UBE2H: Difference between revisions

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{{Infobox_gene}}
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'''Ubiquitin-conjugating enzyme E2 H''' is a [[protein]] that in humans is encoded by the ''UBE2H'' [[gene]].<ref name="pmid8132613">{{cite journal | vauthors = Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R | title = A human ubiquitin-conjugating enzyme homologous to yeast UBC8 | journal = J Biol Chem | volume = 269 | issue = 12 | pages = 8797–802 |date=Apr 1994 | pmid = 8132613 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7328| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
{{GNF_Protein_box
| image = PBB_Protein_UBE2H_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1yh6.
| PDB = {{PDB2|1yh6}}
| Name = Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)
| HGNCid = 12484
| Symbol = UBE2H
| AltSymbols =; E2-20K; UBC8; UBCH; UBCH2
| OMIM = 601082
| ECnumber = 
| Homologene = 2510
| MGIid = 104632
| Function = {{GNF_GO|id=GO:0004842 |text = ubiquitin-protein ligase activity}} {{GNF_GO|id=GO:0016874 |text = ligase activity}}
| Component =
| Process = {{GNF_GO|id=GO:0006511 |text = ubiquitin-dependent protein catabolic process}} {{GNF_GO|id=GO:0006512 |text = ubiquitin cycle}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7328
    | Hs_Ensembl = 
    | Hs_RefseqProtein = NP_003335
    | Hs_RefseqmRNA = NM_003344
    | Hs_GenLoc_db =
    | Hs_GenLoc_chr =
    | Hs_GenLoc_start =
    | Hs_GenLoc_end =   
    | Hs_Uniprot =   
    | Mm_EntrezGene = 22214
    | Mm_Ensembl = ENSMUSG00000039159
    | Mm_RefseqmRNA = XM_989140
    | Mm_RefseqProtein = XP_994234
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 6
    | Mm_GenLoc_start = 30161299
    | Mm_GenLoc_end = 30254549
    | Mm_Uniprot = Q3V2N4
  }}
}}
'''Ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)''', also known as '''UBE2H''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7328| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7328| accessdate = }}</ref>
| summary_text = The modification of proteins with [[ubiquitin]] is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. [[Ubiquitination]] involves at least three classes of [[enzymes]]: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and [[ubiquitin-protein ligases]], or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded [[protein sequence]] is 100% identical to the mouse [[homolog]] and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct [[isoforms]].<ref name="entrez">{{cite web | title = Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7328| accessdate = }}</ref>
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Wefes I, Mastrandrea LD, Haldeman M, ''et al.'' |title=Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 11 |pages= 4982-6 |year= 1995 |pmid= 7761435 |doi= }}
*{{cite journal   |vauthors=Wefes I, Mastrandrea LD, Haldeman M, etal |title=Induction of ubiquitin-conjugating enzymes during terminal erythroid differentiation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 11 |pages= 4982–6 |year= 1995 |pmid= 7761435 |doi=10.1073/pnas.92.11.4982  | pmc=41831 }}
*{{cite journal  | author=Kaiser P, Seufert W, Höfferer L, ''et al.'' |title=A human ubiquitin-conjugating enzyme homologous to yeast UBC8. |journal=J. Biol. Chem. |volume=269 |issue= 12 |pages= 8797-802 |year= 1994 |pmid= 8132613 |doi=  }}
*{{cite journal  | vauthors=Kaiser P, Mandl S, Schweiger M, Schneider R |title=Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2. |journal=FEBS Lett. |volume=377 |issue= 2 |pages= 193–6 |year= 1996 |pmid= 8543049 |doi=10.1016/0014-5793(95)01323-7 }}
*{{cite journal  | author=Kaiser P, Mandl S, Schweiger M, Schneider R |title=Characterization of functionally independent domains in the human ubiquitin conjugating enzyme UbcH2. |journal=FEBS Lett. |volume=377 |issue= 2 |pages= 193-6 |year= 1996 |pmid= 8543049 |doi=  }}
