Follicular lymphoma classification: Difference between revisions
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====2-Three variants of follicular lymphoma==== | ====2-Three variants of follicular lymphoma==== | ||
Three variants of follicular lymphoma are<ref name=”seer”>National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref> | Three variants of follicular lymphoma are<ref name=”seer”>National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov</ref> | ||
A.Pediatric follicular lymphoma | A.Pediatric follicular lymphoma | ||
:*Involves [[cervical lymph nodes]], other peripheral lymph nodes, or Waldeyer ring | :*Involves [[cervical lymph nodes]], other peripheral lymph nodes, or Waldeyer ring | ||
Revision as of 15:21, 27 August 2015
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Sowminya Arikapudi, M.B,B.S. [2]
Overview
Follicular lymphoma may be classified according to WHO criteria into 3 groups: low grade follicular lymphoma, high grade follicular lymphoma and diffuse large B cell lymphoma.
Classification
1-WHO Classification
The World Health Organization (WHO) classifies follicular lymphoma as follows[1]
- Grades 1 and 2 now as low grade follicular lymphoma
- Grade 3A as high grade follicular lymphoma
- Grade 3B as diffuse large B cell lymphoma.
2-Three variants of follicular lymphoma
Three variants of follicular lymphoma are[2]
A.Pediatric follicular lymphoma
- Involves cervical lymph nodes, other peripheral lymph nodes, or Waldeyer ring
- Typically have early stage disease
- Lacks BCL-2 protein expression and t(14;18)
B.Primary intestinal follicular lymphoma
- Occurs most commonly in the small intestine, and frequently involves the duodenum
- Duodenal follicular lymphoma
- Found in the second portion of the duodenum
- Present as multiple polyps
- Diagnosis is most often an incidental finding
- Most patients have localized disease
- Prognosis is excellent even without treatment
C.Other extranodal follicular lymphomas
- Usually have localized extranodal disease
- Systemic relapses are rare
- Testicular follicular lymphoma are reported with increased frequency in children, but also are reported in adults.
References
- ↑ "Follicular Lymphomas". Retrieved 2008-07-26.
- ↑ National Cancer Institute. Surveillance, Epidemiology, and End Results Program 2015. http://seer.cancer.gov