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Advani RJ, Bae HR, Bock JB, Chao DS, Doung YC, Prekeris R, Yoo JS, Scheller RH | title = Seven novel mammalian SNARE proteins localize to distinct membrane compartments | journal = The Journal of Biological Chemistry | volume = 273 | issue = 17 | pages = 10317–24 | date = April 1998 | pmid = 9553086 | doi = 10.1074/jbc.273.17.10317 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Prekeris R, Klumperman J, Chen YA, Scheller RH | title = Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes | journal = The Journal of Cell Biology | volume = 143 | issue = 4 | pages = 957–71 | date = November 1998 | pmid = 9817754 | pmc = 2132958 | doi = 10.1083/jcb.143.4.957 }}
*{{cite journal  | author=Tang BL, Tan AE, Lim LK, ''et al.'' |title=Syntaxin 12, a member of the syntaxin family localized to the endosome. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6944-50 |year= 1998 |pmid= 9507000 |doi=  }}
* {{cite journal | vauthors = Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH | title = Three novel proteins of the syntaxin/SNAP-25 family | journal = The Journal of Biological Chemistry | volume = 273 | issue = 51 | pages = 34171–9 | date = December 1998 | pmid = 9852078 | doi = 10.1074/jbc.273.51.34171 }}
*{{cite journal | author=Advani RJ, Bae HR, Bock JB, ''et al.'' |title=Seven novel mammalian SNARE proteins localize to distinct membrane compartments. |journal=J. Biol. Chem. |volume=273 |issue= 17 |pages= 10317-24 |year= 1998 |pmid= 9553086 |doi= }}
* {{cite journal | vauthors = McBride HM, Rybin V, Murphy C, Giner A, Teasdale R, Zerial M | title = Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13 | journal = Cell | volume = 98 | issue = 3 | pages = 377–86 | date = August 1999 | pmid = 10458612 | doi = 10.1016/S0092-8674(00)81966-2 }}
*{{cite journal | author=Prekeris R, Klumperman J, Chen YA, Scheller RH |title=Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. |journal=J. Cell Biol. |volume=143 |issue= 4 |pages= 957-71 |year= 1998 |pmid= 9817754 |doi= }}
* {{cite journal | vauthors = Huang L, Kuo YM, Gitschier J | title = The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency | journal = Nature Genetics | volume = 23 | issue = 3 | pages = 329–32 | date = November 1999 | pmid = 10610180 | doi = 10.1038/15507 }}
*{{cite journal | author=Steegmaier M, Yang B, Yoo JS, ''et al.'' |title=Three novel proteins of the syntaxin/SNAP-25 family. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34171-9 |year= 1999 |pmid= 9852078 |doi= }}
* {{cite journal | vauthors = Minakami R, Kato A, Sugiyama H | title = Interaction of Vesl-1L/Homer 1c with syntaxin 13 | journal = Biochemical and Biophysical Research Communications | volume = 272 | issue = 2 | pages = 466–71 | date = June 2000 | pmid = 10833436 | doi = 10.1006/bbrc.2000.2777 }}
*{{cite journal | author=McBride HM, Rybin V, Murphy C, ''et al.'' |title=Oligomeric complexes link Rab5 effectors with NSF and drive membrane fusion via interactions between EEA1 and syntaxin 13. |journal=Cell |volume=98 |issue= 3 |pages= 377-86 |year= 1999 |pmid= 10458612 |doi= }}
* {{cite journal | vauthors = Hirling H, Steiner P, Chaperon C, Marsault R, Regazzi R, Catsicas S | title = Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking | journal = The European Journal of Neuroscience | volume = 12 | issue = 6 | pages = 1913–23 | date = June 2000 | pmid = 10886332 | doi = 10.1046/j.1460-9568.2000.00076.x }}