*{{cite journal   |vauthors=Hayashida S, Yamasaki K, Asada Y, etal |title=Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. |journal=Genomics |volume=66 |issue= 2 |pages= 221–5 |year= 2000 |pmid= 10860668 |doi= 10.1006/geno.2000.6206 }}
*{{cite journal | author=Hayashida S, Yamasaki K, Asada Y, ''et al.'' |title=Construction of a physical and transcript map flanking the imprinted MEST/PEG1 region at 7q32. |journal=Genomics |volume=66 |issue= 2 |pages= 221-5 |year= 2000 |pmid= 10860668 |doi= 10.1006/geno.2000.6206 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 | pmc=2882961 |doi= 10.1126/science.1083423 }}
*{{cite journal | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal   |vauthors=Hillier LW, Fulton RS, Fulton LA, etal |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal   |vauthors=Vourc'h P, Martin I, Bonnet-Brilhault F, etal |title=Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder. |journal=Psychiatr. Genet. |volume=13 |issue= 4 |pages= 221–5 |year= 2005 |pmid= 14639049 |doi= 10.1097/01.ypg.0000084946.07075.37 }}
*{{cite journal | author=Vourc'h P, Martin I, Bonnet-Brilhault F, ''et al.'' |title=Mutation screening and association study of the UBE2H gene on chromosome 7q32 in autistic disorder. |journal=Psychiatr. Genet. |volume=13 |issue= 4 |pages= 221-5 |year= 2005 |pmid= 14639049 |doi= 10.1097/01.ypg.0000084946.07075.37 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal   |vauthors=Bartee E, Mansouri M, Hovey Nerenberg BT, etal |title=Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. |journal=J. Virol. |volume=78 |issue= 3 |pages= 1109–20 |year= 2004 |pmid= 14722266 |doi=10.1128/JVI.78.3.1109-1120.2004  | pmc=321412 }}
*{{cite journal | author=Bartee E, Mansouri M, Hovey Nerenberg BT, ''et al.'' |title=Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. |journal=J. Virol. |volume=78 |issue= 3 |pages= 1109-20 |year= 2004 |pmid= 14722266 |doi=  }}
*{{cite journal  | vauthors=Chuang TH, Ulevitch RJ |title=Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. |journal=Nat. Immunol. |volume=5 |issue= 5 |pages= 495–502 |year= 2004 |pmid= 15107846 |doi= 10.1038/ni1066 }}
*{{cite journal  | author=Chuang TH, Ulevitch RJ |title=Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors. |journal=Nat. Immunol. |volume=5 |issue= 5 |pages= 495-502 |year= 2004 |pmid= 15107846 |doi= 10.1038/ni1066 }}
*{{cite journal   |vauthors=Kim HJ, Chong KH, Kang SW, etal |title=Identification of cyclophilin A as a CD99-binding protein by yeast two-hybrid screening. |journal=Immunol. Lett. |volume=95 |issue= 2 |pages= 155–9 |year= 2005 |pmid= 15388255 |doi= 10.1016/j.imlet.2004.07.001 }}
*{{cite journal | author=Kim HJ, Chong KH, Kang SW, ''et al.'' |title=Identification of cyclophilin A as a CD99-binding protein by yeast two-hybrid screening. |journal=Immunol. Lett. |volume=95 |issue= 2 |pages= 155-9 |year= 2005 |pmid= 15388255 |doi= 10.1016/j.imlet.2004.07.001 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=7328}}
{{Ubiquitin-conjugating enzymes}}
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Latest revision as of 18:57, 15 February 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ubiquitin-conjugating enzyme E2 H is a protein that in humans is encoded by the UBE2H gene.[1][2]

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein sequence is 100% identical to the mouse homolog and 98% identical to the frog and zebrafish homologs. Two alternatively spliced transcript variants have been found for this gene and they encode distinct isoforms.[2]

References

  1. ↑ Kaiser P, Seufert W, Hofferer L, Kofler B, Sachsenmaier C, Herzog H, Jentsch S, Schweiger M, Schneider R (Apr 1994). "A human ubiquitin-conjugating enzyme homologous to yeast UBC8". J Biol Chem. 269 (12): 8797–802. PMID 8132613.
  2. ↑ 2.0 2.1 "Entrez Gene: UBE2H ubiquitin-conjugating enzyme E2H (UBC8 homolog, yeast)".

Further reading



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