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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Vesicle-associated membrane protein 3''' is a [[protein]] that in humans is encoded by the ''VAMP3'' [[gene]].<ref name="pmid9885218">{{cite journal | vauthors = Bernstein AM, Whiteheart SW | title = Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets | journal = Blood | volume = 93 | issue = 2 | pages = 571–9 | date = January 1999 | pmid = 9885218 | pmc = | doi = }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VAMP3 vesicle-associated membrane protein 3 (cellubrevin)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9341| access-date = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_VAMP3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kil.
| PDB = {{PDB2|1kil}}, {{PDB2|1n7s}}
| Name = Vesicle-associated membrane protein 3 (cellubrevin)
| HGNCid = 12644
| Symbol = VAMP3
| AltSymbols =; CEB
| OMIM = 603657
| ECnumber = 
| Homologene = 3511
| MGIid = 1321389
| GeneAtlas_image1 = PBB_GE_VAMP3_201336_at_tn.png
| GeneAtlas_image2 = PBB_GE_VAMP3_201337_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_VAMP3_211749_s_at_tn.png
| Function =  
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0019717 |text = synaptosome}} {{GNF_GO|id=GO:0045202 |text = synapse}}
| Process = {{GNF_GO|id=GO:0006461 |text = protein complex assembly}} {{GNF_GO|id=GO:0006904 |text = vesicle docking during exocytosis}} {{GNF_GO|id=GO:0006944 |text = membrane fusion}} {{GNF_GO|id=GO:0017156 |text = calcium ion-dependent exocytosis}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 9341
    | Hs_Ensembl = ENSG00000049245
    | Hs_RefseqProtein = NP_004772
    | Hs_RefseqmRNA = NM_004781
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 7753916
    | Hs_GenLoc_end = 7764079
    | Hs_Uniprot = Q15836
    | Mm_EntrezGene = 22319
    | Mm_Ensembl = ENSMUSG00000028955
    | Mm_RefseqmRNA = NM_009498
    | Mm_RefseqProtein = NP_033524
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 149891105
    | Mm_GenLoc_end = 149901753
    | Mm_Uniprot = P63024
  }}
}}
'''Vesicle-associated membrane protein 3 (cellubrevin)''', also known as '''VAMP3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VAMP3 vesicle-associated membrane protein 3 (cellubrevin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9341| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.<ref name="entrez">{{cite web | title = Entrez Gene: VAMP3 vesicle-associated membrane protein 3 (cellubrevin)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9341| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
VAMP3 has been shown to [[Protein-protein interaction|interact]] with
* [[BCAP31]],<ref name="pmid9396746">{{cite journal | vauthors = Annaert WG, Becker B, Kistner U, Reth M, Jahn R | title = Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31 | journal = The Journal of Cell Biology | volume = 139 | issue = 6 | pages = 1397–410 | date = December 1997 | pmid = 9396746 | pmc = 2132629 | doi = 10.1083/jcb.139.6.1397 }}</ref>
* [[Blood vessel epicardial substance|BVES]],<ref name="pmid20057356">{{cite journal | vauthors = Hager HA, Roberts RJ, Cross EE, Proux-Gillardeaux V, Bader DM | title = Identification of a novel Bves function: regulation of vesicular transport | journal = The EMBO Journal | volume = 29 | issue = 3 | pages = 532–45 | date = February 2010 | pmid = 20057356 | pmc = 2830705 | doi = 10.1038/emboj.2009.379 }}</ref>
* [[SNAP23]],<ref name=pmid12828989/><ref name=pmid10820264/><ref name="pmid12556468">{{cite journal | vauthors = Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ | title = Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain | journal = The Journal of Biological Chemistry | volume = 278 | issue = 15 | pages = 13462–7 | date = April 2003 | pmid = 12556468 | doi = 10.1074/jbc.M210483200 }}</ref>
* [[STX4]],<ref name="pmid12828989">{{cite journal | vauthors = Imai A, Nashida T, Yoshie S, Shimomura H | title = Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane | journal = Archives of Oral Biology | volume = 48 | issue = 8 | pages = 597–604 | date = August 2003 | pmid = 12828989 | doi = 10.1016/S0003-9969(03)00116-X }}</ref><ref name="pmid10820264">{{cite journal | vauthors = Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, Roa M | title = Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment | journal = Journal of Immunology | volume = 164 | issue = 11 | pages = 5850–7 | date = June 2000 | pmid = 10820264 | doi = 10.4049/jimmunol.164.11.5850 }}</ref><ref name="pmid16189514">{{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | authorlink30 = Huda Zoghbi | bibcode = 2005Natur.437.1173R }}</ref><ref name="pmid12130530">{{cite journal | vauthors = Polgár J, Chung SH, Reed GL | title = Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion | journal = Blood | volume = 100 | issue = 3 | pages = 1081–3 | date = August 2002 | pmid = 12130530 | doi = 10.1182/blood.V100.3.1081 }}</ref>
* [[STX6]].<ref name="pmid11839770">{{cite journal | vauthors = Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L | title = Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform | journal = The Journal of Cell Biology | volume = 156 | issue = 4 | pages = 653–64 | date = February 2002 | pmid = 11839770 | pmc = 2174079 | doi = 10.1083/jcb.200110081 }}</ref>
 
