Transitional cell carcinoma classification: Difference between revisions

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Latest revision as of 03:30, 30 October 2019

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Suveenkrishna Pothuru, M.B,B.S. [2] Ramyar Ghandriz MD [3]

Overview

Based on the growth pattern, transitional cell carcinoma may be classified into either papillary urothelial carcinoma or non-papillary urothelial carcinoma. Transitional cell carcinoma may be classified according to World Health Organization in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) into two groups: infiltrating urothelial carcinomas and non-invasive urothelial carcinomas.Based on the degree of cellular differentiation , transitional cell carcinoma may be classified into two grades: low grade and high grade.

Classification

Based on the growth pattern, transitional cell carcinoma may be classified into two subtypes:^[1]


Type	Description

Papillary urothelial carcinoma	Slim finger-like projections that grow from the lining of the renal pelvis or ureter into the cavity
Non-papillary urothelial carcinoma	Sessile or nodular tumors They grow deeper into the layers of the wall of the renal pelvis or ureter rather than into its cavity

WHO Classification

Transitional cell carcinomas may be classified according to World Health Organization in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) into two groups: infiltrating urothelial carcinomas and non-invasive urothelial carcinomas:^[2]

Transitional cell tumors

Infiltrating urothelial carcinoma

with squamous differentiation
with glandular differentiation
with trophoblastic differentiation
Nested
Microcystic
Micropapillary
Lymphoepithelioma-like
Lymphoma-like
Plasmacytoid
Sarcomatoid
Giant cell
Undifferentiated

Non-invasive urothelial carcinoma

Urothelial carcinoma in situ
High grade papillary urothelial carcinoma
Low grade papillary urothelial carcinoma
Non-invasive papillary urothelial neoplasm of low malignant potential
Urothelial papilloma
Inverted urothelial papilloma

Grading

According to the WHO grading criteria, there are two grades of transitional cell carcinoma based on the degree of cellular differentiation:


Grade	Description

Low grade	Tumors with the least degree of cellular anaplasia Rarely invades the muscular wall of the bladder or spreads to other parts of the body Often recurs after treatment
High grade	Tumors with the most severe degrees of cellular anaplasia Commonly recurs and also has a strong tendency to invade the muscular wall of the bladder and spread to other parts of the body High grade transitional cell carcinoma is much more likely to result in death

References

↑ Leder, R A; Dunnick, N R (1990). "Transitional cell carcinoma of the pelvicalices and ureter". American Journal of Roentgenology. 155 (4): 713–722. doi:10.2214/ajr.155.4.2119098. ISSN 0361-803X.
↑ Oosterhuis JW, Schapers RF, Janssen-Heijnen ML, Pauwels RP, Newling DW, ten Kate F (2002). "Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems". J Clin Pathol. 55 (12): 900–5. PMC 1769816. PMID 12461053.

Template:WH Template:WS

[LederDunnick1990-1] Leder, R A; Dunnick, N R (1990). "Transitional cell carcinoma of the pelvicalices and ureter". American Journal of Roentgenology. 155 (4): 713–722. doi:10.2214/ajr.155.4.2119098. ISSN 0361-803X.

[pmid12461053-2] Oosterhuis JW, Schapers RF, Janssen-Heijnen ML, Pauwels RP, Newling DW, ten Kate F (2002). "Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems". J Clin Pathol. 55 (12): 900–5. PMC 1769816. PMID 12461053.

[1]

[2]

