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{{Infobox_gene}}
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'''Ubiquitin-conjugating enzyme E2 B''' is a [[protein]] that in humans is encoded by the ''UBE2B'' [[gene]].<ref name="pmid1559696">{{cite journal |vauthors=Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH | title = Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31 | journal = Genomics | volume = 12 | issue = 3 | pages = 447–53 |date=May 1992 | pmid = 1559696 | pmc =  | doi =10.1016/0888-7543(92)90433-S }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7320| accessdate = }}</ref>
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{{GNF_Protein_box
| image = PBB_Protein_UBE2B_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1jas.
| PDB = {{PDB2|1jas}}
| Name = Ubiquitin-conjugating enzyme E2B (RAD6 homolog)
| HGNCid = 12473
| Symbol = UBE2B
| AltSymbols =; UBC2; E2-17kDa; HHR6B; HR6B; RAD6B
| OMIM = 179095
| ECnumber =
| Homologene = 37761
| MGIid = 102944
| GeneAtlas_image1 = PBB_GE_UBE2B_202334_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_UBE2B_202333_s_at_tn.png
  | GeneAtlas_image3 = PBB_GE_UBE2B_202335_s_at_tn.png
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006301 |text = postreplication repair}} {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}} {{GNF_GO|id=GO:0007288 |text = sperm axoneme assembly}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7320
    | Hs_Ensembl = ENSG00000119048
    | Hs_RefseqProtein = NP_003328
    | Hs_RefseqmRNA = NM_003337
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 133734769
    | Hs_GenLoc_end = 133755698
    | Hs_Uniprot = P63146
    | Mm_EntrezGene = 22210
    | Mm_Ensembl = ENSMUSG00000020390
    | Mm_RefseqmRNA = NM_009458
    | Mm_RefseqProtein = NP_033484
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 51828985
    | Mm_GenLoc_end = 51843810
    | Mm_Uniprot = P63147
  }}
}}
'''Ubiquitin-conjugating enzyme E2B (RAD6 homolog)''', also known as '''UBE2B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7320| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.<ref name="entrez">{{cite web | title = Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7320| accessdate = }}</ref>
| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.<ref name="entrez"/>
}}
}}
==Interactions==
UBE2B has been shown to [[Protein-protein interaction|interact]] with [[RAD18]].<ref name=pmid10908344>{{cite journal |doi=10.1093/nar/28.14.2847 |last=Xin |first=H |authorlink= |author2=Lin W |author3=Sumanasekera W |author4=Zhang Y |author5=Wu X |author6=Wang Z  |date=July 2000  |title=The human RAD18 gene product interacts with HHR6A and HHR6B |journal=Nucleic Acids Res. |volume=28 |issue=14 |pages=2847–54 |publisher= |location = ENGLAND| issn = | pmid = 10908344 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=102657 }}</ref><ref name=pmid10884424>{{cite journal |doi=10.1073/pnas.97.14.7927 |last=Tateishi |first=S |authorlink= |author2=Sakuraba Y |author3=Masuyama S |author4=Inoue H |author5=Yamaizumi M  |date=July 2000  |title=Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens |journal=[[PNAS|Proc. Natl. Acad. Sci. U.S.A.]] |volume=97 |issue=14 |pages=7927–32 |publisher= |location = UNITED STATES| issn = 0027-8424| pmid = 10884424 | bibcode =2000PNAS...97.7927T | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = |pmc=16647 }}</ref>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Koken MH, Smit EM, Jaspers-Dekker I, ''et al.'' |title=Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31. |journal=Genomics |volume=12 |issue= 3 |pages= 447-53 |year= 1992 |pmid= 1559696 |doi=  }}
*{{cite journal   |vauthors=Koken MH, Reynolds P, Jaspers-Dekker I, etal |title=Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 20 |pages= 8865–9 |year= 1991 |pmid= 1717990 |doi=10.1073/pnas.88.20.8865  | pmc=52611 |bibcode=1991PNAS...88.8865K }}
*{{cite journal  | author=Koken MH, Reynolds P, Jaspers-Dekker I, ''et al.'' |title=Structural and functional conservation of two human homologs of the yeast DNA repair gene RAD6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 20 |pages= 8865-9 |year= 1991 |pmid= 1717990 |doi=  }}
*{{cite journal   |vauthors=Woffendin C, Chen ZY, Staskus K, etal |title=Mammalian mRNAs encoding protein closely related to ubiquitin-conjugating enzyme encoded by yeast DNA repair gene RAD6. |journal=Biochim. Biophys. Acta |volume=1090 |issue= 1 |pages= 81–5 |year= 1991 |pmid= 1883845 |doi=  10.1016/0167-4781(91)90039-o}}
*{{cite journal | author=Woffendin C, Chen ZY, Staskus K, ''et al.'' |title=Mammalian mRNAs encoding protein closely related to ubiquitin-conjugating enzyme encoded by yeast DNA repair gene RAD6. |journal=Biochim. Biophys. Acta |volume=1090 |issue= 1 |pages= 81-5 |year= 1991 |pmid= 1883845 |doi=  }}
*{{cite journal  |vauthors=Schneider R, Eckerskorn C, Lottspeich F, Schweiger M |title=The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6. |journal=EMBO J. |volume=9 |issue= 5 |pages= 1431–5 |year= 1990 |pmid= 2158443 |doi= | pmc=551831 }}
*{{cite journal  | author=Schneider R, Eckerskorn C, Lottspeich F, Schweiger M |title=The human ubiquitin carrier protein E2(Mr = 17,000) is homologous to the yeast DNA repair gene RAD6. |journal=EMBO J. |volume=9 |issue= 5 |pages= 1431-5 |year= 1990 |pmid= 2158443 |doi=  }}
*{{cite journal   |vauthors=Koken MH, Hoogerbrugge JW, Jasper-Dekker I, etal |title=Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification. |journal=Dev. Biol. |volume=173 |issue= 1 |pages= 119–32 |year= 1996 |pmid= 8575614 |doi=10.1006/dbio.1996.0011 }}
