Amenorrhea differential diagnosis

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Differential Diagnosis Organized by Category of Causes

• Physiologic

  • Pregnancy
  • Lactation
  • Menopause

• Hypothalamic

  • Structural

    • Craniopharyngioma
    • Lymphoma
    • Sarcoidosis
    • Hemochromatosis

  • Functional

    • Anorexia/bulimia
    • Excessive exercise/weight loss
    • Stress

• Pituitary

  • Secretory tumors

    • Prolactinoma
    • Cushing’s disease
    • Acromegaly

  • Destructive lesions

    • Non-functional tumors
    • Sheehan's syndrome
    • Hemochromatosis

• Ovarian

  • Premature ovarian failure
  • Hyperandrogenic disorders

    • Polycystic ovary syndrome (PCOS)
    • Nonclassical congenital adrenal hyperplasia (NCCAH)
    • Adrenal/ovarian androgen-secreting tumors

• Anatomic

  • Destruction of uterine cavity

    • Asherman’s syndrome
    • Tuberculosis (TB)

• Other

  • Hyperthyroidism/hypothyroidism
  • Cushing’s syndrome

References

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