== References ==
{{Reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Timmers KI, Clark AE, Omatsu-Kanbe M, Whiteheart SW, Bennett MK, Holman GD, Cushman SW | title = Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein | journal = The Biochemical Journal | volume = 320 ( Pt 2) | issue = 2 | pages = 429–36 | date = December 1996 | pmid = 8973549 | pmc = 1217948 | doi = 10.1042/bj3200429 | series = 320 }}
| citations =
* {{cite journal | vauthors = Annaert WG, Becker B, Kistner U, Reth M, Jahn R | title = Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31 | journal = The Journal of Cell Biology | volume = 139 | issue = 6 | pages = 1397–410 | date = December 1997 | pmid = 9396746 | pmc = 2132629 | doi = 10.1083/jcb.139.6.1397 }}
*{{cite journal | author=Timmers KI, Clark AE, Omatsu-Kanbe M, ''et al.'' |title=Identification of SNAP receptors in rat adipose cell membrane fractions and in SNARE complexes co-immunoprecipitated with epitope-tagged N-ethylmaleimide-sensitive fusion protein. |journal=Biochem. J. |volume=320 ( Pt 2) |issue= |pages= 429-36 |year= 1997 |pmid= 8973549 |doi= }}
* {{cite journal | vauthors = Galli T, Zahraoui A, Vaidyanathan VV, Raposo G, Tian JM, Karin M, Niemann H, Louvard D | title = A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells | journal = Molecular Biology of the Cell | volume = 9 | issue = 6 | pages = 1437–48 | date = June 1998 | pmid = 9614185 | pmc = 25366 | doi = 10.1091/mbc.9.6.1437 }}
*{{cite journal | author=Annaert WG, Becker B, Kistner U, ''et al.'' |title=Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. |journal=J. Cell Biol. |volume=139 |issue= 6 |pages= 1397-410 |year= 1998 |pmid= 9396746 |doi= }}
* {{cite journal | vauthors = Riento K, Galli T, Jansson S, Ehnholm C, Lehtonen E, Olkkonen VM | title = Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells | journal = Journal of Cell Science | volume = 111 ( Pt 17) | issue =  | pages = 2681–8 | date = September 1998 | pmid = 9701566 | doi =  | series = 111 }}
*{{cite journal | author=Galli T, Zahraoui A, Vaidyanathan VV, ''et al.'' |title=A novel tetanus neurotoxin-insensitive vesicle-associated membrane protein in SNARE complexes of the apical plasma membrane of epithelial cells. |journal=Mol. Biol. Cell |volume=9 |issue= 6 |pages= 1437-48 |year= 1998 |pmid= 9614185 |doi= }}
* {{cite journal | vauthors = Prekeris R, Klumperman J, Chen YA, Scheller RH | title = Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes | journal = The Journal of Cell Biology | volume = 143 | issue = 4 | pages = 957–71 | date = November 1998 | pmid = 9817754 | pmc = 2132958 | doi = 10.1083/jcb.143.4.957 }}
*{{cite journal | author=Riento K, Galli T, Jansson S, ''et al.'' |title=Interaction of Munc-18-2 with syntaxin 3 controls the association of apical SNAREs in epithelial cells. |journal=J. Cell. Sci. |volume=111 ( Pt 17) |issue=  |pages= 2681-8 |year= 1999 |pmid= 9701566 |doi=  }}
* {{cite journal | vauthors = Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, Roa M | title = Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment | journal = Journal of Immunology | volume = 164 | issue = 11 | pages = 5850–7 | date = June 2000 | pmid = 10820264 | doi = 10.4049/jimmunol.164.11.5850 }}
*{{cite journal | author=Prekeris R, Klumperman J, Chen YA, Scheller RH |title=Syntaxin 13 mediates cycling of plasma membrane proteins via tubulovesicular recycling endosomes. |journal=J. Cell Biol. |volume=143 |issue= 4 |pages= 957-71 |year= 1998 |pmid= 9817754 |doi= }}