*{{cite journal | author=Koken MH, Hoogerbrugge JW, Jasper-Dekker I, ''et al.'' |title=Expression of the ubiquitin-conjugating DNA repair enzymes HHR6A and B suggests a role in spermatogenesis and chromatin modification. |journal=Dev. Biol. |volume=173 |issue= 1 |pages= 119-32 |year= 1996 |pmid= 8575614 |doi=  }}
*{{cite journal   |vauthors=Tateishi S, Sakuraba Y, Masuyama S, etal |title=Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7927–32 |year= 2000 |pmid= 10884424 |doi=10.1073/pnas.97.14.7927  | pmc=16647 |bibcode=2000PNAS...97.7927T }}
*{{cite journal | author=Tateishi S, Sakuraba Y, Masuyama S, ''et al.'' |title=Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 14 |pages= 7927-32 |year= 2000 |pmid= 10884424 |doi=  }}
*{{cite journal   |vauthors=Xin H, Lin W, Sumanasekera W, etal |title=The human RAD18 gene product interacts with HHR6A and HHR6B. |journal=Nucleic Acids Res. |volume=28 |issue= 14 |pages= 2847–54 |year= 2000 |pmid= 10908344 |doi=10.1093/nar/28.14.2847  | pmc=102657 }}
*{{cite journal | author=Xin H, Lin W, Sumanasekera W, ''et al.'' |title=The human RAD18 gene product interacts with HHR6A and HHR6B. |journal=Nucleic Acids Res. |volume=28 |issue= 14 |pages= 2847-54 |year= 2000 |pmid= 10908344 |doi=  }}
*{{cite journal   |vauthors=Miura T, Klaus W, Ross A, etal |title=The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. |journal=J. Biomol. NMR |volume=22 |issue= 1 |pages= 89–92 |year= 2003 |pmid= 11885984 |doi=10.1023/A:1013807519703 }}
*{{cite journal | author=Miura T, Klaus W, Ross A, ''et al.'' |title=The NMR structure of the class I human ubiquitin-conjugating enzyme 2b. |journal=J. Biomol. NMR |volume=22 |issue= 1 |pages= 89-92 |year= 2003 |pmid= 11885984 |doi=  }}
*{{cite journal   |vauthors=Shekhar MP, Lyakhovich A, Visscher DW, etal |title=Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation. |journal=Cancer Res. |volume=62 |issue= 7 |pages= 2115–24 |year= 2002 |pmid= 11929833 |doi=  }}
*{{cite journal | author=Shekhar MP, Lyakhovich A, Visscher DW, ''et al.'' |title=Rad6 overexpression induces multinucleation, centrosome amplification, abnormal mitosis, aneuploidy, and transformation. |journal=Cancer Res. |volume=62 |issue= 7 |pages= 2115-24 |year= 2002 |pmid= 11929833 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Kwon YT, Xia Z, An JY, etal |title=Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. |journal=Mol. Cell. Biol. |volume=23 |issue= 22 |pages= 8255–71 |year= 2003 |pmid= 14585983 |doi=10.1128/MCB.23.22.8255-8271.2003  | pmc=262401 }}
*{{cite journal | author=Kwon YT, Xia Z, An JY, ''et al.'' |title=Female lethality and apoptosis of spermatocytes in mice lacking the UBR2 ubiquitin ligase of the N-end rule pathway. |journal=Mol. Cell. Biol. |volume=23 |issue= 22 |pages= 8255-71 |year= 2003 |pmid= 14585983 |doi=  }}
*{{cite journal  |vauthors=Lyakhovich A, Shekhar MP |title=RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response. |journal=Oncogene |volume=23 |issue= 17 |pages= 3097–106 |year= 2004 |pmid= 14981545 |doi= 10.1038/sj.onc.1207449 }}
*{{cite journal  | author=Lyakhovich A, Shekhar MP |title=RAD6B overexpression confers chemoresistance: RAD6 expression during cell cycle and its redistribution to chromatin during DNA damage-induced response. |journal=Oncogene |volume=23 |issue= 17 |pages= 3097-106 |year= 2004 |pmid= 14981545 |doi= 10.1038/sj.onc.1207449 }}
*{{cite journal   |vauthors=Watanabe K, Tateishi S, Kawasuji M, etal |title=Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. |journal=EMBO J. |volume=23 |issue= 19 |pages= 3886–96 |year= 2005 |pmid= 15359278 |doi= 10.1038/sj.emboj.7600383 | pmc=522788 }}
*{{cite journal | author=Watanabe K, Tateishi S, Kawasuji M, ''et al.'' |title=Rad18 guides poleta to replication stalling sites through physical interaction and PCNA monoubiquitination. |journal=EMBO J. |volume=23 |issue= 19 |pages= 3886-96 |year= 2005 |pmid= 15359278 |doi= 10.1038/sj.emboj.7600383 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Stelzl U, Worm U, Lalowski M, etal |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957–68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal | author=Stelzl U, Worm U, Lalowski M, ''et al.'' |title=A human protein-protein interaction network: a resource for annotating the proteome. |journal=Cell |volume=122 |issue= 6 |pages= 957-68 |year= 2005 |pmid= 16169070 |doi= 10.1016/j.cell.2005.08.029 }}
*{{cite journal  |vauthors=Shekhar MP, Tait L, Gerard B |title=Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. |journal=Mol. Cancer Res. |volume=4 |issue= 10 |pages= 729–45 |year= 2007 |pmid= 17050667 |doi= 10.1158/1541-7786.MCR-06-0136 }}
*{{cite journal  | author=Shekhar MP, Tait L, Gerard B |title=Essential role of T-cell factor/beta-catenin in regulation of Rad6B: a potential mechanism for Rad6B overexpression in breast cancer cells. |journal=Mol. Cancer Res. |volume=4 |issue= 10 |pages= 729-45 |year= 2007 |pmid= 17050667 |doi= 10.1158/1541-7786.MCR-06-0136 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=7320}}
{{Ubiquitin-conjugating enzymes}}
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Latest revision as of 22:59, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin-conjugating enzyme E2 B is a protein that in humans is encoded by the UBE2B gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.[2]

