Chondrosarcoma pathophysiology: Difference between revisions
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| [[Image:790px-Bone Chondrosarcoma Myxoid MP2 PA.JPG|thumb|350px|Anastomizing chords of small neoplastic cells surround mucin pools]] | | [[Image:790px-Bone Chondrosarcoma Myxoid MP2 PA.JPG|thumb|350px|Anastomizing chords of small neoplastic cells surround mucin pools]] | ||
| [[Image:800px-Bone Chondrosarcoma Myxoid MP PA.JPG|thumb|350px|Chords of neoplastic cells surround mucin pools]] | | [[Image:800px-Bone Chondrosarcoma Myxoid MP PA.JPG|thumb|350px|Chords of neoplastic cells surround mucin pools]] | ||
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====Clear cell chondrosarcoma==== | ====Clear cell chondrosarcoma==== | ||
*Lobules of uniform to polymorphic densely-packed large cells. | *Lobules of uniform to polymorphic densely-packed large cells. | ||
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*May contain conventional low-grade chondrosarcoma. | *May contain conventional low-grade chondrosarcoma. | ||
*May have secondary aneurysmal bone cyst changes. | *May have secondary aneurysmal bone cyst changes. | ||
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| [[Image:800px-Bone Chondrosarcoma ClearCell HP PA.jpg|thumb|350px|High grade round cells with cytoplasmic clearing]] | |||
| [[Image:800px-Bone Chondrosarcoma ClearCell MP PA.jpg|thumb|350px|The lesion also had areas of more conventional chondrosarcoma]] | |||
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====Dedifferentiated chondrosarcoma==== | ====Dedifferentiated chondrosarcoma==== | ||
*Poorly differentiated (mesenchymal) malignancy. | *Poorly differentiated (mesenchymal) malignancy. | ||
*Well-differentiated cartilaginous component. | *Well-differentiated cartilaginous component. | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Orthopedics]] | [[Category:Orthopedics]] | ||
Revision as of 20:57, 27 August 2015
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Chondrosarcoma Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Chondrosarcoma pathophysiology On the Web |
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American Roentgen Ray Society Images of Chondrosarcoma pathophysiology |
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Risk calculators and risk factors for Chondrosarcoma pathophysiology |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1];Associate Editor(s)-in-Chief: Shivali Marketkar, M.B.B.S. [2]
Overview
Pathophysiology
Microscopic Pathology
In general chondrosarcomas are multilobulated (due to hyaline cartilage nodules) with central high water content and peripheral enchondral ossification. Each chondrosarcoma subtype has specific characteristics:
Mesenchymal chondrosarcoma
Mesenchymal chondrosarcoma is a malignant tumor with a characteristic biphasic pattern:
- Poorly differentiated small round blue cells.
- Islands of well-differentiated hyaline cartilage.
- Progressive maturation of cartilage towards the center.
- Central calcification or bone formation.
- Can have a hemangiopericytomatous vascular pattern.
Myxoid chondrosarcoma
- Myxoid background.
- small cells with eosinophilic cytoplasm.
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Clear cell chondrosarcoma
- Lobules of uniform to polymorphic densely-packed large cells.
- Well defined pushing borders.
- Clear to intensively acidophilic granular cytoplasm with vacuoles.
- Central nuclei with occasional prominent nucleoli.
- Low mitotic rate.
- Clear cell areas lack production of hyaline chondroid matrix.
- Areas with osteoclast-type giant cells mixed with small trabeculae of reactive bone.
- May contain conventional low-grade chondrosarcoma.
- May have secondary aneurysmal bone cyst changes.
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Dedifferentiated chondrosarcoma
- Poorly differentiated (mesenchymal) malignancy.
- Well-differentiated cartilaginous component.
Shown below is a micrograph of chondrosarcoma.(H&E stain)
.jpg)
Video
Below is a video of Extraskeletal Myxoid chondrosarcoma {{#ev:youtube|DxljkFd9xew}}