* {{cite journal | vauthors = Antonin W, Holroyd C, Fasshauer D, Pabst S, Von Mollard GF, Jahn R | title = A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function | journal = The EMBO Journal | volume = 19 | issue = 23 | pages = 6453–64 | date = December 2000 | pmid = 11101518 | pmc = 305878 | doi = 10.1093/emboj/19.23.6453 }}
*{{cite journal  | author=Bernstein AM, Whiteheart SW |title=Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets. |journal=Blood |volume=93 |issue= 2 |pages= 571-9 |year= 1999 |pmid= 9885218 |doi=  }}
* {{cite journal | vauthors = Wade N, Bryant NJ, Connolly LM, Simpson RJ, Luzio JP, Piper RC, James DE | title = Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells | journal = The Journal of Biological Chemistry | volume = 276 | issue = 23 | pages = 19820–7 | date = June 2001 | pmid = 11278762 | doi = 10.1074/jbc.M010838200 }}
*{{cite journal | author=Paumet F, Le Mao J, Martin S, ''et al.'' |title=Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment. |journal=J. Immunol. |volume=164 |issue= 11 |pages= 5850-7 |year= 2000 |pmid= 10820264 |doi= }}
* {{cite journal | vauthors = Antonin W, Fasshauer D, Becker S, Jahn R, Schneider TR | title = Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs | journal = Nature Structural Biology | volume = 9 | issue = 2 | pages = 107–11 | date = February 2002 | pmid = 11786915 | doi = 10.1038/nsb746 }}
*{{cite journal | author=Antonin W, Holroyd C, Fasshauer D, ''et al.'' |title=A SNARE complex mediating fusion of late endosomes defines conserved properties of SNARE structure and function. |journal=EMBO J. |volume=19 |issue= 23 |pages= 6453-64 |year= 2001 |pmid= 11101518 |doi= 10.1093/emboj/19.23.6453 }}
* {{cite journal | vauthors = Poschet JF, Skidmore J, Boucher JC, Firoved AM, Van Dyke RW, Deretic V | title = Hyperacidification of cellubrevin endocytic compartments and defective endosomal recycling in cystic fibrosis respiratory epithelial cells | journal = The Journal of Biological Chemistry | volume = 277 | issue = 16 | pages = 13959–65 | date = April 2002 | pmid = 11809765 | doi = 10.1074/jbc.M105441200 }}
*{{cite journal | author=Wade N, Bryant NJ, Connolly LM, ''et al.'' |title=Syntaxin 7 complexes with mouse Vps10p tail interactor 1b, syntaxin 6, vesicle-associated membrane protein (VAMP)8, and VAMP7 in b16 melanoma cells. |journal=J. Biol. Chem. |volume=276 |issue= 23 |pages= 19820-7 |year= 2001 |pmid= 11278762 |doi= 10.1074/jbc.M010838200 }}
* {{cite journal | vauthors = Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L | title = Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform | journal = The Journal of Cell Biology | volume = 156 | issue = 4 | pages = 653–64 | date = February 2002 | pmid = 11839770 | pmc = 2174079 | doi = 10.1083/jcb.200110081 }}
*{{cite journal | author=Antonin W, Fasshauer D, Becker S, ''et al.'' |title=Crystal structure of the endosomal SNARE complex reveals common structural principles of all SNAREs. |journal=Nat. Struct. Biol. |volume=9 |issue= 2 |pages= 107-11 |year= 2002 |pmid= 11786915 |doi= 10.1038/nsb746 }}
* {{cite journal | vauthors = Polgár J, Chung SH, Reed GL | title = Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion | journal = Blood | volume = 100 | issue = 3 | pages = 1081–3 | date = August 2002 | pmid = 12130530 | doi = 10.1182/blood.V100.3.1081 }}
