Follicular lymphoma natural history, complications and prognosis

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Prognosis is generally poor. The median survival is around 10 years.

Prognosis

The disease is regarded as incurable (although allogenic stem cell transplantation may be curative, the mortality from the procedure is too high to be a first line option). The median survival is around 10 years, but the range is wide, from less than one year, to more than 20 years.

• The Follicular Lymphoma International Prognostic Index (FLIPI) includes

• Age,
• Ann Arbor stage
• Number of nodal sites involved
• Hemoglobin levels
• Serum LDH levels

• The Follicular Lymphoma International Prognostic Index (FLIPI-2) includes

• Age,
• Hemoglobin levels
• Longest diameter of largest involved lymph node
• Beta-2 microglobulin levels
• Bone marrow involvement

Both the FLIPI-1 and FLIPI-2 predict for prognosis, but not yet useful for selecting treatment options.

• Most recently,a simpler prognostic index includes

• baseline serum beta 2-microglobulin
• LDH levels