Follicular lymphoma laboratory findings: Difference between revisions
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==Overview== | ==Overview== | ||
==Laboratory Findings== | ==Laboratory Findings== | ||
Laboratory findings consistent with the diagnosis of follicular lymphoma includes | Laboratory findings consistent with the diagnosis of follicular lymphoma includes<ref>{{cite web | title = Non-Hodgkin's Lymphomas (NCCN.org) | url = http://www.nccn.org/professionals/physician_gls/PDF/nhl.pdf }}</ref> | ||
* Histological confirmation by centroblasts and centrocytes. | * Histological confirmation by centroblasts and centrocytes. | ||
* Immunophenotyping using flow cytometry to detect immunophenotypes like CD20+, CD10+, BCL2+, CD23+/-, CD43-, CD5-, CCND1-, CD10-, BCL2- and BCL6+ | * Immunophenotyping using flow cytometry to detect immunophenotypes like CD20+, CD10+, BCL2+, CD23+/-, CD43-, CD5-, CCND1-, CD10-, BCL2- and BCL6+ | ||
Revision as of 18:10, 24 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
Laboratory Findings
Laboratory findings consistent with the diagnosis of follicular lymphoma includes[1]
- Histological confirmation by centroblasts and centrocytes.
- Immunophenotyping using flow cytometry to detect immunophenotypes like CD20+, CD10+, BCL2+, CD23+/-, CD43-, CD5-, CCND1-, CD10-, BCL2- and BCL6+
- Immunohistochemistry for Ki-67,Aggressive clinical behavior is in association with low-grade follicular lymphoma with a high proliferation index. ( determined by Ki-67 immunostaining)
- Molecular genetic analysis for BCL2 rearrangement
- Cytogenetics or FISH for t(14;18)