*{{cite journal | author=Poschet JF, Skidmore J, Boucher JC, ''et al.'' |title=Hyperacidification of cellubrevin endocytic compartments and defective endosomal recycling in cystic fibrosis respiratory epithelial cells. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13959-65 |year= 2002 |pmid= 11809765 |doi= 10.1074/jbc.M105441200 }}
* {{cite journal | vauthors = Gevaert K, Goethals M, Martens L, Van Damme J, Staes A, Thomas GR, Vandekerckhove J | title = Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides | journal = Nature Biotechnology | volume = 21 | issue = 5 | pages = 566–9 | date = May 2003 | pmid = 12665801 | doi = 10.1038/nbt810 }}
*{{cite journal | author=Mallard F, Tang BL, Galli T, ''et al.'' |title=Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform. |journal=J. Cell Biol. |volume=156 |issue= 4 |pages= 653-64 |year= 2002 |pmid= 11839770 |doi= 10.1083/jcb.200110081 }}
* {{cite journal | vauthors = Imai A, Nashida T, Yoshie S, Shimomura H | title = Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane | journal = Archives of Oral Biology | volume = 48 | issue = 8 | pages = 597–604 | date = August 2003 | pmid = 12828989 | doi = 10.1016/S0003-9969(03)00116-X }}
*{{cite journal | author=Polgár J, Chung SH, Reed GL |title=Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion. |journal=Blood |volume=100 |issue= 3 |pages= 1081-3 |year= 2002 |pmid= 12130530 |doi= }}
* {{cite journal | vauthors = Dai J, Li J, Bos E, Porcionatto M, Premont RT, Bourgoin S, Peters PJ, Hsu VW | title = ACAP1 promotes endocytic recycling by recognizing recycling sorting signals | journal = Developmental Cell | volume = 7 | issue = 5 | pages = 771–6 | date = November 2004 | pmid = 15525538 | doi = 10.1016/j.devcel.2004.10.002 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Boal F, Zhang H, Tessier C, Scotti P, Lang J | title = The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions | journal = Biochemistry | volume = 43 | issue = 51 | pages = 16212–23 | date = December 2004 | pmid = 15610015 | doi = 10.1021/bi048612+ }}
*{{cite journal | author=Gevaert K, Goethals M, Martens L, ''et al.'' |title=Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. |journal=Nat. Biotechnol. |volume=21 |issue= 5 |pages= 566-9 |year= 2004 |pmid= 12665801 |doi= 10.1038/nbt810 }}
* {{cite journal | vauthors = Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M | title = Towards a proteome-scale map of the human protein-protein interaction network | journal = Nature | volume = 437 | issue = 7062 | pages = 1173–8 | date = October 2005 | pmid = 16189514 | doi = 10.1038/nature04209 | bibcode = 2005Natur.437.1173R }}
*{{cite journal | author=Imai A, Nashida T, Yoshie S, Shimomura H |title=Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane. |journal=Arch. Oral Biol. |volume=48 |issue= 8 |pages= 597-604 |year= 2003 |pmid= 12828989 |doi= }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal | author=Dai J, Li J, Bos E, ''et al.'' |title=ACAP1 promotes endocytic recycling by recognizing recycling sorting signals. |journal=Dev. Cell |volume=7 |issue= 5 |pages= 771-6 |year= 2004 |pmid= 15525538 |doi= 10.1016/j.devcel.2004.10.002 }}
*{{cite journal  | author=Boal F, Zhang H, Tessier C, ''et al.'' |title=The variable C-terminus of cysteine string proteins modulates exocytosis and protein-protein interactions. |journal=Biochemistry |volume=43 |issue= 51 |pages= 16212-23 |year= 2005 |pmid= 15610015 |doi= 10.1021/bi048612+ }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
}}
{{refend}}
{{refend}}
{{PDB Gallery|geneid=9341}}