*{{cite journal | author=Huang L, Kuo YM, Gitschier J |title=The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency. |journal=Nat. Genet. |volume=23 |issue= 3 |pages= 329-32 |year= 1999 |pmid= 10610180 |doi= 10.1038/15507 }}
* {{cite journal | vauthors = Steiner P, Sarria JC, Glauser L, Magnin S, Catsicas S, Hirling H | title = Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD | journal = The Journal of Cell Biology | volume = 157 | issue = 7 | pages = 1197–209 | date = June 2002 | pmid = 12070131 | pmc = 2173541 | doi = 10.1083/jcb.200202022 }}
*{{cite journal | author=Minakami R, Kato A, Sugiyama H |title=Interaction of Vesl-1L/Homer 1c with syntaxin 13. |journal=Biochem. Biophys. Res. Commun. |volume=272 |issue= 2 |pages= 466-71 |year= 2000 |pmid= 10833436 |doi= 10.1006/bbrc.2000.2777 }}
* {{cite journal | vauthors = Sun W, Yan Q, Vida TA, Bean AJ | title = Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex | journal = The Journal of Cell Biology | volume = 162 | issue = 1 | pages = 125–37 | date = July 2003 | pmid = 12847087 | pmc = 2172712 | doi = 10.1083/jcb.200302083 }}
*{{cite journal | author=Hirling H, Steiner P, Chaperon C, ''et al.'' |title=Syntaxin 13 is a developmentally regulated SNARE involved in neurite outgrowth and endosomal trafficking. |journal=Eur. J. Neurosci. |volume=12 |issue= 6 |pages= 1913-23 |year= 2000 |pmid= 10886332 |doi= }}
* {{cite journal | vauthors = Bared SM, Buechler C, Boettcher A, Dayoub R, Sigruener A, Grandl M, Rudolph C, Dada A, Schmitz G | title = Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells | journal = Molecular Biology of the Cell | volume = 15 | issue = 12 | pages = 5399–407 | date = December 2004 | pmid = 15469992 | pmc = 532019 | doi = 10.1091/mbc.E04-03-0182 }}
*{{cite journal | author=Steiner P, Sarria JC, Glauser L, ''et al.'' |title=Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD. |journal=J. Cell Biol. |volume=157 |issue= 7 |pages= 1197-209 |year= 2002 |pmid= 12070131 |doi= 10.1083/jcb.200202022 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Sun W, Yan Q, Vida TA, Bean AJ |title=Hrs regulates early endosome fusion by inhibiting formation of an endosomal SNARE complex. |journal=J. Cell Biol. |volume=162 |issue= 1 |pages= 125-37 |year= 2003 |pmid= 12847087 |doi= 10.1083/jcb.200302083 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Bared SM, Buechler C, Boettcher A, ''et al.'' |title=Association of ABCA1 with syntaxin 13 and flotillin-1 and enhanced phagocytosis in tangier cells. |journal=Mol. Biol. Cell |volume=15 |issue= 12 |pages= 5399-407 |year= 2005 |pmid= 15469992 |doi= 10.1091/mbc.E04-03-0182 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=23673}}
{{WikiDoc Sources}}
{{Vesicular transport proteins}}
 
 
{{gene-1-stub}}

Latest revision as of 23:04, 6 September 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Syntaxin-12 is a protein that in humans is encoded by the STX12 gene.[1][2]

Interactions

STX12 has been shown to interact with PLDN.[3]

References

  1. ↑ Tang BL, Tan AE, Lim LK, Lee SS, Low DY, Hong W (March 1998). "Syntaxin 12, a member of the syntaxin family localized to the endosome". The Journal of Biological Chemistry. 273 (12): 6944–50. doi:10.1074/jbc.273.12.6944. PMID 9507000.
  2. ↑ "Entrez Gene: STX12 syntaxin 12".
  3. ↑ Huang L, Kuo YM, Gitschier J (November 1999). "The pallid gene encodes a novel, syntaxin 13-interacting protein involved in platelet storage pool deficiency". Nature Genetics. 23 (3): 329–32. doi:10.1038/15507. PMID 10610180.

Further reading


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