@@ Line 1: / Line 1: @@
 __NOTOC__
 {{Transitional cell carcinoma}}
-{{CMG}}
+{{CMG}};{{AE}} {{PSK}} {{RG}}
 ==Overview==
-== Classification ==
+Based on the growth pattern, [[transitional cell carcinoma]] may be classified into either papillary [[urothelial carcinoma]] or non-papillary [[urothelial carcinoma]]. [[Transitional cell carcinoma]] may be classified according to [[World Health Organization]] in a collaborative effort conjointly with the [[International Society of Urological Pathologists]] (ISUP) into two groups: infiltrating [[Urothelial carcinoma|urothelial carcinomas]] and non-invasive [[urothelial carcinoma]]<nowiki/>s.Based on the degree of [[cellular differentiation]][[Transitional cell carcinoma|, transitional cell carcinoma]] may be classified into two grades: low [[Grading (tumors)|grade]] and high [[Grading (tumors)|grade.]]
-In the United States, bladder cancers usually start from the cells lining the bladder (called transitional cells).
-These tumors are classified based on the way they grow:
+==Classification==
+Based on the growth pattern, transitional cell carcinoma may be classified into two subtypes:<ref name="LederDunnick1990">{{cite journal|last1=Leder|first1=R A|last2=Dunnick|first2=N R|title=Transitional cell carcinoma of the pelvicalices and ureter.|journal=American Journal of Roentgenology|volume=155|issue=4|year=1990|pages=713–722|issn=0361-803X|doi=10.2214/ajr.155.4.2119098}}</ref>
+{| style="border: 0px; font-size: 90%; margin: 3px; width: 800px"
+|valign=top|
+|+
+! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''Type'''}}
+! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''Description'''}}
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; align=left" |
+Papillary urothelial carcinoma
+| style="padding: 5px 5px; background: #F5F5F5;" align=left |
+*Slim finger-like projections that grow from the lining of the [[renal pelvis]] or [[ureter]] into the cavity
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; align=left" |
+Non-papillary urothelial carcinoma
+| style="padding: 5px 5px; background: #F5F5F5;" align=left |
+*Sessile or nodular tumors
+*They grow deeper into the layers of the wall of the [[renal pelvis]] or [[ureter]] rather than into its cavity
+|}
+===WHO Classification===
+Transitional cell carcinomas may be classified according to [[World Health Organization]] in a collaborative effort conjointly with the International Society of Urological Pathologists (ISUP) into two groups: infiltrating urothelial carcinomas and non-invasive urothelial carcinomas:<ref name="pmid12461053">{{cite journal| author=Oosterhuis JW, Schapers RF, Janssen-Heijnen ML, Pauwels RP, Newling DW, ten Kate F| title=Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems. | journal=J Clin Pathol | year= 2002 | volume= 55 | issue= 12 | pages= 900-5 | pmid=12461053 | doi= | pmc=PMC1769816 | url=http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=12461053  }} </ref>
+{{Family tree/start}}
+{{familytree | | | A01 | | | A01= '''Transitional cell tumors'''}}
+{{familytree | |,|-|^|-|.| | }}
+{{familytree | B01 | | |!| | B01= <div style="float: left; text-align: left; width: 30em; padding:1em;">'''Infiltrating urothelial carcinoma'''<br>
+:*with squamous differentiation
+:*with glandular differentiation
+:*with trophoblastic differentiation
+:*Nested
+:*Microcystic
+:*Micropapillary
+:*Lymphoepithelioma-like
+:*Lymphoma-like
+:*Plasmacytoid
+:*Sarcomatoid
+:*Giant cell
+:*Undifferentiated
+</div>}}
+{{familytree | | | | | B02 | B02= <div style="float: left; text-align: left; width: 30em; padding:1em;">'''Non-invasive urothelial carcinoma'''
+:*Urothelial [[carcinoma in situ]]
+:*High grade papillary urothelial carcinoma
+:*Low grade papillary urothelial carcinoma
+:*Non-invasive papillary urothelial neoplasm of low [[malignant]] potential
+:*Urothelial [[papilloma]]
+:*Inverted urothelial papilloma
+</div>}}
+{{Family tree/end}}
+===Grading===
+According to the [[WHO]] grading criteria, there are two grades of transitional cell carcinoma based on the degree of [[cellular differentiation]]:
+{| style="border: 0px; font-size: 90%; margin: 3px; width: 800px"
+|valign=top|
+|+
+! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''Grade'''}}
+! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|'''Description'''}}
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; align=left" |
+Low grade
+| style="padding: 5px 5px; background: #F5F5F5;" align=left |
+*Tumors with the least degree of cellular anaplasia
+*Rarely invades the muscular wall of the bladder or spreads to other parts of the body
+*Often recurs after treatment
+|-
+| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold; align=left" |
+High grade
+| style="padding: 5px 5px; background: #F5F5F5;" align=left |
+*Tumors with the most severe degrees of cellular [[anaplasia]]
+*Commonly recurs and also has a strong tendency to invade the muscular wall of the [[bladder]] and spread to other parts of the body
+*High grade transitional cell carcinoma is much more likely to result in death
+|}
-*Papillary tumors have a wart-like appearance and are attached to a stalk.
-*Nonpapillary (sessile) tumors are much less common. However, they are more invasive and have a worse outcome.
 ==References==
 {{reflist|2}}
 {{WH}}
 {{WS}}
 [[Category:Disease]]
+ [[Category:Up-To-Date]]
 [[Category:Oncology]]
+[[Category:Medicine]]