{{protein-stub}}
{{Vesicular transport proteins}}
{{WikiDoc Sources}}

Latest revision as of 05:37, 6 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Vesicle-associated membrane protein 3 is a protein that in humans is encoded by the VAMP3 gene.[1][2]

Function

Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.[2]

Interactions

VAMP3 has been shown to interact with

References

  1. ↑ Bernstein AM, Whiteheart SW (January 1999). "Identification of a cellubrevin/vesicle associated membrane protein 3 homologue in human platelets". Blood. 93 (2): 571–9. PMID 9885218.
  2. ↑ 2.0 2.1 "Entrez Gene: VAMP3 vesicle-associated membrane protein 3 (cellubrevin)".
  3. ↑ Annaert WG, Becker B, Kistner U, Reth M, Jahn R (December 1997). "Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31". The Journal of Cell Biology. 139 (6): 1397–410. doi:10.1083/jcb.139.6.1397. PMC 2132629. PMID 9396746.
  4. ↑ Hager HA, Roberts RJ, Cross EE, Proux-Gillardeaux V, Bader DM (February 2010). "Identification of a novel Bves function: regulation of vesicular transport". The EMBO Journal. 29 (3): 532–45. doi:10.1038/emboj.2009.379. PMC 2830705. PMID 20057356.
  5. ↑ 5.0 5.1 Imai A, Nashida T, Yoshie S, Shimomura H (August 2003). "Intracellular localisation of SNARE proteins in rat parotid acinar cells: SNARE complexes on the apical plasma membrane". Archives of Oral Biology. 48 (8): 597–604. doi:10.1016/S0003-9969(03)00116-X. PMID 12828989.
  6. ↑ 6.0 6.1 Paumet F, Le Mao J, Martin S, Galli T, David B, Blank U, Roa M (June 2000). "Soluble NSF attachment protein receptors (SNAREs) in RBL-2H3 mast cells: functional role of syntaxin 4 in exocytosis and identification of a vesicle-associated membrane protein 8-containing secretory compartment". Journal of Immunology. 164 (11): 5850–7. doi:10.4049/jimmunol.164.11.5850. PMID 10820264.
  7. ↑ Freedman SJ, Song HK, Xu Y, Sun ZY, Eck MJ (April 2003). "Homotetrameric structure of the SNAP-23 N-terminal coiled-coil domain". The Journal of Biological Chemistry. 278 (15): 13462–7. doi:10.1074/jbc.M210483200. PMID 12556468.
  8. ↑ Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514.
  9. ↑ Polgár J, Chung SH, Reed GL (August 2002). "Vesicle-associated membrane protein 3 (VAMP-3) and VAMP-8 are present in human platelets and are required for granule secretion". Blood. 100 (3): 1081–3. doi:10.1182/blood.V100.3.1081. PMID 12130530.
  10. ↑ Mallard F, Tang BL, Galli T, Tenza D, Saint-Pol A, Yue X, Antony C, Hong W, Goud B, Johannes L (February 2002). "Early/recycling endosomes-to-TGN transport involves two SNARE complexes and a Rab6 isoform". The Journal of Cell Biology. 156 (4): 653–64. doi:10.1083/jcb.200110081. PMC 2174079. PMID 11839770.

Further reading

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