Interactions

UBE2B has been shown to interact with RAD18.[3][4]

References

  1. ↑ Koken MH, Smit EM, Jaspers-Dekker I, Oostra BA, Hagemeijer A, Bootsma D, Hoeijmakers JH (May 1992). "Localization of two human homologs, HHR6A and HHR6B, of the yeast DNA repair gene RAD6 to chromosomes Xq24-q25 and 5q23-q31". Genomics. 12 (3): 447–53. doi:10.1016/0888-7543(92)90433-S. PMID 1559696.
  2. ↑ 2.0 2.1 "Entrez Gene: UBE2B ubiquitin-conjugating enzyme E2B (RAD6 homolog)".
  3. ↑ Xin, H; Lin W; Sumanasekera W; Zhang Y; Wu X; Wang Z (July 2000). "The human RAD18 gene product interacts with HHR6A and HHR6B". Nucleic Acids Res. ENGLAND. 28 (14): 2847–54. doi:10.1093/nar/28.14.2847. PMC 102657. PMID 10908344.
  4. ↑ Tateishi, S; Sakuraba Y; Masuyama S; Inoue H; Yamaizumi M (July 2000). "Dysfunction of human Rad18 results in defective postreplication repair and hypersensitivity to multiple mutagens". Proc. Natl. Acad. Sci. U.S.A. UNITED STATES. 97 (14): 7927–32. Bibcode:2000PNAS...97.7927T. doi:10.1073/pnas.97.14.7927. ISSN 0027-8424. PMC 16647. PMID 10884424.

Further reading



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